ugweier.lbl.gov
(510) 486-5347, 486-5363 (lab)
(510) 486-6746 (fax)

Lawrence Berkeley National Lab
One Cyclotron Road, MS 74-157
Berkeley, CA 94720

University Hanover, Hanover, Germany, B.S., 1978, Physics
University Hanover, Hanover, Germany, M.S., 1982, Physics
University Hanover, Hanover, Germany, Ph.D., 1985, Biophysics
University of California, San Francisco, 1988, Postdoctoral Fellow
UC Lawrence Livermore National Laboratory, 1988-1990, Postdoctoral Fellow

(selected from more than 130 publications)

Robbins WA, Meistrich ML, Moore D, Hagemeister FB, Weier H-U, Cassel MJ, Wilson G, Eskenazi B, Wyrobek AJ (1997) Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm. Nature Genetics 16:74-78

Nilsson SK, Dooner MS, Tiarks CY, Weier HUG, Quesenberry PJ (1997) Potential and distribution of transplanted hematopoietic cells in an on nonablated mouse model. Blood 89:4013-4020

Fung J, Munnë S, Duell T, Weier H-UG (1998) Rapid cloning of translocation breakpoints: from blood to YAC in 50 days. J Biochem Mol Biol Biophys 1:181-192

Fung J, Hyun W, Dandekar P, Pedersen RA, Weier H-UG (1998) Spectral imaging in preconception/ preimplantation genetic diagnosis (PGD) of aneuploidy: multi-colour, multi-chromosome screening of single cells. J Ass Reprod Genet 15:322-329

Fung J, Moronne MM, Weier H-UG (1998) A simple blocking system for use with maleimide-labeled nucleic acid probes. BioTechniques 25: 390-394

Munnë S, Fung J, Cassel MJ, Márquez C, Weier HUG (1998) Preimplantation genetic analysis of trans-locations: case-specific probes for interphase cell analysis. Human Genetics 102:663-674

Zitzelsberger H, Lehmann L, Hieber L, Weier HUG, Janish C, Fung J, Negele T, Spelsberg F, Lengfelder E, Demidchik E, Salassidis K, Kellerer AM, Werner M, Bauchinger M (1999) Cytogenet changes in radiation-induced tumors of the thyroid. Cancer Res 58:135-140

Fung J, Weier HUG , Goldberg JD , Pedersen RA (1999) Simultaneous scoring of 10 chromosomes (9, 13, 14, 15, 16, 18, 21, 22, X, Y) in interphase nuclei by using Spectral Imaging. Proc of SPIE 3604:218-226

Nilsson SK, Dooner MS, Weier HU, Frenkel B, Lian JB, Stein GS, Quesenberry PJ (1999) Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J Exp Med 189:729-734

Weier HUG, Munné S, Fung J (1999) Patient-specific probes for preimplantation genetic diagnosis (PGD) of structural and numerical aberrations in interphase cells. J Ass Reprod Genet 16:182-189

Weier HUG, Fung J, Lersch RA (1999) Assignment of protooncogene MERTK (aka c-mer) to human chromosome 2q14.1 by in situ hybridization. Cytogenet Cell Genet 84:91-92

Fung J, Munné S, Garcia J, Kim U-J, Weier H-UG (1999) Reciprocal translocations and infertility: molecular cloning of breakpoints in a case of constitutional translocation t (11;22)(q23;q11) and preparation of probes for preimplan-tation genetic diagnosis (PGD). Reproduction, Fertility and Development 11:17-23

Weier H-UG, George CX, Lersch RA, Breitweser S, Cheng J-F, Samuel CE (2000) Assignment of the RNA-specific adenosine deaminase gene to mouse chromosome 3F2 by in situ hybridization. Cytogenet Cell Genet 89:214-215

Greulich KM, Kreja L, Heinze, Rhein AP, Weier HUG, Brckner M, Fuchs P, Molls M (2000) Rapid detection of radiation-induced chromosomal aberrations in lymphocytes and hemato-poietic progenitor cells by M-FISH. Mutation Res 452:73-81

