Anthony Wynshaw-Boris, MD, PhD

Franklin and Marshall College, Lancaster, PA, BA, 1977, Biology
Case Western Reserve University, Cleveland, OH, PhD, 1984, Biochemistry
Case Western Reserve University, Cleveland, OH, MD, 1987, Medicine
Rainbow Babies and Children’s Hosp.Cleveland, OH, Pediatrics, 1989, Pediatrics Residency
Harvard Medical School, Boston MA, Research,  1994, Research Fellowship

• 1989-1994
  Fellow in Genetics, The Children's Hospital, Boston, MA
• 1991-1994
  Physician Research Fellow, Howard Hughes Medical Institute
• 1994-1999
  Unit Head, Mouse Models Section, GDRB/NHGRI/NIH, Bethesda, MD
• 1996-1999
  Director, Animal Core Facility, GDRB/NHGRI/NIH, Bethesda, MD
• 1999-2002
  Assistant Professor, Pediatrics and Medicine, UCSD School of Medicine, La Jolla, CA
• 2002-2004
  Associate Professor, Pediatrics and Medicine, UCSD School of Medicine, La Jolla, CA
• 2003-2007
  Chief, Division of Genetics, Department of Pediatrics, UCSD School of Medicine
• 2004-2007
  Professor, Pediatrics and Medicine, UCSD School of Medicine, La Jolla, CA
• 2004-2007
  Director, Center for Human Genetics and Genomics
• 2006-2007
  Vice Chair for Research, Department of Pediatrics
• 2007-present
  Charles J. Epstein Professor in Human Genetics and Pediatrics, UCSF School of Medicine 2007-present
  Chief, Division of Genetics, Department of Pediatrics, UCSF School of Medicine

• 1987
  Alpha Omega Alpha, Case Western Reserve University School of Medicine
• 1987
  The Martin Wahl Memorial Fund Award, CWRU School of Medicine
• 1987
  Science Day Award, Department of Pediatrics, Rainbow Babies and Children's Hospital
• 1995
  Special Achievement Award, NCHGR/NIH
• 1997
  NIH Director's Award
• 2000-2003
  EJLB Foundation Research Scholars Program Fellowship
• 2002
  Election to American Society of Clinical Investigation
• 2007
  Election to Association of American Physicians
• 2008
  Election to American Pediatric Society

