Christian Vaisse, MD, PhD

University of Paris XI, MD, 1983-88, Medicine
University of Paris XI, PhD, 1988-91, Molecular Endocrinology

• 1991-1995
  Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
• 1995-1997
  Post-Doctoral Fellow, Rockefeller University, New-York
• 1997
  Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
• 1997-1999
  Senior Scientist (INSERM Tenure) Pasteur institute and Attending Physician Department of Internal medicine and Nutrition at Hospital Hotel-Dieu, Paris
• 1999-present
  Assistant Professor in Residence, Department of Medicine and Diabetes Research Center, University of California San Francisco

• 1995
  ALFEDIAM/NOVO-NORDISK-Post-doctoral research award
• 1996
  Philippe Foundation Post-Doctoral Research Award
• 1998
  INSERM-CR1 tenure
• 1999-00
  Served as an expert on genetics of childhood obesity on an Advisory Committee to the French government entitled "Overweight and Obesity in Children and Adolescents, Diagnosis, Prevention and Treatment"
• 2000
  American Diabetes Association-Career Development Award
• 2000
  North American Association for the Study of Obesity-Pilot Study Award
• 2002
  Greenberg Young Investigator Award in Cardiovascular Genetics

• Mellon SH and Vaisse C. (1989) cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig cells. Proceedings of the National Academy of Science USA 86: 7775-79
• Vaisse C, Atger M, Potier B & Milgrom E (1990) Human Placental Protein 14 Gene: Sequence and characterization of a short duplication. DNA and Cell Biology 9: 401-13
• Mellon SH, Kushner TA, Vaisse C (1991) Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues. DNA and Cell Biology 10:339-347
• Nguyen VC, Vaisse C, Gross MS, Slim R, Milgrom E & Bernheim A (1991) The human placental protein 14 (PP14) gene is localized on chromosome 9q34. Human Genetics 86:515-518
• Charpentier G. & Vaisse C. pour le groupe EVADIAC (1994) Implantable insulin pumps in France Infusysteme. 11:15-18.
• Ruiz J., Blanché H., James R.W., Blatter Garin M- C, Vaisse C, Charpentier G., Passa Ph & Froguel Ph. (1995) The paraoxonase polymorphic site at position 192 is associated with coronary heart disease in non-insulin dependent diabetic patients. Lancet. 346:869-72
• Hager J., Hansen L., Vaisse C., Vionnet N., Phillipi A., Poller W., Cambien F., Passa Ph., Julier C., Velho G., Kindsvogel W., Demenais F., Froguel Ph. (1995) A missense mutation in the glucagon receptor gene is linked to familial non-insulin-dependent diabetes mellitus. Nature Genetics. 9:299-304.
• Clement K., Vaisse C., Manning B., Basdevant A., Guygrand B., Froguel P. and Strosberg D. (1995) A point mutation in the b3 adrenoreceptor is correlated with increased dynamic capacity to gain weight in patients with morbid obesity. New England Journal of Medicine. 333(6):352-4.
• Vaisse C , Halaas J.L., Horvath C.M., Darnell J.E.Jr., Stoffel M., Friedman J.M. (1996) Leptin activation of Stat3 in hypothalamus of wild type and ob/ob mice but not db/db mice. Nature Genetics 14:95-97.
• Vaisse C., Kim J., Espinosa III R., Le Beau M.M., Stoffel M. (1997) Pancreatic Islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factors HNF3a, HNF3b, HNF3g,HNF4g and HNF6. Diabetes 46: 1364-67
• Vaisse C, Clément K, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte J-M, Basdevant A, Bougnères P, Lebouc Y, Froguel P & Guy-Grand B.(1998): Severe obesity and hypothalamic pituitary dysfunction in a family with a mutation in the leptin receptor gene. Nature 392:398-400
• Taylor R.N., Savouret J.-F., Vaisse C., Vigne J.-L., Ryan I., Hornung D., Seppälä M. & Milgrom E. (1998) Promegestone (R5020) and Mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in Isolated human epithelial cells. Journal of Clinical Endocrinology and Metabolism, 83: 4006-12
• Vaisse C., Clément K., Guy-Grand B., Froguel P. (1998) A Frameshift mutation in human melanocortin-4 receptor results in a dominant form of obesity. Nature Genetics 20:113-114
• Mueller MD, Vigne JL, Vaisse C, Taylor RN (2000) Glycodelin: A pane in the implantation window Seminars in reproductive Medicine 18 (3): 289-298.
• Lahlou N, Clément K., Carel J.-C.., Vaisse C., Lotton, C., Le Bihan Y., Basdevant A., Lebouc, Y., Froguel P., Roger M., Guy-Grand B. (2000) Soluble Leptin Receptor in Serum of Subjects with complete Resistance to Leptin. Relation to Fat Mass, Diabetes 49:1347-52
• Navas M.A., Vaisse C., Boger S., Kolee L.A., Stoffel, M., (2000): Mutation screening of HNF-3 genes in early and late onset type II diabetes mellitus. Human Heredity 50: 370-381
• Clément K., Hercberg S., Passinge B., Galan P., Varroud-Vial M., Charpentier G., Guy-Grand B., Froguel P. & Vaisse C. (2000) The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type II diabetes. International Journal of Obesity 24: 3
• Vaisse C., Clément K., Durand E., Legall A., Bonhomme G., Basdevant A., Guy-Grand B., Froguel P. (2000) Heterogeneity of obesity associated with Melanocortin 4 receptor mutations. Journal of Clinical Investigation 106:253-262
• Cummings, D.E., Clement K., Purnell, JQ., Vaisse, C., Foster, EK, Frayo, S., Schwartz, MW, Basdevant, A., Weigle, DS. (2002) . Elevated Plasma Ghrelin Levels in Prader-Willi Syndrome. Nature Medicine 8(7):643-4-
• Lubrano-Berthelier C., Durand E., Haas K., Dubern B., Shapiro A., Dazin, P., Weil J., Ferron C. Froguel P. & Vaisse C (2003) Intracellular Retention Is A Common Characteristic Of Childhood Obesity Associated Mc4r Mutations. Human Molecular Genetics 12:145-153
• Lubrano-Berthelier C., Cavazos M., Shapiro A, Dubern B., Lestunff C.,.Zhang S, Picart F., Govaerts C., Froguel P. Bougneres P., Clement K & Vaisse C (2003) Molecular Genetics Of Human Obesity-Associated With Mc4r Mutations. Annals of the New York Academy of Science (in press)
• Srinivasan, S., Vaisse C & Conklin, BR. (2003) Engineering the Melanocortin-4 receptor to study GS signaling in vivo. Annals of the New York Academy of Science (in press)
• Vaisse C. (2003) The Leptin/Melanocortin Axis and Human Obesity, Journal of Clinical Pediatric Endocrinology (in press)
• Swarbrick M. & Vaisse C. (2003) New trends in the search for genetic variants predisposing to human obesity. Current Opinion in Clinical Nutrition and Metabolic Care. (In press)