1.00-1.10PM

Introduction by Frank Mc Cormick (Director, UCSF Helen Diller Family Comprehensive Cancer Center)

1.10-3.10PM

Session 1: Stem Cells in Normal Development - Part I
Chair: Frank McCormick

• Judith Kimble (University of Wisconsin)
  Vilas Professor, Investigator HHMI
  "Control of germline stem cells in C. elegans"
• Yuh Nung Jan (University of California San Francisco)
  Professor of Physiology and Biochemistry and Investigator, HHMI
  "The roles of tumor suppressor genes in the formation of the nervous system"
• Arturo Alvarez-Buylla (University of California San Francisco)
  Professor, Heather and Melanie Muss Chair in Neurological Surgery
  "Adult Neural Progenitor Cells: Emerging Links to Cancer"
• Thomas A. Rando (Stanford University)
  Associate Professor, Department of Neurology and Neurological Sciences
  "Molecular control of muscle stem cell fate"

3.10-3.40PM

Coffee break

3.40-5.40PM

Session 2: Stem Cells in Normal Development - Part II
Chair: Emmanuelle Passegué

• Elaine Fuchs (Rockefeller University)
  Rebecca C. Lancefield Professor
  "Skin Stem Cells: Morphogenesis & Cancer"
• Stuart Orkin (Harvard Stem Cell Institute)
  David G. Nathan Professor, Harvard Medical School, Investigator, HHMI
  "Regulation of stem cells"
• Thomas Look (Dana Farber Cancer Institute, Boston)
  TBA
• Irving L. Weisman (Stanford University)
  Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Director, Stanford Comprehensive Cancer Center, Director, Stanford Ludwig Center for Stem Cell Research, Professor of Pathology and Developmental Biology
  "Hematopoietic and Leukemic Stem Cells"

5.45-7.45PM

Reception and mixer

7.45PM-

Speaker Dinner

8.30-10.00AM:

Session 3: Origin of Cancer Stem Cells
Chair: William Weiss

• Michael F. Clarke (Stanford University)
  Professor of Medicine, Associate Director, Stanford University Institute of Stem Cell Biology and Regenerative Medicine
  "Self renewal in normal and cancer stem cells"
• Max S. Wicha (University of Michigan)
  Distinguished Professor of Oncology, Director, University of Michigan Comprehensive Cancer Center
  "Breast Cancer Stem Cells: Implications for Prevention and Therapy"
• Peter Dirks (Hospital for Sick Children, Toronto)
  Scientist, Developmental and Stem Cell Biology
  "Stem Cell Hierarchies in Brain Cancers from Genetically Engineered Mice"

10.00-10.30AM:

Coffee break

10.30AM-12.00PM

Session 4: Stem cells in mouse models of human cancer
Chair: Martin McMahon

• Ronald A. DePinho (Dana Farber Cancer Institute, Boston)
  Professor of Medicine, Harvard Medical School
  "Modeling and Mining Cancer genomes"
• Owen N. Witte (University of California Los Angeles)
  President's Chair in Developmental Immunology, Microbiology, Immunology & Molecular Genetics
  "Prostate Stem Cells and Cancer Development"
• Zena Werb (University of California San Francisco)
  Professor and Vice-Chair, Anatomy
  "Cancer stem cells and the cancer stem cell niche: do they exist?"
• Carla Kim (Harvard University Children's Hospital)
  Assistant Professor, Department of Genetics
  "Examining stem cell biology in normal lung and lung cancer"

12.00-1.00PM:

Buffet lunch

1.00-2.30PM:

Session 5: Stem cells and their microenvironment
Chair: Gabrielle Bergers

• Sean Morrison (University of Michigan)
  Henry Sewall Professor in Medicine, Director, University of Michigan Center for Stem Cell Biology, Investigator, Howard Hughes Medical Institute
  "Stem cell self-renewal versus cancer cell proliferation"
• Shahin Rafii (Weill-Cornell Medical College, New York)
  
• Meenhard Herlyn (Wistar Institute, Philadelphia)
  Professor and Program Leader, Molecular and Cellular Oncogenesis Program
  "Melanocyte and Melanoma Stem Cells"

2.30-3.00PM:

Coffee break

3.00-4.30PM

Session 6: Cancer stem cell targeted therapies
Chair: Neil Shah

• Jeremy Rich (Duke University)
  Associate Professor, Departments of Pharmacology, Cancer Biology & Surgery
  "Learning from the Brain: Cancer Stem Cells in Therapeutic Resistance and "as Molecular Targets"
• Jeffrey Rosen (Baylor College of Medicine, Houston)
  C.C. Bell Professor of Molecular and Cellular Biology and Medicine Distinguished Service Professor
  "Stem/progenitor cells in the etiology and treatment of breast cancer"
• Fred de Sauvage (Genentech)
  Vice President-Research Molecular Biology
  "Targeting Morphogenic Pathways in Cancer"

4.30-6.00PM:

Panel Discussion: A critical evaluation of the role of stem cells in cancer initiation, progression and targets of therapy
Chair: Kevin Shannon

• Ron De Pinho
• Irv Weissman
• Owen Witte
• Elaine Fuchs
• Zena Werb
• Gerard Evan