Davide Ruggero, PhD

University of Rome, La Sapienza, Italy, BS, magna cum laude, Molecular & Cellular Biology, 1994
University of Rome, La Sapienza, Italy, PhD, magna cum laude, Molecular & Cellular Biology, 1998

• 1998-2000
  Post-doctoral fellow in the Laboratory of Molecular and Developmental Biology of P.P. Pandolfi, Memorial Sloan Kettering Cancer Center, New York
• 2001-2003
  Research Associate, in the Laboratory of Molecular and Developmental Biology of P.P. Pandolfi, Memorial Sloan Kettering Cancer Center, New York
• 2004-2007
  Associate Member, Fox Chase Cancer Center, Philadelphia, PA
• 2007-2010
  Assistant Professor, Dept. of Urology, University of California, San Francisco, CA
• 2010-present
  Associate Professor, Dept. of Urology, University of California, San Francisco, CA

• 1994
  Enichem Society fellowship
• 1998-2000
  American-Italian Cancer Foundation fellowship
• 2003
  Outstanding Research Fellow Award, Memorial Sloan Kettering Cancer Center
• 2005
  V Foundation Scholar Grant
• 2006
  Commonwealth Universal Research Enhancement Program Award, Pennsylvania Department of Health
• 2008
  Gertrude B. Elion Award, American Association for Cancer Research
• 2010
  Leukemia & Lymphoma Society Scholar Award
• 2010
  UCSF Program for Breakthrough Biomedical Research Integrative Award

• Ruggero, D., Creti, R., Londei, P. Translation of archaeal natural mRNAs at high temperatures. FEMS Microbiol. Let. 107:89-94, 1993.
• Ruggero, D., Londei, P. Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea. J. Bacteriol. 178:3396-3398, 1996.
• Ruggero, D., Ciammaruconi, A., Londei, P. The chaperonin of the archaeon Sulfolbus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing. EMBO J. 17:3471-3477, 1998.
• Condo, I., Ruggero, D., Reinhardt, R., Londei, P. An novel aminopeptidase associated with the 60 kDa chaperonin in the thermophilic archaeon Sulfolobus solfataricus. Molec. Microbiol. 29:775-786, 1998.
• Ruggero, D., Wang, Z.G., Ronchetti, S., Zhong, S., Gaboli, M., Rivi, R., Pandolfi, P.P. Pml is essential for multiple apoptotic pathways. First author shared. Nat. Genet. 20:266-272, 1998. (News and Views; Life, death and nuclear spots. Nat. Genet. 20:220-222, 1998.)
• Condo, I., Ciammaruconi, A., Benelli, D., Ruggero, D., Londei, P. Cis-acting signals controlling translation initiation in the thermophilic archaeon Sulfolobus solfataricus. Molec. Microbiol. 34:377-384, 1999.
• Zhong, S., Salomoni, P., Ronchetti, S., Guo, A., Ruggero, D., Pandolfi, P.P. Promyelocytic Leukemia (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191:631-639, 2000.
• Ruggero, D., Wang, Z.G., Pandolfi, P.P. The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays 22:827-835, 2000.
• Barna, M., Merghoub, T., Costoya, J.A., Ruggero, D., Branford, M., Bergia, A., Samori, B., Pandolfi, P.P. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev. Cell 3:499-510, 2002.
• Ruggero, D., Grisendi, S., Piazza, F., Rego, E., Mari, F., Cordon-Cardo, C., Pandolfi, P.P. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science 299:259-262, 2003. (News and Views; Dissecting dyskeratosis. Nat. Genet. 33:116-117, 2003.) (Highlights; Translating cancer. Nat. Rev. Cancer 3:87, 2003.) (Research news: Translation, please. Nat. Med. 9:172, 2003.)
• Ruggero, D. and Pandolfi, P.P. Does the ribosome translate cancer? Nat. Rev. Cancer 3:179-192, 2003.
• Ruggero, D., Montanaro, L., Ma, L., Xu, W., Londei, P., Cordon-Cardo, C., and Pandolfi, P.P. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat. Med. 10:484-486, 2004.
• Ruggero, D. and Sonenberg, N. The Akt of translational control. Oncogene 24:7426-7434, 2005.
• Kaplan, R., Riba, R., Zacharoulis, S., Jin, D., Costa, C., Vincent, L., MacDonald, D., Bramley, A., Shido, K., Kerns, S., Ruggero, D., Jensen, K.K., Shmelkov, S., Hicklin., D., Port, E., Port, J., Altorki, N., Rafii, S., Lyden, D. VEGFR1-positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820-827, 2005.
• Rego, E.M., Ruggero, D., Tribioli, C., Cattoretti, G., Kogan, S., Redner, R.L., Pandolfi, P.P. Leukemia with distinct phenotypes in transgenic mice expressing PML/RARalpha, PLZF/RARalpha or NPM/RARalpha. Oncogene 25:1974-1979, 2006.
• Yoon, A., Peng, G., Brandenburger, Y., Zollo, O., Xu, W., Rego, E., Ruggero, D. Impairments in IRES-mediated translational control underlie X-linked dyskeratosis congenita. Science 312:902-906, 2006.
• Barna, M., Pusic, A., Zollo, O., Costa, M., Kondrashov, N., Rego, E., Rao, P., Ruggero, D. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 456: 971-975, 2008.
• Feldman, M.E., Apsel, B., Uotila, A., Loewith, R., Knight, Z.A., Ruggero, D., Shokat, K.M. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009. Feb 10;7(2):e38.
• Hsieh AC, Costa M, Zollo O, Davis C, Feldman M, Testa J, Meyuhas O, Shokat K, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 17(3):249-261, 2010.
• Bellodi C, Kopmar N, Ruggero D. Deregulations of p53 translational control in X-linked Dyskeratosis Congenita. EMBO J, 2;29(11):1865-76, 2010.
• Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D. Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis. Cancer Res, in press.