zxu@cc.ucsf.edu
(415) 502-0555 (voice)
(415) 502-6779 (fax)

Box 0875, UCSF, San Francisco, CA 94143-0875

additional websites:

Thoracic Oncology Lab
Dept. of Surgery

Shanghai Fisheries University, B.S., 1982, Marine Aquaculture
Western Illinois University, M.S., 1986, Biology/Cytogenetics
The University of Texas Medical Branch, Galveston, Ph.D., 1992, Molecular Mutagenesis

Xu, Z., Yu, Y.J., Schwarts, J., Meltz, M., Hsie, A.W. (1995) Molecular nature of spontaneous mutations at the hypoxanthine-guanine phosphoribolsyltransferase (hprt) locus in Chinese hamster ovary cells. Envion. Mol. Mutagen. 26: 127-138.

Lei, D.C., Kunzelmann, K., Koslowsky, T., Yezzi, M.J., Escobar, L.C., Xu, Z., Ellison, A.R., Rommens, J.M., Tsui, L.-C., Tykocinski, M., Gruenert, D.C. (1996) Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells. Gene Therapy, 3: 427-436.

Hsie, A.W., Porter, R.C., Xu, Z., Yu, Y.J., Sun, J., Meltz, M.L., Schwartz, J.L. (1996) Molecular markers of ionizing radiation-induced gene mutations in mammalian cells. Environmental Health Perspectives, 104 Suppl 3: 675-678

Kunzelmann, K., Legendre, J-Y., Kneoll, D., Escobar, L.C., Xu, Z., Gruenert, D.C. (1996) Targeted replacement of mutant CFTR DNA: mRNA expression and ion transport in CF epithelial cells. Gene Therapy, 3: 859-867.

Xu, Z., Gruenert, D.C. (1996) Human CFTR gene sequences flanking exon 10: A simple repeat sequence polymorphism in intron 9. Bioch. Bioph. Res. Comm. 219: 140-145.

Xu, Z., Ma, T.H. (1997) Clastogenicity of formaldehyde fumes and X-rays evaluated by the Tradescantia-micronucleus assay. Environ. Experim. Botany. 39: 169-175.

Xu, Z., Gupta, V., Lei, D, Holmes, A., Carlson, E., Gruenert, D.C. (1998) In-frame elimination of exon 10 in Cftrtm1Unc CF mice. Gene, 211: 117-123.

Goncz, K.K., Kunzelmann, K.K., Xu, Z., Gruenert, D.C. (1998) Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments. Hum. Mol. Gen. 7:1913-1919.

Yang, B., Ma, T., Xu, Z., Verkman, A.S. (1999) cDNA and genomic cloning of mouse aquaporin-2: Functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 57: 79-83.

Colosimo, A., Xu, Z., Novelli, G., Dallapiccola, B., Gruenert, G.C. (1999) A simple version of "megaprimer" PCR for site-directed mutagenesis. BioTech, 26: 870-873.

Xu, Z., Xia, C., Eng, K., Jablons, D. (2001) Direct full-length cloning of mammalian mRNAs using a novel library-free method mediated with ligation anchored cDNA (in preparation)

Xu, Z., Jablons, D., Gruenert, D.C. (2001) Expressed sequence tag-specific full-length cDNA cloning: Actin cDNAs. Gene, 263: 265-272.

Goncz, K.K., Colosimo, A., Gagné, L., Hong, K., Papahadjoupolos, D., Sawa, T., Schreier, H., Wiener-Kronish, J., Xu, Z., Gruenert, D.C. (2001) Expression of deltaF508 CFTR in normal mouse lung after site-specific modification of CFTR sequences by SFHR. Gene Therapy, 8: 961-965.

Xia, C., Xu, Z., Yuan, X., You, L., Uematsu, K., Li, K., Li, L., McCormick, F., Jablons, D. (2002) Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides. Mol. Cancer Ther. 1: 687-694.31.

Biao He, L. You, K. Uematsu, M. Matsangou, Xu Z., M. He, F. McCormick and D. M. Jablons. Cloning and characterization of a functional promoter of the human SOCS-3 gene, Biochem. Biophys. Res. Comm., 2003, 301: 386-391.

R. Jensen, M. Tirikainen, L. You, D. Ginzinger, Biao He, K. Uematsu, Xu Z., P. Treseler, F. McCormick and D. M. Jablons. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q, Anticancer Research, 2003, 23 (3B): 2281-2289.

K. Uematsu, S. Kanazawa, L. You, Biao He, Xu Z., M. Peterlin, F. McCormick and D. M. Jablons. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Research, 2003, 63 (15): 4547-4551.

K. Uematsu, Biao He, L. You, Xu Z., F. McCormick and D. M. Jablons. Activation of the Wnt pathway in human non-small-cell lung cancer: evidence of Dishevelled (Dvl) overexpression, Oncogene, 2003, 22(46): 7218-7221.

Biao He, L. You, K. Uematsu, K. Zang, Xu Z., J. F. Costello, F. McCormick and D. M. Jablons. SOCS-3 suppresses cell growth and is silenced by frequent hyper-methylation in human lung cancer, Proc. Natl. Acad. Sci. USA, 2003, 100 (24): 14133-14138.

Biao He, L. You, K. Uematsu, K. Zang, Xu Z., M. Matsangou, F. McCormick and D. M. Jablons. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells, Neoplasia, 2004, 6: 7-14.

You, L., B. He, Xu Z., F. McCormick and D. M. Jablons. Future directions-oncolytic viruses. Clinical Lung Cancer, 2004, 5 (4): 226-230.

