Education
University of California, Berkeley, B.A., 06/2003, Molecular and Cell Biology
University of California, Berkeley, Ph.D., 05/2008, Molecular Toxicology
The Scripps Research Institute, Postdoc, 07/2011, Chemical Physiology
Honors & Awards
- 2010
NIH Pathway to Independence (PI) Award (K99/R00) - 2012
Searle Scholar Award - 2012
Outstanding Research Achievement Award from Nature Biotechnology/Amgen at SF SciCafe - 2013
Eicosanoid Research Foundation Young Investigator Award - 2013
Selected US (ACS) Representative for Transatlantic Frontiers of Chemistry Conference - 2013
Hellman Fellows Awardee - 2013
Michael J. Fox Foundation Target Validation Award - 2014
ACS Research Scholar Award - 2014
DOD Breakthroughs Award Recipient - 2014
Finalist in DOD Era of Hope Breast Cancer Research Award
Selected Publications
- Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK. (2016) GSTP1 is a driver of triple-negative breast cancer cell metabolism and pathogenicity. Cell Chemical Biology 5, 567-578. PMID 27185638
- Medina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK. (2015) Mapping proteome-wide targets of environmental chemicals using reactivity-based chemoproteomic platforms. Chemistry and Biology 22, 1394-1405. PMID26496688
- Benjamin DI, Li DS, Lowe, W, Heuer T, Kemble G, Nomura DK. (2015) Diacylglycerol metabolism and signaling is a predictive and driving force underlying FASN inhibitor sensitivity in cancer cells. ACS Chemical Biology 10, 1616-1623. PMID: 25871544
- Mulvihill MM, Benjamin DI, LeScolan E, Ji X, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK. (2014) Metabolic Profiling Reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity. Chemistry & Biology 21, 831-840. PMID: 24954006
- Morris PJ*, Medina-Cleghorn D*, Heslin A, King S, Orr J, Krauss RM, Nomura DK. (2014) Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia. ACS Chemical Biology 9, 1097-1103. PMID: 24597639
- Hunerdosse D, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh J, Zhong S, Nomura DK. (2014) Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target. ACS Chemical Biology. Doi: 10.1021/cb500717g. PMID: 25343321
- Medina-Cleghorn D, Heslin A, Morris PJ, Mulvihill MM, Nomura DK. (2014) Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides. ACS Chemical Biology 9, 423-432. PMID: 24205821
- Benjamin DI, Cozzo A, Ji X, Roberts LS, Louie SM, Luo K, Nomura DK. (2013) The ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids that fuel cancer pathogenicity. Proceedings of the National Academy of Sciences, USA 110, 14912-14917. PMID: 23980144
- Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdelyi K, Hao E, Holovac E, Hasko G, Cravatt BF, Nomura DK#, Pal Pacher#. (2013) Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology 144, 808-817. PMID: 23295443
- Piro JR, Benjamin DI, Duerr JM, Pi YQ, Gonzales C, Schwartz JW, Nomura DK#, Samad TA#. (2012) A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease. Cell Reports 1, 617-623. PMID: 22813736
- Nomura DK#, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF#. (2011) Endocannabinoid hydrolysis generates brain eicosanoids that promote neuroinflammation. Science 334, 809-813. PMID: 22021672
- Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008) Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 4, 373-378. PMID: 18438404