University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
A. James Barkovich, MD

A. James Barkovich, MD

Professor in Residence, Departments of Radiology, Pediatrics, Neurology, and Neurological Surgery, UCSF

Cancer Center Program Memberships

Affiliate Member

Research Summary

A. James Barkovich, MD, is a Professor in Residence and he is Chief of Pediatric Neuroradiology in the Department of Radiology at the University of California, San Francisco. Dr. Barkovich received his medical degree from George Washington University, Washington, D.C., and completed his residency in Radiology from Letterman AMC, San Francisco in 1984, followed by a fellowship in Neuroradiology from Walter Reed AMC in 1986. Dr. Barkovich was also President of the American Society of Neuroradiology 1998-1999 and Secretary General of the World Federation of Neuroradiological Societies from 2002-2006.

Dr. Barkovich serves as the Chief of Pediatric Neuroradiology in the UCSF Department of Radiology and Biomedical Imaging. He specializes in the diagnosis of neurological disorders in infants and children. His main research interests include neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development.

Dr. Barkovich’s research established correlations between MR findings and the outcome in affected patients. He has 385 published articles, and has authored or co-authored 9 textbooks and 41 book chapters, and he has written and contributed to a collective of more than 400 research documents.

Expertise:

NeuroRadiologist

Specialty:

Pediatric Neuroradiology

Professional Interests:

Neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development

Education and Training:

• Medical School: George Washington University, Washington, DC (1976-1980)

• Internship: Letterman AMC, San Francisco - Radiology (1980-1981)

• Residency: Letterman AMC, San Francisco - Radiology (1981-1984)

• Fellowship: Walter Reed AMC, Washington, DC - Neuroradiology (1984-1986)

• California Medical License

• Ohio State Medical License (inactive)

• New York State Medical License (inactive)

• American Board of Radiology (1984)

• Certificate of Added Qualification in Neuroradiology (1996, 2006)

Education

Univ. of CA, Davis, BS, 1974, Chemistry
Univ. of CA, Berkeley, MS, 1977, Chemistry Passed Oral Examination for Ph.D., was advanced to candidacy for Ph.D., but did not complete dissertation
Geo. Washington Univ., Washington, D.C., MD, 1980, Medicine
Letterman AMC, San Francisco, CA, Intern, 1980-1981, Radiology
Letterman, AMC, San Francisco, CA, Resident, 1981-1984, Radiology
Walter Reed AMC, Washington, D.C., Fellowship, 1984-1986, Neuroradiology
 


Professional Experience

  • 1971-1972
    Chemistry Department, Research Assistant, Univ. of CA, Davis
  • 1972
    Chemistry Dept. Research Assistant Univ. of CA, Berkeley Teaching Assistant
  • 1974-1972
    U.S. Army, Medical Student, Intern, Radiology Resident, Neuroradiology Fellow, Neuroradiologist, Served on active duty (highest rank - Major) in U.S. Army
  • 1984-1982
    Instructor in Radiology, F. Edward Hébert School of Medicine, Uniformed Services University of Health Sciences
  • 1987-1982
    Assistant Clinical Professor of Radiology, Uniformed Services University of Health Sciences
  • 1986-1982
    Assistant Clinical Professor of Radiology, University of California, San Francisco
  • 1989-1992
    Associate Professor of Radiology, Pediatrics, Neurology and Neurological Surgery in Residence, University of California, San Francisco
  • Present
    Professor of Radiology, Pediatrics, Neurology and Neurosurgery in Residence, University of California, San Francisco

Honors & Awards

  • 1972
    Edward F. Kraft Scholarship Award, U.C. Davis
  • 1973-1972
    President's Undergraduate Research Fellow
  • 1972
    U.S. Atomic Energy Commission Summer Research Fellow,
  • 1982
    Honorable Mention, Exhibit, RSNA Annual Meeting
  • 1992
    Outstanding Teacher Award, Department of Neurology, UCSF
  • 1992
    Editors Excellence for Outstanding Scientific Research, J Comput Assist Tomogr
  • 1992
    Elected to "Best Doctors in America"
  • 1992
    Elected to "Best Doctors in America, Pacific Region"
  • 1992
    Nycomed Distinguished Visiting Lecturer, Armed Forces Institute of Pathology
  • 1992
    Selected to Who's Who in Medicine and Health Care
  • 1992
    Goldenson Technology Award, United Cerebral Palsy Research Foundation
  • 1992
    Selected to Who's Who in the World, 15th Edition
  • 2002
    Selected to Who's Who in Medicine and Health Care
  • 2002
    Selected to Who's Who in America, 57th Edition
  • 2002 and 2002
    Listed in "America's Top Doctors"
  • 2002 and 2002
    Elected to "Best Doctors in America"

