Hassan Lemjabbar-Alaoui, PhD

Education

University of Paris VII, B.S., Biology, 1988-1989
University of Paris VII, M.S., Molecular Biology and Immunology, 1989-1991
University of Paris VI, M.S., Biochemistry, 1991-1992
University of Paris VI, Post-Master University Diploma (DU), Clinical Pharmacokinetics and Therapeutics, 1992-1993
University of Paris XIII, Post-Master DE.A of Science, Medical and Biological Engineering, 1993-1994
University of Paris XII, Ph.D., Molecular and Cell Biology, 1994-1997

Honors & Awards

• 2002
  Exceptional rating by Faculty of 1000 Biology, (Lemjabbar and Basbaum. 2002 Nat Med article)*
• 1999
  Cover page: American Journal of Respiratory Cell and Molecular Biology, (Lemjabbar H., et al. Am J Respir Cell Mol Biol, 1999)
• 1995-1997
  Research Student travel grant: French Respiratory Society;.
• 1997
  Travel award from the European Connective Tissue Association;.
• 1994-1998
  French DEBIOPHARM Association Scholarship;
• 1996
  Graduate Student Association Award, University of Paris XII, Faculte de Medecine, Creteil, France
• 1995
  Travel award from the French connective tissue society;
• 1992-1994
  Students and trainees international center Scholarship. France;
• 1986-1991
  Scholarship from the Moroccan Ministry of Research and Higher Education

Selected Publications

1. Yang YW, Jablons DM, Lemjabbar-Alaoui H. Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer. Exp Lung Res. 2021 May-Aug; 47(6):261-279.  View on PubMed
2. Luo X, Campbell NA, He L, O'Brien DR, Singer MS, Lemjabbar-Alaoui H, Ahn KS, Smoot R, Torbenson MS, Rosen SD, Roberts LR. Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis. Hepatology. 2021 Sep; 74(3):1411-1428.  View on PubMed
3. Yang YW, Phillips JJ, Jablons DM, Lemjabbar-Alaoui H. Development of novel monoclonal antibodies and immunoassays for sensitive and specific detection of SULF1 endosulfatase. Biochim Biophys Acta Gen Subj. 2021 02; 1865(2):129802.  View on PubMed
4. Yang YW, Marrufo A, Chase J, Woodard GA, Jablons DM, Lemjabbar-Alaoui H. Ponatinib is a potential therapeutic approach for malignant pleural mesothelioma. Exp Lung Res. 2021 Feb; 47(1):9-25.  View on PubMed
5. Lemjabbar-Alaoui H, Peto CJ, Yang YW, Jablons DM. AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020; 10(8):2649-2676.  View on PubMed
6. Lui NS, Yang YW, van Zante A, Buchanan P, Jablons DM, Lemjabbar-Alaoui H. SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer. PLoS One. 2016; 11(2):e0148911.  View on PubMed
7. Lemjabbar-Alaoui H, Hassan OU, Yang YW, Buchanan P. Lung cancer: Biology and treatment options. Biochim Biophys Acta. 2015 Dec; 1856(2):189-210.  View on PubMed
8. Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips JJ. Glycosylation alterations in lung and brain cancer. Adv Cancer Res. 2015; 126:305-44.  View on PubMed
9. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. Clin Chim Acta. 2015 Feb 02; 440:72-8.  View on PubMed
10. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN. Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection. Cell Microbiol. 2013 Sep; 15(9):1560-71.  View on PubMed
11. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6).  View on PubMed
12. Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C. TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. PLoS One. 2011 Mar 15; 6(3):e17489.  View on PubMed
13. Rosen SD, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49.  View on PubMed
14. Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C. EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis. Oncogene. 2010 Jul 22; 29(29):4145-56.  View on PubMed
15. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64.  View on PubMed
16. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 04; 29(5):635-46.  View on PubMed
17. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C. Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One. 2006 Dec 20; 1:e93.  View on PubMed
18. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9.  View on PubMed
19. Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C. Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK. J Biol Chem. 2004 Sep 10; 279(37):39085-93.  View on PubMed
20. Londhe V, McNamara N, Lemjabbar H, Basbaum C. Viral dsRNA activates mucin transcription in airway epithelial cells. FEBS Lett. 2003 Oct 09; 553(1-2):33-8.  View on PubMed

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