HFVanBrocklin@lbl.gov
(510) 486-4083 (voice)
(510) 486-4768 (fax)

Lawrence Berkeley Nat'l Laboratory, 1 Cyclotron Road, MS 55-121, Berkeley, CA 94720

Rensselaer Polytechnic Institute, Troy, NY, B.S., 1984, Chemistry
Rensselaer Polytechnic Institute, Troy, NY, M.S., 1986, Nuclear Chemistry
Washington University, St. Louis, MO, M.A., 1988, Nuclear Chemistry
Washington University, St. Louis, MO, Ph.D., 1990, Radiopharm. Chemistry
University of Illinois, Urbana, IL, Postdoctoral, 1992, Radiopharm. Chemistry

(selected from a total of 54)

Lagunas-Solar MC, Zeng N, Castaneda CM, Carvacho OF, VanBrocklin HF, Budinger TF. Accelerator Production of 122Xe (20.1 h) as a Source of 122I (3.6 m) Labeled Radiopharmaceuticals for Applications in Positron Emission Tomography. in "Proceedings of the 15th International Conference on the Applications of Accelerators in Research and Industry" Duggan, JL; Morgan, IL. ed. AIP Press 1999; 994-997.

O'Neil JP, VanBrocklin HF. Preparation of fluorine-18 gas from a 11 MeV cyclotron: A target system for the CTI RDS 111 cyclotron. Nuc Inst Meth Phys Res Section A 1999; 438(1):166-172.

Lim JK, Negash K, VanBrocklin HF. Synthesis of 4-(3'[125I]Iodophenylamino)-6,7-dialkoxyquinazoline: Epidermal Growth Factor Receptor Tyrosine Kinase (EGFrTK) Inhibitors. J Lab Comp Radiopharm 2000; 43:1183-1191.

Joosten R, Powell J, Guo FQ, Haustein PE, Larimer R-M, McMahan MA, Norman EB, O'Neil JP, . Rowe MW, VanBrocklin HF, Wutte D, Xu XJ, Joseph Cerny. Measurement of excitation functions in the reactions 197Au(11C,xn)208-xAt using a radioactive 11C beam. Phys Rev Lett 2000; 84:5066-5069.

Marshall RC, Powers-Risius P, Reutter BW, Taylor SE, VanBrocklin HF, Huesman RH, Budinger TF. Kinetic Analysis of 7'-[125I]Iodorotenone as a Depositied Myocardial Flow Tracer: Comparison to [99mTc]Sestamibi. J Nucl Med 2001; 42:272-281.

Eberling JL, Roberts,JA, Taylor SE, VanBrocklin HF, O'Neil JP, Nordahl TE. Effects of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain. Neurobiology of Aging, 2002; 23(3): 479-83.

Lange CW, VanBrocklin HF, Taylor SE. Photoconjugation of 3-azido-5-nitrobenzyl-[18F]fluoride to an ologonucleotide. J Lab Comp Radiopharm 2002; 45: 257-268.

Gibbs AR, Morimoto H, Biegon A, VanBrocklin HF, Williams PG. Synthesis of N-(2-chloro-5-methylthiophenyl)-N'-(3-methyl-thiophenyl)-N'-[3H3]methylguanidine, {[3H3]CNS-5161}. J Lab Comp.Radiopharm 2002; 45: 395-400.

Collier TL, Lecomte R, McCarthy TJ, Meikle S, Ruth TJ, Scopinaro F, Signore A, VanBrocklin HF, Van de Wiele C, Waterhouse RN. Assessment of Cancer Associated Biomarkers by Positron Emission Tomography: Advances and Challenges. Dis Markers. 2002; 18(5-6):211-47.

VanBrocklin HF, Blagoev M, Hoepping A, O'Neil JP, Klose M, Schubiger PA, Ametamey S. A new precursor for the preparation of 6-[18F]-Fluoro-L-m-tyrosine (FMT): Efficient synthesis and comparison of radiolabeling. Appl Rad Isot. 61(6):1289-1294, 2004.

Marshall RC, Powers-Risius P, Reutter BW, O'Neil JP, LaBelle M, Huesman RH, VanBrocklin HF; Kinectic Analysis of 18F-Fluorodihydrorotenone as a Deposited Myocardial Flow Tracer: Comparison tozThallium-201. J. Nucl. Med 45(11): 1950-1959, 2004.

Vasdev N, Dorff PN, Gibbs AR, Erathodiyil N, Reid L, O'Neill JP, VanBrocklin HF; Synthesis of 6-acrylimido-4-(2-[18F]fluoroanilino)quinazoline; A fluorine-18 labeled irreversible binding probe for EGFR imaging. J Labelled Comp Radiopharm, 48:109-115, 2005.

