Research Summary

A. James Barkovich, MD, is a Professor in Residence and he is Chief of Pediatric Neuroradiology in the Department of Radiology at the University of California, San Francisco. Dr. Barkovich received his medical degree from George Washington University, Washington, D.C., and completed his residency in Radiology from Letterman AMC, San Francisco in 1984, followed by a fellowship in Neuroradiology from Walter Reed AMC in 1986. Dr. Barkovich was also President of the American Society of Neuroradiology 1998-1999 and Secretary General of the World Federation of Neuroradiological Societies from 2002-2006.

Dr. Barkovich serves as the Chief of Pediatric Neuroradiology in the UCSF Department of Radiology and Biomedical Imaging. He specializes in the diagnosis of neurological disorders in infants and children. His main research interests include neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development.

Dr. Barkovich’s research established correlations between MR findings and the outcome in affected patients. He has 385 published articles, and has authored or co-authored 9 textbooks and 41 book chapters, and he has written and contributed to a collective of more than 400 research documents.


Pediatric Neuroradiology

Professional Interests:
Neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development

Education and Training:
• Medical School: George Washington University, Washington, DC (1976-1980)
• Internship: Letterman AMC, San Francisco - Radiology (1980-1981)
• Residency: Letterman AMC, San Francisco - Radiology (1981-1984)
• Fellowship: Walter Reed AMC, Washington, DC - Neuroradiology (1984-1986)
• California Medical License
• Ohio State Medical License (inactive)
• New York State Medical License (inactive)
• American Board of Radiology (1984)
• Certificate of Added Qualification in Neuroradiology (1996, 2006)

Research Funding

  • January 1, 2014 - December 31, 2018 - Repair after Neonatal Brain Injury, Co-Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: P01NS082330
  • July 1, 2003 - August 31, 2014 - DTI, MRSI, and Volumetry of Cerebellar Injury in Preterm Neonates, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01NS046432
  • September 1, 2009 - June 30, 2014 - Development of Advanced Techniques for MR of the Newborn Brain, Principal Investigator. Sponsor: NIH/NIBIB, Sponsor Award ID: R01EB009756
  • December 1, 1981 - September 29, 2006 - PEDIATRIC CLINICAL RESEARCH CENTER, Co-Investigator. Sponsor: NIH/NCRR, Sponsor Award ID: M01RR001271


Univ. of CA, Davis, BS, 1974, Chemistry
Univ. of CA, Berkeley, MS, 1977, Chemistry Passed Oral Examination for Ph.D., was advanced to candidacy for Ph.D., but did not complete dissertation
Geo. Washington Univ., Washington, D.C., MD, 1980, Medicine
Letterman AMC, San Francisco, CA, Intern, 1980-1981, Radiology
Letterman, AMC, San Francisco, CA, Resident, 1981-1984, Radiology
Walter Reed AMC, Washington, D.C., Fellowship, 1984-1986, Neuroradiology

Honors & Awards

  • 1972
    Edward F. Kraft Scholarship Award, U.C. Davis
  • 1973-1972
    President's Undergraduate Research Fellow
  • 1972
    U.S. Atomic Energy Commission Summer Research Fellow,
  • 1982
    Honorable Mention, Exhibit, RSNA Annual Meeting
  • 1992
    Outstanding Teacher Award, Department of Neurology, UCSF
  • 1992
    Editors Excellence for Outstanding Scientific Research, J Comput Assist Tomogr
  • 1992
    Elected to "Best Doctors in America"
  • 1992
    Elected to "Best Doctors in America, Pacific Region"
  • 1992
    Nycomed Distinguished Visiting Lecturer, Armed Forces Institute of Pathology
  • 1992
    Selected to Who's Who in Medicine and Health Care
  • 1992
    Goldenson Technology Award, United Cerebral Palsy Research Foundation
  • 1992
    Selected to Who's Who in the World, 15th Edition
  • 2002
    Selected to Who's Who in Medicine and Health Care
  • 2002
    Selected to Who's Who in America, 57th Edition
  • 2002 and 2002
    Listed in "America's Top Doctors"
  • 2002 and 2002
    Elected to "Best Doctors in America"

