Research Summary

Yvonne Kapila is a clinician scientist with over 20 years of experience studying the basic mechanisms and translational and clinical aspects of periodontal disease pathogenesis and head and neck cancer carcinogenesis using in vitro and in vivo models and human clinical studies. Her early research focused on understanding the basic extracellular matrix (ECM) processes and host-microbial mechanisms that govern head and neck cancer tumorigenesis and periodontal disease pathogenesis. Kapila made important discoveries focused on the cell and molecular biology mechanisms that regulate anoikis; programmed cell death or apoptosis triggered by loss of extracellular matrix contacts. Kapila's recent research has extended to omics approaches and biomarker discovery for head and neck cancer using metabolomic and microbiome approaches. Her related work in sirtuin biology and oral cancer were seminal in showing that sirtuin 3, a metabolic enzyme, regulates and promotes oral cancer tumorigenesis. Recently funded projects in her lab have focused on host-microbial interactions and the novel role of bacteriocins in biomedical applications, including as modulators of tumorigenesis and disease-associated biofilms and the oral microbiome.

Research Funding

  • July 1, 2015 - May 31, 2020 - Oral Treponema Surface Proteins: Host Cell Interactions, Co-Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE025225
  • September 25, 2013 - August 31, 2015 - Biomarkers of Aggressive Oral Cancer, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R56DE023333
  • December 1, 2001 - April 30, 2012 - Fibronectin Regulation of Anoikis, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R56DE014429
  • April 1, 2000 - September 30, 2011 - Apoptosis Regulated by Fibronectin Signaling Pathways, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE013725


Stanford University, BA, 1986, Human Biology
University of California, San Francisco, DDS, BS, 1990, Dentistry
University of California, San Francisco, Certificate, 1994, Periodontology
University of California, San Francisco, PhD, 1997, Oral Biology
University of California, San Francisco, Postdoc, 1997-1998, Cell Biology

Honors & Awards

  • 2000
    UCSF Faculty Development Award
  • 2000
    American Dental Association Health Foundation New Dentist Scientist Award
  • 2000
    UCSF Dean’s Creativity Fund Award
  • 2002
    UCSF Hellman Family Award for Early Career Faculty
  • 2002
    Oral-B/Robert W. Hutson Faculty Prize in Periodontology
  • 2013
    International College of Dentists, Inducted as Fellow
  • 2014
    IADR/GSK Innovation in Oral Care Award
  • 2015
    UM MICHR Distinguished Clinical and Translational Research Mentor Award
  • 2016
    UCSF Chancellor’s Mid-Career Faculty Award
  • 2017
    AAP Sunstar Innovation Research Award
  • 2017
    ELAM Fellow

Selected Publications

  1. Pirih FQ, Monajemzadeh S, Singh N, Sinacola RS, Shin JM, Chen T, Fenno JC, Kamarajan P, Rickard AH, Travan S, Paster BJ, Kapila Y. Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome. Periodontol 2000. 2021 Oct; 87(1):50-75.  View on PubMed
  2. Alsaleh A, Kapila A, Shahriar I, Kapila YL. Dental informed consent challenges and considerations for cognitively impaired patients. Periodontol 2000. 2021 Oct; 87(1):43-49.  View on PubMed
  3. Rangé H, Colon P, Godart N, Kapila Y, Bouchard P. Eating disorders through the periodontal lens. Periodontol 2000. 2021 Oct; 87(1):17-31.  View on PubMed
  4. Kapila YL. Oral health's inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions. Periodontol 2000. 2021 10; 87(1):11-16.  View on PubMed
  5. Ye C, Kapila Y. Oral microbiome shifts during pregnancy and adverse pregnancy outcomes: Hormonal and Immunologic changes at play. Periodontol 2000. 2021 Oct; 87(1):276-281.  View on PubMed
  6. Radaic A, Ganther S, Kamarajan P, Grandis J, Yom SS, Kapila YL. Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial-based therapeutics. Periodontol 2000. 2021 Oct; 87(1):76-93.  View on PubMed
  7. Kuraji R, Sekino S, Kapila Y, Numabe Y. Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis. Periodontol 2000. 2021 Oct; 87(1):204-240.  View on PubMed
  8. Nguyen T, Brody H, Radaic A, Kapila Y. Probiotics for periodontal health-Current molecular findings. Periodontol 2000. 2021 Oct; 87(1):254-267.  View on PubMed
  9. Martínez A, Kuraji R, Kapila YL. The human oral virome: Shedding light on the dark matter. Periodontol 2000. 2021 Oct; 87(1):282-298.  View on PubMed
  10. Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL. The oral microbiome: Role of key organisms and complex networks in oral health and disease. Periodontol 2000. 2021 Oct; 87(1):107-131.  View on PubMed
  11. Decker AM, Kapila YL, Wang HL. The psychobiological links between chronic stress-related diseases, periodontal/peri-implant diseases, and wound healing. Periodontol 2000. 2021 Oct; 87(1):94-106.  View on PubMed
  12. Curtis DA, Lin GH, Rajendran Y, Gessese T, Suryadevara J, Kapila YL. Treatment planning considerations in the older adult with periodontal disease. Periodontol 2000. 2021 Oct; 87(1):157-165.  View on PubMed
  13. Kao RT, Lin GH, Kapila Y, Sadowsky S, Curtis DA. A Commentary on strategic extraction. J Periodontol. 2021 Aug 26.  View on PubMed
  14. Curtis DA, Sadowsky SJ, Daubert DM, Kapila Y. Survival Versus Success. J Am Dent Assoc. 2021 08; 152(8):586-587.  View on PubMed
  15. Radaic A, Joo NE, Jeong SH, Yoo SI, Kotov N, Kapila YL. Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis. Pharmaceutics. 2021 Jul 17; 13(7).  View on PubMed
  16. Ganther S, Radaic A, Malone E, Kamarajan P, Chang NN, Tafolla C, Zhan L, Fenno JC, Kapila YL. Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells. PLoS Pathog. 2021 Jul; 17(7):e1009311.  View on PubMed
  17. Malone ET, Ganther S, Mena N, Radaic A, Shariati K, Kindberg A, Tafolla C, Kamarajan P, Fenno JC, Zhan L, Kapila YL. Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts. Front Cell Infect Microbiol. 2021; 11:671968.  View on PubMed
  18. Nguyen T, Lee KJ, Chen JL, Xenoudi P, Kapila YL, Kao RT, Lin GH. Therapeutic Prognosis System for Root Coverage Procedures. Int J Periodontics Restorative Dent. 2021 May-Jun; 41(3):383-389.  View on PubMed
  19. Clark D, Halpern B, Miclau T, Nakamura M, Kapila Y, Marcucio R. The Contribution of Macrophages in Old Mice to Periodontal Disease. J Dent Res. 2021 Apr 27; 220345211009463.  View on PubMed
  20. Radaic A, Kapila YL. The oralome and its dysbiosis: New insights into oral microbiome-host interactions. Comput Struct Biotechnol J. 2021; 19:1335-1360.  View on PubMed

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