University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Human Biospecimen Repository Services

To order work or inquire about new projects, please fill out this form.
 

Prospective and Retrospective Tissue Specimen Procurement Service

Quality assured, annotation-rich biospecimens collected with traceable informed consent. Whenever possible, blood is collected and processed to be paired with the tissue collection. 

Solid Tissue Rapid Freezing Methods:

  • Mirror-image, snap frozen tissue with FFPE for QC**: Tumor and matching normal is snap frozen in 100mg portions in cryovials. A mirror image portion is processed to FFPE and available for quality control. **Preferred method
  • A digital image of an H&E stained FFPE section will be available, if necessary, for diagnosis/quality assessment.
  • OCT embedded, snap frozen: Tumor and matching normal embedded in OCT and snap frozen. Tissue quality control is available by frozen section preparation.

Optimally Processed Formalin Fixed Paraffin Embedded Tissue:

  • Tissue fixed in formalin and optimally processed: Tissue fixed for prescribed duration and then processed at low temperature to facilitate downstream molecular applications.
  • Duration of fixation and processing conditions documented for quality control.
  • A digital image of the H&E/Biomarker stained FFPE section will be available, if necessary, for diagnosis/quality assessment and biomarker research.

Fresh/Viable Tissue Procurement:

  • Fresh tissue collected and placed in investigator prescribed culture media available for immediate distribution.
  • A mirror image section is always taken and processed to FFPE for quality control.
  • A digital image of the H&E/Biomarker stained FFPE section will be available, if necessary for diagnosis/quality assessment of the “founder tissue”.

Retrospective FFPE Block Retrieval

  • QA/QC FFPE blocks and research FFPE blocks
  • Retrieval of FFPE blocks from pathology archives in coordination with Pathology
  • FFPE block storage and management

Biofluid Processing

Blood Processing and Aliquoting: Whole blood, Plasma, Serum, Crude Buffy Coat

  • Whole blood
  • Plasma
  • Buffy Coat
  • Serum

Urine Processing and Aliquoting
 

Saliva Processing and Aliquoting