joe.wiemels@ucsf.edu
(415) 514-0577 (voice)
(415) 502-7411 (fax)

Box 0441, UCSF; San Francisco, CA 94143-0441

Kenyon College, B.A., 1988, Biology
University of California Berkeley, Ph.D., 1997, Environmental Health Science/Toxicology

Wiemels J, Smith MT. Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species. Free Radical Res 30: 93-103, 1999.

Wiemels J, Wiencke JK, Varkonyi A, Smith MT. Modulation of toxicity and macromolecular binding of benzene metabolites by NAD(P)H:quinone oxidoreductase in transfected HL-60 Cells. Chem Res Toxicology 12: 467-475, 1999.

Wiemels JL, Pagnamenta A, Taylor GM, Eden OB, Alexander FE, Greaves MF. Lack of function NAD(P)H:quinone oxidoreductase alleles are selectively associated with paediatric leukaemias that have MLL fusions. Cancer Res 59: 4095-4099, 1999.

Wiemels JL, Greaves M. Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukaemia. Cancer Res 59: 4075-4082, 1999.

Wiemels JL, Ford AM, Van Wering ER, Postma A, Greaves MF. Protracted and variable latency of acute lymphoblastic leukaemia after TEL/AML1 gene fusion in utero. Blood 94: 1057-1062, 1999.

Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, Saha V, Biondi A, Greaves MF. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet. 354: 1499-1503, 1999.

Wiemels JL, Alexander FE, Cazzaniga G, Biondi A, Mayer SP, Greaves M. Micro-clustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia. Genes Chromosomes and Cancer 29:219-28, 2000.

Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylene Tetrahydrofolate Reductase (MTHFR) Polymorphisms and Risk of Molecularly Defined Subtypes of Childhood Acute Leukemia. Proc Natl Acad Sci USA, 98:4004-9, 2001.

Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks, BM, Wiencke, JK, Wiemels JL. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia, 15:1906-1913, 2001.

Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M. History of Allergies among adults with glioma and controls. Int J Cancer, 98:609-615, 2002.

Segal, MR, Wiemels JL. Clustering of translocation breakpoints. Journal of the American Statistical Association, 97:66-76, 2002.

Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves M. In utero origin of T(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood, 99(10):3801-3805, 2002.

Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SP. Site-specific translocations and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 99(23):15101-6, 2002.

Pine SR, Wiemels JL, Jayabose S, Sandoval C. TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. Leukemia Res, 27(2):155-64, 2003.

McHale CM, Wiemels JL, Zhang LP, Ma X, Buffler PA, Guo W, Loh ML and Smith MT. Pre-natal origin of TEL-AML1 positive acute lymphoblastic leukemia in children born in California, Genes Chromosomes Cancer, 37:36-43, 2003.

McHale CM, Wiemels JL, Zhang LP, Ma X, Buffler PA, Feusner J and Smith MT. Prenatal origin of childhood acute promyelocytic leukemia and childhood acute myeloid leukemia: t(15;17) and inv(16) rearrangements backtracked to birth, Blood, 101(11):4640-1, 2003.

Greaves M, and Wiemels J. Origin of chromosomal translocations in childhood leukemia. Nature Reviews Cancer 2003 Sep;3(9):639-49.

Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res. 64:2000-6, 2004.

Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, Miike R, Barger G, Wrensch MR. Reduced Immunoglobulin E in adults with brain cancer compared to controls. Cancer Res, 64: 8468-73, 2004.

Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia, 19(3):415-9, 2005.

Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Ades L, Blair A, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NCP, Chomienne C, Solomon E, Fenaux P, Grimwade D. DNA topoisomerase II mediates the DNA damage at t(15;17) chromosomal translocation breakpoints in therapy-related acute promyelocytic leukemia. New England J Medicine, 352(15):1529-38, 2005.

Wrensch M, Weinberg A, Wiencke J, Miike R, Sison J, Wiemels J, Barger G, Delorenze G, Aldape K, Kelsey K. History of Chickenpox and Shingles and Prevalence of Antibodies to Varicella-Zoster Virus and Three Other Herpesviruses among Adults with Glioma and Controls. Am J Epidemiol. 161:929-38, 2005.

Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does M, Wiencke JK. Ethnic difference in daycare attendance, early infections, and risk of childhood ALL. Cancer Epi Biomark Prevent 14:1928-34.

Wiencke JK, Aldape K, McMillan A, Wiemels J, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, and Wrensch M. Molecular Features of adult glioma associated with patient race, age, and the polymorphic MGMT (O6-alkylguanine-DNA-alkyltransferase). Cancer Epi Biomark Prevent., 14:1928-34, 2005.

Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. Epidemiology of intracranial meningioma. Neurosurgery. 2005 Dec;57(6):1088-9

Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):578-81

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