(415) 476-2757 (appts)

Box 0794, UCSF; San Francisco, CA 94143-0794

additional websites:

UCSF Physician Referral Directory

Franklin and Marshall College, Lancaster, PA, BA, 1977, Biology
Case Western Reserve University, Cleveland, OH PhD, 1984, Biochemistry
Case Western Reserve University, Cleveland, OH MD, 1987, Medicine
Rainbow Babies and Children's Hosp.Cleveland, OH, Pediatrics, 1989, Pediatrics Residency
Harvard Medical School, Boston MA, Research, 1994, Research Fellowship

Barlow, C., Hirotsune, S. Paylor, R., Liyanage, M. Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J.N., Ried, T., Tagle, D. and Wynshaw-Boris, A. Atm-deficient mice: a paradigm of ataxia-telangiectasia. Cell. 1996; 86:159-171.

Lijam, N., Paylor, R., McDonald, M.P., Crawley, J.N., Deng, C-X., Herrup, K. Stevens, K.E., Macaferri. G., McBain, C.J., Sussman, D.J. and Wynshaw-Boris, A. Social interaction and sensorimotor gating abnormalities in mice lacking Dvl-1. Cell. 1997; 90:895-905.

Hirotsune, S., Fleck, M.W., Gambello, M.J., Bix, G.J., Chen, A., Clark, G.D., Ledbetter, D.H., McBain, C.J. and Wynshaw-Boris, A. Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. Nature Genet. 1998; 19:333-339.

Xu, X., Wagner, K-U., Larson, D., Weaver, Z., Li, C., Ried, T., Hennighausen, L., Wynshaw-Boris, A. and Deng, C.-X. Conditional knock-out of Brca1 in the mammary epithelial cells results in blunted ductal morphogenesis and tumor formation. Nature Genet. 1999; 22:37-43.

Smith, D.S., Niethammer, Ayala, R., M., Zhou, Y., Gambello, M.J., Wynshaw-Boris, A. and Tsai, L.-H. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Nature Cell Biol. 2000; 2:767-775.

The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium. Functional annotation of 21,076 sequenced mouse cDNAs prepared from full-length enriched libraries. Nature. 2001; 409:685-690

Merscher, S., Funke, B., Epstein, J.A., Heyer, J., Puech, A., Russell, R.G., Factor, S., Tokooya, K., St. Jore, B., Lopez, M., Pandita, R.K., Lia, M., Carrion, D., Scambler, P., Wynshaw-Boris, A., Skoultchi, A.I., Morrow, B.E. and Kucherlapati, R. TBX1 is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome. Cell.. 2001; 104:619-629.

Corbo, J.C., Deuel, T., Long, J.M., LaPorte, P., Tsai, E. Wynshaw-Boris, A. and Walsh, C.A. Doublecortin is required in mice for lamination of the hippocampus but not the cerebral cortex. J Neuro. 2002; 22:7548-7557.

Kioussi, C., Briata, P., Baek, S.H., Rose, D., Hamblet, N.S., Herman, T., Ohgi, K.A., Lin, C., Gleiberman, A., Wang, J., Brault, V., Ruiz-Lozano, P., Nguyen, H.D., Kemler, R., Glass, C. K., Wynshaw-Boris, A.* and Rosenfeld, M.G.* Identification of a Wnt/Dvl/-catenin  Pitx2 pathway mediating cell type-specific proliferation during development. Cell. 2002;111:673-685. *co-corresponding authors

Hamblet, N.S., Lijam, N., Ruiz-Lozano, P., Wang, J., Yang, Y., Mei, L., Chien K.R., Sussman, D.J. and Wynshaw-Boris, A. Dishevelled-2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002;129: 5827-5838.

The FANTOM Consortium* and The RIKEN Genome Exploration Research Group Phase I & II. Analysis of the Mouse Transcriptome based upon Functional Annotation of 60,770 full length cDNAs. Nature. 2002; 420: 563-573.

