University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Manish K. Aghi, MD, PhD

Manish K. Aghi, MD, PhD

Associate Professor in Residence, Department of Neurological Surgery, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

I am a neurosurgeon-scientist, and I have been running a neurosurgical practice caring for brain tumor patients and a basic science lab in the UCSF Brain Tumor Research Center (BTRC) since my initial faculty appointment at UCSF in 2008. Throughout that time, my lab has been well funded by the NIH and numerous private foundations, with the central focus of the lab being mechanisms of angiogenesis, invasion, and therapeutic resistance in brain tumors like glioblastoma, metastases, and pituitary tumors. My clinical practice has developed in parallel with my laboratory, with my glioblastoma and pituitary tumor surgical cases often providing valuable tissue for lab research as part of my clinical and translational research programs. The expertise from my scientific and clinical research has been supplemented by numerous successful collaborations with academic and industry investigators in the past eight years. As a neurosurgeon-scientist, I have mentored numerous medical and graduate students, postdoctoral fellows, and neurosurgery residents on scientific and clinical projects, as well as assisting them developing their careers integrating dual roles combining neurosurgical practices with scientific investigation. My position as a neurosurgeon and scientist specializing in the care of patients with aggressive brain tumors and the role of the tumor microenvironment in driving this aggressive biology and therapeutic resistance uniquely positions me to serve as PI for a variety of grants.

Education

Stanford University (Stanford, CA), BS, 1993, Biological Sciences
Stanford University (Stanford, CA), MS, 1993, Biological Sciences
Harvard Medical School (Boston, MA), MD, 2000, Medicine
Harvard Medical School (Boston, MA), PhD, 2000, Neuroscience


Professional Experience

  • 2000-2001
    Intern, General Surgery, Massachusetts General Hospital, Boston, MA
  • 2001-2007
    Resident, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2007
    Assistant Professor, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2008-2012
    Assistant Professor in Residence, Neurosurgery, University of California, San Francisco, CA
  • 2012-present
    Associate Professor in Residence, Neurosurgery, University of California, San Francisco, CA

Honors & Awards

  • 2004
    Preuss Award, best basic science brain tumor research, American Association of Neurologic Surgeons (AANS) meeting, "Generation of Brain Tumor Neovasculature from Transplanted Bone Marrow."
  • 2005
    Ronald L. Bittner Award, best brain tumor research, American Association of Neurologic Surgeons (AANS) meeting
  • 2005
    William Scoville Resident Research Award, New England Neurosurgery meeting, "Generation of Glioma Neovasculature from Transplanted Bone Marrow."
  • 2005
    Congress of Neurologic Surgeons (CNS) Resident Research Award, "Enhanced Replication of Oncolytic HSV in Glioma Cells that Evade Temozolomide Chemotherapy Through DNA Repair."
  • 2005
    American Academy of Neurologic Surgeons Resident Research Award, "Stromal Derived Factor-1 Interacts with Environmental Cues to Induce Bone Marrow-Derived Cells to Differentiate into Tumor Endothelium and Pericytes."
  • 2006
    Mahaley Award, best clinical study in neuro-oncology, presented at American Association of Neurologic Surgeons (AANS) meeting
  • 2006
    Integra Foundation Award, best benign brain and peripheral nerve tumor research, presented at Congress of Neurologic Surgeons (CNS) meeting
  • 2007
    Synthes Skull Base Award, Congress of Neurologic Surgeons (CNS) meeting
  • 2009
    American Brian Tumor Association (ABTA) Young Investigator Award, Congress of Neurological Surgeons (CNS) meeting

