David P. Toczyski, PhD

State University of New York/Buffalo, B.S., 1987, Biology
Yale University, M.Phil., 1990, Biophysics & Biochem
Yale University, Ph.D., 1992, Biophysics & Biochem

• 1984-1986
  State University New York - Buffalo, Undergrad Research
• 1987-1992
  Yale University, Graduate Student
• 1993-1998
  University of Washington/FHCRC, Postdoctoral Associate
• 1998-2005
  UCSF Biochemistry & Biophysics/CRI, Assistant Professor
• 2005-present
  UCSF Biochemistry & Biophysics/CRI, Associate Professor

• 1993-1996
  Jane Coffin Childs Fellow
• 2003-2009
  Leukemia and Lymphoma Society Scholar
• 2005-present
  NDT study section, permanent member
• 2009
  Keynote address, NIH Cell Cycle meeting

• Paulovich, A., Toczyski, D.P., and Hartwell, L.H. (1997) "When checkpoints fail". Cell 88: 315-321.
• Toczyski,D.P., Galgoczy, D.J., and Hartwell, L.H. (1997) "CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint". Cell 90: 1097-1106.
• Hartwell, L., Paulovich, A., and Toczyski, D. P. (1997). "The DNA damage Checkpoint" in Genomic instability and immortality in Cancer pg. 149-157. Plenum Press, NY
• Galgoczy, D.J., and Toczyski, D.P. (2001) "Checkpoint adaptation precedes spontaneous and DNA damage-induced genomic instability in S. cerevisiae" MCB 21: 1710-1718
• Melo, J., Cohen, J. and Toczyski, D.P. (2001) "Two checkpoint complexes are independently recruited to sites of DNA damage in vivo" Genes and Development 15: 2809-2821
• Melo, J. and Toczyski, D. P. (2002) "The DNA damage checkpoint response" Current Opinions in Cell Biology 14: 237-245
• Thornton B.R., and Toczyski D.P. (2003) "Securin and B-cyclin/CDK are the only essential targets of the APC." Nature Cell Biology 5(12): 1090-4.
• Thornton, B.R., Chen, K.C., Cross, F.R., Tyson, J.J., and Toczyski, D.P. (2004) "Cycling without the cyclosome: Modeling a yeast strain lacking the APC." The Cell Cycle. 3(5): 629-33
• Kaye, J., Melo, J., Cheung, S.K., Vaze, M.B., Haber, J. and Toczyski, D. P. (2004) "DNA breaks promote genomic instability by impeding proper chromosome segregation" Current Biology14(23):2096-2106.
• Garber, P.M., Vidanes, G.M., Toczyski, D.P. (2005) Damage in transition. Trends Biochem Sci. 30(2): 63-6.
• Vidanes, G.M., Bonilla, C.Y., Toczyski, D.P. (2005) Complicated tails: histone modifications and the DNA damage response. Cell. Jul 1;121(7):973-6.
• Toczyski, D.P. (2006) "Methods for studying adaptation to the DNA damage checkpoint in yeast." Methods in Enzymology. Methods Enzymol. 2006;409:150-65.
• Thornton, B.R., Ng, T.M., Matyskiela, M.E., Carroll, C.W. Morgan, D.O., and Toczyski, D.P. (2006) "An architectural map of the anaphase promoting complex." Genes & Development 20(4):449-60.
• Maas, N. Miller, K. DeFazio, L. and Toczyski, D.P. (2006) "Cell cycle and checkpoint regulation of H3 K56 Acetylation by Hst3 and Hst4." Mol Cell 23(1):109-19.
• Thornton B.R., and Toczyski D.P. (2006) "Precise destruction: an emerging picture of the APC." Genes & Development 20:3069-3078.
• Collins et al. (2007) Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 446(7137):806-10
• Vega, L., Phillips, J., Thornton, B., Benanti, J., Onigbanjo, M., Toczyski, D., Zakian, V. (2007) "A Role for Telomerase in Telomere End Protection as Revealed by Altering Pif1p Levels." PLoS Genetics 3(6):105
• Benanti, J., Brady, M., Cheung, S., and Toczyski, D.P. (2007) "A Proteomic Screen Reveals SCFGrr1 Targets that Regulate the Glycolytic- Gluconeogenic Switch" Nature Cell Biology (10):1184-91
• Bonilla, C.Y. Melo, J.A. and Toczyski, D. P. (2008) "Co-localization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage" Molecular Cell 30(3) 267-276.
• Benanti J.A., Toczyski D.P. (2008) "Cdc20, an activator at last." Molecular Cell. 2008 32(4):460-1.
• Benanti, J.A., Matyskiela, M.E., Morgan, D.O., and Toczyski, D.P. (2009) "Functionally Distinct Isoforms of Cik1 are Differentially Regulated by APC/C-Mediated Proteolysis. Molecular Cell 33(5):581-90.