rischn@humgen.ucsf.edu
(415) 476-1127 (voice)

Box 0794, UCSF; San Francisco, CA 94143-0794

additional websites:

Institute for Human Genetics

California Institute of Technology, BS, 1972, Mathematics
Univ of Illinois at Urbana, MS, 1973, Mathematics
Univ of California, Los Angeles, PhD, 1979, Biomathematics

Hallmayer, J., Glasson E.J., Bower, C., Petterson, B., Croen, L., Grether, J., Risch, N. "On the twin risk in autism." Am J Hum Genet 71:941-946, 2002

Shifman, S., Bronstein, M., Sternfeld, M., Pisante-Shalom, A., Lev-Lehman, E., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L., Schiffer R., Kotler, M., Strous, R.D., Swartz-Vanetik, M., Knobler, H.Y., Shinar, E., Beckmann, J.S., Yakir, B., Risch, N., Zak, N.B., Darvasi, A. "A highly significant association between COMT haplotype and schizophrenia." Am J Hum Genet 71:1296-1302, 2002

Bressman, S.B., Raymond, D., Wendt, K., Saunders-Pullman, R., DeLeon, D., Fahn, S., Ozelius, L., Risch, N. "Diagnostic criteria for dystonia in DYT1 families." Neurology 10:1780-1782, 2002

Ranade, K., Hinds, D., Hsiung, A., Chuang, L-M., Chang, M-S., Chen, Y-T., Pesich, R., Hebert, J., Chen, Y.I., Dzau, V., Olshen, R., Curb, D., Botstein, D., Cox, D.R., Risch, N. "A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins." Am J Hypertens 16:158-162, 2003

Kim, U.K., Jorgenson, E., Coon, H., Leppert, M., Risch, N., Drayna, D. "Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide." Science 299:1221-1225, 2003

Botstein, D., Risch, N. "Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease." Nat Genet 33 Suppl:228-237, 2003

Risch, N., Tang, H., Katzenstein, H., Ekstein, J. "Geographic distribution of disease mutations in the Ashkenazi Jewish population supports genetic drift over selection." Am J Hum Genet 72:812-822, 2003

Burchard, E.G., Ziv, E., Coyle, N., Lin-Gomez, S., Tang, H., Karter, A.J., Mountain, J.L, Perez-Stable, E.J., Sheppard, D., Risch, N. "The importance of race and ethnic background in biomedical research and clinical practice." N Engl J Med 348:1170-1175, 2003

Merikangas, K.R., Risch, N. "Will the genomics revolution revolutionize psychiatry?" Am J Psychiatry 160:625-635, 2003

Leabman, M.K., Huang, C.C., DeYoung, J., Carlson, E.J., Taylor, T.R., de la Cruz, M., Johns, S.J., Stryke, D., Kawamoto, M., Urban, T.J., Kroetz, D.L., Ferrin, T.E., Clark, A.G., Risch, N., Herskowitz, I., Giacomini, K.M. "Natural variation in human membrane transporter genes reveals evolutionary and functional constraints." Proc Natl Acad Sci USA 100:5896-5901, 2003

Willer, C.J., Dyment, D.A., Risch, N.J., Sadovnick, A.D., Ebers, G.C. "Twin concordance and sibling recurrence rates in multiple sclerosis." Proc Natl Acad Sci USA 100:12877-12882, 2003

McIntire, J.J., Umetsu, S.E., Macaubas, C., Hoyte, E.G., Cinnioglu, C., Cavalli-Sforza, L.L., Barsh, G.S., Hallmayer, J.F., Underhill, P.A., Risch, N.J., Freeman, G.J., DeKruyff, R.H., Umetsu, D.T. "Immunology: hepatitis A virus link to atopic disease." Nature 425:576, 2003

Varon-Mateeva, R., Gooding, R., Steglich, C., Marns, L., Tang, H., Angelicheva, D., Yong, K.K., Ambrugger, P., Reinhold, A., Morar, B., Baas, F., Kwa, M., Tournev, I., Guerguelcheva, V., Kremensky, I., Lochmuller, H., Mullner-Eidenbock, A., Merlini, L., Neumann, L., Burger, J., Walter, M., Swoboda, K., Thomas, P.K., von Moers, A., Risch, N., Kalaydjieva, L. "Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome." Nat Genet 35:185-189, 2003

Tukel, T., Shalata, A., Present, D., Rachmilewitz, D., Mayer, L., Grant, D., Risch, N., Desnick, R.J. "Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families." Am J Hum Genet 74:623-636, 2004

Li, J., Nguyen, L., Gleason, C., Lotspeich, L., Spiker, D., Risch, N., Myers, R.M. "Lack of evidence for an association between WNT2 and RELN polymorphisms and autism." Am J Med Genet 126B:51-57, 2004

Dyment, D.A., Sadovnick, A.D., Willer, C.J., Armstrong, H., Cader, Z.M., Wiltshire, S., Kalman, B., Risch, N., Ebers, G.C. "An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group." Hum Mol Genet 13:1005-1015, 2004

Ebers, G.C., Sadovnick, A.D., Dyment, D.A., Yee, I.M., Willer, C.J., Risch, N. "Parent-of-origin effect in multiple sclerosis: observations in half siblings." Lancet 363:1773-1774, 2004

Dyment, D.A., Steckley, J.L., Morrison, K., Willer, C.J., Cader, M.Z., DeLuca, G.C., Sadovnick, A.D., Risch, N., Ebers, G.C. "TCR beta polymorphisms and multiple sclerosis." Genes Immun 5:337-342, 2004

