weinerr@obgyn.ucsf.edu
(415) 476-2514 (voice)
(415) 753-3271 (fax)

Box 0556, UCSF; San Francisco, CA 94143-0556

Pennsylvania State University, PA, B.S., 1963, Pre-Med
Pennsylvania State University, PA, M.S., 1965, Zoology
University of California San Francisco, CA, Ph.D., 1969, Endocrinology
University of California, Los Angeles, CA, Postdoc., 1971, Neuroendocrinology

Cronin MJ, Faure N, Martial J, Weiner RI. 1980. Absence of high affinity dopamine receptors in GH3 cells: A prolactin-secreting clone resistant to the inhibitory action of dopamine. Endocrinology 106:718-723.

Cooke NE, Coit D, Weiner RI, Baxter JD, Martial JA. 1980. Structure of cloned DNA complementary to rat prolactin messenger RNA. J. Biol. Chem. 255:6502-6510.

Ferrara N, Fujii DK, Goldsmith PC, Widdicombe JH, Weiner RI. 1987. Transport epithelial characteristics of cultured bovine anterior pituitary and pars tuberalis follicular cells. Am. J. Physiol. 252:E304-312.

Martinez de la Escalera G, Weiner RI. 1988. Effect of dopamine withdrawal on activation of adenylate cyclase and phospholipase C in enriched lactotrophs. Endocrinology 123(3):1682-1687.

Schechter J, Goldsmith P, Wilson C, Weiner R. 1988. Morphological evidence for the presence of arteries in human prolactinomas. J. Clin. Endo. Metab. 67:713-719.

Windel JJ, Weiner RI, and Mellon PL. 1990. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol. Endocrinol. 4:597-603.

Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI. 1990. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10.

Ferrara N, Clapp C and Weiner RI. 1991. The 16K fragment of prolactin specifically inhibits basal or FGF stimulated growth of capillary endothelial cells. Endocrinology 129:896-900.

Martinez de la Escalera G, Choi A. Weiner RI. 1992. Generation and synchronization of GnRH pulses are intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA 89:1852-1855.

Martinez de la Escalera G, Choi A, Weiner RI. 1992. §-Adrenergic Regulation of the GT1 Gonadotropin releasing hormone (GnRH) neuronal cell lines: stimulation of GnRH release via receptor positively coupled to adenylate cyclase. Endocrinology 131: 1397-1402.

Martinez de la Escalera G, Gallo F, Choi AL, Weiner RI. 1992. Dopaminergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: stimulation of GnRH release via D1-receptors positively coupled to adenylate cyclase. Endocrinology 131:2965-2971.

Werner S, Weinberg W, Liao X, Peters K, Blessing M, Yuspa S, Weiner R, Williams L. 1993. Targeted expression of a dominant negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J. 12:2635-2643.

Clapp C, Martial J, Guzman R, Rentier-Delrue R, Weiner R. 1993. The 16 kDa n-terminal fragment of human prolactin is a potent inhibitor of angiogenesis. Endocrinology.133:1292-1299.

Mellon SH, Miller WL, Bair SR, Moore CCD, Vigne J-L, Weiner R. 1994. Steroidogenic adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice. Mol. Endo. 8:97-108.

Martinez de la Escalera G, Choi A, Weiner RI. 1995. Signaling pathways involved in GnRH secretion in GT1 cells. Neuroendocrinology 61:310-317.

D'Angelo G, Struman I, Martial J and Weiner RI. 1995. Activation of mitogen-activated protein kinases by vascular endothelial growth factor and bFGF in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin. PNAS USA 92:6374-6378.

Tsai P-S, Werner S and Weiner RI. 1995. Basic fibroblast growth factor is a neurotropic factor in GT1 gonadotropin-releasing hormone neuronal cell lines. Endocrinology 136:3831-3838.

Lee H, Struman I, Clapp C, Martial J and Weiner RI. 1998. Inhibition of urokinase activity by the antiangiogenic factor 16K PRL: Activation of plasminogen activator inhibitor-1 expression. Endocrinology 139:3696-3703.

Sakakibara H, Conti M and Weiner RI. 1998. Role of phosphodiesterases in the regulation of gonadotropin releasing-hormone secretion in GT1 cells. Neuroendocrinology 68:365-373.

