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Helen Diller Family Compr Cancer Ctr
FREDERIC M. WALDMAN, PHD, MD

Professor, Laboratory Medicine, Urology, UCSF
Member and Director, Immunohistochemistry and Molecular Pathology Core Facility, UCSF Helen Diller Family Comprehensive Cancer Center
Director, Molecular Pathology Clinical Laboratory, UCSF Hospitals and Services

CONTACT

waldman@cc.ucsf.edu
(415) 476-3821 (voice)
(415) 476-8218 (fax)

Box 0808, UCSF; San Francisco, CA 94143-0808

additional website:

Waldman Lab Website

EDUCATION

Williams College, Williamstown, MA, B.A., 1972, Biology
New York University, New York, NY, Ph.D., 1980, Cell Biology
New York University, New York, NY, M.D., 1980, Medicine

PROFESSIONAL EXPERIENCE

1980-1982

Resident, Anatomic Pathology, University of California San Francisco, CA

1982-1983

Resident, Laboratory Medicine, University of California San Francisco, CA

1983-1984

Chief Resident, Laboratory Medicine, University of California San Francisco, CA

1984-1991

Assistant Professor, Laboratory Medicine, University of California San Francisco, CA

1991-1997

Associate Professor, Laboratory Medicine, University of California San Francisco, CA

1997-present

Professor, Laboratory Medicine, University of California San Francisco, CA

2000-present

Director, Molecular Cytogenetics and Immunohistochemistry Core, UCSF Cancer Center

2000-present

Director, Molecular Pathology Clinical Laboratory, UCSF Hospitals and Services

SELECTED PUBLICATIONS

(from a total of 178)

Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, and Pinkel D. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258(5083):818-21, 1992.

Kallioniemi OP, Kallioniemi A, Kurisu W, Thor A, Chen LC, Smith HS, Waldman FM, Pinkel D, and Gray JW. Erbb2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proceedings of the National Academy of Sciences of the United States of America 89(12):5321-5, 1992.

Kallioniemi A, Kallioniemi OP, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, and Waldman FM. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proceedings of the National Academy of Sciences of the United States of America 91(6):2156-60, 1994.

Isola JJ, Kallioniemi OP, Chu LW, Fuqua SA, Hilsenbeck SG, Osborne CK, and Waldman FM. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. American Journal of Pathology 147(4):905-11, 1995.

Moch H, Presti JC, Jr., Sauter G, Buchholz N, Jordan P, Mihatsch MJ, and Waldman FM. Genetic aberrations detected by comparative genomic hybridization are associated with clinical outcome in renal cell carcinoma. Cancer Research 56(1):27-30, 1996.

Presti JC, Jr., Moch H, Reuter VE, Huynh D, and Waldman FM. Comparative genomic hybridization for genetic analysis of renal oncocytomas. Genes, Chromosomes and Cancer 17(4):199-204, 1996.

Presti JC, Jr., Moch H, Reuter VE, Cordon-Cardo C, and Waldman FM. Renal cell carcinoma genetic analysis by comparative genomic hybridization and restriction fragment length polymorphism analysis. Journal of Urology 156(1):281-5, 1996.

Moch H, Sauter G, Buchholz N, Gasser TC, Bubendorf L, Waldman FM, and Mihatsch MJ. Epidermal growth factor receptor expression is associated with rapid tumor cell proliferation in renal cell carcinoma. Human Pathology 28(11):1255-9, 1997.

Moch H, Sauter G, Gasser TC, Bubendorf L, Richter J, Presti JC, Jr., Waldman FM, and Mihatsch MJ. Egf-r gene copy number changes in renal cell carcinoma detected by fluorescence in situ hybridization. Journal of Pathology 184(4):424-9, 1998.

Presti JC, Jr., Moch H, Gelb AB, Huynh D, and Waldman FM. Initiating genetic events in small renal neoplasms detected by comparative genomic hybridization. Journal of Urology 160(4):1557-61, 1998.

