UCSF Helen Diller Family Comprehensive Cancer Center - People

Roma and Marvin Auerback Distinguished Professorship in Pediatric Molecular Oncology, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS)
Leader, Hematopoietic Malignancies Program, UCSF Helen Diller Family Comprehensive Cancer Center

CONTACT

(415) 476-3831 (appts)
(415) 502-5127 (fax)

Box 0519, UCSF; San Francisco, CA 94143-0519

additional websites:

UCSF Physician Referral Directory
Shannon Lab Website

EDUCATION
Williams College, Williamstown, MA, A.B., 1976, Biology, Liberal Arts Cornell University, New York, NY, M.D., 1979, Medicine University of Texas Southwestern, Dallas, TX, Resident, 1982, Pediatrics University of California, San Francisco (UCSF), Postdoctoral, 1988, Hematology/Oncology
PROFESSIONAL EXPERIENCE
1982-85	Attending Pediatrician, Naval Hospital, Oakland, CA
1985-88	Fellow in Pediatric Hematology/Oncology and Instructor in Pediatrics, UCSF
1988-92	Attending Pediatric Hematologist/Oncologist, Naval Hospital, Oakland, CA
1992-94	Assistant Professor of Pediatrics and Attending Pediatric Hematologist/Oncologist, UCSF
1989-93	Hematopoietic Growth Factors Subcommittee, American Society of Hematology
1990-present	Acute Myelogenous Leukemia Strategy Group Children's Cancer Study Group (Co-Chair 1997-99)
1988-93	Cancer Biology Committee, Children's Cancer Study Group (Chair 1991-94)
1991-92	Pediatric Residency Program Director, Naval Hospital, Oakland, CA
1994-98	Associate Professor of Pediatrics, UCSF
1997-present	Leader, Program in Hematopoietic Malignancies, UCSF Cancer Center
1997-present	Professor of Pediatrics, UCSF
2005	Vice Chair for Research, Department of Pediatrics, UCSF
2006	Director, UCSF Medical Scientist Training Program
HONORS & AWARDS
1985 and 1989	Outstanding Teacher, Pediatrics Department, Naval Hospital, Oakland
1985 and 1993	Navy Commendation Medals
1986	Outstanding Fellow's Teaching Award, Pediatrics Department, UCSF
1988	David W. Smith Research Award, Western Society for Pediatric Research
1988 and 1989	Navy Achievement Medals
1992	Winner, Navy Academic Medicine Research Competition
1993	Nycomed Research Award of the International Society for Pediatric Oncology (SIOP)
1994	Ross Outstanding Young Investigator Award, Western Society for Pediatric Research
1998	American Academy of Pediatrics Award for Excellence in Pediatric Research
2000	Roma and Marvin Auerback Distinguished Professor of Pediatric Molecular Oncology, UCSF
2004	Samuel Rosenthal Prize for Excellence in Academic Pediatrics
2006	National Cancer Institute MERIT Award
SELECTED PUBLICATIONS
(selected publications since 2000)
Shannon KM, Le Beau MM, Largaespada DA, Killeen N. Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse. Semin Cancer Biol 2001; 11: 191-199.
Donovan S, Shannon KM, Bollag GE. GTPase activating proteins: critical regulators of intracellular signaling. Biochem Biophys Acta 2002; 1602: 23-45.
Le DT, Shannon KM. Ras processing as a therapeutic target in hematologic malignancies. Curr Opin Hematol 2002; 9: 308-315.
Shannon KM. Resistance in the land of molecular cancer therapeutics. Cancer Cell 2002; 2: 99-102.
Houghton PJ, Adamson PC, Blaney S, Fine H, Gorlick R, Haber M, Helman L, Hirschfeld S, Hollingshead MG, Israel MA, Lock RB, Maris JM, Merlino G, Patterson W, Reynolds CP, Shannon K, Yu A, Yu J, Smith MA. Testing of new agents in childhood cancer preclinical modelsÑmeeting summary. Clin Cancer Res 2002; 8:3646-57.
Downing JR, Shannon KM. Acute leukemia: a pediatric perspective. Cancer Cell 2002; 2: 437-445.
Kratz CP, Antonietti L, Shannon KM, Dole MG, Friebert SE. Acute myeloid leukemia associated with t(8;21) or trisomy 8 in children with neurofibromatosis, type 1 (letter). J Pediatr Hematol Oncol 2003; 25: 343.