Lersch RA, Fung J, Munné S, Pedersen RA, Weier H-UG (2000) Case-specific, breakpoint-spanning DNA probes for analysis of single interphase cells. Genet Test 4:273-278

Lin SD, Cooper P, Fung J, Weier HU, Rubin EM (2000) Genome scan identifies a locus affecting gamma-globulin levels in human beta-cluster YAC transgenic mice. Mamm Genome 11:1024-1029

Fung J, Weier H-UG, Goldberg JD, Pedersen RA (2000) Chromosome enumeration in interphase amniocytes using spectral imaging. Hum Genet 107:615-622

Weier HUG (2001) Quantitative DNA fiber mapping. Methods Cell Biol 64:33-53

Fung J, Munné S, Weier HUG (2001) Detection of chromosome translocation products in single interphase cell nuclei. Methods Cell Biol 64:97-114

Fung J, Weier H-UG, Pedersen RA (2001) Detection of structural and numerical chromosome abnormalities in interphase cells using spectral imaging. J Histochem Cytochem 49: 797-798

Fung J, Weier H-UG, Pedersen RA, Zitzelsberger HF (2002) Spectral imaging analysis of metaphase and interphase cells. in: FISH technology. B. Rautenstrauss and T. Liehr (Eds.), Springer Verlag, Heidelberg, pp.363-387

Weier, H.-U.G. (2002) Quantitative DNA Fiber Mapping. In: FISH Technology. B. Rautenstrauss and T. Liehr (Eds.), Springer Verlag, Heidelberg, pp.226-253

Zitzelsberger HF, O'Brien B, Weier HUG (2002) Multicolor FISH techniques for the detection of inter- and intrachromosomal rearrangements. In: FISH Technology. B. Rautenstrauss and T. Liehr (Eds.), Springer Verlag, Heidelberg, pp. 408-424

Weier H-UG, Greulich-Bode KM, Ito Y, Lersch RA, Fung J (2002) Fluorescence in situ hybridization (FISH) in cancer diagnosis and prognostication: from the cause to course of the disease. Exp Rev Mol Diagn 2(2):109-119.

Liehr T, Weise A, Heller A, Starke H, Mrasek K, Kuechler A, Weier H-UG, Claussen U (2002) Multicolor chromosome banding (MCB) with YAC/BAC-based probes and region-specific microdissection DNA libraries. Cytogenet Genome Res 97:43-50

Wu CW, Chen GD, Fann CS, Lee AF, Chi CW, Liu JM, Weier U, Chen JY (2002) Clinical implications of chromosomal abnormalities in gastric adenocarcinomas. Genes Chromosomes Cancer 35:219-31.

Weier HU, Chu LW, Murnane JP, Weier JF (2004) Applications and technical challenges of fluorescence in situ hybridization in stem cell research. Blood Cells Mol Dis. 32(1):68-76

Abedi M, Greer DA, Colvin GA, Demers DA, Dooner MS, Harpel JA, Weier HU, Lambert JF, Quesenberry PJ. (2004) Robust conversion of marrow cells to skeletal muscle with formation of marrow-derived muscle cell colonies: a multifactorial process. Exp Hematol. 32(5):426-434

Liehr T, Weier H-UG (2005) The 14th Workshop on Fetal Cells and Fetal DNA. J Histochem Cytochem 53: 253-254

Weier H-UG, Weier JF, Oter Renom M, Zheng X, Colls P, Nureddin A, Pham CD, Chu LW, Racowsky C, Munné S (2005) Fluorescence in situ Hybridization (FISH) and Spectral Imaging (SIm) Analysis of Human Oocytes and First Polar Bodies. J Histochem Cytochem 53:269-272

Weier JF, Weier H-UG, Jung CJ, Gormley M, Yan Zhou Y, Chu LW, Genbacev O, Wright AA, Fisher SJ (2005) Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype. Dev Biology 279: 420-432

Breier AM, Weier H-UG, Cozzarelli NR (2005) Independence of replisomes in Escherichia coli chromosomal replication. Proc Natl Acad Science USA 102(11):3942-3947

6/15/05