Professor of Pediatrics, University of California, San Francisco
| CONTACT | |
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RowitchD@peds.ucsf.edu Box 0734, UCSF; San Francisco, CA 94143-0734 |
| EDUCATION | |
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University of California, San Diego, B.A., 1982, Biochem/Cell Biol. | |
| PROFESSIONAL EXPERIENCE | |
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1989-1992 |
Internship and Residency, Dept. of Medicine, Children's Hospital, Boston, MA, |
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1992-1995 |
Fellow in Newborn Medicine, Joint Program in Neonatology, Children's Hospital, Boston, MA |
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1993-1998 |
Postdoctoral Research Fellow in the laboratory of Professor Andrew P. McMahon, Ph.D., Dept. of Molecular and Cellular Biology, Harvard University, Cambridge, MA, |
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1996-1999 |
Instructor in Pediatrics, Harvard Medical School, Boston, MA |
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1999-2004 |
Assistant Professor of Pediatrics, Harvard Medical School, Boston, MA |
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2004-present |
Associate Professor of Pediatrics, Harvard Medical School |
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2006-present |
Professor of Pediatrics, University of California, San Francisco |
| HONORS & AWARDS | |
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1982 |
Magna Cum Laude and Departmental Honors with Distinction, University of California, San Diego |
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1985-1987 |
Oliver Gaty Studentship in Biophysics, University of Cambridge, U.K. |
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1987-1989 |
Medical Scientist Training Program, UCLA School of Medicine |
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1993-1996 |
Postdoctoral Fellowship for Physicians, Howard Hughes Medical Institute |
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1997-2000 |
N.I.H. Clinical Investigator Award (Individual) |
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1998-2000 |
Claudia Adams Barr Investigator, Dana-Farber Cancer Institute |
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1998-2000 |
Basil O'Connor Starter Scholar Award, March of Dimes Foundation |
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2000-2002 |
Kimmel Scholar, Sidney Kimmel Foundation |
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2000-2005 |
Harry Weaver Junior Faculty Award, National Multiple Sclerosis Society |
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2002-2007 |
James S. McDonnell Foundation Research Award |
| SELECTED PUBLICATIONS | |
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Rowitch DH and Perham RN. Cloning and expression of the filamentous bacteriophage Pf1 major coat protein gene in Escherichia coli. J Mol Biol, 1987; 195:873-884. Hunter GJ, Rowitch DH and Perham RN. Interactions between DNA and coat protein in the structure and assembly of filamentous bacteriophage fd. Nature, 1987; 327:252-254. | |
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Rowitch DH, Hunter GJ and Perham RN. Variable electrostatic interaction between DNA and coat protein in filamentous bacteriophage assembly. J Mol Biol, 1988; 204:663-674. | |
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Rowitch DH, Echelard Y, Danielian PS, Gellner K, Brenner S and McMahon AP. Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence which governs Wnt-1 expression in the murine neural plate. Development, 1998; 125:2735-2746. | |
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Rowitch DH, St. Jacques B, Lee SMK, Flax JD, Snyder EY and McMahon AP. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J. Neurosci, 1999; 19:8954-8965. | |
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Kenney AM and Rowitch DH. Sonic hedgehog promotes G1 cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. MCB, 2000; 20, 9055-9067. | |
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Lu QR, Yuk DI, Alberta JA, Zhu Z, Pawlitzky I, McMahon AP, Stiles CD and Rowitch DH. Sonic hedgehog-regulated Oligodendrocyte lineage genes encoding bHLH factors in the mammalian central nervous system. Neuron, 2000; 25, 317-329. | |
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Lu QR, Park J, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH and Black PM. Oligodendrocyte Lineage Genes (OLIG) as Molecular Markers for Human Glial Brain Tumors. PNAS, 2001; 98, 10851-10856. | |
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Sun T, Echelard Y, Lu R, Yuk D, Kaing S, Stiles CD and Rowitch DH. Olig basic helix-loop-helix proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol, 2001; 18, 1413-1420. | |
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Alberta J, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD and Rowitch DH. Sonic hedgehog signaling is required during an early phase of oligodendrocyte development in the mammalian brain. MCN, 2001; 18, 434-441. | |
