1.00-1.10PM

Introduction by Frank Mc Cormick (Director, UCSF Helen Diller Family Comprehensive Cancer Center)

1.10-3.10PM

Session 1: Stem Cells in Normal Development - Part I
Chair: Frank McCormick

• Judith Kimble
  "Control of Germline Stem Cells in C. Elegans"
• Yuh Nung Jan
  "The Roles of Tumor Suppressor Genes in the Formation of the Nervous System"
• Arturo Alvarez-Buylla
  "Adult Neural Progenitor Cells: Emerging Links to Cancer"
• Thomas A. Rando
  "Molecular Control of Muscle Stem Cell Fate"

3.10-3.40PM

Coffee break

3.40-5.40PM

Session 2: Stem Cells in Normal Development - Part II
Chair: Emmanuelle Passegué

• Elaine Fuchs
  "Skin Stem Cells: Morphogenesis & Cancer"
• Stuart Orkin
  "Regulation of Stem Cells"
• Thomas Look
  "Targeting Stem Cell Pathways - The Role of Notch"
• Irving L. Weissman
  "Hematopoietic and Leukemic Stem Cells"

5.45-7.45PM

Reception and mixer

7.45PM-

Speaker Dinner

8.30-10.00AM:

Session 3: Origin of Cancer Stem Cells
Chair: Martin McMahon

• Michael F. Clarke
  "Self Renewal in Normal and Cancer Stem Cells"
• Max S. Wicha
  "Breast Cancer Stem Cells: Implications for Prevention and Therapy"
• Peter Dirks
  "Stem Cell Hierarchies in Brain Cancers from Genetically Engineered Mice"

10.00-10.20AM:

Coffee break

10.20AM-12.20PM

Session 4: Stem Cells in Mouse Models of Human Cancer
Chair: Bill Weiss

• Ronald A. DePinho
  "Modeling and Mining Cancer Genomes"
• Owen N. Witte
  "Prostate Stem Cells and Cancer Development"
• Zena Werb
  "Cancer Stem Cells and the Cancer Stem Cell Niche: Do They Exist?"
• Carla Kim
  "Examining tem Cell Biology in Normal Lung and Lung Cancer"

12.20-1.10PM:

Buffet lunch

1.10-2.40PM:

Session 5: Stem Cells and Their Microenvironment
Chair: Gabrielle Bergers

• Sean Morrison
  "Stem Cell Self-Renewal Versus Cancer Cell Proliferation"
• Shahin Rafii
  "Homing of Bone Marrow-derived Vascular Progenitor Cells"
• Meenhard Herlyn
  "Melanocyte and Melanoma Stem Cells"

2.40-3.00PM:

Coffee break

3.00-4.30PM

Session 6: Cancer Stem Cell Targeted Therapies
Chair: Neil Shah

• Jeremy Rich
  "Learning from the Brain: Cancer Stem Cells in Therapeutic Resistance and "as Molecular Targets"
• Jeffrey Rosen
  "Stem/progenitor Cells in the Etiology and Treatment of Breast Cancer"
• Fred de Sauvage
  "Targeting Morphogenic Pathways in Cancer"

4.30-6.00PM:

Panel Discussion: A Critical Evaluation of the Role of Stem Cells in Cancer Initiation, Progression, and Targets of Therapy
Chair: Kevin Shannon

• Ron De Pinho
• Irv Weissman
• Owen Witte
• Elaine Fuchs
• Zena Werb
• Gerard Evan