Professor, Departments Biochemistry and Biophysics, Dept. of Pharmaceutical Chemistry, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
|
stroud@msg.ucsf.edu Box 2240, UCSF; San Francisco, CA 94158-2517 |
additional websites: |
| EDUCATION | |
|
Clare College, U. of Cambridge, U.K., B.A., 1964, Natural Sciences
|
|
| PROFESSIONAL EXPERIENCE | |
|
1973-1975 |
Assistant Professor of Chemistry, Cal Tech |
|
1975-1977 |
Associate Professor of Chemistry, Cal Tech |
|
1977-1979 |
Associate Professor of Biophysics, Department of Biochemistry & Biophysics, UCSF |
|
1977-1979 |
Associate Professor, Dept. of Pharmaceutical Chemistry, UCSF |
|
1979-present |
Professor, Department of Biochemistry & Biophysics, UCSF |
| HONORS & AWARDS | |
|
1961-1964 |
State Scholar, University of Cambridge, England |
|
1965-1968 |
Moulton Trust Fellow, University of London |
|
1972-1977 |
National Institutes of Health Career Development Award |
|
1975-1977 |
Alfred P. Sloan Foundation Fellow |
|
1984 |
DeWitt Stetton Jr. Lecturer of the National Institutes of Health |
|
1988-1989 |
President, Biophysical Society of the United States |
|
1988 |
Fellow of the Royal Society of Medicine (United Kingdom) |
|
1993-2004 |
The Editor, Annual Review of Biophysics and Biomolecular Structure |
|
1997 |
Member National Committee for the IUPAB |
|
1998 |
Founding Fellow of the Biophysical Society of the United States |
|
2003 |
Member of the National Academies of Science (NAS) |
|
2004 |
Tenth Annual Lectureship on Applications of Molecular Biology to Biomedical Sciences, Carnegie Mellon University |
|
2005 |
The 'Fred Richards' Lecturer at Yale University |
|
2006 |
The 'Friedman' Lecturer Rutgers University |
| SELECTED PUBLICATIONS | |
|
Fu, D., Libson, A., Miercke, L., Weitzman, C., Nollert, P., Krucinski, J., and Stroud, R.M. (2000) Science 290, 481-486. The Structure of a Glycerol Conducting Channel Reveals the Basis for its Selectivity. | |
|
Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E.M., and Wells, J.A. (2000). Proc. Natl Acad Sci 97, 9367-72. Site-directed Ligand Discovery. | |
|
Nollert, P., Harries, W.E.C., Fu, D., Miercke, L.J.W., Stroud, R.M. (2001). FEBS Letters 504, 112-7. Atomic Structure of a Glycerol Channel and Implications for Substrate Permeation in Aqua(glyero)porins. | |
|
Tajkhorshid, E. Nollert, P. Jensen, M.O. Miercke, L.J.W. O'Connell, J. Stroud, R.M. Schulten, K. (2002) Science 296, 525-530. Control of the Selectivity of the Aquaporin Water Channel Family by Global Orientational Tuning | |
|
Fu D., Libson A., Stroud R. (2002). Novartis Found Symp 245, 51-61. The structure of GlpF, a glycerol conducting channel. | |
|
Finer-Moore, J. S., Santi, D. V., Stroud, R. M. (2003). Biochemistry 42, 248-256. Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. | |
|
Stroud, R.M., and Finer-Moore, J.S. (2003). Biochemistry 42, 239-247. Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the Movie" | |
|
Stroud, R.M., Miercke, L.J.W., O'Connell, J., Khademi, S., Lee, J. K., Remis, J., Harries, W., Robles, Y., and Akhavan, D. (2003). Curr Opin Struct Biol 13, 424-431. Glycerol facilitator GlpF and the aquaporin family of channels | |
|
Keatinge-Clay, A.T., Shelat, A.A., Savage, D.F., Tsai, S.C., Miercke, L.J.W., O'Connell, J.D.3rd., Khosla, C., and Stroud, R.M. Structure 11, 147-154. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA: ACP transacylase | |
|
Pan, H. Agarwalla, S., Moustakas, D.T., Finer-Moore, J.S., and Stroud, R.M. (2003) Proc Nat. Acad. Sci 100, 12648-12653. Crystal Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA-protein recognition through a combination of rigid docking and induced fit | |
