Research Summary

Carolyn S. Calfee, MD MAS is Professor of Medicine and Anesthesia at the University of California, San Francisco, where she attends in the intensive care units. Her primary academic focus is the pathogenesis and treatment of the acute respiratory distress syndrome (ARDS). Current research projects include: (1) molecular subphenotypes of ARDS and precision medicine in critical care; (2) the role of environmental exposures including smoking, air pollution, and novel tobacco products in susceptibility to lung injury; and (3) novel treatments for ARDS. During the COVID-19 pandemic, she has been the UCSF clinical lead and steering committee member for the NIAID-funded Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study and she is one of the lead PI’s for the ISPY COVID clinical trial, a Phase 2 platform clinical trial of novel treatments for COVID-19 associated ARDS.

Research Funding

  • January 16, 2018 - December 31, 2024 - Precision Medicine in the Acute Respiratory Distress Syndrome , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R35HL140026
  • July 15, 2016 - June 30, 2021 - ARDS Endotypes: Expanded Analysis of Clinical and Biological Phenotypes and Evolution Over Time , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K24HL133390
  • March 15, 2016 - February 28, 2020 - Molecular Endotypes of ARDS: Identification, Biology, and Differential Response to Therapy , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL131621
  • September 19, 2013 - August 31, 2018 - Improved Models to Inform Tobacco Product Regulation , Co-Investigator . Sponsor: NIH/NCI, Sponsor Award ID: P50CA180890

Education

Yale University, BA, 1991-1995, English
University of Pennsylvania, MD, 1995-1999, Medicine
University of California, San Francisco Internship/Residency, 1999-2002, Internal Medicine
University of California, San Francisco Chief Residency, 2002-2003, Internal Medicine
University of California, San Francisco Fellowship, 2003-2007, Pulmonary/Critical Care
University of California, San Francisco Masters in Clinical Research (expected), 2007-2009, Clinical Research

Honors & Awards

  • 1994
    Phi Beta Kappa, Yale University
  • 1995
    Bachelor of Arts awarded magna cum laude, with Distinction in the Major
  • 1998
    Alpha Omega Alpha, University of Pennsylvania School of Medicine
  • 1999
    Julia M. Glasgow Award, University of Pennsylvania School of Medicine
  • 1999
    Spencer Morris Prize, University of Pennsylvania School of Medicine
  • 2000
    Intern of the Year, University of California, San Francisco, Department of Medicine
  • 2005
    Walter Travel Award, American Lung Association
  • 2012
    Associate Scientific Advisor, Science Translational Medicine
  • 2013
    American Society for Clinical Investigation Young Physician-Scientist Award
  • 2013
    Highlighted abstract, 2013 American Thoracic Society International Conference (sr. author)
  • 2013
    Finalist, UCSF Pathways to Discovery Mentor Award

Selected Publications

  1. Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT. New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. Am J Respir Cell Mol Biol. 2022 Jun 09.  View on PubMed
  2. Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA. Impact of E-Cigarette Aerosol on Primary Human Alveolar Epithelial Type 2 Cells. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 07.  View on PubMed
  3. Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD, ISPY COVID Adaptive Platform Trial Network, undefined. I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations. BMJ Open. 2022 Jun 06; 12(6):e060664.  View on PubMed
  4. Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COMET consortium and the Co-ACIT Study Group
    . COVID-19-Associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective. Am J Respir Crit Care Med. 2022 Jun 01.  View on PubMed
  5. Siegel ER, Zhuo H, Sinha P, Papolos AI, Ni SA, Vessel K, Belzer A, Minus EB, Calfee CS, Matthay MA, Wick KD. Ventilatory Ratio is a Valuable Prognostic Indicator in an Observational Cohort of Patients With ARDS. Respir Care. 2022 May 31.  View on PubMed
  6. Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17.  View on PubMed
  7. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11.  View on PubMed
  8. Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS. Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. Am J Respir Crit Care Med. 2022 Apr 15; 205(8):927-935.  View on PubMed
  9. Tran A, Fernando SM, Brochard LJ, Fan E, Inaba K, Ferguson ND, Calfee CS, Burns KEA, Brodie D, McCredie VA, Kim DY, Kyeremanteng K, Lampron J, Slutsky AS, Combes A, Rochwerg B. Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis. Eur Respir J. 2022 Apr; 59(4).  View on PubMed
  10. Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA. Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 01; 322(6):L771-L783.  View on PubMed
  11. Burnett CE, Hauge Okholm TL, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, Spitzer MH. A conserved immune trajectory of recovery in hospitalized COVID-19 patients. bioRxiv. 2022 Mar 16.  View on PubMed
  12. Bos LDJ, Laffey JG, Ware LB, Heijnen NFL, Sinha P, Patel B, Jabaudon M, Bastarache JA, McAuley DF, Summers C, Calfee CS, Shankar-Hari M. Towards a biological definition of ARDS: are treatable traits the solution? Intensive Care Med Exp. 2022 Mar 11; 10(1):8.  View on PubMed
  13. Hayes D, Board A, Calfee C, Ellington S, Pollack LA, Kathuria H, Eakin MN, Weissman DN, Callahan SJ, Esper AM, Crotty Alexander LE, Sharma NS, Meyer NJ, Smith LS, Novosad S, Evans ME, Goodman AB, Click ES, Robinson RT, Ewart G, Twentyman E. Pulmonary and Critical Care Considerations for E-Cigarette, or Vaping, Product Use-Associated Lung Injury. Chest. 2022 Mar 05.  View on PubMed
  14. Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM. Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Crit Care Med. 2022 03 01; 50(3):e284-e293.  View on PubMed
  15. Brodie D, Abrams D, MacLaren G, Brown CE, Evans L, Barbaro RP, Calfee CS, Hough CL, Fowles JA, Karagiannidis C, Slutsky AS, Combes A. ECMO During Respiratory Pandemics: Past, Present, and Future. Am J Respir Crit Care Med. 2022 Feb 25.  View on PubMed
  16. Furfaro DM, Sinha P, Calfee CS, Brodie D, O'Donnell MR. Reply to Kuindersma and Spronk: Time to Tailor the One-Size-Fits-All Approach? Am J Respir Crit Care Med. 2022 02 15; 205(4):480-481.  View on PubMed
  17. Alipanah N, Calfee CS. Phenotyping in acute respiratory distress syndrome: state of the art and clinical implications. Curr Opin Crit Care. 2022 02 01; 28(1):1-8.  View on PubMed
  18. Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 02; 66(2):e1-e14.  View on PubMed
  19. Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA. Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance In early Human Sepsis. Shock. 2022 Jan 20.  View on PubMed
  20. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respir Med. 2022 Apr; 10(4):367-377.  View on PubMed

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