UCSF Helen Diller Family Comprehensive Cancer Center

Photo of Steven D. Rosen, PhD  Steven D. Rosen, PhD

Professor and Vice-Chair, Department of Anatomy, UCSF

Member, UCSF Biomedical Sciences Graduate Program (BMS)
Member, UCSF Herbert W. Boyer Program in Biological Sciences (PIBS)
Member, UCSF Immunology Graduate Program

Contact

.(JavaScript must be enabled to view this email address)
(415) 476-1579 (voice)
(415) 476-4845 (fax)

Box 0452, UCSF; San Francisco, CA 94143-0452

Education

University of California, Berkeley, CA, B.A., 1966, Physics
Cornell University, Ithaca, NY, Ph.D., 1972, Neurobiology
University of California, San Diego, CA, Postdoc, 1972-76, Cell Biology

Professional Experience

  • 1976-1982
    Assistant Professor, University of California, Anatomy
  • 1982-1986
    Associate Professor of Anatomy, University of California, San Francisco
  • 1987-present
    Professor of Anatomy, University of California, San Francisco
  • 1989-present
    Member, Program in Immunology, UCSF
  • 1992-present
    Member, Biomedical Sciences Program, UCSF
  • 1999-present
    Investigator, Cardiovascular Research Institute, UCSF
  • 2000-present
    Program Member, Comprehensive Cancer Center, UCSF
  • 2001-present
    Member, Steering Committee, NIH Consortium for Functional Glycomics
  • 2005-present
    Vice-Chair and Executive Committee, Dept of Anatomy

Honors & Awards

  • Phi Beta Kappa
  • American Cancer Society Postdoctoral Fellowship
  • Phi Kappa Phi
  • NIH Career Development Award
  • 1993
    Feulgen Lecture
  • 2005
    Keynote address to Keystone Symposium on Complex Carbohydrates
  • 1996-2006
    NIH Merit Award

