Jack F. Youngren, PhD

University of California, Los Angeles, B.S., March 1986, Kinesiology
University of California, Los Angeles, M.S., June 1990, Kinesiology
University of California, Los Angeles, Ph.D., Dec. 1993, Physiological Science
University of California, San Francisco, Postdoctoral, Oct. 1993-Oct. 1997, Diabetes/Endocrine Research

• 1987-1991
  Teaching Associate, Dept. of Kinesiology, UCLA
• 1987-1993
  Graduate Student Rsch Associate, Dept. of Kinesiology/Dept. of Physiological Science, UCLA
• 1991-1993
  Teaching Fellow, Dept. of Physiological Science, UCLA
• 1993-1997
  Postdoctoral Fellow, Division of Diabetes & Endocrine Research, Dept. of Medicine, UCSF
• 1997-2003
  Assistant Research Biochemist. Department of Medicine, UCSF
• 2003-2008
  Associate Research Biochemist. Department of Medicine, UCSF
• 2008-present
  Associate Adjunct Professor. Department of Medicine, UCSF

• 1989-1993
  UCLA Departmental Graduate Fellowship
• 1993-1995
  NIH Gerontology & Geriatric Medicine Fellowship
• 1995-1996
  UCSF Endocrine Training Fellowship
• 1995
  Young Investigator Award, American Diabetes Association, Northern California Affiliate

• Maddux BA, P Sbraccia, S Kumakura, S Sasson, JF Youngren, A Fisher, S Spencer, A Grupe, W Henzel, TA Stewart, GM Reaven, and ID Goldfine. Membrane Glycoprotein PC-1 and Insulin Resistance in Non-Insulin-Dependent Diabetes. Nature 373:448-451, 1995.
• Pender C, V Manchem, J Evans, W Spevak, S Shi, S Rao, S Bajjalieh, B Maddux, I Goldfine, JF Youngren. Regulation of Insulin Receptor Function by a Small Molecule Insulin Receptor Activator. J Biol Chem. 277:43565-571, 2003.
• Youngren JF, Gable K, Peñaranda C, Maddux B, Zavodovskaya M, Lobo M, Campbell M, Kerner J, Goldfine I. NDGA Inhibits the IGF-1 and c-erbB2/HER2/new Receptors and Suppresses Growth in Breast Cancer Cells. Breast Cancer Research & Treatment. 2005 Nov; 94 (1):37-46.
• Gable K, Maddux B, Peñaranda C, Zavodovskaya M, Campbell M, Lobo M, Robinson L, Schow S, Kerner J, Goldfine ID, Youngren JF. Diarylureas are Small Molecule Inhibitors of IGF-1 Receptor Signaling and Breast Cancer Cell Growth. Molecular Cancer Therapeutics. 5(4). April 2006.
• Anderson MO, Yu H, Peñaranda C, Maddux B, Goldfine I, Youngren JF, Guy RK. Parallel Synthesis of Diarylureas and Their Evaluation as Inhibitors of Insulin-Like Growth Factor Receptor. J Comb Chem Sep-Oct;8(5):784-90, 2006.
• Pender C, Trentadue AR, Pories WJ, Dohm GL, Houmard JA, Youngren JF. Expression of Genes Regulating Malonyl-CoA in Human Skeletal Muscle. J Cellular Biochem. 99:860-867, 2006.
• Youngren, JF. Regulation of Insulin Receptor Function. Cell Mol Life Sci. 64:873-91, 2007.
• Blecha JE, MO Anderson, JM Chow, CC Guevarra, C Pender, C Penaranda, M Zavodovskaya, JF Youngren, CE Berkman. Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs. Bioorg Med Chem Lett. 17(14):4026-9, 2007.
• Zavodovskaya M, MJ Campbell, BA Maddux, L Shiry, G Allan, L Hodges, P Kushner, JA Kerner, JF Youngren, ID Goldfine. Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells. J Cell Biochem. 103(2):624-35, 2008.
• Ryan CJ, AH Harzstark, J Rosenberg, A Lin, CC Claros, ID Goldfine, JF Kerner, EJ Small, JF Youngren. A pilot dose escalation study of the effects of nordihydroguaiaretic acid on hormone and prostate-specific antigen levels in patients with relapsed prostate cancer. BJU Int. 101(4):436-9, 2008.
• Ryan CJ, Zavodovskaya M, Youngren JF, Campbell M, Diamond M, Jones J, Shiry L, Allan G, Maddux BA, ID Goldfine. Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells. Prostate 68(11):1232-40, 2008.
• Li F, Pham JD, Anderson MO, Youngren JF. Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling. Eur J Pharmacol. 616(1-3):31-7, 2009.
• Masharani U, Goldfine ID, Youngren JF. Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects. Metabolism. 58(11):1602-8, 2009.
• Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID. Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome. J Diabetes Sci Technol. 4(2):359-64. 2010.
• Engen, W, O’Brien, TE, Kelly B, Do J, Rillera L, Stapleton LK, Youngren JF, Anderson MO. Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R). Bioorg Med Chem. 18(16):5995-6005, 2010.