yen@itsa.ucsf.edu
(415) 476-5334 (voice)
(415) 750-6947 (fax)

VAMC Pathology 113B, 4150 Clement St., San Francisco, CA 94121

additional websites:

Yen Lab Website

Stanford University, BS, 1973, Chemistry
Duke University, MD, 1982, Medicine
Duke University, PhD, 1982, Biochemistry
University of California San Francisco, Residency, 1982-85, Pathology

Zheng YW, Yen TSB: Negative regulation of hepatitis B virus gene expression and replication by oxidative stress. J Biol Chem, 269:8857-8862, 1994.

Huang ZM, Yen TSB: Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm. J Virol, 68:3193-3199, 1994.

Chu P, Van, SL, Yen TSB, Berger TG: Minocycline hyperpigmentation localized to the lips: An unusual fixed drug reaction? J Am Acad Dermatol, 30:802-803, 1994.

Teitz T, Yen TSB, Chang JC, Kan YW: SV40 T antigen directed by a powerful erythroid enhancer-promoter produced sarcoma and pancreatic tumors but not erythroid specific tumors in transgenic mice. DNA Cell Biol, 13:705-710, 1994.

Teitz T, Yen TSB, Kan YW: Amplification of a SV40 T antigen transgene is associated with sarcomagenesis in mice. Carcinogenesis, 15:2049-2051, 1994.

Zheng YW, Riegler J, Wu J, Yen TSB: Novel short transcripts of the hepatitis B virus X gene derived from an intragenic promoter. J Biol Chem, 269:22593-22598, 1994.

Lu CC, Chen M, Ou JH, Yen TSB: Key role of a CCAAT element in regulating hepatitis B virus surface protein expression. Virology, 206:1155-1158, 1995.

Teitz T, Chang JC, Kan YW, Yen TSB: Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid-specific enhancer. J Pathol, 177:309-315, 1995.

Liegler TJ, Hyun W, Yen TSB, Stites DP: Detection and quantification of live, apoptotic and necrotic human peripheral lymphocytes using single laser flow cytometry. Clin Diagn Lab Immunol, 2:369-376, 1995.

Huang ZM, Yen TSB: Role of hepatitis B virus post-transcriptional regulatory element in export of intronless transcripts. Mol Cell Biol, 15:3864-3869, 1995.

Greeer CE, Wheeler CM, Ladner MB, Beutner K, Coyne MY, Liang H, Langenberg A, Yen TSB, Ralston R: Human papillomavirus (HPV) type distribution and serological response to HPV type 6 virus-like particles in patients with genital warts. J Clin Microbiol, 33:2058-2063, 1995.

Lipschutz JH, Miller T, Yen TSB, Vartanian RK, Graber ML, Damon L: Unreliability of the abdominal fat pad biopsy in the evaluation of nephrosis: report of 3 consecutive cases. Am J Nephrol, 15:431-435, 1995.

Xu Z, Yen TSB: Intracellular retention of surface protein by hepatitis B virus mutant that releases virion particles. J Virol, 70:133-140, 1996.

Huang ZM, Zang WQ, Yen TSB: Cellular proteins that bind to the hepatitis B virus posttranscriptional regulatory element [published correction appears in Virology, 240:382]. Virology, 217:573-581, 1996.

Buckwold VE, Xu Z, Chen M, Yen TSB, Ou JH: The effects of a naturally occuring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol, 70:5845-5851, 1996.

Lu CC, Yen TSB: Activation of the hepatitis B virus S promoter by transcription factor NF-Y via a CCAAT element. Virology, 225:387-394, 1996.

Fleiszig SM, Wiener-Kronish JP, Miyazaki H, Vallas V, Mostov KE, Kanada D, Sawa T, Yen TSB, Frank DW: Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S. Infect Immun, 65:579-586, 1997.

Mathur VS, Olson JL, Darragh TM, Yen TSB: Polyomavirus-induced interstitial nephritis in two renal transplant recipients: Case reports and review of the literature. Am J Kid Dis, 29:754-758, 1997.

