jack.youngren@ucsf.edu
(415) 885-7725 (voice)
(415) 885-3787 (fax)

Box 1616, UCSF; San Francisco, CA 94143-1616

University of California, Los Angeles, B.S., March 1986, Kinesiology
University of California, Los Angeles, M.S., June 1990, Kinesiology
University of California, Los Angeles, Ph.D., Dec. 1993, Physiological Science
University of California, San Francisco, Postdoctoral, Oct. 1993-Oct. 1997, Diabetes/Endocrine Research

Youngren JF and RJ Barnard. Effects of Acute and Chronic Exercise on Skeletal Muscle Glucose Transport in Aged Rats. J. Appl. Physiol. 78(5):1750-56, 1995.

Maddux BA, P Sbraccia, S Kumakura, S Sasson, JF Youngren, A Fisher, S Spencer, A Grupe, W Henzel, TA Stewart, GM Reaven, and ID Goldfine. Membrane Glycoprotein PC-1 and Insulin Resistance in Non-Insulin-Dependent Diabetes. Nature 373:448-451, 1995.

Youngren JF, BA Maddux, S Sasson, P Sbraccia, EB Tapscott, MS Swanson, GL Dohm, and ID Goldfine. Skeletal Muscle Content of Membrane Glycoprotein PC-1 in Obesity: Relationship to Muscle Glucose Transport. Diabetes 45:1324-1328, 1996.

Ůzel, B, JF Youngren, JK Kim, ID Goldfine, CK Sung, and JH Youn. The Development Of Insulin Resistance With High Fat Feeding In Rats Does Not Involve Either Decreased Insulin Receptor Tyrosine Kinase Activity Or Membrane Glycoprotein PC-1. Biochem. and Mol. Med. 59:174-181, 1996.

Youngren JF, ID Goldfine, and RE Pratley. Decreased Insulin-Mediated Glucose Disposal is Related to Defects of Skeletal Muscle Insulin Receptor Tyrosine Kinase Activation in Pima Indians With Normal Fasting Glucose Levels. Am. J. Physiol. 273:E276-E283, 1997.

Barnard, RJ, JF Youngren, and SH Scheck. Reversibility of Diet-Induced Skeletal Muscle Insulin Resistance. Diabetes Res. 32:213-221, 1997.

Youngren, JF, ID Goldfine and RE Pratley. Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians. Am. J. Physiol. 276: E990-E994, 1999.

Shao, J, PM Catalano, H Yamashita, I Ruyter, S Smith, JF Youngren, and JE Friedman. Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM. Diabetes 49:603-610 2000.

Youngren, JF, S Keen, JL Kulp, CL Tanner, JA Houmard, and ID Goldfine. Improvements in muscle insulin receptor autophosphorylation with exercise training. Am. J. Physiol. 280:E528-E533, 2001.

Youngren, JF, J Paik and RJ Barnard. Long term fat feeding induces alterations in the muscle insulin receptor signaling pathway. J. Appl. Physiol, 91: 2240-2247, 2001.

Li, M, JF Youngren, VP Manchem, M Kozlowski, BB Zhang, BA Maddux, ID Goldfine. Small molecule insulin receptor activators potentiate insulin action in insulin resistant cells. Diabetes 50:2323-2328, 2001.

Pender, C, H Ortmeyer, B Hansen, ID Goldfine, JF Youngren. Elevated PC-1 levels and diminished insulin receptor autophosphorylation levels in obese, insulin resistant rhesus monkeys. Metab 51:465-70, 2002.

Stefan, N, B Vozarova, T Funahashi, Y Matsuzawa, C Weyer, RS Lindsay, JF Youngren, PJ Havel, RE Pratley, C Bogardus, and PA Tataranni. Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans. Diabetes 51:1884-1888, 2002.

Li, M, JF Youngren, ID Goldfine, BA Maddux, A Dunaif, BB Zhang, JL Evans Decreased Insulin Receptor Autophosphorylation in Fibroblasts from Patients with PCOS: Effects of Serine Kinase Inhibitors and Insulin Receptor Activators. J. Clin. Endo.Metab. 87:4088-4093, 2002.

