jat@scripps.edu
(858) 784-8119 (voice)
(858) 784-2277 (fax)

Scripps Research Institute
10550 North Torrey Pines Rd., MB-04
La Jolla, CA 92037

Trinity College, Duke University. Durham, NC, B.S., 1974, Zoology & Anthropology
Duke University. Durham, NC, Ph.D., 1982, Biochemistry

Tainer, J. A., Getzoff, ED, Richardson, JS, Richardson, DC (1983). Structure and mechanism of Cu,Zn superoxide dismutase. Nature 306, 284-287

Parge, H. E., Arvai, A. S., Murtari, D. J., Reed, S. I., and Tainer, J. A. (1993). "Human CksHs2 atomic structure: a role for its novel hexameric assembly in cell cycle control", Science, 262, 387-395.

Kuo, C. F., McRee, D.E., Fisher, C. L., O'Handley, S., Cunningham, R. P., and Tainer, J.A. (1992). "Atomic Structure of the DNA Repair [4Fe-4S] Enzyme Endonuclease III", Science, 258, 434-440.

Mol, C. D., Kuo, C. F., Thayer, M. M., Cunningham, R. P., and Tainer, J.A. (1995). "Structure of the multifunctional DNA repair enzyme exonuclease III", Nature, 374, 381--386.

Mol, C. D., Arvai, A. S., Slupphaug, G., Kavli, B., Alseuth, I., Krokan H. E., and Tainer, J.A. (1995). "Human uracil-DNA glycosylase: Structural basis for specificity and catalysis", Cell, 80, 869--878.

Parge, H.E., Forest, K. T., Hickey, M. J., Christensen, D.A., Getzoff, E.D. and Tainer, J.A. (1995). "Structure of the fibre-forming protein pilin at 2.6 Å resolution", Nature, 378, 32--38.

Arvai, A.S., Bourne, Y., Hickey, M. J., and Tainer, J.A. (1995). "Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain", J. Mol. Biol., 249, 835-842.Bourne, Y., Arvai, A.S., Bernstein, S. L., Watson, M. H., Reed, S. I., Endicott, J. E., Noble, M. E., Johnson. L. N., and Tainer, J.A. (1995). "Crystal structure of the cell cycle control protein Suc1 reveals ab-hinge controlling fold and assembly", Proc. Natl. Acad. Sci. U.S.A., 92, 10232--10236.

Mol, C. D., Arvai, A. S., Sanderson, R. J., Slupphaug, G., Kavli, B., Krokan H. E., Mosbaugh, D. W., and Tainer, J.A. (1995). "Human uracil-DNA glycosylase and protein inhibitor: protein mimicry of DNA", Cell, 82, 701-708.

McTigue M. A., Williams, D. R., and Tainer, J.A. (1995). "Crystal structures of a glutathione S-transferase and its complex with the leading antischistosomal drug praziquantel", J. Mol. Biol., 246, 21-27.

Slupphaug, G, Mol, CD, Kavli, B, Arvai, AS, Krokan, HE, Tainer, JA (1996). "A nucleotide flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA", Nature 384,87-92.

Bourne, Y., Watson, M. H., Hickey, M. J., Holmes, W., Rocque, W., Reed, S. I., and Tainer, J.A. (1996). "Crystal structure and mutational analysis of human CDK2 complex with CksHs1", Cell, 84, 863--874.

Crane, BR, Arvai, AS, Gachhui, R, Wu, C, Ghosh, DKP, Getzoff, ED, Stuehr, DJ, Tainer, JA (1997). The structure of NO synthase oxygenase domain & inhibitor complexes. Science 278,425-431.

Parikh, SS, Mol, CD, Slupphaug, G, Bharati, B, Krokan, HE, Tainer, JA (1998). "Base-excision repair initiation revealed by structures & kinetics of human uracil-DNA glycosylase bound to DNA," EMBO J. 17,5214-5226.

Crane, BR, Arvai, AS, Gachhui, R, Wu, C, Ghosh, DKP, Getzoff, ED, Stuehr, DJ, Tainer, JA (1998). "Structure of nitric oxide synthase oxygenase dimer w/pterin & substrate," Science 279,2121-2126.

Hosfield, DJ, Mol, CD, Shen, B, Tainer, JA (1998).Crystal structures of the DNA repair & replication nuclease FEN-1:implications for coupling DNA repair & PCNA binding to enzymatic activity Cell 95,135-146.