Selected Publications

  1. Wadhwa H, Shah SS, Shan J, Cheng J, Beniwal AS, Chen JS, Gill SA, Mummaneni N, McDermott MW, Berger MS, Aghi MK. The neurosurgery applicant's "arms race": analysis of medical student publication in the Neurosurgery Residency Match. J Neurosurg. 2019 Nov 01; 1-9.
    View on PubMed
  2. Aghi MK, Blevins LS. Introduction to Pituitary Adenomas. Neurosurg Clin N Am. 2019 10; 30(4):xiii.
    View on PubMed
  3. Wang L, Babikir H, Muller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Philips JJ, Aghi MK, Diaz AA. The phenotypes of proliferating glioblastoma cells reside on a single axis of variation. Cancer Discov. 2019 Sep 25.
    View on PubMed
  4. Jahangiri A, Flanigan PM, Arnush M, Chandra A, Rick JW, Choi S, Chou A, Berger MS, Aghi MK. From bench to bedside: trends in National Institutes of Health funding for neurosurgeons from 1991 to 2015. J Neurosurg. 2019 Aug 30; 1-10.
    View on PubMed
  5. Chandra A, Rick J, Yagnik G, Aghi MK. Autophagy as a mechanism for anti-angiogenic therapy resistance. Semin Cancer Biol. 2019 Aug 28.
    View on PubMed
  6. Rick JW, Chandra A, Dalle Ore C, Nguyen AT, Yagnik G, Aghi MK. Fibronectin in malignancy: Cancer-specific alterations, protumoral effects, and therapeutic implications. Semin Oncol. 2019 06; 46(3):284-290.
    View on PubMed
  7. Butowski NA, Bringas JR, Bankiewicz KS, Aghi MK. Editorial. Chronic convection-enhanced delivery: the next frontier in regional drug infusion for glioblastoma. J Neurosurg. 2019 Aug 02; 1-3.
    View on PubMed
  8. Rick JW, Shahin M, Chandra A, Dalle Ore C, Yue JK, Nguyen A, Yagnik G, Sagar S, Arfaie S, Aghi MK. Systemic therapy for brain metastases. Crit Rev Oncol Hematol. 2019 Oct; 142:44-50.
    View on PubMed
  9. Faltermeier CM, Magill ST, Blevins LS, Aghi MK. Molecular Biology of Pituitary Adenomas. Neurosurg Clin N Am. 2019 Oct; 30(4):391-400.
    View on PubMed
  10. Yagnik G, Rutkowski M, Shah SS, Aghi MK. Correction: Stratifying nonfunctional pituitary adenomas into two groups distinguished by macrophage subtypes. Oncotarget. 2019 Jul 02; 10(42):4350.
    View on PubMed
  11. Chandra A, Young JS, Dalle Ore C, Dayani F, Lau D, Wadhwa H, Rick JW, Nguyen AT, McDermott MW, Berger MS, Aghi MK. Insurance type impacts the economic burden and survival of patients with newly diagnosed glioblastoma. J Neurosurg. 2019 Jun 21; 1-11.
    View on PubMed
  12. Dalle Ore CL, Magill ST, Yen AJ, Shahin MN, Lee DS, Lucas CG, Chen WC, Viner JA, Aghi MK, Theodosopoulos PV, Raleigh DR, Villanueva-Meyer JE, McDermott MW. Meningioma metastases: incidence and proposed screening paradigm. J Neurosurg. 2019 Apr 05; 1-9.
    View on PubMed
  13. Lee TJ, Nair M, Banasavadi-Siddegowda Y, Liu J, Nallanagulagari T, Jaime-Ramirez AC, Guo JY, Quadri H, Zhang J, Bockhorst KH, Aghi MK, Carbonell WS, Kaur B, Yoo JY. Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus-1 with Integrin ß1 Blocking Antibody OS2966. Mol Cancer Ther. 2019 Jun; 18(6):1127-1136.
    View on PubMed
  14. Yagnik G, Rutowski MJ, Shah SS, Aghi MK. Stratifying nonfunctional pituitary adenomas into two groups distinguished by macrophage subtypes. Oncotarget. 2019 Mar 15; 10(22):2212-2223.
    View on PubMed
  15. Young JS, Dayani F, Morshed RA, Okada H, Aghi MK. Immunotherapy for High Grade Gliomas: A Clinical Update and Practical Considerations for Neurosurgeons. World Neurosurg. 2019 Jan 21.
    View on PubMed
  16. Flanigan PM, Jahangiri A, Weinstein D, Dayani F, Chandra A, Kanungo I, Choi S, Sankaran S, Molinaro AM, McDermott MW, Berger MS, Aghi MK. Postoperative Delirium in Glioblastoma Patients: Risk Factors and Prognostic Implications. Neurosurgery. 2018 12 01; 83(6):1161-1172.
    View on PubMed
  17. Dalle Ore CL, Chandra A, Rick J, Lau D, Shahin M, Nguyen AT, McDermott M, Berger MS, Aghi MK. Presence of Histopathological Treatment Effects at Resection of Recurrent Glioblastoma: Incidence and Effect on Outcome. Neurosurgery. 2018 Nov 16.
    View on PubMed
  18. Flanigan PM, Jahangiri A, Golubovsky JL, Karnuta JM, May FJ, Berger MS, Aghi MK. A cross-sectional study of neurosurgical department chairs in the United States. J Neurosurg. 2018 11 01; 129(5):1342-1348.
    View on PubMed
  19. Magill ST, Dalle Ore CL, Diaz MA, Jalili DD, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW. Surgical outcomes after reoperation for recurrent non-skull base meningiomas. J Neurosurg. 2018 Nov 01; 1-9.
    View on PubMed
  20. López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. The genetic landscape of gliomas arising after therapeutic radiation. Acta Neuropathol. 2019 Jan; 137(1):139-150.
    View on PubMed

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