Research Summary

I have trained more than 100 postdoctoral fellows and visiting scientists during my career, most of whom currently hold faculty positions at various academic institutions. I have published over 350 research manuscripts in peer-reviewed journals. I completed my postdoctoral fellowship in Oncology and Molecular Biology from the University of Chicago Pritzker School of Medicine. I joined University of California San Francisco School of Medicine (UCSF) in 1987. I am currently a Professor and Director of Urology Research Center at UCSF/VAMC and a Senior Research Career Scientist (Department of Veterans Affairs, Washington DC) at the Veterans Affairs Health Care System, San Francisco. My research projects are funded through the VA and NIH and focused on investigating the following areas: (1) The role of non-coding RNAs in the initiation, progression and metastasis of urological cancers using in vitro and in vivo models. (2) Genetic biomarkers for diagnosis and prognosis of urological malignancies using clinical specimens. (3) Molecular mechanism of prostate cancer health disparities. (4) Mechanisms of drug resistance and its reversal using various pathways in vitro and in vivo models. (5) Role of dietary compounds for treatment and prevention of urological malignancies.

Research Funding

  • October 1, 2018 - September 30, 2025 - BLR&D Research Career Scientist Award Application, Principal Investigator. Sponsor: VA, Sponsor Award ID: IK6BX004473
  • June 1, 2016 - May 31, 2021 - Molecular biomarkers for kidney cancer prognosis using non-coding RNAs, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA199694
  • October 1, 2011 - September 30, 2020 - Regulation of c-Myc/HIF pathway in the management of kidney cancer, Principal Investigator. Sponsor: VA, Sponsor Award ID: I01BX001123
  • July 1, 2015 - June 30, 2020 - Genetic factors for race related prostate cancer., Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA184966

Education

Kurukshetra University, India, MS, 1978, Biochemistry
Postgraduate Institute of Medical Education and Research, Chandigarh, India, PhD, 1982, Biochemistry
University of Chicago, Chicago, IL, Post-Doc, 1983-1987, Biochemistry

Honors & Awards

  • 2006-2013
    Associate Editor, Cancer Research
  • 2013-present
    Associate Editor Clinical Cancer Research
  • 2011-present
    Academic Editor, PLoS ONE
  • 2011-present
    Senior Editor, Amer. J. Cancer Res.