Selected Publications

  • Stoolman, L.M. and Rosen, S.D. (1983). A possible role for a cell surface carbohydrate binding molecule in lymphocyte recirculation. J. Cell Biol. 96:722-729.
  • Rosen, S.D., Singer, M.S., Yednock, T.A. and Stoolman, L.M. Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation. Science 228:1005-1009.
  • Yednock, T.A., Butcher, E.C., Stoolman, L.M. and Rosen, S.D. (1987) Receptors involved in lymphocyte homing: Relationship between a carbohydrate-binding receptor and the MEL-14 antigen. J. Cell Biol. 104:725-731.
  • Lasky, L.A., Singer, M.S., Yednock, T.A., Dowbenko, D., Fennie, C., Rodriguez, H., Nguyen, T., Stachel, S. and Rosen, S.D. (1989). Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell. 56:1045-1055.
  • Imai, Y., True, D.D., Singer, M. S. and Rosen, S.D. (1990. Direct demonstration of the lectin activity of gp 90MEL, a lymphocyte homing receptor. J. Cell Biology 111:1225-1232..
  • Imai, Y., Singer, M.S., Fennie, C., Lasky, L.A. and Rosen, S.D. (1991). Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. J. Cell Biology 113:1213-1221.
  • Ley, K., Gaehtgens, P., Fennie, C., Lasky, L.A., Singer, M.S. and Rosen, S.D. (1991). Inhibition of leukocyte rolling in mesenteric venules by homing receptor-IgG chimera. Blood 77:2553-2555..
  • Lasky, L.A., Singer, M.S., Dowbenko, D., Imai, Y., Henzel, E.J., Fennie, C., Gillett, N., Watson, S.R., and Rosen, S.D. (1992). An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell, 69:927-938.
  • Imai, Y., Lasky, L.A., and Rosen, S.D. (1993). Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin. Nature, 361: 555- 557.
  • Hemmerich, S., Butcher, E. C. and Rosen, S. D. (1994). Sulfation-dependent recognition of HEV-ligands by L-selectin and MECA 79, an adhesion-blocking mAb. J. Exp. Med. 180: 2219-2226
  • Hemmerich, S., Bertozzi, C., Leffler, H. and Rosen, S.D. (1994). Identification of the sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin. Biochemistry 33, 4820-4829.
  • Hemmerich, S., Leffler, H., and Rosen, S. D. (1995). Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin. J. Biol. Chem. 270: 12035-12047.
  • Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D., and Williams, L. T. (1998) A chemokine expressed in lymphoid high endothelial venules promotes adhesion and chemotaxis of naive T lymphocytes. PNAS. 95: 258-63.
  • Sassetti, C., Tangemann, K., Singer, M. S., Kershaw, D. B., and Rosen, S. D. (1998). Identification of podocalyxin as an HEV ligand for L-selectin: parallels to CD34. J. Exp. Med. 187: 1965-1975.
  • Tangemann, K., Giblin, P., Gunn, M. D., and Rosen, S. D. (1998). A high endothelial cell derived chemokine induces rapid, efficient, and subset-selective arrest of rolling T-lymphocytes on a reconstituted endothelial substrate. J. Immunol 161: 6330-7337
  • Bistrup, A., Bhakta, S., Lee, J. K., Belov, Y. C., Gunn, M. D., Zuo, F.-R., Huang, C.-C., Kannagi, R., Rosen, S. D., and Hemmerich, S. (1999). Sulfotransferases of two specificities function in the reconstitution of high-endothelial-cell ligands for L-Selectin. J. Cell Biol. 145, 899-910.
  • Tangemann, K., Bistrup, A., Hemmerich, S., and Rosen, S. D. (1999). Sulfation of an HEV-expressed ligand for L-selectin: effects on tethering and rolling of lymphocytes. J. Exp. Med. 190, 935-941. .
  • Sassetti, C., Van Zante, M., and Rosen, S. D. (2000). Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. J. Biol. Chem.275, 9001-9010.
  • Palmeri, D., van Zante, A., Huang, C.C., Hemmerich, S. and Rosen, S.D. (2000). Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J. Biol. Chem. 275, 19139-19145.
  • Bruehl, R.E., Bertozzi, C.R. and Rosen, S.D. (2000). Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody. J. Biol. Chem. 275: 32642-8.
  • Hemmerich, S. and Rosen, S.D. (2000). Carbohydrate sulfotransferases in lymphocyte homing. Glycobiol.. 10, 849-856.
  • Hemmerich, S., Lee, J.K., Bhakta, S., Bistrup, A., Ruddle, N.R. and Rosen, S.D. (2001). Chromosomal localization and genomic organization for the GST sulfotransferase gene family. Glycobiology.11, 75-87
  • Hemmerich, S., Bistrup, A., Singer, M.S., van Zante, A., Lee, J.K., Tsay, D., Peters, M., Carminati, J.L., Brennan, T.J., Carver-Moore, K., Leviten, M., Fuentes, M.E., Ruddle, N.H. and Rosen, S.D. (2001). Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity 15, 237-247.
  • Morimoto-Tomita, M, Uchimura, K., Werb, Z., Hemmerich, S. H. and Rosen, S.D. (2002). Cloning and characterization of two extracellular heparin-degrading endosulfatases in mouse and human, J Biol. Chem 277:49175-49185.
  • Lee, J. K, Bistrup, A., and Rosen, S.D. (2003). Activities and expression pattern of the carbohydrate sulfotransferase, GlcNAc6ST-3 (I-GlcNAc6ST): functional implications, Glycobiology, 13:254-54
  • Fieger, C., Sassetti, C, and Rosen, S.D. (2003). Endoglycan, a member of the CD34 family, functions as a L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J. Biol. Chem. 278:27390-27398.
  • Van Zante, M., Gauguet, J-M., Bistrup. A., Tsay, D., Von Andrian, U., and Rosen, S.D. (2003). Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. J Exp. Med, 198:1289-1300.
  • Rosen, S.D. Ligands for L-selectin: homing, inflammation and beyond. (2004). Ann Rev. Immunol. 22:129-156.
  • Palmeri, D., Zuo, Feng-Rong, Rosen, S. D. and Hemmerich, S. (2004). Differential Gene Expression Profile of Human Tonsil High Endothelial Cells: Implications for Lymphocyte Trafficking. J. Leukocyte Research, 75:910-927.
  • Bistrup, A., Tsay, D., Shenoy, P., Banglia, N., Luther, S., Cyster, J.G., Ruddle, N.H., and Rosen, S.D. (2004). Detection of a Sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in HEV-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope, Am J Pathol. 164: 1635-44.
  • Gauget, J, M, Rosen, S.D., Marth, J., and Von Andrian, U. (2004) CORE2GlcNAcT-I and HEC-GlcNAc6ST exert differential control over B and T lymphocyte homing to peripheral lymph nodes, Blood, 104: 4104-12
  • Uchimura, K., Kadomatsu, K., El-Fasakhany, F. M., Singer, M. S., Izawa, M, Kannagi, R., Takeda, N., Rosen, S. D., and Muramatsu, T. (2004). N-acetylglucosamine 6-O-Sulfotransferase-1 Regulates Lymphocyte Homing and Expression of Abluminal L-Selectin Ligands in High Endothelial Venules of Lymph Nodes, J. Biol. Chem 279:35001-8
  • Rosen, S.D., Tsay, D., Singer, M.S., Hemmerich, S., and Abraham, W.M. (2005). Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma. Am. J. Pathol. 166: 935-44
  • Pablos, J.L., B. Santiago, D. Tsay, M.S. Singer, G. Palao, M. Galindo, and S.D. Rosen. (2005). A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells. BMC Immunol. 6
  • Uchimura, K., Gauguet, J.-M., Singer, M.S., Tsay, D., Kannagi, R., Muramatsu, T., von Andrian, U.H., and Rosen, S.D. (2005). A major class of L-selectin ligands is eliminated into mice deficient in two high endothelial venule-expressed sulfotransferases. Nat Immunol 6:1105-13.
  • Morimoto-Tomita, M., Uchimura, K., Bistrup, A., Lum, D.H., Egeblad, M., Werb, Z., and Rosen, S.D. (2005). Sulf-2, a pro-angiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia 7: 1001-1010
  • Uchimura, K., Morimoto-Tomita, M., Bistrup, A., Li, J., Lyon, M., Gallagher, J., Werb, Z., and Rosen, S.D. (2006). HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochemistry 7:2.
  • Rosen, S.D. (2006). Homing in on L-selectin. J. Immunol 177: 3-4.
  • Yang, J., S. D. Rosen, P. Bendele, and S. Hemmerich. (2006). Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. BMC Immunol 7:12.

Updated: September 21, 2010