Louis F. Reichardt, PhD

Harvard University, Cambridge, MA, A.B., 1964, Biology
Stanford University, Stanford, CA, Ph.D., 1972, Biochemistry

• 1972-74
  Research Fellow, University of Geneva
• 1974-77
  Research Fellow, Dept. Neurobiology, Harvard Medical School
• 1977-85
  Asst. to Assoc. Professor, Physiology & Biochemistry/Biophysics, UCSF
• 1985-present
  Professor, Physiology & Biochemistry/Biophysics, UCSF
• 1985-present
  Investigator, Howard Hughes Medical Institute
• l989-present
  Director, Neuroscience Program, UCSF
• 1998-present
  Director, Program in Biological Sciences, UCSF

• 1960-1964
  National Merit Scholar
• 1964-1965
  Fulbright Scholar
• 1964 (declined)
  NSF Fellowship
• 1972-74
  Fellow - Jane Coffin Childs
• 1974-1977
  NRSA Postdoctoral Fellowship
• 1978-1981
  McKnight Scholar
• 1978-1980
  Basil O'Conner Award
• 1979-1983
  Sloan Fellow
• 1980-1982
  Wills Award
• 1985-86
  Guggenheim Fellow
• l988
  Pres. Symp. lecturer, Ann. Mtg, Soc. Neurosci.
• l988, l992
  Grass lecturer
• 1989-96
  Javits Award
• l992
  Fellow, AAAS

