Selected Publications

  1. Shin KO, Kim KP, Cho Y, Kang MK, Kang YH, Lee YM, Ikushiro H, Yokota M, Yano T, Choe SJ, Choi EH, Lim CJ, Park K, Holleran WM, Park K, Uchida Y Both Sphingosine Kinase 1 and 2 Coordinately Regulate Cathelicidin Antimicrobial Peptide Production during Keratinocyte Differentiation.  View on PubMed
  2. Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM Topical 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibition Corrects Cutaneous Features of Systemic Glucocorticoid Excess in Female Mice.  View on PubMed
  3. Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.  View on PubMed
  4. Park K, Ikushiro H, Seo HS, Shin KO, Kim YI, Kim JY, Lee YM, Yano T, Holleran WM, Elias P, Uchida Y ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex.  View on PubMed
  5. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo.  View on PubMed
  6. Kim YI, Park K, Kim JY, Seo HS, Shin KO, Lee YM, Holleran WM, Elias PM, Uchida Y An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating ß-defensin production.  View on PubMed
  7. Park K, Kim YI, Shin KO, Seo HS, Kim JY, Mann T, Oda Y, Lee YM, Holleran WM, Elias PM, Uchida Y The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism.  View on PubMed
  8. Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM Increased glucocorticoid activation during mouse skin wound healing.  View on PubMed
  9. Elias PM, Gruber R, Crumrine D, Menon G, Williams ML, Wakefield JS, Holleran WM, Uchida Y Formation and functions of the corneocyte lipid envelope (CLE).  View on PubMed
  10. Loiseau N, Obata Y, Moradian S, Sano H, Yoshino S, Aburai K, Takayama K, Sakamoto K, Holleran WM, Elias PM, Uchida Y Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis.  View on PubMed
  11. Youm JK, Park K, Uchida Y, Chan A, Mauro TM, Holleran WM, Elias PM Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing.  View on PubMed
  12. Bourguignon LY, Wong G, Xia W, Man MQ, Holleran WM, Elias PM Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction.  View on PubMed
  13. Park K, Elias PM, Hupe M, Borkowski AW, Gallo RL, Shin KO, Lee YM, Holleran WM, Uchida Y Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production.  View on PubMed
  14. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity.  View on PubMed
  15. Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin.  View on PubMed
  16. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.  View on PubMed
  17. Kim H, Kim J, Park J, Kim SH, Uchida Y, Holleran WM, Cho Y Water extract of gromwell (Lithospermum erythrorhizon) enhances migration of human keratinocytes and dermal fibroblasts with increased lipid synthesis in an in vitro wound scratch model.  View on PubMed
  18. Chan A, Holleran WM, Ferguson T, Crumrine D, Goker-Alpan O, Schiffmann R, Tayebi N, Ginns EI, Elias PM, Sidransky E Skin ultrastructural findings in type 2 Gaucher disease: diagnostic implications.  View on PubMed
  19. Park K, Elias PM, Oda Y, Mackenzie D, Mauro T, Holleran WM, Uchida Y Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway.  View on PubMed
  20. Rodriguez-Martin M, Martin-Ezquerra G, Man MQ, Hupe M, Youm JK, Mackenzie DS, Cho S, Trullas C, Holleran WM, Radek KA, Elias PM Expression of epidermal CAMP changes in parallel with permeability barrier status.  View on PubMed

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