Research Summary

Taken together with our previous studies of the KCNK9 potassium channel upregulation in breast cancer (Mu et al., 2003, Cancer Cell 3, 297-302; Pei et al., 2003, PNAS 100, 7803-7807) and the EAG2 potassium channel upregulation in multiple subgroups of medulloblastoma (MB) that facilitates MB cell proliferation and migration (Huang et al., 2012, Genes & Development 26, 1780-1796; Huang et al., 2015, Nature Neuroscience 18, 1236-1246), our recent study of the TMEM16A calcium activated chloride channel upregulation in pancreatic cancer that is associated with the ligand-dependent EGF receptor signaling pathway and poor prognosis (Crottes et al., 2019, PNAS 116, 13026-13035) and our on-going studies of ion channels that are up- or down-regulated in various cancers support the notion that different types of cancer may involve different ion channels for their rapid proliferation, extensive migration and invasion.

Research Funding

  • April 15, 2020 - March 31, 2025 - Central neuronal circuitry for homeostatic thermoregulation modulated by brain temperature, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS116588
  • February 15, 2020 - January 31, 2025 - Molecular and Genetic Studies of TMEM16C Control of Thermoregulation and Neuronal Excitability, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS108946
  • September 15, 2017 - August 31, 2023 - Illuminating Druggable Dark Matter, Co-Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: U24DK116214
  • July 15, 2011 - June 30, 2018 - Molecular, genetic & physiological studies of calcium-activated chloride channels, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS069229

Education

National Taiwan University, Taipei, Taiwan, B.Sc., 06/1968, Physics
California Institute of Technology, Pasadena, CA, M.Sc., 06/1970, Physics
California Institute of Technology, Pasadena, CA, Ph.D., 06/1974, Biophysics & Physics
California Institute of Technology, Pasadena, CA, Postdoc, 06/1977, Neuroscience
Harvard Medical School, Boston, MA, Postdoc, 06/1979, Neuroscience

Honors & Awards

  • 1996-present
    Member, National Academy of Sciences
  • 1998-present
    Member, Academia Sinica
  • 2006
    NIMH MERIT Award
  • 2007-present
    Member, American Academy of Arts and Sciences
  • 2007
    Outstanding Mentorship Award form the Postdoctoral Scholar’s Association of UCSF
  • 2009
    Ralph W. Gerard Prize, Society for Neuroscience
  • 2010
    Edward M. Scolnick Prize in Neuroscience
  • 2010
    Grass Lecture at Society for Neuroscience Annual Meeting
  • 2011
    Wiley Prize in Biomedical Research
  • 2012
    Gruber Prize in Neuroscience

Selected Publications

  1. Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN TMEM16K is an interorganelle regulator of endosomal sorting.  View on PubMed
  2. He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY Chloride channels regulate differentiation and barrier functions of the mammalian airway.  View on PubMed
  3. Jin P, Jan LY, Jan YN Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.  View on PubMed
  4. Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.  View on PubMed
  5. Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.  View on PubMed
  6. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.  View on PubMed
  7. Ye W, Han TW, He M, Jan YN, Jan LY Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity.  View on PubMed
  8. Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.  View on PubMed
  9. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.  View on PubMed
  10. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.  View on PubMed
  11. Crottès D, Jan LY The multifaceted role of TMEM16A in cancer.  View on PubMed
  12. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.  View on PubMed
  13. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.  View on PubMed
  14. Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.  View on PubMed
  15. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.  View on PubMed
  16. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY Chemically induced vesiculation as a platform for studying TMEM16F activity.  View on PubMed
  17. Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT Far away from the lamppost.  View on PubMed
  18. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY Activation of orexin system facilitates anesthesia emergence and pain control.  View on PubMed
  19. Jan LY, Jan YN Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics.  View on PubMed
  20. DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.  View on PubMed

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