Waldman FM, DeVries S, Chew KL, Moore DH, Kerlikowske K, and Ljung BM. Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. Journal of the National Cancer Institute 92(4):313-320, 2000.

Etzell JE, Devries S, Chew K, Florendo C, Molinaro A, Ljung BM, and Waldman FM Loss of chromosome 16q in lobular carcinoma in situ. Human Pathology 32:292-6, 2001.

Gong G, DeVries S, Chew KL, Cha I, Ljung BM, Waldman FM. Genetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization. Clinical Cancer Research 7(8):2410-2414, 2001.

Waldman FM, Hwang ES, Etzell J, Eng C, DeVries S, Bennington J, and Thor A. Genomic alterations in tubular breast carcinomas. Human Pathology 32(2):222-226, 2001.

Moore L, Allan H Smith AH, Clarence Eng C, Sandy DeVries S, Vivek Bhargava V, Karen Chew K, Moore D, Catterina Ferreccio C, Omar Rey O, and Frederic M. Waldman FM. Arsenic related chromosomal alterations in bladder tumors. JNCI 94(22):1688-96, 2002.

Orntoft TF, Thykjaer T, Waldman FM, Wolf H, and Celis JE. Genome-wide study of gene copy numbers, transcripts, and protein levels in pairs of non-invasive and invasive human transitional cell carcinomas. Mol Cell Proteomics 1(1):37-45., 2002.

Presti JC, Jr., Wilhelm M, Reuter V, Russo P, Motzer R and Waldman F. Allelic loss on chromosomes 8 and 9 correlates with clinical outcome in locally advanced clear cell carcinoma of the kidney. J Urol 167(3):1464-8., 2002.

Thor AD, Eng C, Devries S, Paterakos M, Watkin WG, Edgerton S, Moore DH, 2nd, Etzell J, and Waldman FM. Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization. Hum Pathol 33(6):628-31., 2002.

Wilhelm M, Veltman JA, Olshen AB, Jain AN, Moore DH, Presti JC, Jr., Kovacs G, and Waldman FM. Array-based comparative genomic hybridization for the differential diagnosis of renal cell cancer. Cancer Res 62(4):957-60, 2002.

Kerlikowske K, Molinaro A, Cha I, Ljung BM, Ernster VL, Stewart K, Chew K, Moore DH, 2nd and Waldman F. Characteristics associated with recurrence among women with ductal carcinoma in situ treated by lumpectomy. J Natl Cancer Inst 95(22):1692-702, 2003.

Korkola JE, DeVries S, Fridlyand J, Hwang ES, Estep AL, Chen YY, Chew KL, Dairkee SH, Jensen RM and Waldman FM. Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis. Cancer Res 63(21):7167-75, 2003.

Korkola JE, Estep AL, Pejavar S, DeVries S, Jensen R and Waldman FM. Optimizing stringency for expression microarrays. Biotechniques 35(4):828-35, 2003.

Moore LE, Smith AH, Eng C, DeVries S, Kalman D, Bhargava V, Chew K, Ferreccio C, Rey OA, Hopenhayn C, Biggs ML, Bates MN and Waldman FM. P53 alterations in bladder tumors from arsenic and tobacco exposed patients. Carcinogenesis 24(11):1785-91, 2003.

Veltman JA, Fridlyand J, Pejavar S, Olshen AB, Korkola JE, DeVries S, Carroll P, Kuo WL, Pinkel D, Albertson D, Cordon-Cardo C, Jain AN and Waldman FM. Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors. Cancer Res 63(11):2872-80, 2003.

Hwang ES, DeVries S, Chew KL, Moore DH, 2nd, Kerlikowske K, Thor A, Ljung BM and Waldman FM. Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res 10(15):5160-7, 2004.

Hwang SE, Nyante SJ, Yi Chen Y, Moore D, DeVries S, Korkola JE, Esserman LJ and Waldman FM. Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma. Cancer 100(12):2562-72, 2004.

