Research Summary

I am a developmental biologist as well as a pediatrician and clinical geneticist, and I am interested in translating an understanding of developmental mechanisms into advances for regenerative medicine. After completing the MD/PhD degrees and a pediatric residency, I trained in Medical Genetics. As a physician scientist, I treat patients with various syndromes, including those that predispose patients to cancer. As the Chief of the Division of Genetics at UCSF and Chair of the Division of Craniofacial Anomalies at UCSF, I take a strong interest in integrating clinical and research activities. Work in my research group centers on organ development and regeneration, with a major focus on understanding the processes underlying stem cell-based renewal and on integrating evolutionary and developmental approaches.

Research Funding

  • September 5, 2014 - August 31, 2024 - The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironment, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: U01DK103147
  • September 22, 2016 - June 30, 2024 - Harnessing natural stem cell-based strategies for mammalian dental renewal, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R35DE026602
  • July 1, 2019 - April 30, 2024 - Cellular and molecular control of tooth morphogenesis, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE028496
  • March 1, 2018 - January 31, 2023 - Regulation of organogenesis through regional variations in tissue mechanics, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE027620

Education

University of California, Berkeley, B.A., 1993, Spanish
Yale University, New Haven, CT, Ph.D., 1999, Genetics
Yale University, New Haven, CT, M.D., 2000
Yale-New Haven Hospital, New Haven, CT, 2000-2003, Pediatrics
University of California, San Francisco, 2003-2007, Clinical Genetics

Honors & Awards

  • 2010
    New Innovator Award, National Institutes of Health
  • 2013
    Physician Scientist Award, California Institute of Regenerative Medicine
  • 2013
    Elected Member, American Society for Clinical Investigation
  • 2013
    Outstanding Faculty Mentorship Award, UCSF Graduate Students' Association
  • 2014
    Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies, UCSF
  • 2014
    Elected Fellow, American Association for the Advancement of Science (AAAS)
  • 2015
    E. Mead Johnson Award, Society for Pediatric Research
  • 2015
    Faculty Research Lecturer Award, UCSF School of Dentistry
  • 2016
    Charles J. Epstein Professor of Human Genetics, UCSF
  • 2016
    Inaugural Sustaining Outstanding Achievement in Research (SOAR) R35 Award, National Institute of Dental and Craniofacial Research
  • 2017
    Craniofacial Biology Distinguished Scientist Award, International Association for Dental Research
  • 2017
    Lawrence A. Tabak Lecturer, University of Rochester
  • 2018
    Elected Member, National Academy of Medicine (NAM)

Selected Publications

  1. Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition.  View on PubMed
  2. Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.  View on PubMed
  3. Toda S, McKeithan WL, Hakkinen TJ, Lopez P, Klein OD, Lim WA Engineering synthetic morphogen systems that can program multicellular patterning.  View on PubMed
  4. Lu Y, Deng R, You H, Xu Y, Antos C, Sun J, Klein OD, Lu P Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium.  View on PubMed
  5. Krivanek J, Soldatov RA, Kastriti ME, Chontorotzea T, Herdina AN, Petersen J, Szarowska B, Landova M, Matejova VK, Holla LI, Kuchler U, Zdrilic IV, Vijaykumar A, Balic A, Marangoni P, Klein OD, Neves VCM, Yianni V, Sharpe PT, Harkany T, Metscher BD, Bajénoff M, Mina M, Fried K, Kharchenko PV, Adameyko I Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.  View on PubMed
  6. Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research.  View on PubMed
  7. Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions.  View on PubMed
  8. Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.  View on PubMed
  9. Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate.  View on PubMed
  10. Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target.  View on PubMed
  11. Bannister JJ, Crites SR, Aponte JD, Katz DC, Wilms M, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND Fully Automatic Landmarking of Syndromic 3D Facial Surface Scans Using 2D Images.  View on PubMed
  12. Hallgrímsson B, Aponte JD, Katz DC, Bannister JJ, Riccardi SL, Mahasuwan N, McInnes BL, Ferrara TM, Lipman DM, Neves AB, Spitzmacher JAJ, Larson JR, Bellus GA, Pham AM, Aboujaoude E, Benke TA, Chatfield KC, Davis SM, Elias ER, Enzenauer RW, French BM, Pickler LL, Shieh JTC, Slavotinek A, Harrop AR, Innes AM, McCandless SE, McCourt EA, Meeks NJL, Tartaglia NR, Tsai AC, Wyse JPH, Bernstein JA, Sanchez-Lara PA, Forkert ND, Bernier FP, Spritz RA, Klein OD Automated syndrome diagnosis by three-dimensional facial imaging.  View on PubMed
  13. McKinley KL, Castillo-Azofeifa D, Klein OD Tools and Concepts for Interrogating and Defining Cellular Identity.  View on PubMed
  14. Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.  View on PubMed
  15. Körber I, Klein OD, Morhart P, Faschingbauer F, Grange DK, Clarke A, Bodemer C, Maitz S, Huttner K, Kirby N, Durand C, Schneider H Safety and immunogenicity of Fc-EDA, a recombinant ectodysplasin A1 replacement protein, in human subjects.  View on PubMed
  16. Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel M, Itzkovitz S Lgr5+ telocytes are a signaling source at the intestinal villus tip.  View on PubMed
  17. Trentesaux C, Striedinger K, Pomerantz JH, Klein OD From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells.  View on PubMed
  18. Yu T, Klein OD Molecular and cellular mechanisms of tooth development, homeostasis and repair.  View on PubMed
  19. Rajendra C, Wald T, Barber K, Spence JR, Fattahi F, Klein OD Generation of Knockout Gene-Edited Human Intestinal Organoids.  View on PubMed
  20. Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress.  View on PubMed

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