(415) 353-2525 (appts)
(415) 476-0133 (fax)

Box 0663, UCSF; San Francisco, CA 94143-0663

additional websites:

UCSF Physician Referral Directory

Tufts University, Medford, MA, BS, 1978-1982, Biology
Stanford University, Stanford, CA, PhD, 1982-1988, Cancer Biology
Stanford University, Stanford, CA, MD, 1982-1989, Medicine

Jimmy K. Stauffer, J. K., Lincoln, E. Green, B., Khan, T., Salcedo, R., Hoxon, J. A. Black, T. C., Ye, M., Stephen, R., Tsokos, M., Whiteford, C., Eisenhofer, G., Weiss, W. A., Khan, J., and Wigginton, J. M. High-throughput molecular and histopathologic profiling of the tumor microenvironment in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery, Submitted.

Chesler, L., Goldenberg, D., McMillan, A., Tehan, T., and Weiss, W.A. Cyclophosphamide shows efficacy in a MYCN-driven transgenic mouse model for neuroblastoma, and induces apoptosis through p53 and PUMA-dependent pathways, Submitted.

Torbett, N. E., Knight, Z., Houk, Z., Weiss, W.A., Shokat, K. M., and Stokoe, D. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isotype-selective inhibition. Submitted.

Cheng, A, Cheng, N., Ford, J., Smith, J., Murray, J., Flemming, C., Lastowska, M., Jackson, M., Hackett, C., Weiss, W. A., Evans, T,. Marshall, G., Kees, U., Norris, M, and Haber, M. Establishment And Characterisation Of Cell Lines From MYCN Transgenic Murine Tumors. Submitted.

Nguyen, T., Liu, T., Kuljaca, S., Xue, C., Thomas, W., Haber, M., Norris, M. D., Weiss, W. A., and Marshall, G. M. Enhancing the Effectiveness of Histone Deacetylase Inhibitor Therapy by -Interferon. Submitted.

Fan, Q-W, Goldenberg, D, and Weiss, W.A. In-vivo delivery of siRNA directed against EGFR blocks growth of glioma. Submitted.

Fan, Q-W, and Weiss, W.A. Isoform specific inhibitors of PI3 kinase in glioma. (2006) Cell Cycle, 5: 2301-2305.

Ohgaki, H., Kita, D., Faverezux, A., Huang, H., Homma, T, Dessen, P, Weiss, W. A., Kleihues, P., and Heppner, P. Brain tumors in S100-v-erbB transgenic rats. J Neuropathol Exp Neurol. In-press.

Grimmer, M., and Weiss, W.A. Brain tumors arise through disordered mechanisms of development. (2006) Curr Opin Pediatr, 18:634-638.

Goh, S., and Weiss, W, A. Genotype: phenotype correlations in tuberous sclerosis: Who and how to treat. Ann. Neurol. In-press.

Persson, A., Fan, Q-W., Phillips, J., and Weiss, W.A. (2007) Glioma. In Gilman, S. Editor: Neurobiology of Disease. Elsevier, San Diego, CA: pp. 433-444.

Chesler, L., Goldenberg, D., Schlieve, C., Kenney, A., Seales, I, McMillan, A., Matthay, K. K., Rowitch, D., and Weiss, W.A. (2006) Inhibition of PI3-kinase destabilizes Mycn protein and blocks progression of neuroblastoma. Cancer Research, 66: 8139-8146.

Knight, Z. A., Gonzalez-Perez, B., Feldman, M., Zunder, E., Goldenberg, D. D., Loewith, R., Balla, A., Balla, T., Weiss, W. A., Williams, R. A., and Shokat, K. M. (2006) A pharmacological map of the PI3-K family defines a role for p110 in insulin signaling, Cell, 125: 733-747.

Fan, Q-W, Knight, Z., Goldenberg, D. D., Shokat, K. M., and Weiss, W.A. (2006) A dual PI3-kinase/mTOR inhibitor reveals emergent efficacy in glioma, Cancer Cell, 9: 341-349.

Fan, QW, and Weiss, W.A. (2006) Chemical genetics approaches to the development of cancer therapeutics, in Balmain, A., and Montell, D., eds , Curr Opin Genet Dev, 16: 1Ð7.

Ching, T-T, Maunakea, A.K., Jun, P., Hong, C., Zardo, G., Pinkel, D., Alberston, D. G., Fridlyand, J., Mao, J-H., Shchors, K., Weiss, W. A., And Costello, J. (2005) Epigenome analyses using BAC microarrays identifies evolutionary conservation of tissue-specific methylation of SHANK3. Nature Genetics, 627: 645-651.

