William A. Weiss, MD, PhD

Tufts University, Medford, MA, BS, 1978-1982, Biology
Stanford University, Stanford, CA, PhD, 1982-1988, Cancer Biology
Stanford University, Stanford, CA, MD, 1982-1989, Medicine

• 1991-1992
  Resident in Neurology, University of California, San Francisco
• 1992-1994
  Resident in Child Neurology, University of California, San Francisco
• 1994-1998
  Post-Doctoral Fellow, University of California, San Francisco
• 1999-2004
  Assistant Professor of Neurology (Child Neurology), University of California, San Francisco
• 2004-2008
  Associate Professor of Neurology (Child Neurology), University of California, San Francisco
• 2008-present
  Professor, Neurology, Pediatrics, Neurological Surgery, University of California, San Francisco

• 1981
  Phi Beta Kappa
• 1982
  BS degree awarded with honors (Summa Cum Laude)
• 1994-95
  Daland Research Fellow, American Philosophical Society
• 1996-2001
  Burroughs Wellcome Career Development Award
• 1997
  UCSF Grumbach Research Award
• 1997
  Child Neurology Society Young Investigator Award
• 1999
  UCSF Brook Byers Award in Basic Science
• 1999-2004
  Steering Committee Member and Nervous System Cancers Committee Chair: NCI sponsored Mouse Models for Human Cancer Consortium
• 2001-2003
  Sydney Kimmel Scholar Award
• 2002-2004, 2005
  Brain Tumor Society Scholar
• 2005
  Integrative Research Award, UCSF Sandler Program in Basic Sciences
• 2005
  Thrasher Research Fund Award
• 2005
  Samuel Waxman Cancer Research Foundation Award
• 2005
  Goldhirsh Foundation Award
• 2002, 2005, 2008
  Brain Tumor Society Award
• 2006
  Burroughs Wellcome Translational Research Award
• 2006
  National Brain Tumor Foundation Award
• 2008
  Alex Lemonade Stand Foundation Award

