P_Yaswen@lbl.gov
(510) 486-4192 (voice)
(510) 486-4475 (fax)

Lawrence Berkeley Nat'l Lab; Mailstop 70A-1118
1 Cyclotron Road; Berkeley, CA 94720

additional websites:

Yaswen Lab Website

Tufts University, Medford, MA, B.Sc., 1980, Biology
Brown University, Providence, RI, Ph.D., 1984, Cell & Molec. Biology

Yaswen, P., Hayner, N.T., and Yaswen, P., Hayner, N.T., and Fausto, N. (1984) Isolation of oval cells by centrifugal elutriation and comparison with other cell types purified from normal and preneoplastic livers. Cancer Res. 44: 324-331.

Yaswen, P., Goyette, M., Shank, P., and Fausto, N. (1985) Oncogene mRNA levels in specific liver cell types during liver carcinogenesis. Mol. Cell. Biol. 5: 780-786.

Yaswen, P., Hayner, N.T., and Yaswen, P., Hayner, N.T., and Fausto, N. (1984) Isolation of oval cells by centrifugal elutriation and comparison with other cell types purified from normal and preneoplastic livers. Cancer Res. 44: 324-331.

Yaswen, P., Thompson, N.L., and Fausto, N. (1985) Oncodevelopmental expression of rat placental alkaline phosphatase. Amer. J. Pathol. 121: 505-513.

Yaswen, P., Smoll, A., Peehl, D., Trask, D.K., Sager, R., and Stampfer, M.R. (1990) Downregulation of a novel calmodulin-related gene during transformation of human mammary epithelial cells. Proc. Natl. Acad. Sci. USA 87: 7360-7364.

Yaswen, P., Hosoda, J., Parry, G., Smoll, A., and Stampfer, M. Protein product of a human intronless calmodulin-like gene shows tissue-specific expression and reduced abundance in transformed cells. Cell Growth and Diff., 3: 335-345, 1992.

Yaswen, P., Stampfer, M.R., Ghosh, K., and Cohen, J.S. Effects of sequence of thioated oligonucleotides on cultured human mammary epithelial cells. Antisense Research and Development 3: 67-77, 1993.

Stampfer, M.R., Pan, C.-H., Hosoda, J., Bartholomew, J., Mendelsohn, J., and Yaswen, P. Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous reentry into the cell cycle. Exp. Cell Res. 208: 175-188, 1993.

Edman, C.F., George, S.E., Means, A.R., Schulman, H., and Yaswen, P. Selective activation and inhibition of calmodulin dependent enzymes by a calmodulin-like protein found in human epithelial cells. Eur. J. Biochem. 226: 725-730, 1994.

Sandhu, C., Garbe, J., Bhattacharya, N., Daksis, J., Pan, C-H., Yaswen, P., Koh, J., Slingerland, J.M., and Stampfer, M.R. TGF-β stabilizes p15INK4B protein, increases p15INK4B/cdk4 complexes and inhibits cyclin D1/cdk4 association in human mammary epithelial cells. Mol. Cell Biol. 17:2458-2467, 1997.

Stampfer, M.R., Bodnar, A., Garbe, J., Wong, M., Pan, A., Villeponteau, B., and Yaswen, P. Gradual phenotypic conversion associated with immortalization of cultured human mammary epithelial cells. Mol. Biol. Cell 8:2391-2405, 1997.

Close, M.J., Howlett, A.R., Roskelley, C.D., Desprez, P.Y., Bailey, N., Rowning, B., Teng, C.T., Stampfer, M.R., and Yaswen, P. Lactoferrin expression in mammary epithelial cells is mediated by changes in cell shape and actin cytoskeleton. J. Cell Science 110:2861-2871, 1997.

Collins, C., Rommens, J.M., Kowbel, D., Godfrey, T., Tanner, M.,Hwang, S., Polikoff, D., Nonet, G., Cochran, J., Myambo, K., Jay, K.E., Froula, J., Cloutier, T., Kuo, W-L., Yaswen, P., et al. Positional cloning of ZNF217 and NABC1: Genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc. Natl. Acad. Sci. USA 95:8703-8708, 1998.

Garbe, J., Wong, M., Wigington, D., Yaswen, P., and Stampfer, M.R. Viral oncogenes accelerate conversion to immortality of cultured human mammary epithelial cells. Oncogene 18: 2169-2180, 1999.