Hong, C., Maunakea, A., Jun, P., Bollen, A. W., Goldenberg, D., Weiss, W. A., and Costello, J. (2005) Shared epigenetic mechanisms in human and mouse gliomas inactivate the expression of growth suppressor SLC5A8. Cancer Research, 65: 3617-3623.

Fan, Q-W, and Weiss, W.A. (2004) RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene, 24:829-927.

Hansford, L.M., Thomas, W.D., Keating, J.M., Burkhart, C.A., Peaston, A.E., Norris, M.D., Haber, M., Armati, P.J., Weiss, W.A., and Marshall, G.M. (2004). Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification. Proc Natl Acad Sci USA. 24:12664-9.

Weiss, W. A., and Banerjee, A. (2004) Can mouse models for brain tumors inform treatment in pediatric patients Seminars in Cancer Biology, 14: 71-77.

Gutmann, D. H., Baker, S. J., Giovannini, M, Garbow, J., and Weiss W.A. Mouse Models of Human Cancer Consortium Symposium on Nervous System Tumors. (2003). Cancer Research, 63: 3001-3004.

Hackett, C, Hodgson, J. G, Law, M., Fridlyand, J., , Kazutoyo Osoegawa, K., , de Jong, P. J., Nowak, N. J., Pinkel, D., Albertson, D. G., Jain, A., ,Jenkins, R, Gray, J., and Weiss, W.A. (2003). Genome wide array CGH analysis of murine neuroblastoma; Distinct patterns of chromosomal gains and loss parallel those found in human tumors. Cancer Research, 63:266Ð5273.

Fan, Q-W, Specht, K., Zhang, C., Goldenberg, D. D., Shokat, K. M., and Weiss, W.A. (2003). Combinatorial efficacy achieved through two-point blockade within a signalling pathway: a chemical genetic approach. Cancer Research, 63:8930Ð8938.

Burkhart, C. A,, Cheng, A., Madafiglio, J., Kavallaris, M., Mili, M., Marshall, G. M., Weiss, W. A., Khachigian, L. M., Norris, M. D., and Haber, M. (2003) In vivo administration of N-myc antisense oligonucleotides reduces tumorigenesis in a murine model of neuroblastoma. J Natl Cancer Inst. 95:1394-403.

Weiss, W.A., Aldape, K, Hackett, C., Kuriyama, H., Kuriyama, N., Milshteyn, N, Burns, M, Roberts, T., Wendland, M., DePinho, R., and Israel, M. (2003) Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Research 63: 1589-1595.

Seales, I., Aldape, K., and Weiss, W.A. (2003) Mouse models for infiltrating gliomas. Genomic and Molecular Neuro-oncoclogy. Wei Zhang and Greg Fuller (Eds) Jones and Bartlett, Sudbury MA. 223-232.

Yip S., Aboody K. S., Burns M., Imitola J., Boockvar J. A., Allport J., Park K. I., Teng Y. D., Lachyankar M., McIntosh T., O'Rourke D. M., Khoury S., Weissleder R., Black P. M., Weiss W. A., Snyder E. Y. (2003) Neural stem cell biology may be well suited for improving brain tumor therapies. Cancer J. 9:189-204.

Weiss, W. A., Israel, M., Cobbs, C, Holland, EC., James, CD., Louis, DN., Marks, C., McClatchey, AI., Roberts, T., Van Dyke, T., Wetmore, C., Chiu, I-M., Giovannini, M., Guha, A., Higgins, RJ., Marino, S,. Radovanovic, I., Reilly, K., and Aldape, K. (2002) Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 21:7453-7463.

Burns, M. J., and Weiss, W.A.Targeted therapy of brain tumors utilizing neural stem and progenitor cells. (2003) Frontiers Biosc. 8:228-234.

Chesler L. and Weiss, W.A. Tumor Models in Cancer Research (review) Drug Discovery Today (2002). 19: 997.

Fan, Q-W, Zhang, C., Shokat, K. M., and Weiss, W.A.(2002) Chemical Genetic Blockade of Transformation Reveals Dependence on Aberrant Oncogenic Signalling. Current Biology, 12: 1386-1394.

Weiss, W. A., and Aldape, K., editors. (2002) Nervous System Cancer Models-NCI/MMHCC sponsored web site (http://emice.nci.nih.gov/mouse_models/organ_models/cns_models).

Tada, T., Wendland, M., Watson, N., Kuriyama, N, Kuriyama, H., Roberts, T., Burns, M,. Weiss, W. A., and Israel, M. (2002) A head holder for magnetic resonance imaging that allows the stereotaxic alignment of spontaneously occurring intracranial mouse tumors. (2002) J. Neurosci. Methods 116: 1-7.

12/12/06