• Cheng, C.K., Fan Q-W and Weiss, W.A. (2008) PI3K Signaling in glioma: Lessons from animal models. Brain Pathology, 19: 112-120.
• Chesler, L., Goldenberg, D.D, Collins, R., Grimmer, M., Kim, G.E., Tihan, T., Nguyen, K., Yakovenko, S., Matthay, K.K. and Weiss, W.A. (2008). Cyclophosphamide induced apoptosis in a murine transgenic model of neuroblastoma proceeds through induction of p53 and PUMA, Neoplasia, 10: 1268-1274.
• Yu, W., Swhean, A.M., Brakeman, P., Eastburn, D.J. Datta, A., Bryant, D.M., Fan, Q-W., Weiss, W.A., Zegers, M.M.P., and Mostov, K. (2008). Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep. 9: 923-9.
• Chen J.S., Zhou, L.J., Entin-Meer M., Yang, X., Donker, M., Knight, Z.A., Weiss, W., Shokat, K.M., Haas-Kogan, D. and Stokoe, D. (2008). Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther. 7: 841-50.
• Torbett, N. E., Knight, Z., Houk, Z., Weiss, W.A., Shokat, K. M., and Stokoe, D. (2008) A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isotype-selective inhibition. Biochemical Journal, 415: 97-110.
• Silber, J., Lim, D. A., Petritsch, D., Maunakea, A. K., Persson, A., Yu, M., Vandenberg, S., Ginzinger, D., James, C. D., Costello, J. F., Weiss, W. A., Bergers, G., Alvarez-Buylla, A., and Hodgson, J. G. (2008) miR-124a and miR-137 induce differentiation of postnatal neural progenitor cells and glioma stem cells. BMC Med, 22:693-699.
• Grimmer, M., and Weiss, W.A. (2008) BMPs oppose Math1 in cerebellar development and in medulloblastoma. Genes & Dev, 22:693-699.
• Weiss, W. A, Taylor, S. S., and Shokat, K. M. (2007) Recognizing and exploiting differences between RNAi and small molecule inhibitors. Nature Chemical Biology, 3: 739-744.
• Chesler, L., Goldenberg, D., Seales, I., Satchi-Rainaro, R., Grimmer, M., Collins, R., Struett, C., Nguyen, K.M., Kim, G., Tihan, T., Bao, Y., Brekken, R.A., Bergers, G., Folkman, J., and Weiss, W.A. (2007) Blockade of angiogenesis leads to regression of established tumors in murine neuroblastoma driven by a TH-MYCN transgene. Cancer Research, 67: 9435-9442.
• Fan, Q-W, Cheng, C. K., Nicolaides, T. P., Knight, Z., Shokat, K. M., and Weiss, W. A. (2007) A dual PI3K/mTOR inhibitor cooperates with blockade of EGFR in PTEN-mutant glioma, Cancer Research, 67: 7960-7965.
• Cheng, A, Ching Cheng, N., Ford, J., Smith, J., Murray, J., Flemming, C., Lastowska, M., Jackson, M., Hackett, C.S., Weiss, W. A., Evans, T,. Marshall, G.M., Kees, U.R, Norris, M.D., and Haber, M. (2007) Cell lines from MYCN transgenic murine tumors reflect the molecular and biological characteristics of human neuroblastoma. Eur J. Cancer, 32: 1467-1475.
• Blair, J. A. Rauh, D., Kung, C., Yun C-H., Fan, Q-W., Zhang, C., Eck, M. J., Weiss, W. A., and Shokat, K. M. (2007) Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nature Chemical Biology, 3: 229-238.
• Persson, A., Fan, Q-W., Phillips, J., and Weiss, W.A. (2007) Glioma. In Gilman, S. Editor: Neurobiology of Disease. Elsevier, San Diego, CA: pp. 433-444.
• Fan, Q-W, and Weiss, W.A. Isoform specific inhibitors of PI3 kinase in glioma. (2006) Cell Cycle, 5: 2301-2305.
• Ohgaki, H., Kita, D., Faverezux, A., Huang, H., Homma, T, Dessen, P, Weiss, W. A., Kleihues, P., and Heppner, P. (2006) Brain tumors in S100-v-erbB transgenic rats. J Neuropathol Exp Neurol. 65:1111-1117.
• Grimmer, M., and Weiss, W.A. Brain tumors arise through disordered mechanisms of development. (2006) Curr Opin Pediatr, 18:634-638.
• Goh, S., and Weiss, W, A. (2006) Genotype: phenotype correlations in tuberous sclerosis: Who and how to treat. Ann. Neurol. 60: 505-507.
• Chesler, L., Goldenberg, D., Schlieve, C., Kenney, A., Seales, I, McMillan, A., Matthay, K. K., Rowitch, D., and Weiss, W.A. (2006) Inhibition of PI3-kinase destabilizes Mycn protein and blocks progression of neuroblastoma. Cancer Research, 66: 8139-8146.
• Knight, Z. A., Gonzalez-Perez, B., Feldman, M., Zunder, E., Goldenberg, D. D., Loewith, R., Balla, A., Balla, T., Weiss, W. A., Williams, R. A., and Shokat, K. M. (2006) A pharmacological map of the PI3-K family defines a role for p110 in insulin signaling, Cell, 125: 733-747.
• Fan, Q-W, Knight, Z., Goldenberg, D. D., Shokat, K. M., and Weiss, W.A. (2006) A dual PI3-kinase/mTOR inhibitor reveals emergent efficacy in glioma, Cancer Cell, 9: 341-349.
• Fan, QW, and Weiss, W.A. (2006) Chemical genetics approaches to the development of cancer therapeutics, in Balmain, A., and Montell, D., eds, Curr Opin Genet Dev, 16: 1-7.
• Ching, T-T, Maunakea, A.K., Jun, P., Hong, C., Zardo, G., Pinkel, D., Alberston, D. G., Fridlyand, J., Mao, J-H., Shchors, K., Weiss, W. A., And Costello, J. (2005) Epigenome analyses using BAC microarrays identifies evolutionary conservation of tissue-specific methylation of SHANK3. Nature Genetics, 627: 645-651.
• Hong, C., Maunakea, A., Jun, P., Bollen, A. W., Goldenberg, D., Weiss, W. A., and Costello, J. (2005) Shared epigenetic mechanisms in human and mouse gliomas inactivate the expression of growth suppressor SLC5A8. Cancer Research, 65: 3617-3623.
• Fan, Q-W, and Weiss, W.A. (2004) RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene, 24:829-927.
• Hansford, L.M., Thomas, W.D., Keating, J.M., Burkhart, C.A., Peaston, A.E., Norris, M.D., Haber, M., Armati, P.J., Weiss, W.A., and Marshall, G.M. (2004). Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification. Proc Natl Acad Sci USA. 24:12664-9.
• Weiss, W. A., and Banerjee, A. (2004) Can mouse models for brain tumors inform treatment in pediatric patients Seminars in Cancer Biology, 14: 71-77.