margaret.wrensch@ucsf.edu
(415) 476-1979 (voice)
(415) 502-1787 (fax)

Box 1215, UCSF, San Francisco, CA 94143-1215

Ohio State University, Columbus, OH, B.Sc., 1971, Genetics
Ohio State University, Columbus, OH, M.Sc., 1973, Population Genetics
University of California, Berkeley, CA, M.P.H., 1977, Epidemiology
University of California, Berkeley, CA, Ph.D., 1983, Epidemiology

Lee M, Wrensch M, Miike R. Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California USA). Cancer, Causes & Control 1997;8:13-24.

Wrensch M, Lee M, Miike R, et al. Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls. Am J Epidemiol 1997;145:581-93.

Wrensch M, Weinberg A, Wiencke J, Masters H, Miike R, Barger G, Lee M. Does prior infection with varicella zoster virus influence risk of adult glioma? Am J Epidemiol 1997;145:594-7.

Aldape K, Simmons M, Davis R, Miike R, Wiencke J, Barger G, Lee M, Chen P, Wrensch M. Discrepancies in diagnoses of neuroepithelial neoplasms: The San Francisco Bay Area Adult Glioma Study. Cancer 2000;88:2342-9.

Chen P, Aldape K, Wiencke J, Kelsey K, Miike R, Davis R, Liu J, Diaz A, Takahashi M, and Wrensch M. Ethnicity delineates different genetic pathways in malignant glioma. Cancer Research 2001; 61(10):3949-3954

Wrensch M, Weinberg A, Wiencke J, Miike R, Barger G, Kelsey K. Prevalence of antibodies to four herpesviruses among adults with glioma and controls. American Journal of Epidemiology 2001;154(2):161-65.

Wrensch M, Petrakis NL, Miike R, King EB, Chew K, Neuhaus, Lee MM, Rhys M. Breast cancer risk in women with abnormal cytology in nipple aspirates of breast fluid. JNCI 2001;93:1791-8.

Tedeschi-Blok N, Schwartzbaum J, Lee M, Miike R, Wrensch M. Dietary calcium and adult glioma. Nutrition and Cancer 2001;39:196-203.

Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch MR. History of allergies among adults with glioma and controls. Int J Cancer 2002;98(4):609-15.

Wrensch M, Minn AY, Chew T, Bondy M, Berger M. Epidemiology of primary brain tumors: Current concepts and review of the literature. Neuro-oncology 2002; 4(4):278-299.

Krishnan G, Felini M, Carozza SE, Miike R, Chew T, Wrensch M. Occupation and Adult Gliomas in the San Francisco Bay Area. J Occup Environ Med. 2003 June;45(6):639-47.

Wrensch MR, Kelsey KT, Liu M, Miike R, Moghadassi M, Aldape K, McMillan A, Wiencke J. Constitutive polymorphisms in Glutathione S Transferase (GST) Mu (M1), Theta (T1), and Pi (P) in adults with glioma and controls. Cancer Epidemiology Biomarkers and Prevention, 2004 Mar;13(3):461-7.

Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barger G, Wrensch M. Reduced immunoglobulin E and allergy among adults with glioma compared with controls. Cancer Res. 2004 Nov 15;64(22):8468-73.

Sivak-Sears NR, Schwartzbaum JA, Miike R, Moghadassi M, Wrensch M Case-control study of non-steroidal anti-inflammatory drug use and glioblastoma multiforme, Am J Epidemiol, 2004 Jun 15;159(12):1131-9.

Wrensch MR, Miike R, Sison JD, Kelsey KT, Liu M, McMillan A, Quesenberry C, Wiencke JK. CYP1A1 Variants and smoking related lung cancer in San Francisco Bay Area Latinos and African Americans. Int J Cancer, 2005 Jan 1;113(1):141-7.

Hwang ES, Chew T, Shiboski S, Farren G, Benz CC and Wrensch M. Risk factors for estrogen-receptor positive breast cancer, Archives of Surgery, Arch Surg 2005 Jan;140(1):58-62.

