Research Summary

My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.

Research Funding

  • January 1, 2014 - December 31, 2014 - Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: F32HL117549
  • August 15, 2000 - January 20, 2021 - MECHANISMS OF SVZ EXPANSION FOLLOWING CORTICAL INJURY, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: F31MH012798
  • January 1, 2014 - December 31, 2014 - Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: F32HL117549
  • August 15, 2000 - January 25, 2021 - MECHANISMS OF SVZ EXPANSION FOLLOWING CORTICAL INJURY, Principal Investigator. Sponsor: NIH/NIMH, Sponsor Award ID: F31MH012798

Education

University of Texas at Austin, B.A., 06/1997, Plan II Honors Program
University of California, Los Angeles, M.D., Ph.D., 06/2006, Medicine, Neuroscience
University of California, San Francisco, Residency, 06/2009, Internal Medicine
University of California, San Francisco, Fellowship, 06/2013, Pulmonary/Crit Care

Honors & Awards

  • 2003
    UCLA Kavan Award for Neuroscience Research
  • 2005
    AOA
  • 2006
    ACP Student Internist Award
  • 2009
    UCSF Internal Medicine Residency Professionalism Award
  • 2011
    UCSF Outstanding Pulmonary Fellow Award

Selected Publications

  1. Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA. Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice. Physiol Rep. 2021 Nov; 9(21):e15081.  View on PubMed
  2. Gomez-Sanchez CM, Wu BX, Gotts JE, Chang RW. Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis. J Vasc Surg Cases Innov Tech. 2021 Dec; 7(4):778-780.  View on PubMed
  3. Siegel ER, Croze RH, Fang X, Matthay MA, Gotts JE. Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2021 06 01; 320(6):L1085-L1092.  View on PubMed
  4. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE. Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate. Am J Respir Cell Mol Biol. 2020 12; 63(6):748-757.  View on PubMed
  5. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA. The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L218-L227.  View on PubMed
  6. Matthay MA, Aldrich JM, Gotts JE. Treatment for severe acute respiratory distress syndrome from COVID-19. Lancet Respir Med. 2020 05; 8(5):433-434.  View on PubMed
  7. Gotts JE, Jordt SE, McConnell R, Tarran R. What are the respiratory effects of e-cigarettes? BMJ. 2019 09 30; 366:l5275.  View on PubMed
  8. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L717-L736.  View on PubMed
  9. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 04; 7(4):e14.  View on PubMed
  10. Gotts JE. High-power vaping injures the human lung. . 2019 May 01; 316(5):L703-L704.  View on PubMed
  11. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019 02; 7(2):154-162.  View on PubMed
  12. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 11; 27(Suppl 1):s20-s25.  View on PubMed
  13. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. Possible hepatotoxicity of IQOS. Tob Control. 2018 11; 27(Suppl 1):s39-s40.  View on PubMed
  14. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. . 2018 07 01; 315(1):L25-L40.  View on PubMed
  15. Gotts JE, Matthay MA. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 02 01; 197(3):280-281.  View on PubMed
  16. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". . 2017 11 01; 313(5):L966-L967.  View on PubMed
  17. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039.  View on PubMed
  18. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914.  View on PubMed
  19. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Pulmonary toxicity of e-cigarettes. . 2017 08 01; 313(2):L193-L206.  View on PubMed
  20. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501.  View on PubMed

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