Professor, Pathology, UCSF
Member, Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS), UCSF
Co-Leader, Cell Cycling and Signaling Program, UCSF Helen Diller Family Comprehensive Cancer Center
| CONTACT | |
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thea.tlsty@ucsf.edu Box 0506, UCSF; San Francisco, CA 94143-0506 |
additional websites: |
| EDUCATION | |
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University of South Florida, Tampa, FL, B.S., 1973, Zoology
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| PROFESSIONAL EXPERIENCE | |
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1974-1976 |
Candidate for Ph.D. in the Dept. of Pathology, University of North Carolina, Chapel Hill (transferred) |
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1976-1980 |
Pre-doctoral Fellow in Program for Cellular & Molecular Biology, Washington University, St. Louis, Missouri (advisor, Dr. M. Lieberman) |
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1980-1981 |
Postdoctoral Fellow in Department of Microbiology & Immunology, Washington Univ., St. Louis, MO |
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1981-1985 |
Postdoctoral Fellow/Senior Research Associate in Department of Biological Sciences, Stanford University, Stanford, California (advisor, Dr. R.T. Schimke) |
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1985-1992 |
Assistant Professor of Pathology and Member: UNC Lineberger Comprehensive Cancer Center; Curriculum in Genetics; Curriculum in Toxicology; Program in Molecular Biology & Biotechnology, University of North Carolina at Chapel Hill, North Carolina |
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1992-1995 |
Associate Professor of Pathology and Member: Lineberger Comprehensive Cancer Center; University of North Carolina at Chapel Hill, North Carolina |
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1995-1996 |
Associate Professor of Pathology, Director of Molecular Pathology, Member: Cancer Research Institute; Program in Biological Sciences; Program in Biomedical Sciences, University of California at San Francisco, CA |
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1996-present |
Professor of Pathology, Director of the Center for Translational Research in the Molecular Genetics of Cancer, Member: UCSF Helen Diller Family Comprehensive Cancer Center - Director for the Program in Cell Cycling and Signaling; Program in Biological Sciences; Program in Biomedical Sciences, University of California at San Francisco, CA |
| SELECTED PUBLICATIONS | |
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Smerdon MJ, Tlsty TD, and Lieberman MW "Distribution of Ultraviolet-induced DNA Repair Synthesis in Nuclease Sensitive and Resistant Regions of Human Chromatin." Biochemistry 17:2377-2386, 1978 | |
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Brown PC, Tlsty TD, and Schimke RT "Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea." MCB 3:1097-1107, 1983 | |
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Tlsty TD, Albertini AM and Miller JH "Gene Amplification in the lac Region of Escherichia coli." Cell 37:217-224, 1984 | |
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Tlsty TD, Brown PC, and Schimke RT "UV Radiation Facilitates Methotrexate Resistance and Amplification of the Dihydrofolate Reductase Gene in Cultured 3T6 Cells." MCB 4:1050-1056, 1984 | |
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Otto E, McCord S and Tlsty TD "Increased Incidence of CAD Gene Amplification of Tumorigenic Rat Lines as an Indicator of Genomic Instability of Neoplastic Cells." JBC 264:3390-3396, 1989 | |
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Tlsty TD, Margolin B and Lum K "Differences in the Rates of Gene Amplification in Non-tumorigenic and Tumorigenic Cell Lines as Measured by Luria-DelbrŸck Fluctuation Analysis." PNAS 86,9441-9445, 1989 | |
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Tlsty TD, and Adams P "Replication of the Dihydrofolate Reductase Genes on Double Minute Chromosomes in a Murine Cell Line." Exp. Cell. Res. 188:164-168, 1990 | |
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Tlsty TD "Normal diploid human and rodent cells lack a detectable frequency of gene amplification." PNAS 87:3132-3135, 1990 | |
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Tlsty TD, White A and Sanchez J "Suppression of Gene Amplification in Human Cell Hybrids." Science 255:1425-1427, 1992 | |
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Livingstone L, White A, Sprouse J, Livanos E and Tlsty TD "Altered Cell Cycle Arrest and Gene Amplification Potential Accompany Loss of Wild-Type p53." Cell 70:923-935, 1992 | |
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Jonczyk P, White A, Lum K, Barrett C and Tlsty TD "Amplification Potential in Preneoplastic and Neoplastic Syrian Hamster Embryo Fibroblasts Transformed by Various Carcinogens." Cancer Res. 53:3098-3102, 1993 | |
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Schaefer DI, White A, Livanos E and Tlsty TD "Multiple Mechanisms of N - (Phosphonoacetyl)-L-aspartate Drug Resistance in SV40-infected Precrisis Human Fibroblasts." Cancer Research 53:4946-4951, 1993 | |
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White A, Livanos E and Tlsty TD "Differential Disruption of Genomic Integrity and Cell Cycle Regulation in Normal Human Fibroblasts by the HPV Oncoproteins." Genes & Dev 8:666-677, 1994 | |
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Dulic V, Kaufman WK, Wilson SJ, Tlsty TD, Lees E, Reed S "p53 Dependent Inhibition of Cyclin-Dependent Kinase Activities in Human Fibroblasts During Radiation-Induced G1 Arrest." Cell 76:1013-1023, 1994 | |
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Tlsty TD, White A, Livanos E, Sage M, Roelofs H, Briot A and Poulose B "Genomic Integrity and the Genetics of Cancer." Cold Spring Harbor Symposia on Quantitative Biology 59:265-275, 1994 | |
