Research Summary

My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.

Research Funding

  • January 1, 2014 - December 31, 2014 - Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: F32HL117549
  • August 15, 2000 - January 20, 2021 - MECHANISMS OF SVZ EXPANSION FOLLOWING CORTICAL INJURY, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: F31MH012798
  • January 1, 2014 - December 31, 2014 - Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: F32HL117549
  • August 15, 2000 - January 25, 2021 - MECHANISMS OF SVZ EXPANSION FOLLOWING CORTICAL INJURY, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: F31MH012798

Education

University of Texas at Austin, B.A., 06/1997, Plan II Honors Program
University of California, Los Angeles, M.D., Ph.D., 06/2006, Medicine, Neuroscience
University of California, San Francisco, Residency, 06/2009, Internal Medicine
University of California, San Francisco, Fellowship, 06/2013, Pulmonary/Crit Care

Honors & Awards

  • 2003
    UCLA Kavan Award for Neuroscience Research
  • 2005
    AOA
  • 2006
    ACP Student Internist Award
  • 2009
    UCSF Internal Medicine Residency Professionalism Award
  • 2011
    UCSF Outstanding Pulmonary Fellow Award

Selected Publications

  1. Inhibition of the Lipoxin A4 and Resolvin D1 Receptor Impairs Host Response to Acute Lung Injury Caused by Pneumococcal Pneumonia in Mice.  View on PubMed
  2. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.  View on PubMed
  3. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia.  View on PubMed
  4. Matthay MA, Aldrich JM, Gotts JE Treatment for severe acute respiratory distress syndrome from COVID-19.  View on PubMed
  5. Gotts JE, Jordt SE, McConnell R, Tarran R What are the respiratory effects of e-cigarettes?  View on PubMed
  6. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.  View on PubMed
  7. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.  View on PubMed
  8. Gotts JE High-power vaping injures the human lung.  View on PubMed
  9. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.  View on PubMed
  10. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.  View on PubMed
  11. Chun L, Moazed F, Matthay M, Calfee C, Gotts J Possible hepatotoxicity of IQOS.  View on PubMed
  12. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.  View on PubMed
  13. Gotts JE, Matthay MA Cell-based Therapy in Sepsis. A Step Closer.  View on PubMed
  14. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".  View on PubMed
  15. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.  View on PubMed
  16. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.  View on PubMed
  17. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE Pulmonary toxicity of e-cigarettes.  View on PubMed
  18. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH Cathepsin L Helps to Defend Mice from Infection with Influenza A.  View on PubMed
  19. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR Persistent Pathology in Influenza-Infected Mouse Lungs.  View on PubMed
  20. Gotts JE, Matthay MA Sepsis: pathophysiology and clinical management.  View on PubMed

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