UCSF Helen Diller Family Comprehensive Cancer Center - People

Professor, Biochemistry and Biophysics, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)

CONTACT

dstainier@biochem.ucsf.edu
(415) 502-5679 and 502-5680 (voice)
(415) 476-3892 (fax)

Box 0448, UCSF; San Francisco, CA 94143-0448

additional websites:

Stainier Lab Website

EDUCATION
Brandeis University, Waltham, MA, B.A. (summa cum laude), 1984, Biology Harvard University, Cambridge, MA, Ph.D., 1990, Biochemistry and Molecular Biology Massachusetts General Hospital and Harvard Medical School, Boston, MA, Postdoc, 1994
PROFESSIONAL EXPERIENCE
1982-84	Undergraduate research with Erik Selsing at Brandeis University
1984-90	Doctoral research with Walter Gilbert at Harvard University
1990-94	Postdoctoral research with Mark C. Fishman at the Massachusetts General Hospital, Harvard Medical School
1995-2000	Assitant Professor, Department of Biochemistry and Biophysics, University of California, San Francisco
2000-2003	Associate Professor, Department of Biochemistry and Biophysics, University of California, San Francisco
2003-present	Professor, Department of Biochemistry and Biophysics, University of California, San Francisco
HONORS & AWARDS
1982-84	Wien International Scholarship, Brandeis University
1983	Elihu A. Silver Prize for undergraduate research in Science, Brandeis University
1984	Dr. Joseph Garrison Parker Prize in Biology, Brandeis University
1984	Phi Beta Kappa, Brandeis Chapter
1991-94	Helen Hay Whitney Foundation Postdoctoral Fellowship
1995	Louis N. Katz Basic Science Research Prize Finalist, American Heart Association
1995	Packard Foundation Fellow in Science and Engineering
1996	Basil O'Connor Scholar, March of Dimes Foundation
2000-2003	American Heart Association Established Investigator
2002	Mossman Developmental Biologist Award, American Association of Anatomists
2002	Annual Byers Award in Basic Science, UCSF
2003	Outstanding Faculty Mentorship Award, UCSF
SELECTED PUBLICATIONS
(partial list from 2000)
Kikuchi, Y., Trinh, L., Reiter, J.F., Alexander, A., Yelon, D. and Stainier, D.Y.R. (2000). The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes & Development 14: 1279-1289.
Reifers, F., Walsh, E., Leger, S., Stainier, D.Y.R. and Brand, M. (2000). Induction and differentiation of the zebrafish heart requires Fgf8 (fgf8/acerebellar). Development 127: 225-235.
Griffin, K.J.P., Stoller, J., Gibson, M., Chen, S., Yelon, D., Stainier, D.Y.R. and Kimelman, D. (2000). A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Developmental Biology 218: 235-247.
Yelon, D., Ticho, B, Halpern, M., Ruvinsky, I., Ho, R., Silver, L.M. and Stainier, D.Y.R. (2000). The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development 127: 2573-2582. See Commentary in Nature 406, 953-954.
Kupperman, E., An, S., Osborne, N., Waldron, S. and Stainier, D.Y.R. (2000). A sphingosine 1-phosphate receptor regulates cell migration during vertebrate heart development. Nature 406: 192-195. See Commentaries in Nature 406, 141-142 and in Science 289, 509.
Liao, W., Ho, C.-H., Yan, Y.L., Postlethwait, J. and and Stainier, D.Y.R. (2000). Hhex and Scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development 127, 4303-4313.
Motoike, T., Loughna, S., Perens, E. Roman, B.L., Liao, W., Chau, T.C., Richardson, C.D., Kawate, T., Kuno, J., Weinstein, B.M, Stainier, D.Y.R. and Sato, T.N. (2000). Universal GFP Reporter for the Study of Vascular Development. Genesis 28: 75-81.
Reiter, J.F, Kikuchi, Y. and Stainier, D.Y.R. (2001). Multiple roles for Gata5 in zebrafish endoderm formation. Development 128: 125-135.
Walsh, E. and Stainier, D.Y.R. (2001). Cardiac development in vertebrates. In Genetic Models in Cardiorespiratory Biology (eds. Haddad, G. and Xu, T.; ex. ed. Lenfant, C.), Marcel Dekker, NY, pp 203-238.
Stainier, D.Y.R. (2001). Zebrafish genetics and vertebrate heart formation. Nature Reviews Genetics 2: 39-48.
Reiter, J.F., Verkade, H. and Stainier, D.Y.R. (2001). Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5. Developmental Biology 234: 330-338.
Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B. and Stainier, D.Y.R. (2001). casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & Development 15: 1493-1505.
Walsh, E.C. and Stainier, D.Y.R. (2001). UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science 293: 1670-1673.
Horne-Badovinac, S., Lin, D., Waldron, S., Schwartz, M. Pawson, A., Jan, Y.N. Stainier, D.Y.R. and Abdelilah-Seyfried, S. (2001). Positional cloning of heart and soul reveals multiple roles for PKC in zebrafish organogenesis. Current Biology 11:1492-1502.
Keegan, B.R., Feldman, J.L., Lee, D.H., Koos, D.S., Ho, R.K., Stainier, D.Y.R. and Yelon D. (2002). The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development 129: 1623-1632.
Stainier, D.Y.R. (2002). A glimpse into the molecular entrails of endoderm formation. Genes & Development 16: 893-907.
Sehnert, A., Huq, A., Weinstein, B., Walker, C., Fishman, M.C. and Stainier, D.Y.R. (2002). Cardiac Troponin T plays essential roles in sarcomere assembly and cardiac contractility. Nature Genetics 31: 106-110.
Sehnert, A. and Stainier, D.Y.R. (2002). A window to the heart: can zebrafish mutants help us understand heart disease in humans? Trends in Genetics 18: 491-494.
Warga, R.M. and Stainier, D.Y.R. (2002). The guts of endoderm formation. In Pattern Formation in Zebrafish (ed. Solnica-Krezel, L.). Springer-Verlag, Berlin, pp 28-47.
Jin, S-K, Jungblut, B. and Stainier, D.Y.R. (2002). Angiogenesis during zebrafish development. In Genetics of Angiogenesis, (ed. Jay Hoying). Bios, in press.
Yelon, D. and Stainier, D.Y.R. (2002). Pattern formation: swimming in retinoic acid. Current Biology 12, R707-709.
Scott, I. and Stainier, D.Y.R. (2002). Fishing out a new heart. Science 298, 2141-2142.
Field, H., Ober, E.A., Roeser, T. and Stainier, D.Y.R. (2003). Formation of the digestive system in zebrafish: I. Liver morphogenesis. Developmental Biology 253: 279-290.
Miller, C.T., Yelon, D., Stainier, D.Y.R. and Kimmel, C.B. (2003). Two endothelin1 effectors, Hand2 and Bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development 130: 1353-1365.
Osborne, N. and Stainier, D.Y.R. (2003). Lipid receptors in cardiovascular development. Annual Review in Physiology 65: 23-43.
Field, H.A., Dong, P.D.S., Beis, D. and Stainier, D.Y.R. (2003). Formation of the digestive system in zebrafish: II. Pancreas morphogenesis. Developmental Biology 261: 197-208.
Trinh, L.A., Meyer D. and Stainier, D.Y.R. (2003). The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafish. Development 130: 4989-4998.
Tidyman, W.E., Sehnert, A.J., Huq, A., Agard, J., Deegan, F., Stainier, D.Y.R. and Ordahl, C.P. (2003). In vivo regulation of the chicken cardiac troponin T gene promoter in zebrafish. Dev. Dyn. 227: 484-496.
Scott, I. and Stainier, D.Y.R. (2003). Twisting the body into shape. Nature 425: 461-463.
Horne-Badovinac, S., Rebagliati, M. and Stainier, D.Y.R. (2003). A cellular framework for gut looping morphogenesis in zebrafish. Science 302: 662-665.
Kikuchi, Y., Verkade, H., Reiter, J.F., Kim, C.-H., Chitnis, A.B., Kuroiwa, A. and Stainier, D.Y.R. (2003). Notch signaling can regulate endoderm formation in zebrafish. Dev. Dyn. 229: 756-762.
Ober, E.A., Olofsson, B., Makinen, T., Jin, S.-W., Shoji, W., Koh, G.Y., Alitalo, K. and Stainier, D.Y.R. (2003). Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO reports 5: 78-84.
Reim, G., Mizoguchi, T., Stainier, D.Y., Kikuchi, Y. and Brand, M. (2004). The POU domain protein Spg (Pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein Casanova. Dev. Cell 6: 91-101.
Trinh, L.A. and Stainier, D.Y.R. (2004). Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev. Cell 6: 371-382.
Parker, L.H., Schmidt, M., Jin, S.-W., Gray, A.M., Beis, D., Pham, T., Frantz, G., Palmieri, S., Hillan, K., Stainier, D.Y.R., de Sauvage, F.J., Ye, W. (2004). A novel endothelial cell derived secreted factor VEMF regulates vascular tube formation. Nature 428: 754-758.
Bartman, T., Walsh, E.C., Wen, K.-K., McKane, M., Ren, J., Alexander, J., Rubenstein, P.A. and Stainier, D.Y.R. (2004). Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish. PLoS Biology 2: 673-681.
1/15/05

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