thea.tlsty@ucsf.edu
(415) 502-6116 (voice)
(415) 502-6163 (fax)

Box 0506, UCSF; San Francisco, CA 94143-0506

University of South Florida, Tampa, FL, B.S., 1973, Zoology
Washington University, St. Louis, MO, Ph.D., 1980, Molecular Biology
Washington University, St. Louis, MO, 1976-1980, Predoctoral Fellow
Stanford University, Stanford, CA, 1981-1984, Postdoctoral Fellow
Stanford University, Stanford, CA, 1984-1985, Senior Research Associate

Smerdon MJ, Tlsty TD, and Lieberman MW "Distribution of Ultraviolet-induced DNA Repair Synthesis in Nuclease Sensitive and Resistant Regions of Human Chromatin." Biochemistry 17:2377-2386, 1978

Brown PC, Tlsty TD, and Schimke RT "Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea." MCB 3:1097-1107, 1983

Tlsty TD, Albertini AM and Miller JH "Gene Amplification in the lac Region of Escherichia coli." Cell 37:217-224, 1984

Tlsty TD, Brown PC, and Schimke RT "UV Radiation Facilitates Methotrexate Resistance and Amplification of the Dihydrofolate Reductase Gene in Cultured 3T6 Cells." MCB 4:1050-1056, 1984

Otto E, McCord S and Tlsty TD "Increased Incidence of CAD Gene Amplification of Tumorigenic Rat Lines as an Indicator of Genomic Instability of Neoplastic Cells." JBC 264:3390-3396, 1989

Tlsty TD, Margolin B and Lum K "Differences in the Rates of Gene Amplification in Non-tumorigenic and Tumorigenic Cell Lines as Measured by Luria-DelbrŸck Fluctuation Analysis." PNAS 86,9441-9445, 1989

Tlsty TD, and Adams P "Replication of the Dihydrofolate Reductase Genes on Double Minute Chromosomes in a Murine Cell Line." Exp. Cell. Res. 188:164-168, 1990

Tlsty TD "Normal diploid human and rodent cells lack a detectable frequency of gene amplification." PNAS 87:3132-3135, 1990

Tlsty TD, White A and Sanchez J "Suppression of Gene Amplification in Human Cell Hybrids." Science 255:1425-1427, 1992

Livingstone L, White A, Sprouse J, Livanos E and Tlsty TD "Altered Cell Cycle Arrest and Gene Amplification Potential Accompany Loss of Wild-Type p53." Cell 70:923-935, 1992

Jonczyk P, White A, Lum K, Barrett C and Tlsty TD "Amplification Potential in Preneoplastic and Neoplastic Syrian Hamster Embryo Fibroblasts Transformed by Various Carcinogens." Cancer Res. 53:3098-3102, 1993

Schaefer DI, White A, Livanos E and Tlsty TD "Multiple Mechanisms of N - (Phosphonoacetyl)-L-aspartate Drug Resistance in SV40-infected Precrisis Human Fibroblasts." Cancer Research 53:4946-4951, 1993

White A, Livanos E and Tlsty TD "Differential Disruption of Genomic Integrity and Cell Cycle Regulation in Normal Human Fibroblasts by the HPV Oncoproteins." Genes & Dev 8:666-677, 1994

Dulic V, Kaufman WK, Wilson SJ, Tlsty TD, Lees E, Reed S "p53 Dependent Inhibition of Cyclin-Dependent Kinase Activities in Human Fibroblasts During Radiation-Induced G1 Arrest." Cell 76:1013-1023, 1994

Tlsty TD, White A, Livanos E, Sage M, Roelofs H, Briot A and Poulose B "Genomic Integrity and the Genetics of Cancer." Cold Spring Harbor Symposia on Quantitative Biology 59:265-275, 1994

Xiong Y, Kuppuswamy D, Hixon M, Livanos E, Beach D and Tlsty TD "Disruption of Cyclin Quaternary Complexes in Normal Human Fibroblasts by Addition of Viral Oncoproteins." Journal of Virology 70:999-1008, 1996

Chen CYM, Hall IJ, Lansing TJ, Gilmer TM, Tlsty TD, and Kastan MB "Separate Pathways for p53 Induction by Ionizing Radiation and N- (Phosphonoacetyl)-L-aspartate" Cancer Research 56:3659-3662, 1996

Nigro JM, Aldape KD, Tlsty TD "Anchorage-dependent expression of p53 protein in primary human keratinocytes in culture" Cancer Research, 57:3635-3639, 1997