• Kim, W.-Y., Fritzsch, B., Serls, A., Bakel, L.A., Huang, E.J., Reichardt, L.F., Barth, D.S., & Lee, J.E. (2001) NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 128: 417-426.
• Mischel, P.S., Smith, S.G., Vining, E.R., Valletta, J.S., Mobley, W.C. & Reichardt, L.F. (2001) The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. J. Biol. Chem. 276: 11294-301.
• Karlsson, M., Mayordomo, R., Reichardt, L.F., Catsicas, S., Karten, H.J., & Hallbook, F. (2001) Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action. Development 128: 471-479.
• Huang, E.J, Liu, W., Fritzsch, B., Bianchi, L.M. Reichardt, L.F., & Xiang, M. (2000). Brn-3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons. Development 128: 2421-38.
• Giehl, K.M., Rohrig, S., Bonatz, H., Gutjahr, M., Leiner, B., Bartke, I., Yan, Q., Reichardt, L.F., Backus, C., Welcher, A.A., Dethleffsen, K., Mestres, P., & Meyer, M. (2001) Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. J. Neuroscience 21: 3492-3502.
• Fariñas, I., Jones, K.R., Tessarollo, L., Vigers, A.J., Huang, E., de Caprona, D.C., Reichardt, L.F., and Fritzsch, B. (2001) Spatial shaping of cochlear innervation by temporally-regulated neurotrophin expression. J. Neuroscience 21: 6170-80.
• Brandenberger, R., Schmidt, A., Linton, J., Wang, D., Denda, S., Müller, U., & Reichardt, L.F. (2001) Identification and Characterization of a Novel ECM Protein Nephronectin that is Associated with Integrin 81 in the Embryonic Kidney. J. Cell Biol. 154: 447-458.
• Rohrer B., LaVail M.M., Jones K.R., & Reichardt L.F. 2001. Neurotrophin Receptor TrkB activation is not required for the postnatal survival of retinal ganglion cells in vivo. Exp Neurol 172:81-91.
• Feltri, M. L., Graus Porta, D., Previtali, S. C., Nodari, A., Migliavacca, B., Cassetti, A., Littlewood-Evans, A., Reichardt, L. F., Messing, A., Quattrini, A., Mueller, U. & Wrabetz, L. (2002). Conditional disruption of beta1 integrin in Schwann cells impedes interactions with axons. J Cell Biol 156, 199-209.
• Rico, B., Xu, B., & Reichardt, L.F. (2002) TrkB receptor signaling is required for the establishment of GABAergic synapses in the cerebellum. Nature Neuroscience 5: 225-233.
• Zhu, J., Motejlek, K., Wang, D., Zang, K., Schmidt, A. & Reichardt, L.F. (2002) 8 integrins are required forvascular morphogenesis in mouse embryos. Development 129, 2891-2903.
• Cronk, K.M., Wilkinson, G.A., Grimes, R., Wheeler, E.F., Jhaveri, S., Fundin, B.T., Silos-Santiago, I., Tessarollo, L., Reichardt, L.F. & Rice, F.L. (2002) Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC. Development 129:3739-3750.
• Funfschilling, U. & Reichardt, L.F. 2002. Cre-mediated recombination in rhombic lip derivatives. Genesis 33: 160-169.
• Jullien, J., Guli, V., Reichardt, L.F., & Rudkin, B.B. 2002. Molecular kinetics of NGF receptor trafficking and activation. J. Biol. Chem. 277:38700-708.
• Rohrer, B., Matthes, M., LaVail, M.M. & Reichardt, L.F. 2002. lack of p75 does not protect photoreceptors from light induced cell death. Exper. Eye Res. 76: 125-129.
• Jullien, J., Guili, V., Ibanez, C., Reichardt, L.F. & Rudkin, B.B. 2002. Trafficking of TrkA-GFP chimera during NGF-induced differentiation. J. Biol. Chem. 278: 8706-16.
• Tran, P.V., Lee, M.B., Marin, O., Xu, B., Jones, K.R., Reichardt, L.F. Rubenstein, J.R. & Ingraham, H.A. (2003) Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventral medial hypothalamic neurons. Molec. Cell. Neurosci.22: 441-453.
• Xu, B., Goulding, E., Zang, K., Cepoi, D., Cone, R.D., Jones, K.R., Tecott, L.H., & Reichardt, L.F. (2003). Brain-derived Neurotrophic Factor is a Component of the Melanocortin-4 Receptor Pathway in the Regulation of Energy Balance. Nature Neuroscience 6: 736-742.
• Elul, T.M., Kimes, N.E., Kohwi, M., & Reichardt, L.F. (2003) Amino- and carboxyl-terminal domains of beta catenin initiate and shape axon arbors in retinal ganglion cells in vivo. J. Neuroscience 23:6567-6575.
• Beggs, H.E., Schahin-Reed, D., Sretavan, D., Zang, K., Jones, K.R. Goebbels, S., Nave, K.-A., & Reichardt, L.F. (2003) FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron 40: 501-514.
• Bamji, S.X., Shimazu, K., Kimes, N., Huelsken, J., Birchmeier, W., Lu, B., & Reichardt, L.F. (2003) Role of -catenin in synaptic vesicle localization and presynaptic assembly. Neuron. 40: 719-731.
• Paredes, A., Romero, C., Disen, G.A., DeChiara, T.M., Reichardt, L.F., Cornea, A., Ojeda, S.R. & Xu, B. (2004) TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary. Dev. Biol. 267: 430-449.
• Blaess, S., Graus-Porta, D., Belvindrah, R., Radakovits, R., Pons, S., Littlewood-Evans, A., Senften, M., Guo, H., Li, Y., Miner, J.H., Reichardt, L.F. & Müller, U. (2004) Defective Granule Cell Precursor Proliferation in the Absence of 1-Class Integrins. J. Neuroscience 24: 3402-3412.
• Chan, J.R., Watkins, T.A., Cosgaya, J.M., Zhang, C.-Z., Chen, L., Reichardt, L.F., Shooter, E.M., & Barres. B.A. (2004) NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron 43: 183-191.
• Moqrich, A., Earley, T.J., Watson, J., Andahazy, M., Backus, C., Martin-Zanca, D., Wright, D.E., Reichardt, L.F. & Patapoutian, A. (2004) Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nature Neuroscience 7: 812-818.
• Rico, B., Beggs, H.E., Schahin-Reed, D., Kimes, N., Schmidt, A. & Reichardt. (2004) Control of axonal branching and synapse formation by focal adhesion kinase. Nature Neuroscience 7: 1059-1069.
• Liu, G, Beggs, H., Jürgensen, C., Park, H.-T., Tang, H., Gorski, J. , Jones K. R., Reichardt, L. F., Wu, J., & Rao, Y. 2004. Netrin Requires the Focal Adhesion Kinase and the Src Family Kinases to Induce Axon Outgrowth and Attraction. Nature Neuroscience 7: 1222-32.
• Wiggins, A. K., Wei, G., Doxakis, E., Wong, C., Tang, A. A., Zang, K., Luo, E. J., Neve, R. L., Reichardt, L. F., and Huang, E. J. (2004): Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol. 167:257-267.
• Rohrer, B., Blanco, R., Marc, R.E., Bok, D., Schneeweis, D., & Reichardt, L.F. (2004) Functional glutamate-mediated pathways in the trkB mutant retina. Visual Neuroscience. In press
• Funfschilling, U., Ng, Y.-G., Zang, K., Miyazaki, J.-I., Reichardt, L.F., & Rice, F.L. TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and non-neuronal cells. J. Comp. Neurol. 480: 392-414.