Nijjar, T., Wigington, D., Garbe, J., Waha, A., Stampfer, M.R., and Yaswen, P. p57KIP2 expression and loss of heterozygosity during immortal conversion of cultured human mammary epithelial cells. Cancer Res. 59:5112-5118, 1999.

Kim, D.W., Sovak, M.A., Zanieski, G., Nonet, G., Romieu-Mourez, R., Lau, A.W., Hafer, L.J., Yaswen, P., Stampfer, M., Rogers, A.E., Russo, J., and Sonenshein, G.E. Activation of NF-ƒÈB/Rel occurs early during neoplastic transformation of mammary cells. Carcinogenesis 21: 871-879, 2000.

Stampfer, M.R, Yaswen, P. Culture models of human mammary epithelial cell transformation, J. Mam. Gland Bio. Neo. 5: 27-40, 2000.

Nonet, G.H., Stampfer, M.R., Chin, K., Gray, J.W., Collins, C.C., and Yaswen, P. The ZNF217 Gene amplified in breast cancers promotes immortalization of human mammary epithelial cells. Cancer Res. 61: 1250-1254, 2001.

Stampfer, M.R., Garbe, J., Levine, G., Lichtsteiner, S., Vasserot, A.P., and Yaswen, P. hTERT expression can induce resistance to TGFé growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc. Nat. Acad. Sci. (USA), 98: 4498-4503, 2001.

Yaswen, P. and Stampfer, M. Epigenetic changes accompanying human mammary epithelial cell immortalization. J. Mam. Gland Bio. Neo. 6: 223-234, 2001.

Stampfer, M.R. and Yaswen, P. Immortal transformation and telomerase reactivation of human mammary epithelial cells in culture, in: Advances in Cell Aging and Gerontology: Telomerase, Aging and Disease (M. Mattson and T. Pandita, eds.) Elsevier, Amsterdam, 103-130, 2001.

Kaminker, P.G., Kim, S-H., Taylor, R.D., Zebarjadian, Y., Funk, W.D., Morin, G.B., Yaswen, P., and Campisi, J. TANK2, a new TRF1-associated PARP, causes rapid induction of cell death upon overexpression. J. Biol. Chem., 276: 35891-35899, 2001.

Yaswen, P. and Stampfer, M.R. Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells. Int. J. Biochem. Cell Biol., 34 1382-1394, 2002.

Olsen, C.L., Gardie, B., Yaswen, P., and Stampfer, M.R. Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 21: 6328 - 6339, 2002.

Stampfer, M.R. and Yaswen, P. Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett. 194, 199-208, 2003.

Stampfer, M.R., Garbe, J., Nijjar, T., Wigington, D., Swisshelm, K., and Yaswen, P. Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines. Oncogene, 22: 5238-5251, 2003.

Beauséjour, C.M., Krtolica, A., Galimi, F., Narita, M., Lowe, S.W., Yaswen, P. and Campisi, J. Reversibility of human cellular senescence: Roles of the p53 and p16 pathways. EMBO J. 22: 4212-4222, 2003.

Chin, K., Ortiz de Solorzano, C., Knowles, D., Jones, A., Chou, W., Garcia Rodriguez, E., Kuo, W-L. Ljung, B-M., Chew, K., Garbe, J., Myambo, K., Krig, S., Stampfer, M., Yaswen, P., Gray, J.W., and Lockett, S.J. In situ analyses of genome instability in breast cancer. Nature Gen. 36: 984-988, 2004.

Rodier, F., Kim, S-H., Nijjar, T., Yaswen, P., and Campisi, J. Cancer and aging: The importance of telomeres in genome maintenance. Int. J. Biochem. Cell Biol.: 37: 977-990, 2005.

Nijjar, T., Bassett, E., Garbe, J., Takenaka,Y., Stampfer, M.R., Gilley, D., Yaswen, P. Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells. Oncogene 24:3369-3376, 2005.

Huang, G., Krig, S., Kowbel, D., Xu, H., Hyun, B., Volik, S., Feuerstein, B., Mills, G.B., Stokoe, D., Yaswen, P., and Collins, C. ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. Hum Mol Genet. 14:3219-25, 2005.

Fournier, M., Martin, K.J., Xhaja, K., Bosch, I., Yaswen, P., and Bissell, M.J., Gene expression signature in organized and growth arrested mammary acini predicts good outcome in breast cancer. Cancer Res. In press, 2006.

5/22/06