James L. Rubenstein, MD, PhD

Stanford University, B.S., June 1985, Biological Sciences
The Rockefeller University, Ph.D., June 1991, Molecular and Cellular Neuroscience (Medical Scientist Training Program)
Cornell University Medical College, M.D., May 1992, Medicine
Stanford University Medical Center, Stanford, CA, Internship/Residency, 1992-1995, Internal Medicine
University of California, San Francisco, San Francisco, CA, Fellowship, 1992-1998, Hematology/Oncology and Neuro-Oncology

• 1998-2006
  Assistant Adjunct Professor of Medicine, Attending Physician in Hematology/Oncology, University of California, San Francisco
• 2006-2009
  Assistant Professor of Medicine in Residence, University of California, San Francisco
• 2009-present
  Associate Professor of Medicine in Residence, University of California, San Francisco

• 1985
  Phi Beta Kappa
• 1985
  Departmental Honors in Biological Sciences
• 1985
  Honors in Humanities
• 1995
  Housestaff Research Award
• 1998
  Young Investigator Award -American Society of Clinical Oncology
• 1999
  American Brain Tumor Association Fellowship
• 2000
  UCSF/Mt Zion Clinical Investigator Research Program
• 2000
  California Cancer Research Program Clinical Scientist Development Award
• 2001
  UCSF/Mt Zion Clinical Investigator Research Program
• 2001
  Career Development Award-American Society of Clinical Oncology
• 2001
  Accelerate Brain Cancer Cure Foundation Award
• 2002
  UCSF Research Evaluation and Allocation Committee Award
• 2003
  UC Discovery Grant
• 2003
  Tobacco-Related Disease Research Program IDEA Award
• 2004
  National Cancer Institute Research Career Award
• 2004
  American Cancer Society Award
• 2005
  UCSF Brain Tumor SPORE Development Award
• 2006
  G&P Foundation Award
• 2008
  UCSF Clinical and Translational Sciences Grant
• 2009
  Scholar in Clinical Research Award, Leukemia & Lymphoma Society
• 2009
  Cancer and Leukemia Group B Clinical Scholars Award

