Research Funding

  • August 16, 2012 - June 30, 2017 - Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA168878
  • August 16, 2012 - June 30, 2017 - Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA168878
  • August 16, 2012 - June 30, 2017 - Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA168878
  • August 16, 2012 - June 30, 2018 - Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer, Principal Investigator. Sponsor: NIH, Sponsor Award ID: U01CA168878

Education

University of Paris VII, B.S., Biology, 1988-1989
University of Paris VII, M.S., Molecular Biology and Immunology, 1989-1991
University of Paris VI, M.S., Biochemistry, 1991-1992
University of Paris VI, Post-Master University Diploma (DU), Clinical Pharmacokinetics and Therapeutics, 1992-1993
University of Paris XIII, Post-Master DE.A of Science, Medical and Biological Engineering, 1993-1994
University of Paris XII, Ph.D., Molecular and Cell Biology, 1994-1997

Honors & Awards

  • 2002
    Exceptional rating by Faculty of 1000 Biology, (Lemjabbar and Basbaum. 2002 Nat Med article)*
  • 1999
    Cover page: American Journal of Respiratory Cell and Molecular Biology, (Lemjabbar H., et al. Am J Respir Cell Mol Biol, 1999)
  • 1995-1997
    Research Student travel grant: French Respiratory Society;.
  • 1997
    Travel award from the European Connective Tissue Association;.
  • 1994-1998
    French DEBIOPHARM Association Scholarship;
  • 1996
    Graduate Student Association Award, University of Paris XII, Faculte de Medecine, Creteil, France
  • 1995
    Travel award from the French connective tissue society;
  • 1992-1994
    Students and trainees international center Scholarship. France;
  • 1986-1991
    Scholarship from the Moroccan Ministry of Research and Higher Education

Selected Publications

  1. Luo X, Campbell NA, He L, O'Brien DR, Singer MS, Lemjabbar-Alaoui H, Ahn KS, Smoot R, Torbenson MS, Rosen SD, Roberts LR SULF2 monoclonal antibody 5D5 suppresses human cholangiocarcinoma xenograft growth via regulation of a SULF2-PDGFRβ-YAP signaling axis.  View on PubMed
  2. Yang YW, Phillips JJ, Jablons DM, Lemjabbar-Alaoui H Development of novel monoclonal antibodies and immunoassays for sensitive and specific detection of SULF1 endosulfatase.  View on PubMed
  3. Yang YW, Marrufo A, Chase J, Woodard GA, Jablons DM, Lemjabbar-Alaoui H Ponatinib is a potential therapeutic approach for malignant pleural mesothelioma.  View on PubMed
  4. Lemjabbar-Alaoui H, Peto CJ, Yang YW, Jablons DM AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers.  View on PubMed
  5. Lui NS, Yang YW, van Zante A, Buchanan P, Jablons DM, Lemjabbar-Alaoui H SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer.  View on PubMed
  6. Lemjabbar-Alaoui H, Hassan OU, Yang YW, Buchanan P Lung cancer: Biology and treatment options.  View on PubMed
  7. Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips JJ Glycosylation alterations in lung and brain cancer.  View on PubMed
  8. Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis.  View on PubMed
  9. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection.  View on PubMed
  10. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study.  View on PubMed
  11. Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells.  View on PubMed
  12. Rosen SD, Lemjabbar-Alaoui H Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate.  View on PubMed
  13. Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis.  View on PubMed
  14. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD Use of a phage display antibody to measure the enzymatic activity of the Sulfs.  View on PubMed
  15. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis.  View on PubMed
  16. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer.  View on PubMed
  17. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"?  View on PubMed
  18. Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.  View on PubMed
  19. Londhe V, McNamara N, Lemjabbar H, Basbaum C Viral dsRNA activates mucin transcription in airway epithelial cells.  View on PubMed
  20. Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin.  View on PubMed

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