Hosfield, DJ, Guan, Y, Haas, BJ, Cunningham, RP, Tainer, JA (1999). "Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double nucleotide flipping at abasic sites and three-metal-ion catalysis," Cell 98,397-408.

Daniels, DS, Mol, CD, Arvai, AS, Kanugula, S, Pegg, AE, & Tainer, JA, (2000). "Active and alkylated human AGT structures: a novel zinc site, inhibitor, and extrahelical base binding", EMBO J., 19, 1719--1730.

Mol, CD, Izumi, T, Mitra, S, & Tainer, JA (2000). "DNA-bound structures & mutants reveal abasic DNA binding by APE1 & DNA repair coordination," Nature 403,451-456.

Parikh, SS Walcher, G, Jones, GD, Slupphaug, G, Krokan, HE, Blackburn, GM, Tainer, JA (2000). "UDG-DNA substrate & product structures: catalytic efficiency," Proc. Natl. Acad. Sci. U.S.A., 97,5083-5088.

Hopfner, KP, Karcher, A, Shin, DS, Craig, L, Arthur, LM, Carney, JP, Tainer, JA (2000). "Rad50 ATPase: ATP-driven control in DNA double-strand break repair & the ABC-ATPase superfamily," Cell. 101,789-800.

Chapados, BR, Chai, Q, Hosfield, DJ, Qiu, J, Shen, B, Tainer, JA (2001). Structural biochemistry of a type 2 Rnase H:RNA primer recognition & removal during DNA replication. J Mol Biol. 307,541-56.

Hopfner, KP, Karcher, A, Craig, L, Woo, TT, Carney JP, Tainer, JA (2001). Structural biochemistry & interaction architecture of the DNA double-strand break repair MRE11 nuclease & Rad50-ATPase. Cell. 105,473-85.

Putnam, CD, Clancy, SB, Tsuruta, H, Gonzalez, S, Wetmur, JG, Tainer, JA (2001). Structure & mechanism of the RuvB Holliday junction branch migration motor. J Mol Biol. 311, 297-310.

Han, S, Arvai, AS, Clancy, SB, Tainer, JA. (2001). "Crystal structure & novel recognition motif of ADP-ribosylating C3 exoenzyme from C. botulinum: recognition specificity & catalysis," J Mol. Biol. 305,95-107.

Hopfner, KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BAL, Karcher A, Henderson B, Bodmer JL, McMurray CT, Carney JP, Petrini JHJ, Tainer JA (2002). "Rad50 Zn hook: a novel structure joining Mre11 complexes in DNA recombination and repair" Nature, 418, 562-566.

Barondeau DP, Putnam CD, Kassmann CJ, Tainer JA, Getzoff ED (2003). Mechanism and energetics of GFP chromophore synthesis from trapped intermediate structures, PNAS U.S.A., 100, 12111-12115.

McMurray CT and Tainer JA (2003). Cancer, cadmium and genome integrity. Nat Genet. 34, 239-241.

Brudler R, Hitomi K, Daiyasu H, Toh H, Kucho K, Ishiura M, Kanehisa M, Roberts VA, Todo T, Tainer JA, Getzoff ED. (2003). "A new cryptochrome class. Structure, function, and evolution" Mol Cell. 11:59-67.

Craig L, Taylor RK, Pique ME, Adair BD, Arvai AS, Singh M, Lloyd SJ, Shin DS, Getzoff ED, Yeager M, Forest KT, Tainer JA (2003). Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. Mol. Cell. 11, 1139-1150.

DiDonato M, Craig L, Huff ME, Thayer MM, Cardoso RM, Kassmann CJ, Lo TP, Bruns CK, Powers ET, Kelly JW, Getzoff ED, Tainer JA. (2003). ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. J. Mol. Biol. 332, 601-615.

Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi C, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA. (2003). Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J. 22, 4566-4576.

Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, and Tainer JA. (2004) Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell 116, 39-50.

Daniels, D.S. Woo, T.T., Luu, K.X., Noll, D.M., Clarke, N.D., Pegg, A.E., Tainer, J.A. (2004) Novel modes of DNA binding, and nucleotide flipping, and damage detection in the human DNA repair protein AGT. Nature Structural and Molecular Biology, 11:714-20.

6/15/06