• Rubenstein, J.L., Greengard, P., and Czernik, A.J. 1993. Calcium-Dependent Serine Phosphorylation of Synaptophysin. Synapse 13, 161-172.
• Benfenati, F., Valtorta, F., Rubenstein, J.L., Gorelick, F.S., Greengard, P., and Czernik, A.J. 1992. Synaptic Vesicle-Associated Ca2+/Calmodulin-Dependent Protein Kinase II is a Binding Protein for Synapsin I. Nature 359: 417-420.
• Rubenstein, J.L. and Yaari, H. 1993. Von Hippel-Lindau and the Genetics of Astrocytoma. J. Natl. Cancer Inst. 86(2) 142-143
• Ng, S., Tse, V.C., Rubenstein, J.L., Bradford, E., Enzmann, D.R., and Conley, F.K. 1995. Progressive Multifocal Leukoencephelopathy: Unusual MR Findings. J. Computer Assisted Tomography. 19(2) 302-305.
• Rubenstein, E., Giacomini, J.C., Gordon, H.J., Rubenstein, J.L., Brown, G. 1995. Xenon K-edge Dichromographic Bronchography: Synchrotron Radiation Based Medical Imaging. Nuclear Instruments and Methods in Physics Research A365, 360-361
• Rubenstein, J.L., Kim, J., Ozawa, T., Zhang, M., Westphal, M., Deen, D., and Shuman, M.A. 2000. Anti-VEGF Treatment of Glioblastoma Prolongs Survival But Results in Increased Vascular Cooption. Neoplasia. 2(4) 306-314
• Rubenstein, J.L, Fischbein, N., Aldape, K., Burton, E., and Shuman, M. Hemorrhage and VEGF Expression in a Case of Primary Central Nervous System Lymphoma: Role of Vascular Endothelial Growth Factor. 2002. J. Neuro-Oncology 58(1)53-56.
• Rubenstein, J.L., Combs, J. Rosenberg, Levy, A., McDermott, M., Damon, L., Ignoffo, R., Aldape, K., Shen, A., Lee, D., Grillo-Lopez, A. and M.A. Shuman. Rituximab in CNS Lymphoma: Targeting the Leptomeningeal Compartment. Blood, 2003 101(2):466-8.
• Shenkier, T., Blay, J-Y, O'Neill, B, Poortmans, P, Thiel, E., Jahnke, K., Abrey, L., Neuwelt, E., Tsang, R., Batchelor, T., Harris, N., Ferreri, A., Ponzoni, M., O'Brien, P., Rubenstein, J.L. and Connors, J.M. Primary Central Nervous System Lymphoma of T cell origin: A Descriptive Analysis. J Clin Oncol. 2005 Apr 1;23(10):2233-9.
• Rubenstein, J., Treseler, P and O'Brien, J. Pathology and Genetics of Primary CNS Lymphoma. Hematology/Oncology Clinics of North America. 2005 19(4): 705-717.
• Rubenstein, J., Fridlyand, J., Shen, A., Aldape, K., Ginzinger, D., Batchelor, T., Treseler, P., Berger, M., McDermott, M., Prados, M., Karch, J., Okada, C., Hyun, W., Parikh, S., Haqq, C., Shuman, M. Gene Expression and Angiotropism in Primary CNS Lymphoma. Blood, 2006 107(9):3716-23.
• Kadoch, C., Treseler, P. and Rubenstein, J. Molecular Pathogenesis of Primary CNS Lymphoma. Neurosurg. Focus. 2006. (5). 1-5.
• Rubenstein, J., Fridlyand, J., Abrey, L., Shen, A., Karch, J., Wang, E., Issa, S., Damon, L., Prados,M., McDermott, M., O'Brien, J., Haqq, C., and Shuman, M. Phase I Study of Intraventricular Administration of Rituximab in Patients with Recurrent CNS and Intraocular Lymphoma. 2007. 25(11):1350-6. Journal of Clinical Oncology.
• Rubenstein, J., Abrey L., Shuman, M.A., Tsai, T., and O'Brien, J. Correspondence Intrathecal Rituximab in Lymphomatous Meningitis (Response to Chamberlain and Glantz). J Clin Oncol 25:1350-1356, 2007.
• Roy, S., Josephson, S.A., Fridlyand, J., Karch, J., Kadoch, C., Karrim, J., Damon, L., Treseler, P., Kunwar, S., Shuman, M.A., Jones, T., Becker, C.H., Schulman, H., and Rubenstein, J. L. Protein Biomarker Identification in the Cerebrospinal Fluid in Patients with Central Nervous System Lymphoma. 2007 epub Dec, 3, Journal of Clinical Oncology.
• Montesinos-Rongen M., Brunn A., Bentink S., Basso K, Lim WK, Klapper W., Schaller C., Reigenberger, G, Rubenstein J, Wiestler OD, Spang R., Dalla-Favera, R, Siebert R, Deckert M. Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell. Leukemia 2008 22(2) 400-405.
• Yang, I., Delpolyi, A., Sughrue, M.E., Rubenstein, J., Bollen, A.W., and Parsa, A.T. Sarcoidosis of the Pineal Gland: An Unusual Presentation of Neurosarcoidosis. J. Neurooncol. 2008 Aug 31. [Epub]
• Rubenstein, J.L., Ferreri, A.J., Pittaluga, S., Primary lymphoma of the central nervous system: epidemiology, pathology and current approaches to diagnosis, prognosis and treatment. 2008 Leuk Lymphoma. 2008;49 Suppl 1:43-51. In Press..
• Damon, L., Damon, L.E., Gaensler, K., Kaplan, L., Martin, T., Rubenstein, J., and Linker, C. Impact of Intensive Peripheral Blood Stem Cell Mobilization Therapy on Outcomes Following Autologous Stem Cell Transplantation for Non-Hodgkin's Lymphoma. August 4, 2008 Bone Marrow Transplant.[Epub ahead of print].
• Grimm, S.A., Pulido, J.S., Omura, A..M.P., Ferreri, A.J.M., Blay, J.-Y, Neuwelt, E.A., Siegal, T., Batchelor, T., Jahnke, K., Shenkier, T.N., Hall, A.J., Graus, F. Herrlinger, U., Schiff, D., Raiser, Rubenstein, J., Lapierre, N., Thiel, E., Doolittle, N., and Abrey, L. Primary CNS Lymphoma with Intraocular Involvement: An International PCNSL Collaborative Group Report. Neurology. 2008 Oct 21;71(17):1355-60.
• Rubenstein, J.L., Shen, A., Batchelor, T., Kadoch, C., Treseler, P., and Shuman, M. Differential Gene Expression in CNS Lymphoma. Blood. 2009;113(1):266-7
• Insights into the Biology of Primary Central Nervous System Lymphoma. Mrugala, M., Rubenstein, J.L., Ponzoni, M., Batchelor, T.T. 2008. Current Oncol Reports 2009 Jan;11(1):73-80.
• Kadoch, C., Dinca, E.B., Voicu, R., Chen, L., Nguyen, D., Parikh, S., Karrim, J., Shuman, M.A., Lowell, C., Treseler, P., James, C.D., and Rubenstein., J. Pathologic Correlates of Primary CNS Lymphoma Defined in an Orthotopic Xenograft Model. Clinical Cancer Research Mar 10. [Epub ahead of print]. 2009;15(6):1989-97 (Featured on Cover).