Gualberto A, Aldape KD, Tlsty TD "An Oncogenic Form of p53 Confers a Dominant, Gain-of-Function Phenotype that Disrupts Spindle Checkpoint Control" PNAS 95:5166-5171, 1998

Tlsty TD "Cell-adhesion-dependent influences on genomic instability and carcinogenesis" Current Opinion in Cell Biology 10:647-653, 1998

Olumi AF, Dazin P, Tlsty TD "A Novel Coculture Technique Demonstrates That Normal Human Prostatic Fibroblasts Contribute to Tumor Formation of LNCaP Cells by Retarding Cell Death" Cancer Research 58:4525-4530, 1998

Jiang X, Jimenez G, Chang E, Frokis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu C "Telomerase Expression in Human Somatic Cells Does Not Induce Changes Associated With A Transformed Phenotype" Nature Genetics 21:111-114, 1999

Tlsty TD "A Molecular Blueprint for Targeting Cancer?" Nature Genetics 21:4-5, 1999

Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR "Carcinoma-associated Fiborblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium" Cancer Research 61:5002-5011, 1999

Hess SM, Meyer KM, Tlsty TD, Leadon ST "Human Mammary Epithelial Cells Exhibit a Differential p53-Mediated Response Following Exposure to Ionizing Radiation or UV Light" Oncogene 18:5795-5805, 1999.

Felsher DW, Zetterberg A, Zhu J, Tlsty TD, Bishop JM "Overxpression of MYC causes p53-dependent G2 arrest of normal fibroblasts." PNAS 97:10544-8, 2000

Romanov, S, Krystyna Kozakiewicz, Charles R. Holst, Martha R. Stampfer, Larisa M. Haupt, and Tlsty TD "Normal Human Mammary Epithelial Cells Spontaneously Emerge from Senescence and Acquire Genomic Instability" Nature, 409:633-637, 2001

Tlsty TD, Hein Patrick H. "Know thy neighbor: stromal cells can contribute oncogenic signals" Current Opinion in Genetics & Dev. 11:54-59, 2001

Meng M, Grossfeld G, Williams GH, Dilworth S, Stoeber K, Mulley T, Weinberg V, Carroll P, Tlsty TD "Minichromosome Maintenance Protein 2 Expression in Prostate: Characterization and Association with Outcome After Therapy for Cancer" Clinical Cancer Research 7:2712-2718, 2001.

Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD "Methylation of p16INK4a Promoters Occurs in Histologically Normal Human Mammary Epithelia" Cancer Research 63: 1596-1601, 2003.

Tlsty, Thea D. Functions of p53 Supress Critical Consequences of Damage and Repair in the Initiation of Cancer, Cancer Cell 2:2-4, 2002

Shim V, Gauthier ML, Sudilovsky D, Mantei K, Chew K, Moore D, Cha I, Tlsty TD, Esserman L "COX-2 expression is related to nuclear grade in DCIS and is increased in its normal adjacent epithelium" Cancer Research, 63:2347-2350, 2003

Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD. (2004) Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell. 5(3):263-73.

Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. "p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue" Cancer Res. Mar 1;65(5):1792-9, 2005

Tlsty TD, Coussens LM, "Tumor Stroma and Regulation of Cancer Development." Annual Review of Molecular Pathology volume 1, 2005

Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degmin AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty TD, Vachon CM, Melton LJ, Visscher DW. "Benign Breast Disease and the Risk of Breast Cancer" N Engl J Med Jul 21;353(3):229-237, 2005

Berman H, Zhang J, Crawford YG, Gauthier ML, Fordyce CA, McDermott KM, Sigaroudinia M, Kozakiewicz, Tlsty TD, "Genetic and Epigenetic Changes in Mammary Epithelial Cells Identify a Subpopulation of Cells Involved in Early Carcinogenesis" Cold Spring Harbor Symposia on Quantitative Biology, Volume 70:317-27, 2005

McDermott KM, Zhang Z, Holst CR, Kozakiewicz KB, Singla V,Tlsty TD. "p16 Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells " Plos Biology Mar;4(3):e51, 2006

Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD, "Tumor Suppressor p16INK4A Regulates Polycomb-Mediated DNA Hypermethylation in Human Mammary Epithelial Cells" J Biol Chem. J Biol Chem. Aug 25;281(34):24790-802, 2006

Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD. "p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells", Cancer Res. Nov 1;66(21):10325-31, 2006

12/8/06