UC Discovery Grant

Noonan Syndrome


Costello Kids

Neurofibromatosis, Inc. California

Childrens Tumor Foundation


Novo Nordisk


Gene Dx




Genetic Syndromes of the Ras/MAPK Pathway:
From Bedside to Bench and Back

Date: August 1-2, 2009
Location: Berkeley Marina, CA
Doubletree Hotel

>> Saturday, August 1, 2009
>> Sunday, August 2, 2009
Saturday, August 1, 2009
7:00-8:00 am Registration and Breakfast
8:00-8:05 am Welcoming Comments and Introduction: Katherine Rauen and Lisa Schoyer
8:05-8:25 amKeynote Presentation #1: Advocates and Self-Advocates
The Road Less Traveled: Our Journey on the Ras/MAPK Pathway
8:30-9:00 am Keynote Presentation #2: Frank McCormick, PhD, FRS
New Perspectives on an Ancient Pathway
9:00-10:15 am Clinical Consequences of Molecular Alterations
     (10 mins. + 5 min. discussion)
Moderator: Angela Lin, MD
9:00-9:15 am Noonan SyndromeJudith E. Allanson, MD
9:15-9:30 amNeurofibromatosis 1 and Legius SyndromesDavid Stevenson, MD, PhD
9:30-9:45 amCostello SyndromeKaren W. Gripp, MD
9:45-10:00 amCardio-Facio-Cutaneous SyndromeGiovanni Neri, MD
10:00-10:15 amPhenotypic Overlap: The Blurred BoundariesJohn C. Carey, MD
10:15-10:30 am Break
10:30-12:10 pmBiochemical Properties and Function of Altered Proteins: Perturbation of the Pathway
     (15 mins. + 5 min. discussion)
Moderator: Eric Legius, MD
10:30-10:50 amNeurofibromin and SPRED1 Eric Legius, MD
10:50-11:10 amSHP2 Marco Tartaglia, PhD
11:10-11:30 amKRAS and HRAS Suzanne Schubbert, PhD
11:30-11:50 amSOS1 and CRAF Amy E. Roberts, MD
11:50-12:10 pmBRAF and MEK1/2Katherine Rauen, MD, PhD
12:10-1:15 pm Lunch Break
1:15-3:15 pmPre-Clinical Modeling of Ras/MAPK Pathway Syndromes
     (15 mins. + 5 min. discussion)
Moderator: Bruce D. Gelb, MD
1:15-1:35 pm Pre-Clinical Modeling Kevin Shannon, MD
1:35-1:55 pm Neurofibromatosis 1 Mouse ModelsDavid H. Gutmann, MD, PhD
1:55-2:15 pm Overview of Raf Mouse ModelsMartin McMahon, PhD
2:15-2:35 pm HRas G12V Mouse ModelMariano Barbacid, PhD
2:35-2:55 pm HRas G12V Mouse Model James Fagin, MD
2:55-3:15 pm K-Ras Mouse ModelBenjamin Yu, MD, PhD
3:15 - 3:30 pm Break
3:30-5:25 pmPre-Clinical Modeling (continued)

Application of New Technologies
     (20 mins. + 5 min. discussion)
Moderator: Yoko Aoki MD, PhD
3:30-3:50 pmNoonan Syndrome Mouse ModelsBen G. Neel, MD
3:50-4:10 pmNoonan/LEOPARD Syndrome ModelsBruce D. Gelb, MD

4:10-4:35 pmGenetic ArchitectureAllan Balmain, PhD, FRSE
4:35-5:00 pmProteomicsRichard Drake, PhD
5:00-5:25 pmPhospho-Signaling Garry P. Nolan, PhD
6:00-7:30 pmBanquet Dinner
(Free, open to all registered symposium attendees)
7:30-9:30 pmDessert and Poster Session
(Free, open to all symposium attendees and advocacy/family groups)

>> Sunday, August 2, 2009