Osamu Tetsu, MD, PhD

Chiba University, School of Medicine, M.D., 1989, Medicine
Chiba University, Graduate School of Medicine, Ph.D., 1997, Surgery and Immunology
Chiba University Hospital, Department of Surgery, Residency, 1990-1997, General Surgery
University of California, San Francisco, Postdoc, 1997-2002, Cancer Biology

• 1990-1997
  Resident, Department of Surgery, Chiba University Hospital
• 1997-1999
  Visiting Postdoctoral Fellow, Dr. Frank McCormick Lab, Cancer Research Institute, University of California, San Francisco
• 1999-2002
  Assistant Research Biochemist, Dr. Frank McCormick Lab, Cancer Research Institute, University of California, San Francisco
• 2002-2005
  Assistant Adjunct Professor, Cancer Research Institute and Department of Surgery, University of California, San Francisco
• 2005-2007
  Assistant Adjunct Professor, Department of Pathology, University of California, San Francisco
• 2007- 2008
  Assistant Adjunct Professor, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco
• 2008-present
  Assistant Professor In-Residence, Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco

• 1990
  Chiba University Hospital, 6th Isono Prize (1st place) for the Best Resident's Presentation
• 1993-1997
  The Japan Scholarship Foundation, Graduate School Student Fellowship
• 2000
  The Uehara Memorial Foundation, Research Fellowship Award
• 2003
  American Cancer Society, Institutional Individual Research Award
• 2004
  UCSF Research-Evaluation and Allocation Committee (REAC), New Junior Faculty Award
• 2004
  Chiba University School of Medicine Alumni Association, Outstanding Academic Achievement Award
• 2004
  The Concern Foundation, Young Investigator Award
• 2005
  The V Foundation for Cancer Research, V Scholar Award
• 2009-2010
  UC Cancer Research Coordinating Committee Award

• Tetsu O, Kanno R, Isono K, Taniguchi M, Kanno M. Cloning and characterization of two transcripts generated from the mel-13 gene positioned adjacent to the mammalian Polycomb group-related gene mel-18. Biochim Biophys Acta. 1996; 1305:109-12.
• Hasegawa M, Tetsu O, Kanno R, Inoue H, Ishihara H, Kamiyasu M, Taniguchi M, Kanno M. Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking. Mol Immunol. 1998; 35:559-63.
• Tetsu O, Ishihara H, Kanno R, Kamiyasu M, Inoue H, Tokuhisa T, Taniguchi M, Kanno M. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity. 1998; 9:439-48.
• Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999; 398:422-6.
• Wakita K, Tetsu O, McCormick F. A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. Cancer Res. 2001; 61:854-8.
• Wakita K, McCormick F, Tetsu O. Method for screening ecdysone-inducible stable cell lines. Biotechniques. 2001; 31:414-8.
• Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell. 2003; 3:233-45.
• Rodriguez-Viciana P*, Tetsu O*, Tidyman WE, Estep AL, Conger BA, Santa Cruz M, McCormick F, Rauen KA. Germline Mutations in Genes within the MAPK Pathway Cause Cardio-facio-cutaneous Syndrome. Science. 2006 Jan 26; [Epub ahead of print] (*co-first author)
• Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. (2006). A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE 1 e128, 1-12.
• Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. (2008). Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: Implications for therapeutic options. Hum Mol Genet. 17: 419-30. (2007 Nov 2; [Epub ahead of print])
• Phuchareon J, Ohta Y, Woo JM, Eisele DW, Tetsu O. (2009). Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. PLoS One. 2009 Jun 25; 4(6):e6040.