Xu Z, Bruss V, Yen TSB: Formation of intracellular particles by hepatitis B virus large surface protein. J Virol, 71:5487-5494, 1997.

Buckwold VE, Xu Z, Yen TSB, Ou JH: Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication. J Gen Virol, 78:2055-2065, 1997.

Bretan PN, Lobo E, Chang JA, Dumitrescu O, Miller B, Yen TSB: Assessment of preservation induced reperfusion injury via intraoperative renal transplant blood flow and endothelin concentration studies. J Urol, 158: 714-718, 1997.

Xu Z, Jensen G, Yen TSB: Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol, 71:7387-7392, 1997.

Liberman E, Yen TSB: Foamy macrophages in AIDS cholangiopathy with Encephalitozoon intestinalis. Report of a case. Arch Pathol Lab Med, 121:985-988, 1997.

Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D: Parathyroid Ca2+-conducting currents are modulated by muscarinic receptor agonists and antagonists. Am J Physiol, 273:E880-E890, 1997.

Bretan PN, Chang J, Lobo E, Dumitrescu O, Miller B, Yen TSB: Experimental and clinical assessment of preservation-induced reperfusion injury comparing renal transplant blood flow and renal endothelin concentrations. Transplant Proc, 29:3520-3521, 1997.

Bernard CE, Magid AA, Yen TSB, Hoener BA: Mitigation of nitrofurantoin-induced toxicity in the perfused rat lung. Hum Exp Toxicol, 16:727-732, 1997.

Chan JY, Hua RH, Kwong M, Chang J, Yen TSB, Kan YW: Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J, 17: 1779-1787, 1998.

El-Sakka AI, Hassan MU, Nunes L, Bhatnagar RS, Yen TSB, Lue TF: Histological and ultrastructural alterations in an animal model of Peyronie's disease. Brit J Urol, 81:445-450, 1998.

El-Sakka AI, Selph CA, Yen TSB, Dahiya R, Lue TF: The effect of surgical trauma on rat tunica albuginea. J Urol, 159:1700-1707, 1998.

Zang WQ, Fieno AM, Grant RA, Yen TSB: Identification of glyceraldehyde-3-phosphate dehydrogenase as a cellular protein that binds to the hepatitis B virus posttranscriptional regulatory element. Virology, 248:46-52, 1998.

Ul-Hasan M, El-Sakka AI, Lee C, Yen TSB, Dahiya R, Lue TF: Expression of TGF-b-1 mRNA and ultrastructural alterations in pharmacologically induced prolonged penile erection in a canine model. J Urol, 160:2263-2266, 1998.

Liberman E, Fong YL, Selby MJ, Choo QL, Cousens L, Houghton M, Yen TSB: Activation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein. J Virol, 73:3718-3722, 1999.

El-Sakka AI, Bakircioglu ME, Bhatnagar RS, Yen TSB, Dahiya R, Lue TF: The effects of colchicine on a Peyronie's-like condition in an animal model. J Urol, 161:1980-1983, 1999.

Zang WQ, Yen TSB: Distinct export pathway utilized by the hepatitis B virus posttranscriptional regulatory element. Virology, 259:299-304, 1999.

Bastian BC, Kutzner, H. Yen, TSB, LeBoit PE: Signet-ring cell formation in cutaneous neoplasms. J Am Acad Dermatol, 41:606-613, 1999.

Toro JR, Chu P, Yen TSB, LeBoit PE: Granuloma annulare and human immunodeficiency viral infection. Arch Dermatol, 135:1341-6, 1999.

Foo NC, Yen TSB: Activation of promoters for cellular lipogenic genes by hepatitis B virus large surface protein. Virology, 269:420-425, 2000.

Yu CCK, Yen TSB, Lowell CA, DeFranco AL: Lupus-like kidney disease in mice deficient in the Src-family tyrosine kinases Lyn and Fyn. Curr Biol, 11:34-38, 2001.

Xu Z, Choi J, Yen TSB, Lu W, Strohecker A, Govindarajan S, Chien D, Selby MJ, Ou JH: Synthesis of a novel hepatitis C virus protein by ribosomal frameshift. EMBO J, 20:3840-3848, 2001.

