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Helen Diller Family Compr Cancer Ctr
ROBERT STERN, MD

Professor, Pathology, UCSF

CONTACT

(415) 476-4961 (appts)
(415) 476-5669 (fax)

Box 0506, UCSF; San Francisco, CA 94143-0506

additional websites:

UCSF Physician Referral Directory
EDUCATION

Harvard College, Cambridge MA, BA, 1957, Biochemical Science
University of Washington, Seattle WA, MD, 1962, Medicine
King County Hospital, Seattle WA, Intern, 1963, Medicine
National Cancer Institute, NIH, Bethesda MD, Resident, 1976, Pathology

PROFESSIONAL EXPERIENCE

1963-65

Commissioned Officer, USPHS, Research Associate Program, NIDR/NIH

1965-67

Postdoctoral Fellow, NCI/NIH; Weizmann Institute, Rehovoth, Israel

1967-77

Medical Officer for Research, NIDR/NIH

1977-86

Associate Professor, Department of Pathology, University of California San Francisco

1977-87

Director, Graduate Program in Experimental Pathology, UCSF

1978-present

Diplomate, American Board of Anatomic Pathology

1978-present

Attending Pathologist, UCSF-associated hospitals: Moffitt, Veterans Administration, and Mt. Zion Hospitals, San Francisco, CA

1983-87

Basic Science Merit Review Board, Veterans Administration, Washington, DC

1984-85

Fulbright Award; Visiting Professor, Max Planck Institute for Biological Chemistry, Goettingen, West Germany

1986-present

Professor, Department of Pathology, University of California San Francisco, CA

1987-90

Chair, Fulbright Selection Committee, Life Sciences D, Council for the International Exchange of Scholars, Washington, DC

2003-present

Member of the Editorial Board of UC Press

SELECTED PUBLICATIONS

Publications in journals with peer review:

Salamonsen, L.A., Shuster, S. and Stern, R. Distribution of hyaluronan in human endometrium across the menstrual cycle: implications for implantation and menstruation. Cell Tissue Res. 306: 335-40, 2001.

Levin, C., Zhai, H., Bashir, S., Chew, A.-L., Stern, R., and Maibach, H. Efficacy of corticosteroids in acute experimentalmirritant contact dermatitis. 7,:214-218, 2001.

Stern, R., Shuster, S., Neudecker, B., and Formby, B. Lactate stimulates hyaluronan and CD44 expression in cultured fibroblasts: the Warburg effect revisited. Exp. Cell Res. 276: 24-31, 2002.

Nicoll S. B., Barak, O., Csoka, A. B., Bhatnagar, R. S. and Stern, R. Hyaluronidases and CD44 undergo differential modulation during chondrogenesis. Biochem. Biophys. Res. Commun. 292: 819-25, 2002.

Stair Nawy, S., Carlson, K.W. Shuster, S., Wei, E.T. and Stern, R. Modulation of hyaluronan production by mystixin peptides. Eur. J. Pharmacol. 450, 291-6, 2002.

Shuster, S., Frost, G.I., Csoka, A.B., Formby, B. and Stern, R. Hyaluronidase treatment reduces tumor size in human xenografts in SCID mice. Int. J. Cancer 102:192-7, 2002.

Formby, B., and Stern R. Lactate-sensitive response elements in genes involved in hyaluronan catabolism. Biochem. Biophys. Res. Commun. 305,:203-8, 2003.

Pogrel, M.P., Low, M.A., and Stern, R. Hyalurona (hyaluronic acid) andits regulation in humansaliva by hyaluronidase and its inhibitors. J. Oral Science. 45, 85-91, 2003.

Neudecker, B.A., Stern, R., Connolloy, M.K Aberrant serum hyaluronan and hyaluronidase levels in scleroderma. Brit. J. Dermatol. 150: 1-8, 2004.

Bourguignon, L.Y.W., Singleton, P.A, Diedrich, F., Stern R, and Gilad, E. CD44 interaction Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. .J. Biol. Chem., 279, 26991-27007, 2004.

Lishanti U, Brownlee GR, Stern R, and Brown TJ. Inhibition of hyaluronan degradation by dextran sulphate facilitates characterization of hyaluronan synthesis: an in vitro and in vivo study. Glycoconjugate J. 20, 461-71, 2004.

George, J. and Stern, R. Serum hyaluronan and hyaluronidase; Very early markers of toxic liver injury. Clin. Chimca Acta, 348, 189-197, 2004.

Liora Shiftan, L., Cohen, M., Frydman, V., Dafni, H., Stern, R., and Neeman, M. MRI visualization of hyaluronidase activity in ovarian cancer cells. Cancer Res. in press, 2005.

Affify, A. and Stern, R. Differentiation of mesothelioma from adenocarcinoma in serous effusion. The role of hyaluronan and CD44 localization. Diagnostic Cytopathology, in press. 2005.

Chapters and reviews:

Mio, K, and Stern, R. Hyaluronidase Inhibitors, Mini-review series on Vertebrate Hyaluronidases . Matrix Biology , 21, 31-7, 2002.

Stern, R. Devising a pathway for hyaluronan catabolism. Are we there yet? Glycobiology, 13, 105-115, 2003.

Stern, R., Mammalian Hyaluronidases, An Update . Glycoforum website. Science of Hyaluronan http://www.glycoforum.gr.jp , 2004.

Stern, R. Hyaluronan degradation in tumor growth and metastasis. Trends in Glycoscience Glycotechnol. 16, 171-185, 2004.

Stern, R. Devising a pathway for hyaluronan catabolism: How the goo gets cut. Hyaluronan 2003. in press, 2004.

Stern, R. A new metabolic pathway: hyaluronan catabolism. Eur. J. Cell Biol., 83, 1-9, 2004.

Neudecker, B. Maibach, H., Stern, R. Hyaluronan, the natural skin moisturizer in Cosmeceuticals, 2nd edition. Eds.,P. Elsner and H. Maibach. Marcel Dekker Press, Inc. New York, in press 2005.

Stern, R. Hyaluronan: a key molecule for skin moisturization. Eds. M. Loden and H.I. Maibach. Dry Skin and moisturizers: Chemistry and Function. CRC Press, Boca Raton, FL. in press, 2005.

2/1/05

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