Scientific Accomplishments

A.Balmain J.Witte
Program Leader: John Witte, PhD
Program Co-Leader: Allan Balmain, PhD

Scientific Accomplishments

Selected highlights from the Program members are:

  • M.WrenschJ.Wiencke Wrensch and Wiencke: Discovered risk loci for adult glioma from genome-wide association studies. They are in the process of determining the histologic, morphologic, and molecular subtype specificity of these risk loci as well as understanding their relationship to other glioma risk factors, such as immunologic status (Wrensch et al., Nat Genet, 2009).
     
  • UCSFLi: Using yeast as a model organism, Dr. Li’s group showed that re-replication of approximately 50% of the copies of a genomic segment causes 2% to 3% of cells to acquire a direct tandem amplification of that segment at the endogenous chromosomal locus (Green et al., Science, 2010).
     
  • M.WrenschCostello: With colleagues have uncovered a major, previously unknown role for intragenic methylation in regulation of alternative promoters (Maunakea et al., Nature, 2010).
     
  • UCSFBastian: This work discovered that mutations in the GNAQ gene are common in uveal melanomas, providing possible new routes to therapy for these lesions (Van Raamsdonk et al., Nature, 2009).
     
  • UCSFBalmain: The first analysis of the genetic architecture of normal skin identified several pathways associated with control of hair follicle stem cells, inflammation, and tumor susceptibility (Quigley et al., Nature, 2009).
     
  • UCSFWitte: With colleagues have detected novel genetic variants for prostate cancer in a genome-wide association study of African-Americans (Haiman et al., Nat Genet, 2011).