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Scientific Accomplishments

T.Nguyen R.Pasick
Program Leader: Robert A. Hiatt, MD, PhD
Program Co-Leader: Tung T. Nguyen, MD

Scientific Accomplishments

J.PalefskyIn November 2013, Cancer Control Program member Joel Palefsky received an eight-year grant for $89 million from the National Cancer Institute to conduct a multi-site study focusing on the effectiveness of treating anal high-grade squamous intraepithelial lesions (HSIL), which are caused by chronic HPV infection, in reducing the incidence of anal cancer in HIV-infected men and women.

K.Phillips In 2013, Cancer Control Program member Kathryn Phillips received a Transdisciplinary Translational Team (T3) Science Award from the HDFCC on Moving Analysis of Cancer Genomics Into the Clinic. Generating and applying genomic information that can be used for “precision medicine” is a major priority of the HDFCC, UCSF, NIH, and society as a whole.  Dr. Phillips’ team is developing a collaborative, transdisciplinary, translational proposal on factors influencing adoption of cancer genomic analysis, using UCSF as a case study. Her project is focusing on “next generation tumor sequencing” (NGTS), which is defined as targeting of multiple genes using gene panels, pan-cancer tests, exome and/or whole tumor sequencing.

In 2013, Dr. Phillips also received a 4 year study funded by NHGRI on Benefit-Risk Tradeoffs for Whole Genome Sequencing. New technologies are enabling the arrival of the much awaited “affordable genome”—the ability to sequence an individual’s or a tumor’s entire genome quickly and inexpensively [whole genome sequencing (WGS)]. WGS is now being offered in clinical care and is expected to become more widely used in the near future, particularly in cancer. However, this technological advance threatens to outpace our ability to use it effectively in clinical practice and to address the associated health policy issues. This project’s objective is to evaluate the potential benefit-risk tradeoffs of WGS from the perspectives of patients, providers, the health care delivery system, and society by using systematic and quantitative approaches. Dr. Phillips’ team is leveraging a unique opportunity to collaborate with and build upon the first randomized clinical trial of WGS using a general population sample (MedSeq Project), which is being led by Harvard Medical School.

 

M.Potter L.Green J.Walsh In 2013, the Flu-FOBT and Flu-FIT intervention studies to increase colorectal cancer screening in diverse populations led by Cancer Control Program members Michael Potter, Lawrence Green, and Judith Walsh were chosen for the National Cancer Institute's Research-tested Intervention Programs (RTIPs) website. This intervention program was also featured by the AHRQ Health Care Innovations Exchange in September 2013.

J.Tsoh In May 2013, Cancer Control Program members Tung Nguyen and Janice Tsoh received a $2.1 million grant from the Patient-Centered Outcomes Research Institute (PCORI) to conduct a randomized controlled trial testing the efficacy of a mobile application to increase screening for hepatitis B and C in Asian American patients receiving care at UCSF and SFGH.

N.Burke G.Joseph R.Pasick M.Potter L.Karliner In October 2012, Cancer Control Program members Tung Nguyen, Nancy Burke, Rena Pasick, Janice Tsoh, Galen Joseph, Leah Karliner, Michael Potter, and Celia Kaplan created the Asian American Research Center on Health (ARCH), which is supported in part by the UCSF Helen Diller Family Comprehensive Cancer Center.

M.Potter In 2012, Cancer Control Program member Tung Nguyen and colleagues across the U.S. published a study on the application of community-based participatory research across the National Cancer Institute’s Community Network Programs in the American Journal of Public Health.