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Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD and Rowitch DH. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte lineage connection. Cell, 2002; 109, 75-86. | |
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Zhao Q, Kho A, Kenney AM, Yuk D, Kohane I and Rowitch DH. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. PNAS, 2002; 99(8):5704-5709. | |
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Bachoo RM, Maher EA, Ligon K, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Weissleder R, Rowitch DH, Louis DN and DePinho RA. Epidermal Growth Factor Receptor and Ink4a/Arf:Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell, 2002; 1, 269-277. | |
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Ciemerych MA, Kenney AM, Sicinska E, Kalaszczynska I, Bronson RT, Rowitch DH, Gardner H and Sicinski P. Development of mice expressing a single D-type cyclin. Genes Dev, 2002; 16:3277-3289. | |
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Kenney AM, Cole MD and Rowitch DH. N-myc upregulation by Sonic hedgehog promotes proliferation in developing cerebellar granule neuron precursors. Development, 2003; 130:15-28. | |
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Ligon KL, Echelard Y, Assimacopoulos A, Danielian PS, Kiang S, Grove EA, McMahon AP, and Rowitch DH (2003). Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development 130:2275-2287. | |
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Kenney AM, Widlund HR and Rowitch DH. Hedgehog and PI-3 Kinase signaling converge to promote cell cycle progression in neuronal precursors. Development, 2004; 130:15-28. | |
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Ligon, KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD and Rowitch DH. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropath Exp Neurol, 2004; 63:499-509. | |
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Kho AT, Zhao Q, Cai Z, Butte AJ, Pomeroy SL, Rowitch DH and Kohane IS. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes and Development, 2004; 18:629-640. | |
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Arnett HA, Fancy SPJ, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Frankin RJM and Stiles CD. The bHLH Transcription Factor Olig1 is Required for Repair of Demyelinated Lesions in the CNS. Science, 2004; 306:2111-2115. | |
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Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk D, Tsung EF, Cai Z, Alberta JA, Cheng L, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, McMahon AP, Rowitch DH, Stiles CD and Ma Q. Mouse Brain Organization Revealed through Direct Genome Scale Transcription Factor Expression Analysis. Science, 2004; 306: 2255-2257. | |
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Bachoo, RM, Kim S, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA. Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci USA, 2004; 101:8384-9. | |
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Sjostrom S, Finn G, Hahn WC, Rowitch DH and Kenney AM. The cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell, 2005; 9:327-338. | |
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Muroyama Y, Fujiwara Y, Orkin SH and Rowitch DH. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature 2005; 438:360-3. | |
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Sun T, Hafler BP, Kaing S, Katida M, Ligon KL, Widlund HR, Yuk DI and Stiles CD and Rowitch DH. Evidence for motor neuron lineage-specific regulation of Olig2 in the vertevrate neural tube. Dev Biol, 2006 Apr 1; 292 (1):152-64. | |
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Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD and Rowitch DH. Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad of Sci USA, 2006 May 16; 103 (20):7853-8. | |
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Schuller U and Rowitch DH. Beta-catenin function is required for cerebellar morphogenesis. Brain Res, 2006 Jul 4; [Epub ahead of print]. | |
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Kitada M and Rowitch DH. Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord. Glia, 2006 Jul; 54 (1): 35-46 | |
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Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, Matthay KK, Rowitch DH and Weiss WA. Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma. Cancer Res, 2006 Aug 15; 66 (16):8139-8146. | |
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Hatton BA, Knoepfler PS, Kenney AM, Rowitch DH, de Alboran IM, Olson JM and Eisenman RN. N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth. Cancer Res, 2006 Sep 1; 66 (17):8655-61. | |
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Schuller U, Kho AT, Zhao Q, Ma Q and Rowitch DH. Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis. Mol Cell Neurosci, 2006 Sep 7; [Epub ahead of print]. | |
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2/1/07 |
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