Jeroen Roose, PhD

University of Utrecht, The Netherlands, MS, 1993, Medical Biology
University of Utrecht, The Netherlands, PhD, 1999, Immunology/Transcription
University of Utrecht, The Netherlands, Fellowship, 1997-1999, Immunology/Transcription
University of California San Francisco, San Francisco, Fellowship, 1999-2004, Immunology/Signaling

• 2004-2006
  Adjunct Instructor, Div. of Rheumatology, Dept. of Medicine, UCSF, San Francisco
• 2006-2007
  Assistant Adjunct Professor, Div. of Rheumatology, Dept. of Medicine, UCSF, San Francisco
• 2007-present
  Assistant Professor, Dept. of Anatomy, School of Medicine, UCSF, San Francisco

• 2006
  Howard Temin Career Development Award (K01; NCI/NIH)
• 2006
  Arthritis Investigator Award
• 2008
  Sydney Kimmel Foundation Award
• 2009
  Physical Science – Oncology Center (PSOC) Award (U54; NCI/NIH)
• 2011
  Program grant (P01; NIAID/NIH)
• 2012
  Gabrielle’s Angel Foundation for Cancer Research Award

• Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, van de Wetering M, Destree O, Clevers H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 1998 Oct 8;395(6702):608-12.
• Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 1999 Sep 17;285(5435):1923-6.
• Roose J, Diehn M, Tomlinson M, Lin J, Alizadeh A, Botstein D, Brown P, Weiss A. T cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG gene Expression. PLOS Biology. 2003 1(2):271-287.
• Roose J, Mollenauer M, Gupta V, Stone J, and Weiss A. A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation Upon Antigen Receptor Stimulation of T cells. Mol. Cell Biol. 2005 25(11);4426-41.
• Roose J, Mollenauer M, Ho M, Kurosaki T, and Weiss A. Unusual Interplay of Two Types of Ras Activators, RasGRP and SOS, Establishes Robust and Controlled Ras Activation in Lymphocytes. Mol Cell Biol. 2007 27(7):2732-45
• Ashok Prasad, Julie Zikherman, Jayajit Das, Jeroen Roose, Arthur Weiss, Arup K. Chakraborty. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. PNAS. 2009 Jan 13;106(2):528-33.
• Jayajit Das, Mary Ho, Julie Zikherman, Christopher Gover, Ming Yang, Arthur Weiss, Arup K. Chakraborty, and Jeroen P. Roose. Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell. 2009 136, 337-351.
• Jennifer O. Lauchle, Doris Ki, Doan T. Le, Keiko Akagi, Michael Crone, Kimberly Krisman, Kegan Warner, Jeannette M. Bonifas, Qing Li, Kristin M. Coakley, Ernesto Diaz-Flores, Matthew Gorman, Sally Przybranowski, Mary Tran, Scott C. Kogan, Jeroen P. Roose, Neal Copeland, Nancy Jenkins, Luis Parada, Linda Wolff, Judith Sebolt-Leopold, and Kevin Shannon. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature. 2009 Sep 17;461(7262):411-4.
• Andre Limnander, Philippe Depeille, Jen Liou, Micheal Leitges, Jeroen P. Roose, and Arthur Weiss. Stim1 and PKCδ Set a Threshold for Activation of Pro-Apoptotic Erk Signaling During B cell Development. Nature Immunology, May 2011.
• Evan Markegard, Evan Trager, Chih-wen Ou Yang, Weiguo Zhang, Arthur Weiss, and Jeroen P. Roose. Basal LAT-diacylglycerol-RasGRP1 Signals in T cells Maintain TCR-alpha Gene Expression. PLoS ONE, 2011;6(9):e25540. Epub 2011 Sep 26.