Liu D, Liu C, DeVries S, Waldman F, Cote RJ and Datar RH. LM-PCR permits highly representative whole genome amplification of DNA isolated from small number of cells and paraffin-embedded tumor tissue sections. Diagn Mol Pathol 13(2):105-15, 2004.

Nakao K, Mehta KR, Fridlyand J, Moore DH, Jain AN, Lafuente A, Wiencke JW, Terdiman JP and Waldman FM. High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization. Carcinogenesis 25(8):1345-57, 2004.

Blaveri E, Simko JP, Korkola JE, Brewer JL, Baehner F, Mehta K DeVries S, Koppie T, Pejavar S, Carroll P, and Waldman FM. Bladder cancer outcome and subtype classification by gene expression. Clinical Cancer Research 11:4044-4055, 2005.

Blaveri, E., Brewer, J. L., Roydasgupta, R., Fridlyand, J., Devries, S., Koppie, T., Pejavar, S., Mehta, K., Carroll, P., Simko, J. P., and Waldman, F. M. Bladder cancer stage and outcome by array-based comparative genomic hybridization. Clin Cancer Res, 11: 7012-7022, 2005.

DeVries S, Nyante S, Korkola J, Segraves R, Nakao N, Moore D, Bae H, Wilhelm M, Hwang S, Waldman FM. Array based comparative genomic hybridization from formalin fixed paraffin embedded breast tumors. Journal of Molecular Diagnostics 7:65-71, 2005.

Mehta KR, Nakao K, Zuraek MB, Ruan DT, Bergsland EK, Venook AP, Fridlyand J, Moore DH, Tokuyasu TA, Jain AN, Warren RS, Terdiman JP and Waldman FM. Fractional genomic alteration detected by array-based comparative genomic hybridization independently predicts survival after hepatic resection for metastatic colorectal cancer. Clinical Cancer Research 11:1791-1797, 2005.

Wa CV, DeVries S, Chen YY, Waldman FM, and Hwang HS. Clinical application of array-based comparative genomic hybridization to define the relationship between multiple synchronous tumors. Modern Pathology 18:591-597, 2005.

Chin K, Devries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, Lapuk A, Neve RM, Qian Z, Ryder T, Chen F, Feiler H, Tokuyasu T, Kingsley C, Dairkee S, Meng Z, Chew K, Pinkel D, Jain A, Ljung BM, Esserman L, Albertson DG, Waldman FM, Gray JW. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10(6):529-41, 2006.

Deng G, Nguyen A, Tanaka H, Matsuzaki K, Bell I, Mehta KR, Terdiman JP, Waldman FM, Kakar S, Gum J, Crawley S, Sleisenger MH, Kim YS. Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. Int J Cancer 118(12):2999-3005, 2006.

Fridlyand J, Snijders AM, Ylstra B, Li H, Olshen A, Segraves R, Dairkee S, Tokuyasu T, Ljung BM, Jain AN, McLennan J, Ziegler J, Chin K, Devries S, Feiler H, Gray JW, Waldman F, Pinkel D, Albertson DG. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer 6:96, 2006.

Goodson WH, Moore DH, Waldman FM. Ki-67 correlates with in vivo bromodeoxyuridine labeling index in operable breast cancer. J Clin Oncol 24(23):3809; author reply 3809, 2006.

Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, Devries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10(6):515-27, 2006.

Rini BI, Jaeger E, Weinberg V, Sein N, Chew K, Fong K, Simko J, Small EJ, Waldman FM. Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status. BJU Int 98(4):756-62, 2006.

Sternlicht MD, Dunning AM, Moore DH, Pharoah PD, Ginzinger DG, Chin K, Gray JW, Waldman FM, Ponder BA, Werb Z. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev 15(11):2107-14, 2006.

Trautmann K, Terdiman JP, French AJ, Roydasgupta R, Sein N, Kakar S, Fridlyand J, Snijders AM, Albertson DG, Thibodeau SN, Waldman FM. Chromosomal instability in microsatellite-unstable and stable colon cancer. Clin Cancer Res 12(21):6379-85, 2006.

1/22/07

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