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Helen Diller Family Compr Cancer Ctr
STEVEN D. ROSEN, PHD

Vice-Chair, Dept of Anatomy, UCSF
Member, UCSF Biomedical Sciences Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)

CONTACT

sdr@itsa.ucsf.edu
(415) 476-1579 (voice)
(415) 476-4845 (fax)

Box 0452, UCSF; San Francisco, CA 94143-0452

EDUCATION

University of California, Berkeley, CA, B.A., 1966, Physics
Cornell University, Ithaca, NY, Ph.D., 1972, Neurobiology
University of California, San Diego, CA, Postdoc, 1972-76, Cell Biology

PROFESSIONAL EXPERIENCE

1976-1982

Assistant Professor, University of California, Anatomy

1982-1986

Associate Professor of Anatomy, University of California, San Francisco

1987-present

Professor of Anatomy, University of California, San Francisco

1989-present

Member, Program in Immunology, UCSF

1992-present

Member, Biomedical Sciences Program, UCSF

1999-present

Investigator, Cardiovascular Research Institute, UCSF

2000-present

Program Member, Comprehensive Cancer Center, UCSF

2001-present

Member, Steering Committee, NIH Consortium for Functional Glycomics

2005-present

Vice-Chair and Executive Committee, Dept of Anatomy

HONORS & AWARDS

Phi Beta Kappa

American Cancer Society Postdoctoral Fellowship

Phi Kappa Phi

NIH Career Development Award

1993

Feulgen Lecture

2005

Keynote address to Keystone Symposium on Complex Carbohydrates

1996-2006

NIH Merit Award

SELECTED PUBLICATIONS

(selected from 151)

Stoolman, L.M. and Rosen, S.D. (1983). A possible role for a cell surface carbohydrate binding molecule in lymphocyte recirculation. J. Cell Biol. 96:722-729.

Rosen, S.D., Singer, M.S., Yednock, T.A. and Stoolman, L.M. Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation. Science 228:1005-1009.

Yednock, T.A., Butcher, E.C., Stoolman, L.M. and Rosen, S.D. (1987) Receptors involved in lymphocyte homing: Relationship between a carbohydrate-binding receptor and the MEL-14 antigen. J. Cell Biol. 104:725-731.

Lasky, L.A., Singer, M.S., Yednock, T.A., Dowbenko, D., Fennie, C., Rodriguez, H., Nguyen, T., Stachel, S. and Rosen, S.D. (1989). Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell. 56:1045-1055.

Imai, Y., True, D.D., Singer, M. S. and Rosen, S.D. (1990. Direct demonstration of the lectin activity of gp 90MEL, a lymphocyte homing receptor. J. Cell Biology 111:1225-1232..

Imai, Y., Singer, M.S., Fennie, C., Lasky, L.A. and Rosen, S.D. (1991). Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. J. Cell Biology 113:1213-1221.

Ley, K., Gaehtgens, P., Fennie, C., Lasky, L.A., Singer, M.S. and Rosen, S.D. (1991). Inhibition of leukocyte rolling in mesenteric venules by homing receptor-IgG chimera. Blood 77:2553-2555..

Lasky, L.A., Singer, M.S., Dowbenko, D., Imai, Y., Henzel, E.J., Fennie, C., Gillett, N., Watson, S.R., and Rosen, S.D. (1992). An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell, 69:927-938.

Imai, Y., Lasky, L.A., and Rosen, S.D. (1993). Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin. Nature, 361: 555- 557.

Hemmerich, S., Butcher, E. C. and Rosen, S. D. (1994). Sulfation-dependent recognition of HEV-ligands by L-selectin and MECA 79, an adhesion-blocking mAb. J. Exp. Med. 180: 2219-2226

Hemmerich, S., Bertozzi, C., Leffler, H. and Rosen, S.D. (1994). Identification of the sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin. Biochemistry 33, 4820-4829.

Hemmerich, S., Leffler, H., and Rosen, S. D. (1995). Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin. J. Biol. Chem. 270: 12035-12047.

Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D., and Williams, L. T. (1998) A chemokine expressed in lymphoid high endothelial venules promotes adhesion and chemotaxis of naive T lymphocytes. PNAS. 95: 258-63.

Sassetti, C., Tangemann, K., Singer, M. S., Kershaw, D. B., and Rosen, S. D. (1998). Identification of podocalyxin as an HEV ligand for L-selectin: parallels to CD34. J. Exp. Med. 187: 1965-1975.

Tangemann, K., Giblin, P., Gunn, M. D., and Rosen, S. D. (1998). A high endothelial cell derived chemokine induces rapid, efficient, and subset-selective arrest of rolling T-lymphocytes on a reconstituted endothelial substrate. J. Immunol 161: 6330-7337

Bistrup, A., Bhakta, S., Lee, J. K., Belov, Y. C., Gunn, M. D., Zuo, F.-R., Huang, C.-C., Kannagi, R., Rosen, S. D., and Hemmerich, S. (1999). Sulfotransferases of two specificities function in the reconstitution of high-endothelial-cell ligands for L-Selectin. J. Cell Biol. 145, 899-910.