Huang, J., Lin, A., Narasimhan, B., Quertermous, T., Hsuing, C.A., Ho, L.T., Grove, J.S., Olivier, M., Ranade, K., Risch, N.J., Olshen, R.A. "Tree-structured supervised learning and the genetics of hypertension." Proc Natl Acad Sci USA 101:10529-10534, 2004

Ekstein, J., Rubin, B.Y., Anderson, S.L., Weinstein, D.A., Bach, G., Abeliovich, D., Webb, M., Risch, N. "Mutation frequencies for glycogen storage disease Ia in the Ashkenazi Jewish population." Am J Med Genet 30;129A(2):162-4, 2004

Heiman, G.A., Ottman, R., Saunders-Pullman, R.J., Ozelius, L.J., Risch, N.J., Bressman, S.B. "Increased risk for recurrent depression in DYT1 dystonia mutation carriers." Neurology 24;63(4):631-7. 2004

Mountain, J.L., Risch, N. "Assessing genetic contributions to phenotypic differences among 'racial' and 'ethnic' groups." Nat Genet 36(11 suppl):S48-53, 2004

Tang, H., Quertermous, T., Rodriguez, B., Kardia, S.L., Zhu, X., Brown, A., Pankow, J.S., Province, M.A., Hunt, S.C., Boerwinkle, E., Shork, N.J., Risch, N.J. "Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies." Am J Hum Genet, 76(2):268-75, 2005

Jorgenson, E., Tang, H., Gadde, M., Province, M., Leppert, M., Kardia, S., Schork, N., Cooper, R., Rao, D.C., Boerwinkle, E., Risch, N. "Ethnicity and human genetic linkage maps." Am J Human Genet 76(2):276-90, 2005. Winner of the Cotterman Prize, American Society of Human Genetics, 2005.

Zhu, X., Luke, A., Cooper, R.S., Quertermous, T., Hanis, C., Mosley, T., Gu, C.C., Tang, H., Rao, D.C., Risch, N., Weder, A. "Admixture mapping for hypertension loci with genome-scan markers." Nat Genet 37(2):177-81, 2005

Urban, T.J., Giacomini, K.M., Risch, N. "Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Chrohn's disease." Inflamm Bowel Dis 11(1):78-9, 2005

Tang, H., Peng, J., Wang, P., Risch, N.J. "Estimation of individual admixture: analytical and study design considerations." Genet Epidemiol 28:289-301, 2005

Chiu, Y.F., Chuang, L.M, Hsiao, C.F., Hung, Y.J., Lin, M.W, Chen, Y.T., Grove, J., Jorgenson, E., Quertermous, T., Risch, N., Hsiung, C.A. "An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistence Family Study." Diabetes 54:1200-6, 2005

Salari, K., Choudhry, S., Tang, H., Naqvi, M., Lind, D., Avila, P.C., Coyle, N.E., Ung, N., Nazario, S., Casal, J., Torres-Palacios, A., Clark, S., Phong, A., Gomez, I., Matallana, H., Perez-Stable, E.J., Shriver, M.D., Kwok, P.Y., Sheppard, D., Rodriguez-Cintron, W., Risch, N.J., Burchard, E.G., Ziv, E. "Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics." Genet Epidemiol 29:76-86, 2005

Dyment, D.A., Herrera, B.M., Cader, M.Z., Willer, C.J., Lincoln, M.R., Sadovnick, A.D., Risch, N., Ebers, G.C. "Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance." Hum Mol Genet 14:2019-26, 2005

Gonzalez Burchard, E., Borrell, L.N., Choudhry, S., Naqvi, M., Tsai, H.J., Rodriguez-Santana, J.R., Chapela, R., Rogers, S.D., Mei, R., Rodriguez-Cintron, W., Arena, J.F., Kittles, R., Perez-Stable, E.J., Ziv, E., Risch, N. "Latino populataions: a unique opportunity for the study of race, genetics and social environment in epidemiological research." Am J Public Health 95:2161-8, 2005

Urban T.J., Sebro, R., Hurowitz, E.H., Leabman, M.K., Badagnani, I., Lagpacan, L.L., Risch, N., Giacomini, K.M. "Functional genomics of membrane transporters in human populations." Genome Res 16:223-230, 2006

Choudhry, S., Coyle, N.E., Tang, H., Salari, K., Lind, D., Clark, S.L., Tsai, H.J., Naqvi, M., Phong, A., Ung, N., Matallana, H., Avila, P.C., Casal, J., Torres, A., Nazario, S., Castro, R., Battle, N.C., Perez-Stable, E.J., Kwok, P.Y., Sheppard, D., Shriver, M.D., Rodriguez-Cintron, W., Risch, N., Ziv, E., Burchard, E.G. "Genetics of Asthma in Latino Americans (GALA) Study. Population stratification confounds genetic association studies among Latinos." Hum Genet 118:652-64, 2006

Ozelius, L.J., Senthil, G., Saunders-Pullman, Ohmann, E., Deligtisch, A., Tagliata, M., Hunt, A.L., Klein, C., Henick, B., Hailpern, S.M., Lipton, R.B., Soto-Valencia, J., Risch, N., Bressman, S.B. "LRRK2 G2019S as a cause of Parkinson's Disease in Ashkenazi Jews." N Engl J Med 354:424-425, 2006

Tang, H., Jorgenson, E., Gadde M., Karda, S.L., Rao, D.C., Zhu, X., Schork, N.J., Hanis, C.L., and Risch, N. Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans. Hum Gen 119:624-33, 2006.

Gunderson, E.P., Tsai, A.L., Selby, J.V., Caan, B., Mayer-Davis, E.J., and Risch, N. Twins of mistaken zygosity (TOMZ): Evidence for genetic contributions to dietary patterns and physiologic traits. Twin Res Hum Gen 9:540-549, 2006.

11/21/06