• Barlow, C., Hirotsune, S. Paylor, R., Liyanage, M. Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J.N., Ried, T., Tagle, D. and Wynshaw-Boris, A. Atm-deficient mice: a paradigm of ataxia-telangiectasia. Cell. 1996; 86:159-171.
• Lijam, N., Paylor, R., McDonald, M.P., Crawley, J.N., Deng, C-X., Herrup, K. Stevens, K.E., Macaferri. G., McBain, C.J., Sussman, D.J. and Wynshaw-Boris, A. Social interaction and sensorimotor gating abnormalities in mice lacking Dvl-1. Cell. 1997; 90:895-905.
• Hirotsune, S., Fleck, M.W., Gambello, M.J., Bix, G.J., Chen, A., Clark, G.D., Ledbetter, D.H., McBain, C.J. and Wynshaw-Boris, A. Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. Nature Genet. 1998; 19:333-339.
• Xu, X., Wagner, K-U., Larson, D., Weaver, Z., Li, C., Ried, T., Hennighausen, L., Wynshaw-Boris, A. and Deng, C.-X. Conditional knock-out of Brca1 in the mammary epithelial cells results in blunted ductal morphogenesis and tumor formation. Nature Genet. 1999; 22:37-43.
• Smith, D.S., Niethammer, Ayala, R., M., Zhou, Y., Gambello, M.J., Wynshaw-Boris, A. and Tsai, L.-H. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Nature Cell Biol. 2000; 2:767-775.
• The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium. Functional annotation of 21,076 sequenced mouse cDNAs prepared from full-length enriched libraries. Nature. 2001; 409:685-690
• Merscher, S., Funke, B., Epstein, J.A., Heyer, J., Puech, A., Russell, R.G., Factor, S., Tokooya, K., St. Jore, B., Lopez, M., Pandita, R.K., Lia, M., Carrion, D., Scambler, P., Wynshaw-Boris, A., Skoultchi, A.I., Morrow, B.E. and Kucherlapati, R. TBX1 is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome. Cell.. 2001; 104:619-629.
• Corbo, J.C., Deuel, T., Long, J.M., LaPorte, P., Tsai, E. Wynshaw-Boris, A. and Walsh, C.A. Doublecortin is required in mice for lamination of the hippocampus but not the cerebral cortex. J Neuro. 2002; 22:7548-7557.
• Kioussi, C., Briata, P., Baek, S.H., Rose, D., Hamblet, N.S., Herman, T., Ohgi, K.A., Lin, C., Gleiberman, A., Wang, J., Brault, V., Ruiz-Lozano, P., Nguyen, H.D., Kemler, R., Glass, C. K., Wynshaw-Boris, A.* and Rosenfeld, M.G.* Identification of a Wnt/Dvl/-catenin  Pitx2 pathway mediating cell type-specific proliferation during development. Cell. 2002;111:673-685. *co-corresponding authors
• Hamblet, N.S., Lijam, N., Ruiz-Lozano, P., Wang, J., Yang, Y., Mei, L., Chien K.R., Sussman, D.J. and Wynshaw-Boris, A. Dishevelled-2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002;129: 5827-5838.
• The FANTOM Consortium* and The RIKEN Genome Exploration Research Group Phase I & II. Analysis of the Mouse Transcriptome based upon Functional Annotation of 60,770 full length cDNAs. Nature. 2002; 420: 563-573.
• Gambello, MJ, Darling, DL, Yingling, J., Tanaka, T., Gleeson, JG. and Wynshaw-Boris, A Multiple dose dependent effects of Lis1 on cerebral cortical development. J Neurosci. 2003; 23: 1719-1729.
• Hirotsune, S., Yoshida, N., Chen, A., Garrett, L., Sugiyama, F., Takahashi, S., Yagami, K., Wynshaw-Boris, A. and Yoshiki, A. An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature. 2003; 423:91-96.
• Toyo-oka, K., Shionoya, A. Gambello, M.J., Cardoso, C., Leventer, R.J., Ward, H., Ayala, R., Tsai, L.H., Dobyns, W.B., Ledbetter, D.H., Hirotsune, S. and Wynshaw-Boris, A. 14-3-3 is important for neuronal migration via binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nature Genet. 2003; 34:274-285
• Hurlin, P.J., Zhou, Z-Q., Toyo-oka, K., Ota, S., Walker, W.L, Hirotsune, S. and Wynshaw-Boris, A. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003; 22:4584-96.
• Toyo-oka, K., Hirotsune, S., Gambello, M.J., Zhou, Z., Olson, L., Rosenfeld, M.G., Eisenman, R.N., Hurlin, P.J. and Wynshaw-Boris, A. Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet. 2004; 13:1057-1067.
• Tanaka, T., Serneo, F.F., Higgins, C., Gambello, M.J., Wynshaw-Boris, A. and Gleeson, J.G. Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. J Cell Biol. 2004; 165:709-721.
• Schubert, R., Erker, L., Barlow, C., Yakushiji, H., Larson, D., Russo, A., Mitchell J. and Wynshaw-Boris, A. Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice. Human Mol Genet. 2004; 13:1793-1802.
• Rosso, S.B., Sussman, D., Wynshaw-Boris, A. and Salinas, P.C. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci. 2005; 8:34-42.
• Arkan, M.C., Hevener, A.L., Greten, F.R., Maeda, S., Li, Z.W., Long, J.M., Wynshaw-Boris, A., Poli, G., Olefsky, J. and Karin, M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005; 11:191-198.
• Erker, L., Schubert, R., Barlow, C., Yakushiji, H., Larson, D., Mitchell J. and Wynshaw-Boris, A. Cancer chemoprevention by the antioxidant Tempol acts partially via the p53 tumor suppressor. Hum Mol Genet. 2005; 12:1699-1708.
• Sasaki, S., Mori, D., Toyo-oka, K., Chen, A., Garrett-Beal, L., Muramatsu, M., Miyagawa, S., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A. and Hirotsune, S. Disruption of Ndel1 causes neuronal migration defects and early embryonic lethality. Mol Cell Biol. 2005; 25: 7812-7827.
• Wang, J., Zhang, X., Mark, S., Qian, D., Yoo, S.J., Radde-Gallwitz, K., Zhang, Y., Lin, X., Collazo, A., Wynshaw-Boris, A.* and Chen, P.* Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet. 2005; 37:980-985. *co-corresponding authors
• Wang, J., Hamblet, N.S., Mark, S., Dickinson, M., Brinkman, B., Segil, N., Fraser, S.F., Chen, P., Wallingford, J.B. and Wynshaw-Boris, A. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006; 133:1767-1778.
• Zhou, W., Lin, L., Majumdar, A., Li, X., Zhang, X., Liu, W., Etheridge, S.L., Shi, Y., Martin, J., Van de Ven, W., Kaartinen, V., Wynshaw-Boris, A., McMahon, A.P., Rosenfeld, M.G. and Evans, S. Modulation of morphogenesis by non-canonical Wnt signaling requires ATF2-mediated transcriptional activation of TGF. Nat Genet. 2007; 39:1225-1234.
• Yingling, Y., Youn, Y. H., Darling, D., Toyo-oka, K., Pramparo, T., Hirotsune, S. and Wynshaw-Boris, A. Neuroepithlial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell. 2008; 132, 474-486.