Gambello, MJ, Darling, DL, Yingling, J., Tanaka, T., Gleeson, JG. and Wynshaw-Boris, A Multiple dose dependent effects of Lis1 on cerebral cortical development. J Neurosci. 2003; 23: 1719-1729.

Hirotsune, S., Yoshida, N., Chen, A., Garrett, L., Sugiyama, F., Takahashi, S., Yagami, K., Wynshaw-Boris, A. and Yoshiki, A. An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature. 2003; 423:91-96.

Toyo-oka, K., Shionoya, A. Gambello, M.J., Cardoso, C., Leventer, R.J., Ward, H., Ayala, R., Tsai, L.H., Dobyns, W.B., Ledbetter, D.H., Hirotsune, S. and Wynshaw-Boris, A. 14-3-3 is important for neuronal migration via binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nature Genet. 2003; 34:274-285

Hurlin, P.J., Zhou, Z-Q., Toyo-oka, K., Ota, S., Walker, W.L, Hirotsune, S. and Wynshaw-Boris, A. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003; 22:4584-96.

Toyo-oka, K., Hirotsune, S., Gambello, M.J., Zhou, Z., Olson, L., Rosenfeld, M.G., Eisenman, R.N., Hurlin, P.J. and Wynshaw-Boris, A. Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet. 2004; 13:1057-1067.

Tanaka, T., Serneo, F.F., Higgins, C., Gambello, M.J., Wynshaw-Boris, A. and Gleeson, J.G. Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. J Cell Biol. 2004; 165:709-721.

Schubert, R., Erker, L., Barlow, C., Yakushiji, H., Larson, D., Russo, A., Mitchell J. and Wynshaw-Boris, A. Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice. Human Mol Genet. 2004; 13:1793-1802.

Rosso, S.B., Sussman, D., Wynshaw-Boris, A. and Salinas, P.C. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci. 2005; 8:34-42.

Arkan, M.C., Hevener, A.L., Greten, F.R., Maeda, S., Li, Z.W., Long, J.M., Wynshaw-Boris, A., Poli, G., Olefsky, J. and Karin, M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005; 11:191-198.

Erker, L., Schubert, R., Barlow, C., Yakushiji, H., Larson, D., Mitchell J. and Wynshaw-Boris, A. Cancer chemoprevention by the antioxidant Tempol acts partially via the p53 tumor suppressor. Hum Mol Genet. 2005; 12:1699-1708.

Sasaki, S., Mori, D., Toyo-oka, K., Chen, A., Garrett-Beal, L., Muramatsu, M., Miyagawa, S., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A. and Hirotsune, S. Disruption of Ndel1 causes neuronal migration defects and early embryonic lethality. Mol Cell Biol. 2005; 25: 7812-7827.

Wang, J., Zhang, X., Mark, S., Qian, D., Yoo, S.J., Radde-Gallwitz, K., Zhang, Y., Lin, X., Collazo, A., Wynshaw-Boris, A.* and Chen, P.* Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet. 2005; 37:980-985. *co-corresponding authors

Wang, J., Hamblet, N.S., Mark, S., Dickinson, M., Brinkman, B., Segil, N., Fraser, S.F., Chen, P., Wallingford, J.B. and Wynshaw-Boris, A. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006; 133:1767-1778.

Zhou, W., Lin, L., Majumdar, A., Li, X., Zhang, X., Liu, W., Etheridge, S.L., Shi, Y., Martin, J., Van de Ven, W., Kaartinen, V., Wynshaw-Boris, A., McMahon, A.P., Rosenfeld, M.G. and Evans, S. Modulation of morphogenesis by non-canonical Wnt signaling requires ATF2-mediated transcriptional activation of TGF. Nat Genet. 2007; 39:1225-1234.

Yingling, Y., Youn, Y. H., Darling, D., Toyo-oka, K., Pramparo, T., Hirotsune, S. and Wynshaw-Boris, A. Neuroepithlial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell. 2008; 132, 474-486.

5/13/08