Zang WQ, Li B, Huang PY, Lai MMC, Yen TSB: Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element. J Virol, 75:10779-10786, 2001.

Nojima D, Li LC, Dharia A, Perinchery G, Ribeiro-Filho L, Yen TSB, Dahiya R: CpG hypermethylation of the promoter region inactivates the estrogen receptor-b gene in patients with prostate carcinoma. Cancer, 92:2076-2083, 2001.

El-Sakka A, Yen TSB, Lin CS, Lue TF: Traumatic arteriogenic erectile dysfunction: a rat model. Int J Impot Res. 13:162-171, 2001.

Xu Z, Yen TSB, Wu L, Madden CR, Tan W, Slagle BL, Ou JH: Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol, 76:2579-2584, 2002.

Li B, Yen TSB: Characterization of nuclear export signal of polypyrimidine tract binding protein. J Biol Chem, 277:10306-10314, 2002.

Bounamassa DT, Greer CE, Capo S, Yen TSB, Galeotti CL, Bensi G: Yeast coexpression of human papillomavirus types 6 and 16 capsid proteins. Virology, 293: 335-344, 2002.

Foo NC, Ahn BY, Ma X, Hyun W, Yen TSB: Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein. Hepatology, 36:1400-1407, 2002.

Sung VMH, Shimodaira S, Doughty AL, Picchio GR, Can H, Yen TSB, Lindsay KL, Levine AM, Lai MMC: Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection. J Virol, 77:2134-2146, 2003.

Lin X, Irwin D, Kanazawa S, Huang L, Romeo J, Yen TSB, Peterlin BM: Transcriptional phenotypes of latent HIV in infected individuals: Effects of Tat on the reservoir. J Virol, 77: 8227-8236, 2003.

Cunnane G, Chan OT, Cassafer G, Brindis S, Kauman E, Yen TSB, Daikh DI: Prevention of renal damage in murine lupus nephritis by CTLA4Ig and cyclophosphamide. Arthritis Rheum, 50: 1539-48, 2004.

Schwer B, Ren S, Kartenback J, Kaehlcke K, Pietschmann T, Bartenschlager R, Yen TSB, Ott M: Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol, 78:7958-7968, 2004.

Review Articles, Book Chapters, and Letters to Editors

Yen TSB: Advances and applications of molecular biology techniques in hepatitis B and C. In Diagnostic Problems in Liver Pathology (ed, LD Ferrell), pp 41-56. Hanley & Belfus, Philadelphia, 1994.

Yen TSB: Hepadnaviral X protein: review of recent progress. J Biomed Sci, 3:20-30, 1996.

Ill CR, Gonzales JN, Bidlingmaier SM, Chiou HC, Bartholomew RM, Yen, TSB: The posttranscriptional regulatory element of HBV: An antisense target for HBV inhibition and an element for potentiating factor VIII mRNA nucleocytoplasmic transport. In Viral Hepatitis and Liver Disease (ed, M Rizzetto, R Purcell, J Gerin, G Verme), pp 87-93. Edizione Minerva Medica, Turin, Italy, 1997.

Yen TSB: Posttranscriptional regulation of gene expression in hepadnaviruses. Semin Virol, 8:319-326, 1998.

Yen TSB: Colony-forming units. ASM News, 9:483, 1998.

Yen TSB: Correspondence regarding desmoplastic small round-cell tumor of the paratesticular region. Mod Pathol, 13:836, 2000.

Vyas GN, Yen TSB: Hepatitis B virus: Biology, pathogenesis, epidemiology, clinical description, and diagnosis. In Viral Hepatitis: Diagnosis, Therapy, and Prevention (ed, S. Specter), pp. 35-63. Humana Press Inc., Totowa, NJ, 2000.

Yen TSB: Regulation of lipid biosynthesis by inducers of ER stress. J Clin Invest, electronic edition, http://www.jci.org/cgi/eletters/107/10/1263, 2001.

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