Selected Publications

  1. Kawamoto K, Okino ST, Place RF, Urakami S, Hirata H, Kikuno N, Kawakami T, Tanaka Y, Pookot D, Chen Z, Majid S, Enokida H, Nakagawa M, Dahiya R. Editor's Note: Epigenetic Modifications of RASSF1A Gene through Chromatin Remodeling in Prostate Cancer. Clin Cancer Res. 2021 05 01; 27(9):2665.  View on PubMed
  2. Kulkarni P, Dasgupta P, Hashimoto Y, Shiina M, Shahryari V, Tabatabai ZL, Yamamura S, Tanaka Y, Saini S, Dahiya R, Majid S. A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis. Cancer Res. 2021 03 15; 81(6):1500-1512.  View on PubMed
  3. Kulkarni P, Dasgupta P, Bhat NS, Hashimoto Y, Saini S, Shahryari V, Yamamura S, Shiina M, Tanaka Y, Dahiya R, Majid S. Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells. Toxicol Appl Pharmacol. 2020 12 15; 409:115308.  View on PubMed
  4. Bhagirath D, Liston M, Patel N, Akoto T, Lui B, Yang TL, To DM, Majid S, Dahiya R, Tabatabai ZL, Saini S. MicroRNA determinants of neuroendocrine differentiation in metastatic castration-resistant prostate cancer. Oncogene. 2020 12; 39(49):7209-7223.  View on PubMed
  5. Dasgupta P, Kulkarni P, Majid S, Hashimoto Y, Shiina M, Shahryari V, Bhat NS, Tabatabai L, Yamamura S, Saini S, Tanaka Y, Dahiya R. LncRNA CDKN2B-AS1/miR-141/cyclin D network regulates tumor progression and metastasis of renal cell carcinoma. Cell Death Dis. 2020 08 19; 11(8):660.  View on PubMed
  6. Dasgupta P, Kulkarni P, Bhat NS, Majid S, Shiina M, Shahryari V, Yamamura S, Tanaka Y, Gupta RK, Dahiya R, Hashimoto Y. Activation of the Erk/MAPK signaling pathway is a driver for cadmium induced prostate cancer. Toxicol Appl Pharmacol. 2020 08 15; 401:115102.  View on PubMed
  7. Imai-Sumida M, Dasgupta P, Kulkarni P, Shiina M, Hashimoto Y, Shahryari V, Majid S, Tanaka Y, Dahiya R, Yamamura S. Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer. Cell Physiol Biochem. 2020 01 22; 54(1):53-70.  View on PubMed
  8. Bhagirath D, Dahiya R, Majid S, Tabatabai ZL, Saini S. Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients. J Vis Exp. 2019 11 19; (153).  View on PubMed
  9. Bhagirath D, Yang TL, Tabatabai ZL, Majid S, Dahiya R, Tanaka Y, Saini S. BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2. Clin Cancer Res. 2019 11 01; 25(21):6532-6545.  View on PubMed
  10. Cagle P, Niture S, Srivastava A, Ramalinga M, Aqeel R, Rios-Colon L, Chimeh U, Suy S, Collins SP, Dahiya R, Kumar D. MicroRNA-214 targets PTK6 to inhibit tumorigenic potential and increase drug sensitivity of prostate cancer cells. Sci Rep. 2019 07 05; 9(1):9776.  View on PubMed
  11. Bhagirath D, Yang TL, Tabatabai ZL, Shahryari V, Majid S, Dahiya R, Tanaka Y, Saini S. Role of a novel race-related tumor suppressor microRNA located in frequently deleted chromosomal locus 8p21 in prostate cancer progression. Carcinogenesis. 2019 07 04; 40(5):633-642.  View on PubMed
  12. Hashimoto Y, Shiina M, Dasgupta P, Kulkarni P, Kato T, Wong RK, Tanaka Y, Shahryari V, Maekawa S, Yamamura S, Saini S, Deng G, Tabatabai ZL, Majid S, Dahiya R. Upregulation of miR-130b Contributes to Risk of Poor Prognosis and Racial Disparity in African-American Prostate Cancer. Cancer Prev Res (Phila). 2019 09; 12(9):585-598.  View on PubMed
  13. Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF. The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. Oncotarget. 2019 Feb 19; 10(15):1491-1506.  View on PubMed
  14. Chang I, Mitsui Y, Kim SK, Sun JS, Jeon HS, Kang JY, Kang NJ, Fukuhara S, Gill A, Shahryari V, Tabatabai ZL, Greene KL, Dahiya R, Shin DM, Tanaka Y. Correction: Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation. Oncotarget. 2018 09 25; 9(75):34190.  View on PubMed
  15. Kato T, Hashimoto Y, Wong RK, Mitsui Y, Maekawa S, Chang I, Shahryari V, Yamamura S, Majid S, Saini S, Tabatabai ZL, Dahiya R, Deguchi T, Tanaka Y. Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer. J Cell Mol Med. 2018 10; 22(10):4676-4687.  View on PubMed
  16. Kulkarni P, Dasgupta P, Bhat NS, Shahryari V, Shiina M, Hashimoto Y, Majid S, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R. Elevated miR-182-5p Associates with Renal Cancer Cell Mitotic Arrest through Diminished MALAT-1 Expression. Mol Cancer Res. 2018 11; 16(11):1750-1760.  View on PubMed
  17. Yamamoto Y, Tsunedomi R, Fujita Y, Otori T, Ohba M, Kawai Y, Hirata H, Matsumoto H, Haginaka J, Suzuki S, Dahiya R, Hamamoto Y, Matsuyama K, Hazama S, Nagano H, Matsuyama H. Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma. Oncotarget. 2018 Mar 30; 9(24):17160-17170.  View on PubMed
  18. Dasgupta P, Kulkarni P, Majid S, Shahryari V, Hashimoto Y, Bhat NS, Shiina M, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R. MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma. Mol Cancer Ther. 2018 05; 17(5):1061-1069.  View on PubMed
  19. Bhagirath D, Yang TL, Bucay N, Sekhon K, Majid S, Shahryari V, Dahiya R, Tanaka Y, Saini S. microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer. Cancer Res. 2018 04 01; 78(7):1833-1844.  View on PubMed
  20. Bhagirath D, Yang TL, Dahiya R, Saini S. MicroRNAs as Regulators of Prostate Cancer Metastasis. Adv Exp Med Biol. 2018; 1095:83-100.  View on PubMed

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