Shannon KM. Bypassing the requirement for MYC in lymphoma progression (Inside Blood commentary). Blood 2003; 101: 673.
Weiss BG, Shannon KM. Mouse models as a platform for performing preclinical therapeutic trials. Curr Opin Genes Develop 2003; 13: 84-89.
Tartaglia M, Niemeyer CM, Shannon KM, Loh ML. SHP-2 and myeloid malignancies. Curr Opin Hematol 2004: 11: 44-50.
Braun BS, Shannon KM. The sum is greater than the FGFR1 partner. Cancer Cell 2004; 5: 203-204.
Weiss BG, Shannon KM. Preclinical trials in mouse cancer models in Holland EC (editor): Mouse Models of Human Cancer, Wiley-Liss, Hoboken NJ, 2004: pp. 437-446.
Van Etten RA, Shannon KM. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell 2004; 6: 547-552.
Hoffman R, Shannon K, Sauntharajah Y. Cellular basis of hematopoiesis and marrow failure syndromes in Williams ME and Kahn MJ (editors): American Society of Hematology Self Assessment Program, Second Edition, Blackwell Publishing. Malden MA, 2005: pp. 22-39.
Linenberger M, Shannon K. Myeloid Disorders in Williams ME and Kahn MJ (editors): American Society of Hematology Self Assessment Program, Second Edition, Blackwell Publishing. Malden MA, 2005: pp. 126-151.
Cataland SR, Shannon K, Caligiuri M. Myelodysplasia in Williams ME and Kahn MJ (editors): American Society of Hematology Self Assessment Program, Second Edition, Blackwell Publishing. Malden MA, 2005: pp. 200-210.
Shannon KM, Van Etten RA. JAKing up hematopoietic proliferation. Cancer Cell 2005; 7: 291-93.
Lauchle, JO, Braun BS, Loh ML, Shannon KM. Inherited predispositions and hyperactive Ras in myeloid leukemogenesis. Pediatric Blood and Cancer 2006; 46: 579-586.
Le D, Shannon K, Lange BJ. Heritable predispositions to childhood hematologic malignancies in Pui C-H (editor) Childhood Leukemia, Cambridge University Press, Cambridge UK, 2005 (in press).
Gutmann DH, Hunter-Schaedle K, Shannon KM. Harnessing preclinical mouse models to inform human clinical cancer trials J Clin Invest 2006; 116: 847-852.
Shannon K. Reconsidering how we treat severe congenital neutropenia. Blood 2006; 107: 4575-76.
Silverman LR, Shannon KM. Myelodysplastic syndrome and overlap syndromes. in American Society of Hematology Self Assessment Program, Third Edition, Blackwell Publishing. Malden MA, 2006 (in press).
Schubbert S, Bollag G, Shannon K. Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Curr Opin Genes Develop 2007; 17: 15-22.
Schubbert S, Shannon K, Bollag G. Hyperactive Ras signaling in developmental disorders and cancer. Nat Reviews Cancer 2007; 7: 295-308.
Shannon K, Bollag G. Sending out an SOS. Nat Genet 2007; 39: 8-9.
Diaz-Flores, Shannon K. Targeting oncogenic Ras. Genes Develop 2007; 21: 1989-92.
Shannon KM, Le Beau MM. Hay in a haystack (News and Views). Nature 2008; 451: 252-3.
Braun BS, Lowe SW, Shannon K. Mouse models of leukemia: Pros and cons. The Hematologist 2008; 5: issue 4, p. 5.
Braun BS, Shannon K. Targeting Ras in myeloid leukemias. Clin Cancer Res 2008; 14: 2249-52.
Baumann I, Bennett JM, Niemeyer CM, Thiele J, Shannon K. Juvenile myelomonocytic leukemia in WHO Classification of tumors of hematopoietic and lymphoid tissues, 4th edition. Lyon, France 2008: pp. 82-84.
Baumann I, Niemeyer CM, Bennett JM, Shannon K. Childhood myelodysplastic syndrome, in WHO Classification of tumors of hematopoietic and lymphoid tissues, 4th edition. Lyon, France 2008: pp. 104-107.
Wong JC, Le Beau MM, Shannon K. Tumor suppressor gene inactivation in myeloid malignancies. Best Practice & Research Clinical Haematology 2008; 21: 601-614.
2/17/09

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