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LIANG YOU, MD, PHD

Assistant Adjunct Professor, Surgery, UCSF

CONTACT

lyou@cc.ucsf.edu
(415) 514-0592 (voice)
(415) 502-6799 (fax)

Box 0128, UCSF; San Francisco, CA 94143-0128

additional websites:

Thoracic Oncology Lab
Dept. of Surgery

EDUCATION
Jinzhou Medical College, Jinzhou, PRC, M.D., 1987, Medicine Medical College of Ohio, Toledo, OH, Ph.D., 1994, Pathology
PROFESSIONAL EXPERIENCE
1987-1988	Resident in Medicine, Dalian Seaside Hospital, Dalian, PRC
1994-1996	Intramural Research Training Award Fellow, Biomarker and Prevention Research Branch, National Cancer Institute, NIH, Bethesda, MD
1997-1997	Visiting Postdoctral Fellow, Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA
1997-2002	Postdoc Fellow/Staff Research Associate, Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco
2002-present	Assistant Adjunct Professor, Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco
HONORS & AWARDS
1994-1996	Intramural Research Training Award, Biomarker and Prevention Research Branch, National Cancer Institute, NIH, Bethesda, MD
SELECTED PUBLICATIONS
From a total of 51
You L, Yang CT, Jablons DM. , ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients. Cancer Res. 2000 Feb 15;60(4):1009 13.
Yang CT, You L, Yeh, CC, Chang JWC, Chang F, McCormick F, and Jablons DM. Adenovirus-mediated p14-ARF gene transfer in human mesothelioma cells. J. Natl. Cancer Inst., 92:636-641, 2000.
Casibang M, Purdom S, Jakowlew S, Neckers L, Zia F, Ben-Av P, Hia T, You L, Jablons DM, Moody TM. Postaglandin E2 increase vascular endothelial cell growth factor mRNAs in lung cancer cells. Lung Cancer, March 2001, 31(2-3):203-212.
Choy O, Jahan T, Roach M, You L, and Jablons DM. Stage II (N1) lung cancer. Chest Surgery Clinics of North America (Ginsberg D.J. and Ruckdeschel J.C. ed) W.B. Sunders Company, 2001. 11(1):39-59, viii.
Strickler HD, Goedert JJ, Jablons DM,, You L, Harris CC, Sugarbaker DJ, et al. Reproducibility of Simian Virus (SV40) DNA in Human Tissue-finding from the International SV40 Working Group. Cancer Epidemiology, Biomarkers and Prevention, Vol. 10, 523-32, May 2001.
Yang C, You L, Uematsu K, Yeh C, McCormick F, Jablons DM. P14ARF Modulates the Cytolytic Effect of ONYX-015 in Mesothelioma Cells with Wild-type p53. Cancer Research, August 2001, 61:5959-5963.
Moody TW, Leyton J, Zakowicz H, Hida T, Kang Y, Jakowlew S, You L, Ozbun L, Zia H, Youngberg J, Malkinson A. Indomethacin reduces lung adenoma number in A/J mice. Anticancer Res. 2001 May-Jun;21(3B):1749-55.
Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB. Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. Genomics. 2001 Apr 15;73(2):179-93.
Xia C, Xu Z, Yuan X, Uematsu K, You L, McCormick F, Li K, Li L, Jablons DM Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides. Mol Cancer Ther. 2002 Jul;1(9):687-94.
Yang CT, You L, Lin Y, Lin YC, McCormick F, Jablons DM. A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14 ARF and P16INK4A) in human mesothelioma cells. Anticancer Research, 2003 Jan-Feb;23(1A):33-8.
Jensen RH, Tiirikainen M, You L, Ginzinger D, He B, Uematsu K, Xu Z, Treseler P, McCormick F, Jablons DM. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q. Anticancer Res. 2003 May-Jun;23(3B):2281-9.
He B, You L, Uematsu K, Matsangou M, Xu Z, He M, McCormick F and Jablons DM. Cloning and characterization of a functional promoter of the human SOCS-3 gene, Biochem. Biophys. Res. Comm., 2003, 301: 386-391.
Uematsu K, Kanazawa S, You L, He B, Xu Z, Peterlin M, McCormick F and Jablons DM. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Research, 2003, 63 (15): 4547-4551.
Uematsu K, He B, You L, Xu Z, McCormick F and Jablons DM. Activation of the Wnt pathway in non small-cell lung cancer: evidence of dishevelled overexpression, Oncogene, 2003, 22(46): 7218-7221.
He B, You L, Uematsu K, Zang K, Xu Z, Lee, AY, Costello JF, McCormick F and Jablons DM. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14133-8.
You L, He B, Xu Z, McCormick F and Jablons DM. Future directions: oncolytic viruses. Clinical Lung Cancer, 2004, 5 (4): 226-230.
