Assistant Professor, Urology, UCSF
| CONTACT | |
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ruggerod@urology.ucsf.edu Box 1270, UCSF; San Francisco, CA 94143-1270 |
additional websites: |
| EDUCATION | |
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University of Rome, La Sapienza, Italy, BS, magna cum laude, Molecular & Cellular Biology, 1994
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| PROFESSIONAL EXPERIENCE | |
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1998-2000 |
Post-doctoral fellow in the Laboratory of Molecular and Developmental Biology of P.P. Pandolfi, Memorial Sloan Kettering Cancer Center, New York |
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2001-2003 |
Research Associate, in the Laboratory of Molecular and Developmental Biology of P.P. Pandolfi, Memorial Sloan Kettering Cancer Center, New York |
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2004-2007 |
Associate Member, Fox Chase Cancer Center, Philadelphia, PA |
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2007-present |
Assistant Professor University of California, San Francisco, CA |
| HONORS & AWARDS | |
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1994 |
Enichem Society fellowship |
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1998 - 2000 |
American-Italian Cancer Foundation fellowship |
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2003 |
Outstanding Research Fellow Award, Memorial Sloan Kettering Cancer Center |
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2005 |
V Foundation Scholar Grant |
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2006 |
Commonwealth Universal Research Enhancement Program Award, Pennsylvania Department of Health |
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2008 |
Gertrude B. Elion Award, American Association for Cancer Research |
| SELECTED PUBLICATIONS | |
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Ruggero, D., Creti, R., Londei, P. Translation of archaeal natural mRNAs at high temperatures. FEMS Microbiol. Let. 107:89-94, 1993. | |
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Ruggero, D., Londei, P. Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea. J. Bacteriol. 178:3396-3398, 1996. | |
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Ruggero, D., Ciammaruconi, A., Londei, P. The chaperonin of the archaeon Sulfolbus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing. EMBO J. 17:3471-3477, 1998. | |
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Condó, I., Ruggero, D., Reinhardt, R., Londei, P. An novel aminopeptidase associated with the 60 kDa chaperonin in the thermophilic archaeon Sulfolobus solfataricus. Molec. Microbiol. 29:775-786, 1998. | |
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Ruggero, D., Wang, Z.G., Ronchetti, S., Zhong, S., Gaboli, M., Rivi, R., Pandolfi, P.P. Pml is essential for multiple apoptotic pathways. First author shared. Nat. Genet. 20:266-272, 1998. (News and Views; Life, death and nuclear spots. Nat. Genet. 20:220-222, 1998.) | |
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Cond—, I., Ciammaruconi, A., Benelli, D., Ruggero, D., Londei, P. Cis-acting signals controlling translation initiation in the thermophilic archaeon Sulfolobus solfataricus. Molec. Microbiol. 34:377-384, 1999. | |
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Zhong, S., Salomoni, P., Ronchetti, S., Guo, A., Ruggero, D., Pandolfi, P.P. Promyelocytic Leukemia (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191:631-639, 2000. | |
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Ruggero, D., Wang, Z.G., Pandolfi, P.P. The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays 22:827-835, 2000. | |
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Barna, M., Merghoub, T., Costoya, J.A., Ruggero, D., Branford, M., Bergia, A., Samori, B., Pandolfi, P.P. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev. Cell 3:499-510, 2002. | |
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Ruggero, D., Grisendi, S., Piazza, F., Rego, E., Mari, F., Cordon-Cardo, C., Pandolfi, P.P. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science 299:259-262, 2003. (News and Views; Dissecting dyskeratosis. Nat. Genet. 33:116-117, 2003.) (Highlights; Translating cancer. Nat. Rev. Cancer 3:87, 2003.) (Research news: Translation, please. Nat. Med. 9:172, 2003.) | |
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Ruggero, D. and Pandolfi, P.P. Does the ribosome translate cancer? Nat. Rev. Cancer 3:179-192, 2003. | |
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Ruggero, D., Montanaro, L., Ma, L., Xu, W., Londei, P., Cordon-Cardo, C., and Pandolfi, P.P. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat. Med. 10:484-486, 2004. | |
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Ruggero, D. and Sonenberg, N. The Akt of translational control. Oncogene 24:7426-7434, 2005. | |
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Kaplan, R., Riba, R., Zacharoulis, S., Jin, D., Costa, C., Vincent, L., MacDonald, D., Bramley, A., Shido, K., Kerns, S., Ruggero, D., Jensen, K.K., Shmelkov, S., Hicklin., D., Port, E., Port, J., Altorki, N., Rafii, S., Lyden, D. VEGFR1-positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820-827, 2005. | |
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Rego, E.M., Ruggero, D., Tribioli, C., Cattoretti, G., Kogan, S., Redner, R.L., Pandolfi, P.P. Leukemia with distinct phenotypes in transgenic mice expressing PML/RARalpha, PLZF/RARalpha or NPM/RARalpha. Oncogene 25:1974-1979, 2006. | |
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Yoon, A., Peng, G., Brandenburger, Y., Zollo, O., Xu, W., Rego, E., Ruggero, D. Impairments in IRES-mediated translational control underlie X-linked dyskeratosis congenita. Science 312:902-906, 2006. | |
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Barna, M., Pusic, A., Zollo, O., Costa, M., Kondrashov, N., Rego, E., Rao, P., Ruggero, D. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 456: 971-975, 2008. | |
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Feldman, M.E., Apsel, B., Uotila, A., Loewith, R., Knight, Z.A., Ruggero, D., Shokat, K.M. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009. Feb 10;7(2):e38. | |
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6/23/09 |
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