Joseph L. Wiemels, PhD

Kenyon College, BA, 1988, Biology
University of California Berkeley, PhD, 1997, Environmental Health Science/Toxicology

• 1988-90
  Science Teacher, St. Johns College, Levuka, Fiji
• 1992-97
  Graduate Student Researcher, University of California Berkeley
• 1997-99
  Postdoctoral Fellow, Leukaemia Research Fund Centre, Institute of Cancer Research, London
• 1999-2000
  Assistant Research Molecular Epidemiologist, University of California San Francisco
• 2001-2002
  Assistant Adjunct Professor, University of California San Francisco
• 2002-2006
  Assistant Professor in Residence, University of California San Francisco
• 2006-present
  Associate Professor, University of California San Francisco

• 1986
  Maxwell Elliot Power Prize, Kenyon College
• 1988
  Phi Beta Kappa, Kenyon College
• 1993
  Public Health Alumni Scholarship, University of California Berkeley
• 1993
  National Science Foundation Predoctoral Fellowship in Toxicology awarded
• 1993-97
  Postdoctoral Fellow, Howard Hughes Medical Institute, University of California Berkeley
• 2002
  Scholar, Leukemia and Lymphoma Society of America

• Wiemels J, Smith MT. Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species. Free Radical Res 30: 93-103, 1999.
• Wiemels J, Wiencke JK, Varkonyi A, Smith MT. Modulation of toxicity and macromolecular binding of benzene metabolites by NAD(P)H:quinone oxidoreductase in transfected HL-60 Cells. Chem Res Toxicology 12: 467-475, 1999.
• Wiemels JL, Pagnamenta A, Taylor GM, Eden OB, Alexander FE, Greaves MF. Lack of function NAD(P)H:quinone oxidoreductase alleles are selectively associated with paediatric leukaemias that have MLL fusions. Cancer Res 59: 4095-4099, 1999.
• Wiemels JL, Greaves M. Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukaemia. Cancer Res 59: 4075-4082, 1999.
• Wiemels JL, Ford AM, Van Wering ER, Postma A, Greaves MF. Protracted and variable latency of acute lymphoblastic leukaemia after TEL/AML1 gene fusion in utero. Blood 94: 1057-1062, 1999.
• Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, Saha V, Biondi A, Greaves MF. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet. 354: 1499-1503, 1999.
• Wiemels JL, Alexander FE, Cazzaniga G, Biondi A, Mayer SP, Greaves M. Micro-clustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia. Genes Chromosomes and Cancer 29:219-28, 2000.
• Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylene Tetrahydrofolate Reductase (MTHFR) Polymorphisms and Risk of Molecularly Defined Subtypes of Childhood Acute Leukemia. Proc Natl Acad Sci USA, 98:4004-9, 2001.
• Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks, BM, Wiencke, JK, Wiemels JL. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia, 15:1906-1913, 2001.
• Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M. History of Allergies among adults with glioma and controls. Int J Cancer, 98:609-615, 2002.
• Segal, MR, Wiemels JL. Clustering of translocation breakpoints. Journal of the American Statistical Association, 97:66-76, 2002.
• Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves M. In utero origin of T(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood, 99(10):3801-3805, 2002.
• Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SP. Site-specific translocations and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 99(23):15101-6, 2002.
• Pine SR, Wiemels JL, Jayabose S, Sandoval C. TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. Leukemia Res, 27(2):155-64, 2003.
• McHale CM, Wiemels JL, Zhang LP, Ma X, Buffler PA, Guo W, Loh ML and Smith MT. Pre-natal origin of TEL-AML1 positive acute lymphoblastic leukemia in children born in California, Genes Chromosomes Cancer, 37:36-43, 2003.
• McHale CM, Wiemels JL, Zhang LP, Ma X, Buffler PA, Feusner J and Smith MT. Prenatal origin of childhood acute promyelocytic leukemia and childhood acute myeloid leukemia: t(15;17) and inv(16) rearrangements backtracked to birth, Blood, 101(11):4640-1, 2003.
• Greaves M, and Wiemels J. Origin of chromosomal translocations in childhood leukemia. Nature Reviews Cancer 2003 Sep;3(9):639-49.
• Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res. 64:2000-6, 2004.
• Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, Miike R, Barger G, Wrensch MR. Reduced Immunoglobulin E in adults with brain cancer compared to controls. Cancer Res, 64: 8468-73, 2004.
• Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia, 19(3):415-9, 2005.
• Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, Cassinat B, Parry A, Walz C, Wiemels JL, Segal MR, Ades L, Blair A, Osheroff N, Peniket AJ, Lafage-Pochitaloff M, Cross NCP, Chomienne C, Solomon E, Fenaux P, Grimwade D. DNA topoisomerase II mediates the DNA damage at t(15;17) chromosomal translocation breakpoints in therapy-related acute promyelocytic leukemia. New England J Medicine, 352(15):1529-38, 2005.
• Wrensch M, Weinberg A, Wiencke J, Miike R, Sison J, Wiemels J, Barger G, Delorenze G, Aldape K, Kelsey K. History of Chickenpox and Shingles and Prevalence of Antibodies to Varicella-Zoster Virus and Three Other Herpesviruses among Adults with Glioma and Controls. Am J Epidemiol. 161:929-38, 2005.
• Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does M, Wiencke JK. Ethnic difference in daycare attendance, early infections, and risk of childhood ALL. Cancer Epi Biomark Prevent 14:1928-34.
• Wiencke JK, Aldape K, McMillan A, Wiemels J, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, and Wrensch M. Molecular Features of adult glioma associated with patient race, age, and the polymorphic MGMT (O6-alkylguanine-DNA-alkyltransferase). Cancer Epi Biomark Prevent., 14:1928-34, 2005.
• Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. Epidemiology of intracranial meningioma. Neurosurgery. 2005 Dec;57(6):1088-9
• Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):578-81
• Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD. Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Res. 66:4531-41, 2006.
• Paynter RA, Skibola DR, Skibola CF, Buffler PA, Wiemels JL, Smith MT. Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources. Cancer Epidemiol Biomarkers Prev. 12:2533-6, 2006.
• Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 32:1293-303, 2006.
• Wrensch M, McMillan A, Wiencke J, Wiemels J, Kelsey K, Patoka J, Jones H, Carlton V, Miike R, Sison J, Moghadassi M, Prados M. Nonsynonymous coding single-nucleotide polymorphisms spanning the genome in relation to glioblastoma survival and age at diagnosis. Clin Cancer Res. 13:197-205, 2007.
• Urayama, KY, Wiencke, JK, Buffler, PA, Chokkalingam, AP, Metayer C, and Wiemels, JL. MDR1 Gene Variants, Indoor Insecticide Exposure, and the Risk of Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 16(6):1172-7, 2007.
• Wiemels, JL, Wiencke, JK, Kelsey KT, Moghadassi, M, Rice, T, Urayama, KY, Miike, R, Wrensch, M. Allergy-related polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev. 6(6):1229-35, 2007.
• Hansen HM, Wiemels JL, Wrensch M, Wiencke JK. DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1686-90
• Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL. Epidemiology of brain tumors.Neurol Clin. 2007 25:867-90.
• Chang JS, Yeh RF, Wiencke JK, Wiemels JL, Smirnov I, Pico A, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR. Pathway Analysis of Single-Nucleotide Polymorphisms Potentially Associated with Glioblastoma Multiforme Susceptibility Using Random Forests Cancer Epidem Biomark Prev 17:1368-73, 2008.
• Wiemels J. Chromosomal Translocations in Childhood Leukemia: Natural History, Mechanisms, and Epidemiology. JNCI Monographs, 39:87-90, 2008.
• Guha N, Chang, JS, Chokkalingam AP, Wiemels J, Smith MT, Buffler PA. NQO1 polymorphism and de novo childhood leukemia: a HuGE review and Meta-analysis. American J Epid, 168(11):1221-32, 2008.
• Houseman EA, Christensen BC, Yeh RF, Karagas MR, Wrensch MR, Wiemels JL, Zheng S, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT. Model-based clustering of methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics, 9;9:365-72, 2008.
• Vasconcelos GM, Kang M, Pombo-de-Oliveira MS, Schiffman J, Lorey F, Buffler PA, and Wiemels JL. Adenovirus Detection in Guthrie Cards from pediatric leukemia cases and controls. British J Cancer, 99(10):1668-1672.
• Wiemels J, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit C, Loh M, Buffler PA, Yeh RF. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposons elements and occur postnatally. Cancer Research, 68(23):9935-44, 2008.
• Christensen B, Houseman A, Godleski J, Marsit C, Longacker J, Roelofs C, Karagas M, Wrensch M, Yey RF, Nelson H, Wiemels J, Zheng S, Wiencke J, Bueno R, Sugarbaker D, Kelsey KT. Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. Cancer Research, 69(1):227-34, 2009.
• Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M. SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system. Nucleic Acids Res. 37:803-9, 2009.
• Chang JS, Wiemels JL, Buffler PA. Allergies and childhood leukemia. Blood Cells Mol Dis. 2008
• Walz C, Score J, Mix J, Cilloni D, Roche-Lestienne C, Yeh RF, Wiemels JL, Ottaviani E, Erben P, Hochhaus A, Martinelli G, Saglio G, Cross NCP, Reiter A. The molecular anatomy of the FIP1L1-PDGFRA fusion gene, Leukemia, epub 2009.