Research Summary

I am a developmental biologist as well as a pediatrician and clinical geneticist, and I am interested in translating an understanding of developmental mechanisms into advances for regenerative medicine. After completing the MD/PhD degrees and a pediatric residency, I trained in Medical Genetics. As a physician scientist, I treat patients with various syndromes, including those that predispose patients to cancer. As the Chief of the Division of Genetics at UCSF and Chair of the Division of Craniofacial Anomalies at UCSF, I take a strong interest in integrating clinical and research activities. Work in my research group centers on organ development and regeneration, with a major focus on understanding the processes underlying stem cell-based renewal and on integrating evolutionary and developmental approaches.

Research Funding

  • September 5, 2014 - August 31, 2024 - The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironment, Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: U01DK103147
  • September 22, 2016 - June 30, 2024 - Harnessing natural stem cell-based strategies for mammalian dental renewal, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R35DE026602
  • July 1, 2019 - April 30, 2024 - Cellular and molecular control of tooth morphogenesis, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE028496
  • March 1, 2018 - January 31, 2023 - Regulation of organogenesis through regional variations in tissue mechanics, Principal Investigator. Sponsor: NIH/NIDCR, Sponsor Award ID: R01DE027620

Education

University of California, Berkeley, B.A., 1993, Spanish
Yale University, New Haven, CT, Ph.D., 1999, Genetics
Yale University, New Haven, CT, M.D., 2000
Yale-New Haven Hospital, New Haven, CT, 2000-2003, Pediatrics
University of California, San Francisco, 2003-2007, Clinical Genetics

Honors & Awards

  • 2010
    New Innovator Award, National Institutes of Health
  • 2013
    Physician Scientist Award, California Institute of Regenerative Medicine
  • 2013
    Elected Member, American Society for Clinical Investigation
  • 2013
    Outstanding Faculty Mentorship Award, UCSF Graduate Students' Association
  • 2014
    Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies, UCSF
  • 2014
    Elected Fellow, American Association for the Advancement of Science (AAAS)
  • 2015
    E. Mead Johnson Award, Society for Pediatric Research
  • 2015
    Faculty Research Lecturer Award, UCSF School of Dentistry
  • 2016
    Charles J. Epstein Professor of Human Genetics, UCSF
  • 2016
    Inaugural Sustaining Outstanding Achievement in Research (SOAR) R35 Award, National Institute of Dental and Craniofacial Research
  • 2017
    Craniofacial Biology Distinguished Scientist Award, International Association for Dental Research
  • 2017
    Lawrence A. Tabak Lecturer, University of Rochester
  • 2018
    Elected Member, National Academy of Medicine (NAM)

Selected Publications

  1. Cazares O, Haque AS, Klein OD. Salivary gland: A budding genius. Dev Cell. 2021 Aug 23; 56(16):2271-2272.  View on PubMed
  2. Kim R, Yu T, Li J, Prochazka J, Sharir A, Green JBA, Klein OD. Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development. Development. 2021 07 15; 148(14).  View on PubMed
  3. Matthews HS, Palmer RL, Baynam GS, Quarrell OW, Klein OD, Spritz RA, Hennekam RC, Walsh S, Shriver M, Weinberg SM, Hallgrimsson B, Hammond P, Penington AJ, Peeters H, Claes PD. Large-scale open-source three-dimensional growth curves for clinical facial assessment and objective description of facial dysmorphism. Sci Rep. 2021 Jun 09; 11(1):12175.  View on PubMed
  4. Tallapragada NP, Cambra HM, Wald T, Keough Jalbert S, Abraham DM, Klein OD, Klein AM. Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids. Cell Stem Cell. 2021 Sep 02; 28(9):1516-1532.e14.  View on PubMed
  5. Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ. Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition. Dev Cell. 2021 02 08; 56(3):356-365.e9.  View on PubMed
  6. Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21).  View on PubMed
  7. Toda S, McKeithan WL, Hakkinen TJ, Lopez P, Klein OD, Lim WA. Engineering synthetic morphogen systems that can program multicellular patterning. Science. 2020 10 16; 370(6514):327-331.  View on PubMed
  8. Lu Y, Deng R, You H, Xu Y, Antos C, Sun J, Klein OD, Lu P. Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium. Cell Rep. 2020 10 13; 33(2):108246.  View on PubMed
  9. Krivanek J, Soldatov RA, Kastriti ME, Chontorotzea T, Herdina AN, Petersen J, Szarowska B, Landova M, Matejova VK, Holla LI, Kuchler U, Zdrilic IV, Vijaykumar A, Balic A, Marangoni P, Klein OD, Neves VCM, Yianni V, Sharpe PT, Harkany T, Metscher BD, Bajénoff M, Mina M, Fried K, Kharchenko PV, Adameyko I. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun. 2020 09 23; 11(1):4816.  View on PubMed
  10. Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research. Development. 2020 09 21; 147(18).  View on PubMed
  11. Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA. Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions. J Dent Res. 2020 11; 99(12):1397-1405.  View on PubMed
  12. Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X. FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020 07 14; 18(1):87.  View on PubMed
  13. Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD. YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. J Dent Res. 2020 11; 99(12):1387-1396.  View on PubMed
  14. Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target. BMC Cancer. 2020 Jun 10; 20(1):542.  View on PubMed
  15. Bannister JJ, Crites SR, Aponte JD, Katz DC, Wilms M, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND. Fully Automatic Landmarking of Syndromic 3D Facial Surface Scans Using 2D Images. Sensors (Basel). 2020 Jun 03; 20(11).  View on PubMed
  16. Hallgrímsson B, Aponte JD, Katz DC, Bannister JJ, Riccardi SL, Mahasuwan N, McInnes BL, Ferrara TM, Lipman DM, Neves AB, Spitzmacher JAJ, Larson JR, Bellus GA, Pham AM, Aboujaoude E, Benke TA, Chatfield KC, Davis SM, Elias ER, Enzenauer RW, French BM, Pickler LL, Shieh JTC, Slavotinek A, Harrop AR, Innes AM, McCandless SE, McCourt EA, Meeks NJL, Tartaglia NR, Tsai AC, Wyse JPH, Bernstein JA, Sanchez-Lara PA, Forkert ND, Bernier FP, Spritz RA, Klein OD. Automated syndrome diagnosis by three-dimensional facial imaging. Genet Med. 2020 10; 22(10):1682-1693.  View on PubMed
  17. McKinley KL, Castillo-Azofeifa D, Klein OD. Tools and Concepts for Interrogating and Defining Cellular Identity. Cell Stem Cell. 2020 05 07; 26(5):632-656.  View on PubMed
  18. Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community. G3 (Bethesda). 2020 05 04; 10(5):1503-1510.  View on PubMed
  19. Körber I, Klein OD, Morhart P, Faschingbauer F, Grange DK, Clarke A, Bodemer C, Maitz S, Huttner K, Kirby N, Durand C, Schneider H. Safety and immunogenicity of Fc-EDA, a recombinant ectodysplasin A1 replacement protein, in human subjects. Br J Clin Pharmacol. 2020 10; 86(10):2063-2069.  View on PubMed
  20. Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel M, Itzkovitz S. Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nat Commun. 2020 04 22; 11(1):1936.  View on PubMed

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