University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Manish K. Aghi, MD, PhD

Manish K. Aghi, MD, PhD

Associate Professor in Residence, Department of Neurological Surgery, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

I am a neurosurgeon-scientist, and I have been running a neurosurgical practice caring for brain tumor patients and a basic science lab in the UCSF Brain Tumor Research Center (BTRC) since my initial faculty appointment at UCSF in 2008. Throughout that time, my lab has been well funded by the NIH and numerous private foundations, with the central focus of the lab being mechanisms of angiogenesis, invasion, and therapeutic resistance in brain tumors like glioblastoma, metastases, and pituitary tumors. My clinical practice has developed in parallel with my laboratory, with my glioblastoma and pituitary tumor surgical cases often providing valuable tissue for lab research as part of my clinical and translational research programs. The expertise from my scientific and clinical research has been supplemented by numerous successful collaborations with academic and industry investigators in the past eight years. As a neurosurgeon-scientist, I have mentored numerous medical and graduate students, postdoctoral fellows, and neurosurgery residents on scientific and clinical projects, as well as assisting them developing their careers integrating dual roles combining neurosurgical practices with scientific investigation. My position as a neurosurgeon and scientist specializing in the care of patients with aggressive brain tumors and the role of the tumor microenvironment in driving this aggressive biology and therapeutic resistance uniquely positions me to serve as PI for a variety of grants.

Education

Stanford University (Stanford, CA), BS, 1993, Biological Sciences
Stanford University (Stanford, CA), MS, 1993, Biological Sciences
Harvard Medical School (Boston, MA), MD, 2000, Medicine
Harvard Medical School (Boston, MA), PhD, 2000, Neuroscience


Professional Experience

  • 2000-2001
    Intern, General Surgery, Massachusetts General Hospital, Boston, MA
  • 2001-2007
    Resident, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2007
    Assistant Professor, Neurosurgery, Massachusetts General Hospital, Boston, MA
  • 2008-2012
    Assistant Professor in Residence, Neurosurgery, University of California, San Francisco, CA
  • 2012-present
    Associate Professor in Residence, Neurosurgery, University of California, San Francisco, CA

Honors & Awards

  • 2004
    Preuss Award, best basic science brain tumor research, American Association of Neurologic Surgeons (AANS) meeting, "Generation of Brain Tumor Neovasculature from Transplanted Bone Marrow."
  • 2005
    Ronald L. Bittner Award, best brain tumor research, American Association of Neurologic Surgeons (AANS) meeting
  • 2005
    William Scoville Resident Research Award, New England Neurosurgery meeting, "Generation of Glioma Neovasculature from Transplanted Bone Marrow."
  • 2005
    Congress of Neurologic Surgeons (CNS) Resident Research Award, "Enhanced Replication of Oncolytic HSV in Glioma Cells that Evade Temozolomide Chemotherapy Through DNA Repair."
  • 2005
    American Academy of Neurologic Surgeons Resident Research Award, "Stromal Derived Factor-1 Interacts with Environmental Cues to Induce Bone Marrow-Derived Cells to Differentiate into Tumor Endothelium and Pericytes."
  • 2006
    Mahaley Award, best clinical study in neuro-oncology, presented at American Association of Neurologic Surgeons (AANS) meeting
  • 2006
    Integra Foundation Award, best benign brain and peripheral nerve tumor research, presented at Congress of Neurologic Surgeons (CNS) meeting
  • 2007
    Synthes Skull Base Award, Congress of Neurologic Surgeons (CNS) meeting
  • 2009
    American Brian Tumor Association (ABTA) Young Investigator Award, Congress of Neurological Surgeons (CNS) meeting