He B, You L, Uematsu K, Zang K, Xu Z, Matsangou M, McCormick F and Jablons DM. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells, Neoplasia, 2004, 6: 7-14.
Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, and Jablons DM. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma, Oncogene. 2004 Aug 26;23(39):6672-6.
You L, He B, Uematsu K, Xu Z, McCormick F, and Jablons DM. Inhibition of Wnt-1 signaling induces apoptosis in beta-Catenin-deficient mesothelioma cells, Cancer Research, 2004, 64: 3474-3478.
He B, You L, Xu Z, Mazieres J, Lee AY and Jablons DM. Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer, Clinical Lung Cancer, 2004, 5(6): 366-370.
Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F and Jablons DM. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer, Cancer Research 2004, 64: 4717-4720.
You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh JK, Kashani-Sabet M, McCormick F and Jablons DM. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth, Cancer Research 2004, 64: 5385-5389.
You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, and Jablons DM. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene 2004, 23(36): 6170-6174.
Beseth B, Cameron R, Leland P, You L, Varricchio F, Kreitman J, Maki R, Jablons DM, Husain S, Puri R. Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts. Ann Thorac Surg. 2004 Aug;78(2):436-43.
Reguart N, He B, Xu Z, You L, Lee AY, Mazieres J, Mikami I, Batra S, Rosell R, McCormick F and Jablons DM. Cloning and characterization of the promoter of human Wnt inhibitory factor-1. Biochem Biophys Res Commun. 2004 Oct 8;323(1):229-34.
Lee AY, He B, You L, Xu Z, Mazieres J, Uematsu K, Reguart N, McCormick F and Jablons DM. Dickkopf 1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma. Biochem Biophys Res Commun. 2004 Oct 29;323(4):1246-50.
He B, Lee AY, Dadfarmay S, You L, Xu Z, Mazieres J, Uematsu K, Reguart N, Mikami I, McCormick F, and Jablons DM. SFRP4 is silenced by hypermethylation and induces apoptosis in -Catenin-deficient human mesothelioma cells, Cancer Research, 2005, 65 (3): 743-748.
Mazieres J, He B, You L, Xu Z and Jablons DM. Wnt signaling in lung cancer, Cancer Letters, 2005, 222: 1-10.
He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, McCormick F, and Jablons DM. Blockade of Wnt-1 Signaling Induces Apoptosis in Human Colorectal Cancer Cells Containing Downstream Mutations. Oncogene, 2005, 24 (18): 3054-3058.
Mazieres J, You L, He B, Xu Z, Twogood S, Lee AY, Reguart N, Batra S, Mikami I and Jablons DM. Wnt-2 as a new therapeutic target in malignant pleural mesothelioma, International Journal of Cancer, 2005, 117 (2): 326-332.
Mikami I, You L, He B, Xu Z, Batra S, Lee AY, Mazieres J, Reguart N, Uematsu Koizumi K and Jablons DM. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells, BMC Cancer, 2005, May 24; 5(1): 53.
Mazieres J, You L, He B, Xu Z, Lee AY, Mikami I, McCormick F, and Jablons DM. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis, Oncogene 2005, 24 (34): 5396-5400.
He B, Barg RN, You L, Xu Z, Reguart N, Mikami I, Batra S, Rosell R, and Jablons DM. Wnt signaling in stem cells and non small cell lung cancer. Clinical Lung Cancer, 2005, 7 (1): 54-60.
Reguart N, He B, Taron M, You L, Jablons DM and Rosell R. The role of Wnt signaling in cancer and stem cells, Future Oncology 2005, 1 (6): 787-797.
Lin Y, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecher K, Kim J, Raz D, Yang C, Chen J, and Jablons DM. Activation of Wnt signaling and WIF-1 silencing due to promoter hypermethylation in nasopharyngeal cancer cell lines. Biochem. Biophys. Res. Comm. 2006, 314: 635-640.
Batra S, Shi Y, He B, Kuchenbecher K, Mikami I, You L, Xu Z, Reguart N, and Jablons DM. Wnt Inhibitory Factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem. Biophys. Res. Comm. 2006 342(4):1228-32.
You L, Kim J, He B, Xu Z, McCormick F, Jablons DM. Wnt-1 signal as a potential cancer therapeutic target. Drugs News & Perspectives. 2006 19(1):27-31.
8/21/06

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