Wrensch, M.,, A. Weinberg, J. Wiencke, R. Miike, J. Sison, J. Wiemels, G. Barger, G. DeLorenze, K. Aldape, and K. Kelsey, History of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpes viruses among adults with glioma and controls. Am J Epidemiol., 2005. 161(10): p. 929-38.

Tang, J., W. Shao, M.T. Dorak, Y. Li, R. Miike, E. Lobashevsky, J.K. Wiencke, M. Wrensch, R.A. Kaslow, and C.S. Cobbs, Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev., 2005. 14(8): 2040-4.

Wiencke, J.K., K. Aldape, A. McMillan, J. Wiemels, M. Moghadassi, R. Miike, K.T. Kelsey, J. Patoka, J. Long, and M. Wrensch, Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomarkers Prev., 2005. 14(7): p. 1774-83.

Tice, J.A., R. Miike, K. Adduci, N.L. Petrakis, E. King, and M.R. Wrensch, Nipple aspirate fluid cytology and the Gail model for breast cancer risk assessment in a screening population. Cancer Epidemiol Biomarkers Prev., 2005. 14(2): p. 324-8.

Wrensch, M., K.T. Kelsey, M. Liu, R. Miike, M. Moghadassi, J.D. Sison, K. Aldape, A. McMillan, J. Wiemels, and J.K. Wiencke, ERCC1 and ERCC2 polymorphisms and adult glioma. Neuro-oncol., 2005. 7(4): p. 495-507.

Wrensch, M., J.L. Fisher, J.A. Schwartzbaum, M. Bondy, M. Berger, and K.D. Aldape, The molecular epidemiology of gliomas in adults. Neurosurg Focus., 2005. 19(5): p. E5.

Claus, E.B., M.L. Bondy, J.M. Schildkraut, J.L. Wiemels, M. Wrensch, and P.M. Black, Epidemiology of intracranial meningioma. Neurosurgery., 2005. 57(6): p. 1088-95; discussion 1088-95

Wrensch, M., T. Rice, R. Miike, A. McMillan, K. Lamborn, K. Aldape, and M. Prados, Diagnostic, treatment and demographic factors influencing survival in population based glioma patients in the San Francisco Bay Area. Neuro-oncology, 2006. 8(1): p. 12-26.

Christensen BC, Houseman EA, Godleski JJ, Marsit CJ, Longacker JL, Roelofs CR, Karagas MR, Wrensch MR, Yeh RF, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Bueno R, Sugarbaker DJ, Kelsey KT. Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. Cancer Res. 2009 Jan 1;69(1):227-34. PMID: 19118007 [PubMed - in process]

Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry CP Jr, Seldin MF, Kelsey KT, Wiencke JK. Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. Carcinogenesis. 2008 Nov 24. [Epub ahead of print] PMID: 19029194 [PubMed - as supplied by publisher]

Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M. SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system. Nucleic Acids Res. 2009 Jan;37(Database issue):D803-9. Epub 2008 Nov 4. PMID: 18984625 [PubMed - in process]

Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il'yasova D, Kruchko C, McCarthy BJ, Rajaraman P, Schwartzbaum JA, Sadetzki S, Schlehofer B, Tihan T, Wiemels JL, Wrensch M, Buffler PA; Brain Tumor Epidemiology Consortium. Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 2008 Oct 1;113(7 Suppl):1953-68. Review. PMID: 18798534 [PubMed - indexed for MEDLINE]

Aldrich MC, Selvin S, Hansen HM, Barcellos LF, Wrensch MR, Sison JD, Quesenberry CP, Kittles RA, Silva G, Buffler PA, Seldin MF, Wiencke JK. Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and Latinos. Am J Epidemiol. 2008 Nov 1;168(9):1035-46. Epub 2008 Sep 12. PMID: 18791191 [PubMed - indexed for MEDLINE]

Felini MJ, Olshan AF, Schroeder JC, Carozza SE, Miike R, Rice T, Wrensch M. Reproductive factors and hormone use and risk of adult gliomas. Cancer Causes Control. 2008 Sep 3. [Epub ahead of print] PMID: 18766447 [PubMed - as supplied by publisher]