Pender C, V Manchem, J Evans, W Spevak, S Shi, S Rao, S Bajjalieh, B Maddux, I Goldfine, JF Youngren. Regulation of Insulin Receptor Function by a Small Molecule Insulin Receptor Activator. J Biol Chem. 277:43565-571, 2003.

Youngren JF, C Tanner, C Pender, K MacDonald, W Pories, P Havel, J Houmard, ID Goldfine. Weight Loss in Morbidly Obese Subjects Increases Muscle Insulin Receptor Content. Int J Obesity Jan 13, 2004.

Evans, J, JF Youngren, ID Goldfine. Effective Treatments for Insulin Resistance: Trim the Fat and Douse the Fire. Trends in Endocrinology and Metabolism. 15(9):425-31, 2004.

Dong H, BA Maddux, J Altomonte, M Meseck, D Accili, R Terkeltaub, K Johnson, JF Youngren, ID Goldfine. Increased Hepatic Levels of the Insulin Receptor Inhibitor, PC-1/NPP1, Induce Glucose Intolerance. Diab, 54, 367-72, 2005.

Pender C, ID Goldfine, JL Kulp, CL Tanner, BA Maddux, K MacDonald, JA Houmard, JF Youngren. Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects. Metabolism. 2005 May;54(5):598-603.

Youngren JF, K Gable, C Peñaranda, BA Maddux, M Zavodovskaya, M Lobo, MJ Campbell, J Kerner, ID Goldfine. NDGA Inhibits the IGF-1 and c-erbB2/HER2/new Receptors and Suppresses Growth in Breast Cancer Cells. Breast Cancer Research & Treatment. 2005 Nov; 94 (1):37-46.

Maddux BA, YN Chang, D Accili, O McGuinness, JF Youngren, ID Goldfine. Overexpression of the Insulin Receptor Inhibitor, PC-1/NPP1, Induces Insulin Resistance and Hyperglycemia. Am J Physiol Endocrinol Metab. 290(4):E746-9, 2006.

Gable K, BA Maddux, C Peñaranda, M Zavodovskaya, MJ Campbell, M Lobo, L Robinson, S Schow, J Kerner, Goldfine ID, Youngren JF. Diarylureas are Small Molecule Inhibitors of IGF-1 Receptor Signaling and Breast Cancer Cell Growth. Molecular Cancer Therapeutics. 5(4):1079-86, 2006.

Anderson MO, Yu H, Peñaranda C, Maddux B, ID Goldfine, JF Youngren, RK Guy. Parallel Synthesis of Diarylureas and Their Evaluation as Inhibitors of Insulin-Like Growth Factor Receptor. J Comb Chem Sep-Oct;8(5):784-90, 2006.

Pender C, AR Trentadue, WJ Pories, GL Dohm, JA Houmard, JF Youngren. Expression of Genes Regulating Malonyl-CoA in Human Skeletal Muscle. J Cellular Biochem. 99:860-867, 2006.

Youngren, JF. Regulation of Insulin Receptor Function. Cell Mol Life Sci. 64:873-91, 2007.

Blecha JE, MO Anderson, JM Chow, CC Guevarra, C Pender, C Penaranda, M Zavodovskaya, JF Youngren, CE Berkman. Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs. Bioorg Med Chem Lett. 2007 Apr 29; [Epub ahead of print]

Meyer GE, L Chesler, D Liu, K Gable, BA Maddux, DD Goldenberg, JF Youngren, ID Goldfine, WA Weiss, KK Matthay, SM Rosenthal. Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. J Cell Biochem. 2007 May 7; [Epub ahead of print]

Zavodovskaya M, MJ Campbell, BA Maddux, L Shiry, G Allan, L Hodges, P Kushner, JA Kerner, JF Youngren, ID Goldfine. Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells. J Cell Biochem. 2007 Jun 11. [Epub ahead of print]

6/21/07