VanBrocklin, HF; Lim,JK; Coffig, SL; Hom, DL; Negash, K; Ono, MY; Hanrahan, SM; Taylor, SE; Vanderpoel, JL; Slavik, SM; Morris, AB; Riese II, DJ. Dialkoxyquinazolines: Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Potential Tumor Imaging Probes. J. Med. Chem. 48(23) 7445-7456, 2005.

Hwang, AB; Taylor, CC; VanBrocklin, HF; Dae, MW; Hasegawa, BH. Attenuation Correction of Small Animal SPECT Images Acquired with 125I-Iodorotenone. IEEE Transactions on Nuclear Science. 53:1213-1220, 2006.

VanBrocklin, HF; Enas, JD; Hanrahan, SM; O'Neil, JP. Mitochondrial Electron Transport Chain (ETC) Radioprobes. Preparation and Evaluation of 7'(E)-[125I]Iodorotenone and 7'(E)-[125I]Iodorotenol. Nucl. Med. Biol. In Press.

SELECTED ABSTRACTS (out of a total of 130)

Marshall RC; VanBrocklin HF; O'Neil JP; Powers-Risius P; Reutter BW; Huesman RH. Kinetic Analysis of 18F-fluorodihydrorotenone as a Depositied Myocardial Flow Tracer: Comparison to 201Thallium. J Nucl Med 2003; 44:87P.

Dorff PN, Vasdev N, O'Neil JP, Nandanan E, Gibbs AR, VanBrocklin HF. Synthesis Of 2'-, 3'- And 4'-[18f] Fluoroanilinoquinazoline. J Lab Comp Radiopharm 2003; 46:S117.

O'Neil JP, VanBrocklin HF, Bolstad DB, Gerdes JM, Kusche BR. Serotonin Transporter Ligands: Synthesis Of (±)-[11C]2'-Methoxymethyl-6-Nitroquipazine. J Lab Comp Radiopharm 2003; 46:S171.

VanBrocklin HF, Dorff PN, Gibbs AR, Hanrhan SM, O'Neil JP, Vasdev N. Targeting Tumors with ErbB Receptor Imaging Agents. Academy of Molecular Imaging Annual Meeting, Orlando, Florida. March 2004.

Pareto, D; Gibbs, AR; Hanrahan, SM; VanBrocklin, HF; Brennan, K; Biegon, A; Budinger, TF. SPECT imaging of estrogen receptors in an ovarectomized canine model. J. Nucl. Med. 45:258P, 2004

Vasdev, N; Dorff, PN; Gibbs, AR; Nandanan, E; Reid, L; O'Neil, JP; VanBrocklin, HF. Synthesis of 6-Acrylamido-4-(2-[18F]fluoro-anilino)quiaoline. J. Nucl Med. 45:168P, 2004.

VanBrocklin, HF; Janabi, M; O'Neil, JP; Hanrahan, SM; Zhou, EY; Marks, JD; Hann, B; Wang, D; Tempero, M. ErbB2 Targeted Probes: Fluorine-18 Labelled Single Chain And Diabody Fragments, Mol. Imag. and Biol. 7:119, 2005.

VanBrocklin, HF; Hanrahan, SM; Brennan, KM; Gullberg, GT; Huesman, RH; Reutter, BW; Budinger, TF. Myocardial Perfusion Imaging: Evaluation of Iodine-123 Labeled 7'-(E)-Iodorotenone and 7'-(Z)-Iodorotenone in Normal Canines. J. Nucl. Med. 46 (supp 2):60P, 2005.

VanBrocklin, HF; Hanrahan, SM; Gibbs, AR; O'Neil, JP. Evaluation of Iodine labeled Rotenone and Rotenol: Comparison of the 7'-(E) and 7'-(Z) Stereoisomers. J. Nucl. Med. 46 (supp 2):85P, 2005.

Hu, J; Sitek, A; Reutter, BW; Huesman, RH, Hanrahan, SM; VanBrocklin, HF; Brennan, KT; Gullberg, GT. Dynamic Imaging of 123I-MIBG in SHR models for evaluation of cardiac hypertrophy. J. Nucl. Med. 47 (supp 1): 69P, 2006.

Gullberg, GT; Hu, J; Sitek, A; Reutter, BW; Huesman, RH, Hanrahan, SM; VanBrocklin, HF; Brennan, KT; Qi, J; Feng, Y. A study of changes in glucose and fatty acid metabolism in the heart as a functionof hypertrophy in SHR models using microPET and microSPECT technology. J. Nucl. Med. 47 (supp 1):72P, 2006.

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