Houseman EA, Christensen BC, Yeh RF, Marsit CJ, Karagas MR, Wrensch M, Nelson HH, Wiemels J, Zheng S, Wiencke JK, Kelsey KT. Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics. 2008 Sep 9;9:365. PMID: 18782434 [PubMed - indexed for MEDLINE]

Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry CP Jr, Seldin MF, Kelsey KT, Kittles RA, Silva G, Wiencke JK. Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. Int J Cancer. 2008 Nov 1;123(9):2095-104. PMID: 18709642 [PubMed - indexed for MEDLINE]

Chang JS, Yeh RF, Wiencke JK, Wiemels JL, Smirnov I, Pico AR, Tihan T, Patoka J, Miike R, Sison JD, Rice T, Wrensch MR. Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1368-73. PMID: 18559551 [PubMed - indexed for MEDLINE]

Baltzell KA, Moghadassi M, Rice T, Sison JD, Wrensch M. Epithelial cells in nipple aspirate fluid and subsequent breast cancer risk: a historic prospective study. BMC Cancer. 2008 Mar 19;8:75. PMID: 18366688 [PubMed - indexed for MEDLINE]

Davis FG, Malmer BS, Aldape K, Barnholtz-Sloan JS, Bondy ML, Brännström T, Bruner JM, Burger PC, Collins VP, Inskip PD, Kruchko C, McCarthy BJ, McLendon RE, Sadetzki S, Tihan T, Wrensch MR, Buffler PA. Issues of diagnostic review in brain tumor studies: from the Brain Tumor Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):484-9. PMID: 18349266 [PubMed - indexed for MEDLINE]

Malmer B, Adatto P, Armstrong G, Barnholtz-Sloan J, Bernstein JL, Claus E, Davis F, Houlston R, Il'yasova D, Jenkins R, Johansen C, Lai R, Lau C, McCarthy B, Nielsen H, Olson SH, Sadetzki S, Shete S, Wiklund F, Wrensch M, Yang P, Bondy M. GLIOGENE an International Consortium to Understand Familial Glioma. Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1730-4. Review. PMID: 17855690 [PubMed - indexed for MEDLINE]

Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, Wrensch M. Exogenous hormone use and meningioma risk: what do we tell our patients? Cancer. 2007 Aug 1;110(3):471-6. Review. PMID: 17580362 [PubMed - indexed for MEDLINE]

Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood hydrocephalus. J Neurosurg. 2007 May;106(5 Suppl):334-9. PMID: 17566197 [PubMed - indexed for MEDLINE]

Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R, Wrensch M. Allergy-related polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1229-35. PMID: 17548690 [PubMed - indexed for MEDLINE]

Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, Tamgüney T, Baumber R, Parsons R, Lamborn KR, Berger MS, Wrensch MR, Haas-Kogan DA, Stokoe D. Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol. 2007 Jul;9(3):271-9. Epub 2007 May 15. PMID: 17504928 [PubMed - indexed for MEDLINE]

Wrensch M, McMillan A, Wiencke J, Wiemels J, Kelsey K, Patoka J, Jones H, Carlton V, Miike R, Sison J, Moghadassi M, Prados M. Nonsynonymous coding single-nucleotide polymorphisms spanning the genome in relation to glioblastoma survival and age at diagnosis. Clin Cancer Res. 2007 Jan 1;13(1):197-205. PMID: 17200355 [PubMed - indexed for MEDLINE]

Schwartzbaum JA, Fisher JL, Aldape KD, Wrensch M. Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol. 2006 Sep;2(9):494-503; quiz 1 p following 516. Review. PMID: 16932614 [PubMed - indexed for MEDLINE]

Tedeschi-Blok N, Lee M, Sison JD, Miike R, Wrensch M. Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study. BMC Cancer. 2006 Jun 3;6:148. PMID: 16749939 [PubMed - indexed for MEDLINE]

Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD. Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Res. 2006 Apr 15;66(8):4531-41. PMID: 16618782 [PubMed - indexed for MEDLINE]

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