jeroen.roose@ucsf.edu
(415) 476-3977 (voice)
(415) 476-4845 (fax)

Box 0452, UCSF; San Francisco, CA 94143-0452

University of Utrecht, The Netherlands, MS, 1993, Medical Biology
University of Utrecht, The Netherlands, PhD, 1999, Immunology/Transcription
University of Utrecht, The Netherlands, Fellowship, 1997-1999, Immunology/Transcription
University of California San Francisco, San Francisco, Fellowship, 1999-2004, Immunology/Signaling

Toye PG, Metzelaar MJ, Wijngaard PL, Nene V, Iams K, Roose J, Nyanjui JK, Gobright E, Musoke AJ, Clevers HC. Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva. J Immunol. 1995 Aug 1;155(3):1370-81.

Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destree O, Clevers H. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell. 1996 Aug 9;86(3):391-9.

Korver W, Roose J, Clevers H. The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 1;25(9):1715-9.

Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics. 1997 Dec 15;46(3):435-42.

Korver W, Roose J, Wilson A, Clevers H.The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes. Immunobiology. 1997 Dec;198(1-3):157-61.

Roose J, Korver W, Oving E, Wilson A, Wagenaar G, Markman M, Lamers W, Clevers H. High expression of the HMG box factor sox-13 in arterial walls during embryonic development. Nucleic Acids Res. 1998 Jan 15;26(2):469-76.

Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56.

Molenaar M, Roose J, Peterson J, Venanzi S, Clevers H, Destree O. Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development. Mech Dev. 1998 Jul;75(1-2):151-4.

Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M, Bejsovec A. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 1998 Oct 8;395(6702):604-8.

Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, van de Wetering M, Destree O, Clevers H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 1998 Oct 8;395(6702):608-12.

Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H. The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Genomics. 1999 Apr 15;57(2):301-5.

Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 1999 Sep 17;285(5435):1923-6.

Molenaar M, Brian E, Roose J, Clevers H, Destree O. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mech Dev. 2000 Mar 1;91(1-2):311-5.

Lawrence N, Dearden P, Hartley D, Roose J, Clevers H, Arias AM. dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila. Int J Dev Biol. 2000 Oct;44(7):749-56.

Roose J, Brantjes H, van De Wetering M, Clevers H. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res. 2001 Apr 1;29(7):1410-9.

Roose J, Diehn M, Tomlinson M, Lin J, Alizadeh A, Botstein D, Brown P, Weiss A. T cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG gene Expression. PLOS Biology. 2003 1(2):271-287.

Roose J, Mollenauer M, Gupta V, Stone J, and Weiss A. A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation Upon Antigen Receptor Stimulation of T cells. Mol. Cell Biol. 2005 25(11);4426-41.

Brdicka T, Kadlecek T, Roose J, Pastuszak A, and Weiss A. Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases. Mol. Cell Biol. 2005 25(12);4924-4933.

Nirula A, Ho M, Phee H, Roose J, and Weiss A. Phosphoinositide-dependent kinase-1 (PDK1) targets Protein Kinase A (PKA) in a pathway that regulates interleukin-4 (IL-4). J Exp Med. 2006 203(7):1733-44

Roose J, Mollenauer M, Ho M, Kurosaki T, and Weiss A. Unusual Interplay of Two Types of Ras Activators, RasGRP and SOS, Establishes Robust and Controlled Ras Activation in Lymphocytes. Mol Cell Biol. 2007 27(7):2732-45

3/10/08