Tangemann, K., Bistrup, A., Hemmerich, S., and Rosen, S. D. (1999). Sulfation of an HEV-expressed ligand for L-selectin: effects on tethering and rolling of lymphocytes. J. Exp. Med. 190, 935-941. .

Sassetti, C., Van Zante, M., and Rosen, S. D. (2000). Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. J. Biol. Chem.275, 9001-9010.

Palmeri, D., van Zante, A., Huang, C.C., Hemmerich, S. and Rosen, S.D. (2000). Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J. Biol. Chem. 275, 19139-19145.

Bruehl, R.E., Bertozzi, C.R. and Rosen, S.D. (2000). Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody. J. Biol. Chem. 275: 32642-8.

Hemmerich, S. and Rosen, S.D. (2000). Carbohydrate sulfotransferases in lymphocyte homing. Glycobiol.. 10, 849-856.

Hemmerich, S., Lee, J.K., Bhakta, S., Bistrup, A., Ruddle, N.R. and Rosen, S.D. (2001). Chromosomal localization and genomic organization for the GST sulfotransferase gene family. Glycobiology.11, 75-87

Hemmerich, S., Bistrup, A., Singer, M.S., van Zante, A., Lee, J.K., Tsay, D., Peters, M., Carminati, J.L., Brennan, T.J., Carver-Moore, K., Leviten, M., Fuentes, M.E., Ruddle, N.H. and Rosen, S.D. (2001). Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity 15, 237-247.

Morimoto-Tomita, M, Uchimura, K., Werb, Z., Hemmerich, S. H. and Rosen, S.D. (2002). Cloning and characterization of two extracellular heparin-degrading endosulfatases in mouse and human, J Biol. Chem 277:49175-49185.

Lee, J. K, Bistrup, A., and Rosen, S.D. (2003). Activities and expression pattern of the carbohydrate sulfotransferase, GlcNAc6ST-3 (I-GlcNAc6ST): functional implications, Glycobiology, 13:254-54

Fieger, C., Sassetti, C, and Rosen, S.D. (2003). Endoglycan, a member of the CD34 family, functions as a L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J. Biol. Chem. 278:27390-27398.

Van Zante, M., Gauguet, J-M., Bistrup. A., Tsay, D., Von Andrian, U., and Rosen, S.D. (2003). Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. J Exp. Med, 198:1289-1300.

Rosen, S.D. Ligands for L-selectin: homing, inflammation and beyond. (2004). Ann Rev. Immunol. 22:129-156.

Palmeri, D., Zuo, Feng-Rong, Rosen, S. D. and Hemmerich, S. (2004). Differential Gene Expression Profile of Human Tonsil High Endothelial Cells: Implications for Lymphocyte Trafficking. J. Leukocyte Research, 75:910-927.

Bistrup, A., Tsay, D., Shenoy, P., Banglia, N., Luther, S., Cyster, J.G., Ruddle, N.H., and Rosen, S.D. (2004). Detection of a Sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in HEV-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope, Am J Pathol. 164: 1635-44.

Gauget, J, M, Rosen, S.D., Marth, J., and Von Andrian, U. (2004) CORE2GlcNAcT-I and HEC-GlcNAc6ST exert differential control over B and T lymphocyte homing to peripheral lymph nodes, Blood, 104: 4104-12

Uchimura, K., Kadomatsu, K., El-Fasakhany, F. M., Singer, M. S., Izawa, M, Kannagi, R., Takeda, N., Rosen, S. D., and Muramatsu, T. (2004). N-acetylglucosamine 6-O-Sulfotransferase-1 Regulates Lymphocyte Homing and Expression of Abluminal L-Selectin Ligands in High Endothelial Venules of Lymph Nodes, J. Biol. Chem 279:35001-8

Rosen, S.D., Tsay, D., Singer, M.S., Hemmerich, S., and Abraham, W.M. (2005). Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma. Am. J. Pathol. 166: 935-44

Pablos, J.L., B. Santiago, D. Tsay, M.S. Singer, G. Palao, M. Galindo, and S.D. Rosen. (2005). A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells. BMC Immunol. 6

Uchimura, K., Gauguet, J.-M., Singer, M.S., Tsay, D., Kannagi, R., Muramatsu, T., von Andrian, U.H., and Rosen, S.D. (2005). A major class of L-selectin ligands is eliminated into mice deficient in two high endothelial venule-expressed sulfotransferases. Nat Immunol 6:1105-13.

Morimoto-Tomita, M., Uchimura, K., Bistrup, A., Lum, D.H., Egeblad, M., Werb, Z., and Rosen, S.D. (2005). Sulf-2, a pro-angiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. Neoplasia 7: 1001-1010

Uchimura, K., Morimoto-Tomita, M., Bistrup, A., Li, J., Lyon, M., Gallagher, J., Werb, Z., and Rosen, S.D. (2006). HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochemistry 7:2.

Rosen, S.D. (2006). Homing in on L-selectin. J. Immunol 177: 3-4.

Yang, J., S. D. Rosen, P. Bendele, and S. Hemmerich. (2006). Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. BMC Immunol 7:12.

8/22/06

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