Struman I, Bentzien F, Lee H, Mainfroid V, DÕAngelo G. Goffin V, Weiner R and Martial J. 1999. Opposite actions of the human PRL/GH/PL-family members and their 16kDa fragments on angiogenesis. Proc. Natl. Acad. Sci. USA 96:1246-1251.

DÕAngelo G, Martini J-F, Iiri T, Fantl W, Martial J, Weiner RI. 1999. 16K hPRL inhibits VEGF-induced activation of Ras in capillary endothelial cells. Mol. Endocrinol.13:692-704.

Vitalis E, Costantin J, Tsai P, Sakakibara H, Paruthiyil S, Iiri T, Martini J-F, Taga M, Choi A, Charles A and Weiner RI. 2000. Role of the cAMP Signaling Pathway in GnRH Secretion in GT1 Cells. Proc. Natl. Acad. Sci. USA 97:1861-1866.

Martini J-F, Piot C, Humeau LM, Struman I, Martial J, Weiner RI. 2000. The antiangiogenic factor 16K PRL induces programmed cell death in endothelial cells by caspase activation. Mol. Endocrinol. 14:1536-49.

Charles A, Weiner RI and Costantin J. 2001. cyclic AMP modulates the excitability of immortalized hypothalamic (GT1) neurons via a cyclic nucleotide gated channel. Mol. Endocrinol. 15:997-1009.

Bentzien F, Struman, I, Martial J and Weiner RI. 2001. Expression of the Antiangiogenic Factor 16K hPRL in HCT116 cells Inhibits Tumor Growth in Rag -/- Mice. Cancer Research 61:7356-7362.

El Majdoubi M and Weiner RI. 2002. Localization of olfactory cyclic nucleotide-gated channels in rat gonadotropin-releasing hormone neurons. Endocrinology 143:2441-2444.

Paruthiyil, S El Majdoubi M Conti M, Weiner RI. 2002. Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats. Proc. Natl. Acad. Sci. USA 99:17191-17196.

Tabruyn SP, Sorlet CM, Rentier-Delrue F, Bours V, Weiner RI, Martial JA, Struman I. 2003. The antiangiogenic factor 16K human prolactin induces caspase-dependent apoptosis by a mechanism that requires activation of nuclear factor-kappaB. Mol Endocrinol.17:1815-1823.

Yoshida H Beltran-Parrazal L Butler P Conti M Charles A and Weiner RI. 2003. Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells Mol Endocrinol.17:1982-1989.

El Majdoubi M, Paruthiyil S, Weiner RI. 2003. Pulsatile luteinizing hormone and follicle-stimulating hormone secretion and gonadotropin subunit mRNA levels in the ovariectomized GPR-4 transgenic rat. Neuroendocrinology 78.287-293.

Yoshida H, Paruthiyil S, Butler P, Weiner RI. Role of cAMP signaling in the mediation of dopamine-induced stimulation of GnRH secretion via D1 dopamine receptors in GT1-7 cells. Neuroendocrinology. 2004;80(1):2-10.

Pan, H., N. Nguyen, H. Yosida, F. Bentzien, L. C. Shaw, J. Martial, R. I. Weiner RI. 2004 Struman and M. B. Grant. Molecular targeting of the antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci.; 7:2413-9.

Tsai PS, Moenter SM, Postigo HR, El Majdoubi M, Pak TR, Gill JC, Paruthiyil S, Werner S, Weiner RI. 2005 Targeted expression of a dominant negative fibroblast growth factor FGF receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol. 19: 225-36

Gomez F, la Fleur SE, Weiner RI, Dallman MF, El Majdoubi M. 2005. Decreased gonadotropin-releasing hormone neuronal activity is associated with decreased fertility and dysregulation of food intake in the female GPR-4 transgenic rat. Endocrinol 146(9):3800-8.

Fox MS, Clark AT, El Majdoubi M, Vigne JL, Urano J, Hostetler CE, Griswold MD, Weiner RI, Reijo Pera RA. 2006 Intermolecular interactions of homologs of germ plasm components in mammalian germ cells. Dev Biol. Aug 24. [Epub ahead of print]

2/1/07