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Xiong Y, Kuppuswamy D, Hixon M, Livanos E, Beach D and Tlsty TD "Disruption of Cyclin Quaternary Complexes in Normal Human Fibroblasts by Addition of Viral Oncoproteins." Journal of Virology 70:999-1008, 1996 | |
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Chen CYM, Hall IJ, Lansing TJ, Gilmer TM, Tlsty TD, and Kastan MB "Separate Pathways for p53 Induction by Ionizing Radiation and N- (Phosphonoacetyl)-L-aspartate" Cancer Research 56:3659-3662, 1996 | |
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Nigro JM, Aldape KD, Tlsty TD "Anchorage-dependent expression of p53 protein in primary human keratinocytes in culture" Cancer Research, 57:3635-3639, 1997 | |
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Gualberto A, Aldape KD, Tlsty TD "An Oncogenic Form of p53 Confers a Dominant, Gain-of-Function Phenotype that Disrupts Spindle Checkpoint Control" PNAS 95:5166-5171, 1998 | |
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Tlsty TD "Cell-adhesion-dependent influences on genomic instability and carcinogenesis" Current Opinion in Cell Biology 10:647-653, 1998 | |
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Olumi AF, Dazin P, Tlsty TD "A Novel Coculture Technique Demonstrates That Normal Human Prostatic Fibroblasts Contribute to Tumor Formation of LNCaP Cells by Retarding Cell Death" Cancer Research 58:4525-4530, 1998 | |
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Jiang X, Jimenez G, Chang E, Frokis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu C "Telomerase Expression in Human Somatic Cells Does Not Induce Changes Associated With A Transformed Phenotype" Nature Genetics 21:111-114, 1999 | |
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Tlsty TD "A Molecular Blueprint for Targeting Cancer?" Nature Genetics 21:4-5, 1999 | |
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Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR "Carcinoma-associated Fiborblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium" Cancer Research 61:5002-5011, 1999 | |
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Hess SM, Meyer KM, Tlsty TD, Leadon ST "Human Mammary Epithelial Cells Exhibit a Differential p53-Mediated Response Following Exposure to Ionizing Radiation or UV Light" Oncogene 18:5795-5805, 1999. | |
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Felsher DW, Zetterberg A, Zhu J, Tlsty TD, Bishop JM "Overxpression of MYC causes p53-dependent G2 arrest of normal fibroblasts." PNAS 97:10544-8, 2000 | |
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Romanov, S, Krystyna Kozakiewicz, Charles R. Holst, Martha R. Stampfer, Larisa M. Haupt, and Tlsty TD "Normal Human Mammary Epithelial Cells Spontaneously Emerge from Senescence and Acquire Genomic Instability" Nature, 409:633-637, 2001 | |
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Tlsty TD, Hein Patrick H. "Know thy neighbor: stromal cells can contribute oncogenic signals" Current Opinion in Genetics & Dev. 11:54-59, 2001 | |
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Meng M, Grossfeld G, Williams GH, Dilworth S, Stoeber K, Mulley T, Weinberg V, Carroll P, Tlsty TD "Minichromosome Maintenance Protein 2 Expression in Prostate: Characterization and Association with Outcome After Therapy for Cancer" Clinical Cancer Research 7:2712-2718, 2001. | |
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Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD "Methylation of p16INK4a Promoters Occurs in Histologically Normal Human Mammary Epithelia" Cancer Research 63: 1596-1601, 2003. | |
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Tlsty, Thea D. Functions of p53 Supress Critical Consequences of Damage and Repair in the Initiation of Cancer, Cancer Cell 2:2-4, 2002 | |
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Shim V, Gauthier ML, Sudilovsky D, Mantei K, Chew K, Moore D, Cha I, Tlsty TD, Esserman L "COX-2 expression is related to nuclear grade in DCIS and is increased in its normal adjacent epithelium" Cancer Research, 63:2347-2350, 2003 | |
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Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD. (2004) Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell. 5(3):263-73. | |
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Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. "p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue" Cancer Res. Mar 1;65(5):1792-9, 2005 | |
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Tlsty TD, Coussens LM, "Tumor Stroma and Regulation of Cancer Development." Annual Review of Molecular Pathology volume 1, 2005 | |
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Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degmin AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty TD, Vachon CM, Melton LJ, Visscher DW. "Benign Breast Disease and the Risk of Breast Cancer" N Engl J Med Jul 21;353(3):229-237, 2005 | |
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Berman H, Zhang J, Crawford YG, Gauthier ML, Fordyce CA, McDermott KM, Sigaroudinia M, Kozakiewicz, Tlsty TD, "Genetic and Epigenetic Changes in Mammary Epithelial Cells Identify a Subpopulation of Cells Involved in Early Carcinogenesis" Cold Spring Harbor Symposia on Quantitative Biology, Volume 70:317-27, 2005 | |
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McDermott KM, Zhang Z, Holst CR, Kozakiewicz KB, Singla V,Tlsty TD. "p16 Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells " Plos Biology Mar;4(3):e51, 2006 | |
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Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD, "Tumor Suppressor p16INK4A Regulates Polycomb-Mediated DNA Hypermethylation in Human Mammary Epithelial Cells" J Biol Chem. J Biol Chem. Aug 25;281(34):24790-802, 2006 | |
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Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD. "p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells", Cancer Res. Nov 1;66(21):10325-31, 2006 |
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12/8/06 |
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