|
Lee, T. L., Agarwalla S., and Stroud, R.M. (2003) Structure 12, 397-407. The first structure of an RNA 5-methyluridine methyltransferase contains an iron-sulfur cluster | |
|
Savage, D. F., Egea, P.F., Robles, Y.C., O'Connell III, J.D., and Stroud, R.M. (2003) PLoS Biology 1, 334-340. [with Journal Cover, and Synopsis 1 302.] Architecture and selectivity in aquaporins: 2.5 X-ray structure of aquaporin Z | |
|
O'Neil R.H., Lilien R.H., Donald B.R., Stroud R.M., Anderson A.C. (2003). J Biol Chem 278, 52980-52987. Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase. | |
|
Stroud R.M., Savage D., Miercke L.J., Lee J.K., Khademi S., Harries W. (2003). FEBS Lett 555, 79-84. Selectivity and conductance among the glycerol and water conducting aquaporin family of channels. | |
|
Agarwalla, S., Stroud, RM., Gaffney B.J. (2004). J Biol Chem 279, 34123-34129. Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies. | |
|
Foster P.G., Nunes C.R., Greene P., Moustakas D., Stroud R.M. (2003). Structure (Camb) 11, 1609-1620. The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. | |
|
Keatinge-Clay A.T., Shelat A.A., Savage D.F., Tsai S.C., Miercke L.J., O'Connell, J., Khosla, C., and Stroud, R.M. (2003). Structure (Camb) 11, 147-154. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. | |
|
Lee J.K., Khademi S., Harries W., Savage D., Miercke L., Stroud R.M. (2004). J Synchrotron Radiat 11, 86-88. Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family. | |
|
Egea, P.F., Shan, S.O., Napetschnig, J., Savage, D.F., Walter, P., and Stroud, R.M. (2004) Nature 426, 215-221. Substrate twinning activates the signal recognition particle and its receptor | |
|
Stroud R.M., Wells J.A. (2004). Science STKE 2004, re7. May 4th. Mechanistic diversity of cytokine receptor signaling across cell membranes. | |
|
Harries, W.E.C., Akhavan, D., Miercke, L.J.W., Khademi, S., Stroud, R.M. (2004) Proc Nat Acad Sci 101, 14045-14050. The Channel Architecture of Aquaporin 0 At 2.2 Resolution. | |
|
Khademi, S., O'Connell III, J., Remis, J., Robles-Colmenares, Y., Miercke L.J.W., Stroud, R.M. (2004) Science 305, 1587-1594. [Cover Article, with Perspective by Knepper and Agre. p1573-1574] Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 | |
|
Keatinge-Clay, A. T., Maltby, D. A., Medzihradszky, K. F., Khosla, C., Stroud, R. M. (2004) Nat Struct Mol Biol 11, 888-893. An antibiotic factory caught in action. | |
|
Laporte S.L., Forsyth C.M., Cunningham B.C., Miercke L.J., Akhavan D., Stroud R.M. (2005) Proc Natl Acad Sci 102, 1889-94. De novo design of an IL-4 antagonist and its structure at 1.9 . | |
|
Lee T.T, Agarwalla S, Stroud R.M. (2005) Cell 120, 599-611. A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. | |
|
Egea P.F, Stroud R.M, Walter P. (2005) Curr Opin Struct Biol. 15, 213-20. Targeting proteins to membranes: structure of the signal recognition particle. | |
|
Credle, J.J., Finer-Moore, J.S., Papa, F.R., Stroud, R.M. and Walter, P. (2005) Proc Nat Acad Sci 102, 18773-18773-18784 On the Mechanism of Sensing Unfolded Protein in the Endoplasmic Reticulum. | |
|
Lee, J.K., Kozono, D. Remis, J., Kitagawa, Y., Agre, P., Stroud, R.M. (2005) Proc. Nat Acad Sci 102, 18932-7. Structural Basis for Conductance by the Archaeal Aquaporin AqpM at 1.68 | |
|
Keatinge-Clay, A. T. and Stroud, R. M. (2006) Structure 14, 737-748. The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases |
|
|
12/6/06 |
|
