August 5, 1999 - May 31, 2023 - Cancer Center Support Grant , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30CA082103
December 5, 2012 - August 31, 2018 - Mechanism regulating ErbB signaling network in head and neck cancer , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DE022565
April 1, 1995 - August 31, 2013 - Regulation of Survival in Head and Neck Cancer Progression , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56DE011436
April 1, 1995 - December 31, 2009 - Regulation of Survival in Oral Squamous Cell Carcinoma , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DE011436
Education
University of California, Berkeley, B.A., 1971, Biochemistry Yale University School of Medicine, M.S., 1974, Pharmacology Yale University School of Medicine, Ph.D., 1977, Pharmacology University of California, Irvine, Postdoc., 1977-80, Cell Biology
Honors & Awards
1983, 1988 National Institutes of Health, Ad Hoc Reviewer, Pathology B Study Section
1984 International Institute for Microcirculation, Cambridge, England, Research Award
1985 Veterans1 Administration, Career Development Program, Reviewer
1986 National Cancer Institute, Cancer Therapeutics Review Committee, Consultant
1987-1989 National Cancer Institute of Canada, Ad Hoc Reviewer, Panel B
1987-1996 National Science Foundation, Research Grant Program, Reviewer
1989 National Institutes of Health, Pathobiochemistry Study Section, Ad Hoc Reviewer
1990, 1994 National Cancer Institute, Program Project, Ad Hoc Reviewer
1990-1993 Gordon Conference, Basement Membranes, Cell Contact and Adhesion, Invited Speaker
1991, 1993 American Cancer Institute, Advisory Committee on Cell and Developmental Biology
1995, 1996, 1999 Oral Biology and Medicine Study Section, Ad Hoc Reviewer
1999, 2004 NCI Workshop, Head and Neck Cancer
2000 NIDCR Review Panel, Genetic Basis of Oral Cancer
2001, 2003 NIDCR Special Review Panel on Oral Cancer
2002, 2004 NCI Head and Neck SPORE Panel Review
2005, 2006 NIH Tumor Microenvironment Study Section
2006 NIDCR Special Review Panel
Selected Publications
Yang F, Xiao W, Liu Y, Liu R, Kramer R, Li X, Ajena Y, Baehr CM, Rojalin T, Zhang H, Lam KS. One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer. Oncotarget. 2019 Sep 10; 10(52):5468-5479.
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Humtsoe JO, Pham E, Louie RJ, Chan DA, Kramer RH. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene. 2016 Mar 24; 35(12):1554-64.
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Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc. 2012 Dec; 40(12):939-43.
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Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Exp Cell Res. 2012 Feb 15; 318(4):379-90.
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Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res. 2010 Feb; 8(2):170-82.
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Humtsoe JO, Kramer RH. Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene. 2010 Feb 25; 29(8):1214-26.
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Pawlikowski B, Lee L, Zuo J, Kramer RH. Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal. Dev Dyn. 2009 Jan; 238(1):138-49.
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Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol. 2008 Sep; 84(3):701-12.
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El-Sayed I, Huang X, Macheret F, Humstoe JO, Kramer R, El-Sayed M. Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer. Technol Cancer Res Treat. 2007 Oct; 6(5):403-12.
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Onishi A, Chen Q, Humtsoe JO, Kramer RH. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Exp Cell Res. 2008 Jan 15; 314(2):377-86.
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Jethanandani P, Kramer RH. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005 Oct 28; 280(43):36037-46.
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Kramer RH, Shen X, Zhou H. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev. 2005 Jan; 24(1):35-45.
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Zhou H, Kramer RH. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. J Biol Chem. 2005 Mar 18; 280(11):10624-35.
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Shen X, Kramer RH. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 2004 Oct; 165(4):1315-29.
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Chen Q, Lipkina G, Song Q, Kramer RH. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):850-6.
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Xiao J, Jethanandani P, Ziober BL, Kramer RH. Regulation of alpha7 integrin expression during muscle differentiation. J Biol Chem. 2003 Dec 12; 278(50):49780-8.
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Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003 Jul; 313(1):93-105.
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Yeh MG, Ziober BL, Liu B, Lipkina G, Vizirianakis IS, Kramer RH. The beta1 cytoplasmic domain regulates the laminin-binding specificity of the alpha7X1 integrin. Mol Biol Cell. 2003 Sep; 14(9):3507-18.
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Vizirianakis IS, Chen YQ, Kantak SS, Tsiftsoglou AS, Kramer RH. Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells. Int J Oncol. 2002 Jul; 21(1):135-44.
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