Selected Publications

  1. Misser SK, Barkovich AJ, Lotz JW, Archary M A pictorial review of the pathophysiology and classification of the magnetic resonance imaging patterns of perinatal term hypoxic ischemic brain injury - What the radiologist needs to know….  View on PubMed
  2. Barkovich AJ Imaging of the Newborn Brain.  View on PubMed
  3. Barkovich MJ, Barkovich AJ MR Imaging of Normal Brain Development.  View on PubMed
  4. Jenster M, Bonifacio SL, Ruel T, Rogers EE, Tam EW, Partridge JC, Barkovich AJ, Ferriero DM, Glass HC Maternal or neonatal infection: association with neonatal encephalopathy outcomes.  View on PubMed
  5. Tan YL, Kim H, Lee S, Tihan T, Ver Hoef L, Mueller SG, Barkovich AJ, Xu D, Knowlton R Quantitative surface analysis of combined MRI and PET enhances detection of focal cortical dysplasias.  View on PubMed
  6. Barkovich AJ, Deon S Reprint of "Hypomyelinating disorders: An MRI approach.  View on PubMed
  7. Barkovich AJ, Deon S Hypomyelinating disorders: An MRI approach.  View on PubMed
  8. Al-Maawali A, Barry BJ, Rajab A, El-Quessny M, Seman A, Coury SN, Barkovich AJ, Yang E, Walsh CA, Mochida GH, Stoler JM Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures.  View on PubMed
  9. Fullerton HJ, Hills NK, Elkind MS, Dowling MM, Wintermark M, Glaser CA, Tan M, Rivkin MJ, Titomanlio L, Barkovich AJ, deVeber GA Infection, vaccination, and childhood arterial ischemic stroke: Results of the VIPS study.  View on PubMed
  10. Takanashi J, Mizuguchi M, Terai M, Barkovich AJ Disrupted glutamate-glutamine cycle in acute encephalopathy with biphasic seizures and late reduced diffusion.  View on PubMed
  11. Tunovic S, Barañano KW, Barkovich JA, Strober JB, Jamal L, Slavotinek AM Novel KIF7 missense substitutions in two patients presenting with multiple malformations and features of acrocallosal syndrome.  View on PubMed
  12. Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TT, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJF, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJP, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF, Stewart F, Omran H, Huynen MA, Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.  View on PubMed
  13. Gano D, Andersen SK, Glass HC, Rogers EE, Glidden DV, Barkovich AJ, Ferriero DM Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age.  View on PubMed
  14. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale RD, Barkovich AJ, Sherr EH De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy.  View on PubMed
  15. Barkovich AJ, Dobyns WB, Guerrini R Malformations of cortical development and epilepsy.  View on PubMed
  16. Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan WH, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination.  View on PubMed
  17. D'Gama AM, Geng Y, Couto JA, Martin B, Boyle EA, LaCoursiere CM, Hossain A, Hatem NE, Barry BJ, Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J, Mathern GW, Walsh CA, Poduri A Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.  View on PubMed
  18. Vulto-van Silfhout AT, Nakagawa T, Bahi-Buisson N, Haas SA, Hu H, Bienek M, Vissers LE, Gilissen C, Tzschach A, Busche A, Müsebeck J, Rump P, Mathijssen IB, Avela K, Somer M, Doagu F, Philips AK, Rauch A, Baumer A, Voesenek K, Poirier K, Vigneron J, Amram D, Odent S, Nawara M, Obersztyn E, Lenart J, Charzewska A, Lebrun N, Fischer U, Nillesen WM, Yntema HG, Järvelä I, Ropers HH, de Vries BB, Brunner HG, van Bokhoven H, Raymond FL, Willemsen MA, Chelly J, Xiong Y, Barkovich AJ, Kalscheuer VM, Kleefstra T, de Brouwer AP Variants in CUL4B are associated with cerebral malformations.  View on PubMed
  19. Tate MC, Lindquist RA, Nguyen T, Sanai N, Barkovich AJ, Huang EJ, Rowitch DH, Alvarez-Buylla A Postnatal growth of the human pons: a morphometric and immunohistochemical analysis.  View on PubMed
  20. Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study.  View on PubMed

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