Selected Publications

  1. Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK. Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution. Neurosurg Focus. 2020 Jun; 48(6):E13.
    View on PubMed
  2. Chandra A, Pereira MP, Aghi MK. In Reply to the Letter to the Editor Regarding "The Path to U.S. Neurosurgical Residency for Foreign Medical Graduates: Trends from a Decade 2007-2017". World Neurosurg. 2020 Jun; 138:594.
    View on PubMed
  3. Chandra A, Aghi MK. Letter to the Editor Regarding "Geographic Distribution of International Medical Graduate Residents in U.S. Neurosurgery Training Programs". World Neurosurg. 2020 Jun; 138:591.
    View on PubMed
  4. Chandra A, Aghi MK. Strategies to Address Projected Challenges Facing Foreign Applicants in the U.S. Neurosurgery Match. World Neurosurg. 2020 Jun; 138:553-555.
    View on PubMed
  5. Young JS, Chan AK, Viner JA, Sankaran S, Chan AY, Imershein S, Meary-Miller A, Theodosopoulos PV, Jacques L, Aghi MK, Chang EF, Hervey-Jumper SL, Ward T, Gibson L, Ward MM, Sanftner P, Wong S, Amara D, Magill ST, Osorio JA, Venkatesh B, Gonzales R, Lau C, Boscardin C, Wang M, Berry K, McCullagh L, Reid M, Reels K, Nedkov S, Berger MS, McDermott MW. A Safe Transitions Pathway for post-craniotomy neurological surgery patients: high-value care that bypasses the intensive care unit. J Neurosurg. 2020 May 29; 1-6.
    View on PubMed
  6. David AP, Jiam NT, Reither JM, Gurrola JG, Aghi MK, El-Sayed IH. Endoscopic skull base and transoral surgery during COVID-19 pandemic: Minimizing droplet spread with negative-pressure otolaryngology viral isolation drape. Head Neck. 2020 May 01.
    View on PubMed
  7. Morshed RA, Reihl SJ, Molinaro AM, Kakaizada S, Young JS, Schulte JD, Butowski N, Taylor J, Bush NA, Aghi MK, Berger MS, Chang S, Clarke J, Hervey-Jumper SL. The influence of race and socioeconomic status on therapeutic clinical trial screening and enrollment. J Neurooncol. 2020 Apr 29.
    View on PubMed
  8. Schulte JD, Aghi MK, Taylor JW. Anti-angiogenic therapies in the management of glioblastoma. Chin Clin Oncol. 2020 Apr 21.
    View on PubMed
  9. Ramakrishna R, Zadeh G, Sheehan JP, Aghi MK. Inpatient and outpatient case prioritization for patients with neuro-oncologic disease amid the COVID-19 pandemic: general guidance for neuro-oncology practitioners from the AANS/CNS Tumor Section and Society for Neuro-Oncology. J Neurooncol. 2020 May; 147(3):525-529.
    View on PubMed
  10. Morshed RA, Lee AT, Egladyous A, Avalos LN, Aghi MK, Theodosopoulos PV, McDermott MW, Hervey-Jumper SL. Shunt Treatment for Coccidioidomycosis-Related Hydrocephalus: A Single-Center Series. World Neurosurg. 2020 Jun; 138:e883-e891.
    View on PubMed
  11. Dalle Ore CL, Magill ST, Rodriguez Rubio R, Shahin MN, Aghi MK, Theodosopoulos PV, Villanueva-Meyer JE, Kersten RC, Idowu OO, Vagefi MR, McDermott MW. Hyperostosing sphenoid wing meningiomas: surgical outcomes and strategy for bone resection and multidisciplinary orbital reconstruction. J Neurosurg. 2020 Mar 06; 1-10.
    View on PubMed
  12. Chandra A, Brandel MG, Wadhwa H, Almeida ND, Yue JK, Nuru MO, Cheng J, Lu S, Patel A, Essayed W, McDermott MW, Berger MS, Aghi MK. The Path to U.S. Neurosurgical Residency for Foreign Medical Graduates: Trends from a Decade 2007-2017. World Neurosurg. 2020 May; 137:e584-e596.
    View on PubMed
  13. Chandra A, Jahangiri A, Chen W, Nguyen AT, Yagnik G, Pereira MP, Jain S, Garcia JH, Shah SS, Wadhwa H, Joshi RS, Weiss J, Wolf KJ, Lin JG, Müller S, Rick JW, Diaz AA, Gilbert LA, Kumar S, Aghi MK. Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance. Cancer Res. 2020 Apr 01; 80(7):1498-1511.
    View on PubMed
  14. Molinaro AM, Hervey-Jumper S, Morshed RA, Young J, Han SJ, Chunduru P, Zhang Y, Phillips JJ, Shai A, Lafontaine M, Crane J, Chandra A, Flanigan P, Jahangiri A, Cioffi G, Ostrom Q, Anderson JE, Badve C, Barnholtz-Sloan J, Sloan AE, Erickson BJ, Decker PA, Kosel ML, LaChance D, Eckel-Passow J, Jenkins R, Villanueva-Meyer J, Rice T, Wrensch M, Wiencke JK, Oberheim Bush NA, Taylor J, Butowski N, Prados M, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Berger MS. Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma. JAMA Oncol. 2020 Feb 06.
    View on PubMed
  15. Nagler EM, Aghi M, Rathore A, Lando H, Pednekar MS, Gupta PC, Stoddard AM, Kenwood C, Penningroth B, Sinha DN, Sorensen G. Factors associated with successful tobacco use cessation among teachers in Bihar state, India: a mixed-method study. Health Educ Res. 2020 Feb 01; 35(1):60-73.
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  16. Chen R, Aghi MK. Atypical meningiomas. Handb Clin Neurol. 2020; 170:233-244.
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  17. Shah SS, Aghi MK. The Role of Single-Nucleotide Polymorphisms in Pituitary Adenomas Tumorigenesis. Cancers (Basel). 2019 Dec 09; 11(12).
    View on PubMed
  18. Dalle Ore CL, Chandra A, Rick J, Lau D, Shahin M, Nguyen AT, McDermott M, Berger MS, Aghi MK. Presence of Histopathological Treatment Effects at Resection of Recurrent Glioblastoma: Incidence and Effect on Outcome. Neurosurgery. 2019 12 01; 85(6):793-800.
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  19. Wadhwa H, Shah SS, Shan J, Cheng J, Beniwal AS, Chen JS, Gill SA, Mummaneni N, McDermott MW, Berger MS, Aghi MK. The neurosurgery applicant's "arms race": analysis of medical student publication in the Neurosurgery Residency Match. J Neurosurg. 2019 Nov 01; 1-9.
    View on PubMed
  20. Aghi MK, Blevins LS. Introduction to Pituitary Adenomas. Neurosurg Clin N Am. 2019 10; 30(4):xiii.
    View on PubMed

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