About Cancer, Immunity, and Microenvironment

Z.Werb L.Lanier
Program Leader: Lewis L. Lanier, PhD
Program Co-Leader: Zena Werb, PhD

The Cancer, Immunity, and the Microenvironment Program includes 27 members from 12 academic departments in the UCSF Schools of Medicine and Nursing. The overarching goals of the Program are to (1) explore the relationship between neoplastic cells and stromal cells (i.e., immune, vascular, and mesenchymal) in mouse models of cancer to gain insights into the ability of stromal cells in the tumor microenvironment to promote or deter tumorigenesis; (2) identify molecules and pathways in the tumor microenvironment that regulate anti-tumor activity; (3) study the relationship between viral infections and malignancy, particularly in immunodeficient patients with HIV infection, and to develop new approaches for the prevention and treatment of malignancy in this population; and (4) provide the basic scientific foundation and support for the application of new immune- or microenvironment-based therapeutics in cancer in conjunction with the organ-based HDFCCC Programs.

The Cancer, Immunity, and the Microenvironment Program conducts research under four themes:

  • Theme 1: Tumor - Stroma Interactions
  • Theme 2: Molecules and Pathways in the Tumor Microenvironment with Anti-tumor Activity
  • Theme 3: Viral Infections and Malignancy
  • Theme 4: Clinical Studies of Novel Immune- and Microenvironment-based Therapeutics

Cancers are composed of multiple cell types, including fibroblasts and epithelial cells; innate and adaptive immune cells; and cells forming blood and lymphatic vasculature; as well as specialized mesenchymal cell-types unique to each tissue microenvironment. While tissue homeostasis is maintained by collaborative interactions between these diverse cell types, cancer development is enhanced when genetically altered initiated cells harness these collaborative capabilities to favor their own survival and, in so doing, hijack or exploit normal physiological processes typically involved in maintaining tissue homeostasis.

The Cancer, Immunity, and the Microenvironment Program supports research revealing insights into the interactions between evolving neoplastic cells with activated non-neoplastic host cells, and with soluble or insoluble components of extracellular matrix, as well as studies based on these interactions that foster development of novel cellular or molecular-based strategies to combat cancer.