You, L., B. He, K. Uematsu, Xu Z., F. McCormick, and D. M. Jablons. Inhibition of Wnt-1 signaling induces apoptosis in beta-Catenin-deficient mesothelioma cells, Cancer Research, 2004, 64: 3474-3478.

He, B., L. You, Xu Z., K. Uematsu, J. Mazieres, A. Y. Lee and D. M. Jablons. Activity of the suppressor of cytokine signaling-3 (SOCS-3) promoter in human non-small-cell lung cancer, Clinical Lung Cancer 2004, May; 5(6):366-70.

Lee, A. Y., B. He, S. Dadfarmay, L. You, K. Uematsu, Xu Z., F. McCormick and D. M. Jablons. Expression of the secreted frizzled-related protein (sFRP) family is down-regulated by methylation in human lung cancer and mesothelioma, Oncogene 2004, Aug 26;23(39):6672-6.

You, L. B. He, Xu Z., K. Uematsu, A.Y. Lee, F. McCormick and D.M. Jablons. A novel anti-human Wnt-2 monoclonal antibody induces programmed cell death in human non-small-cell lung cancer cells, Oncogene, 2004 Aug 12;23(36):6170-4.

You, L., B. He, Xu Z., K. Uematsu, A.Y. Lee, J. Mazieres, F. McCormick and D.M. Jablons. A novel anti-human Wnt-2 monoclonal antibody induces programmed cell death in human melanoma cells, Cancer Research, 2004, Aug 1;64 (15):5385-9.

J. Mazieres, Biao He, L. You, Xu Z., A. Lee, I. Mikami, F. McCormick and D. M. Jablons. Wnt Inhibitory Factor-1 (WIF-1) is silenced by promoter hypermethylation in human lung cancer, Cancer Research, 2004, Jul 15;64(14):4717-20.

Lee A, He B, Dadfarmay S, You L, Mazieres J, Mikami I, Xu Z, McCormick F, Jablons DM. Expression of the Secreted Frizzled-Related Protein (sFRP) family is down-regulated by Methylation in Human Mesothelioma. Oncogene 2004 Aug 26;23(39):6672-6.

You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh J, Kashani-Sabet M, McCormick F, Jablons DM. An Anti-Wnt-2 Monoclonal Antibody Induces Apoptosis in Malignant Melanoma Cells and Inhibits Tumor Growth. Cancer Res, 2004 Aug 1;64 (15):5385-9.

Reguart N, He B, Xu Z, You L, Lee A, Mazieres J, Mikami I, Batra S, Rosell R, McCormick F, Jablons DM. Cloning and Characterization of the Promoter of Human Wnt Inhibitory Factor-1. Biochem Biophys Res Commun, 2004 Oct 8;323(1):229-34.

Lee AY, He B, You L, Xu Z, Mazieres J, Reguart N, Mikami I, Batra S, Jablons DM. Dickkopf-1 Antagonizes Wnt Signaling Independent of Beta-Catenin in Human Mesothelioma. Biochem Biophys Res Commun, 2004

He B, Lee AY, Dadfarmay S, You L, Xu Z, Reguart, Mazieres J, Mikami I, McCormick F, Jablons DM. Secreted Frizzled-Related Protein 4 is Silenced by Hypermethylation and Induces Apoptosis in beta-Catenin-Deficient Human Mesothelioma. Cancer Res 2005 Feb 1;65(3):743-8.

He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, McCormick F, Jablons DM. Blockade Of Wnt-1 Signaling Induces Apoptosis in Human Colorectal Cancer Cells Containing Downstream Mutations, Oncogene, 2005 Apr 21;24(18):3054-8.

Mazieres J, He B, You L, Xu Z, Jablons DM. Wnt Signaling in Lung Cancer. Cancer Letters 2005 May 10:222(1) : 1-10.

Mikami I, You L, He B, Xu Z., Batra S, Lee AY, Mazieres J, Reguart N, Uematsu Koizumi K and Jablons DM. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells, BMC Cancer, 2005, May 24; 5(1): 53.

Mazieres J, You L, He B, Xu Z., Twogood S, Lee AY, Reguart N, Batra S, Mikami I and Jablons DM. Wnt-2 as a new therapeutic target in malignant pleural mesothelioma, International Journal of Cancer, 2005, 117 (2): 326-332.

Kim K, Abayasiriwardana K, Nishimura S, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Broaddus C. A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance, Am J Respir Crit Care Med., 2005 Dec;33(6):541-8.

Mazieres J, You L, He B, Xu Z., Lee AY, Mikami I, McCormick F, and Jablons DM. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis, Oncogene 2005, 24 (34): 5396-5400.

He B, Barg RN, You L, Xu Z., Reguart N, Mikami I, Batra S, Rosell R, and Jablons DM. Wnt signaling in stem cells and non small cell lung cancer. Clinical Lung Cancer, 2005, 7 (1): 54-60.

Batra S, Shi Y, He B, Kuchenbecher K, Mikami I, You L, Xu Z., Lin, YC, Clement, G, Reguart N, and Jablons DM. Wnt Inhibitory Factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem. Biophys. Res. Comm 2006, 342: 1228-1232.

Lin Y, You L, Xu Z., He B, Mikami I, Thung E, Chou J, Kuchenbecher K, Kim J, Raz D, Yang C, Chen J, and Jablons DM. Activation of Wnt signaling and WIF-1 silencing due to promoter hypermethylation in nasopharyngeal cancer cell lines. Biochem. Biophys. Res. Comm. 2006, 314: 635-640.

You, L, Kim, J, He, B, Xu, Z, McCormick, F, Jablons, DM. Wnt-1 signal as a potential cancer therapeutic target. Drug News Perspect., 2006, 19: 27-31.

9/28/06