Selected Publications

  1. Oegema R, Barkovich AJ, Mancini GMS, Guerrini R, Dobyns WB. Subcortical heterotopic gray matter brain malformations: Classification study of 107 individuals. Neurology. 2019 Sep 04.
    View on PubMed
  2. Aldinger KA, Timms AE, Thomson Z, Mirzaa GM, Bennett JT, Rosenberg AB, Roco CM, Hirano M, Abidi F, Haldipur P, Cheng CV, Collins S, Park K, Zeiger J, Overmann LM, Alkuraya FS, Biesecker LG, Braddock SR, Cathey S, Cho MT, Chung BHY, Everman DB, Zarate YA, Jones JR, Schwartz CE, Goldstein A, Hopkin RJ, Krantz ID, Ladda RL, Leppig KA, McGillivray BC, Sell S, Wusik K, Gleeson JG, Nickerson DA, Bamshad MJ, Gerrelli D, Lisgo SN, Seelig G, Ishak GE, Barkovich AJ, Curry CJ, Glass IA, Millen KJ, Doherty D, Dobyns WB. Redefining the Etiologic Landscape of Cerebellar Malformations. Am J Hum Genet. 2019 Sep 05; 105(3):606-615.
    View on PubMed
  3. Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH. Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease. Stem Cell Reports. 2019 Aug 13; 13(2):254-261.
    View on PubMed
  4. Sands TT, Miceli F, Lesca G, Beck AE, Sadleir LG, Arrington DK, Schönewolf-Greulich B, Moutton S, Lauritano A, Nappi P, Soldovieri MV, Scheffer IE, Mefford HC, Stong N, Heinzen EL, Goldstein DB, Perez AG, Kossoff EH, Stocco A, Sullivan JA, Shashi V, Gerard B, Francannet C, Bisgaard AM, Tümer Z, Willems M, Rivier F, Vitobello A, Thakkar K, Rajan DS, Barkovich AJ, Weckhuysen S, Cooper EC, Taglialatela M, Cilio MR. Autism and developmental disability caused by KCNQ3 gain-of-function variants. Ann Neurol. 2019 Aug; 86(2):181-192.
    View on PubMed
  5. Numis AL, Foster-Barber A, Deng X, Rogers EE, Barkovich AJ, Ferriero DM, Glass HC. Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. Pediatr Res. 2019 Jun 24.
    View on PubMed
  6. Hsieh A, Tabbutt S, Xu D, Barkovich AJ, Miller S, McQuillen P, Peyvandi S. Impact of Perioperative Brain Injury and Development on Feeding Modality in Infants With Single Ventricle Heart Disease. J Am Heart Assoc. 2019 May 21; 8(10):e012291.
    View on PubMed
  7. Barkovich MJ, Barkovich AJ. MR Imaging of Normal Brain Development. Neuroimaging Clin N Am. 2019 Aug; 29(3):325-337.
    View on PubMed
  8. van der Linden V, de Lima Petribu NC, Pessoa A, Faquini I, Paciorkowski AR, van der Linden H, Silveira-Moriyama L, Cordeiro MT, Hazin AN, Barkovich AJ, Raybaud C, de Brito Abath M, Ribeiro E, Barros Jucá CE, Aragão MFVV, Coelho Travassos PT, Jungmann P. Association of Severe Hydrocephalus With Congenital Zika Syndrome. JAMA Neurol. 2019 Feb 01; 76(2):203-210.
    View on PubMed
  9. Gano D, Barkovich AJ. Cerebellar hypoplasia of prematurity: Causes and consequences. Handb Clin Neurol. 2019; 162:201-216.
    View on PubMed
  10. Kamino D, Chau V, Studholme C, Liu M, Xu D, Barkovich AJ, Ferriero DM, Miller SP, Brant R, Tam EWY. Plasma cholesterol levels and brain development in preterm newborns. Pediatr Res. 2019 Feb; 85(3):299-304.
    View on PubMed
  11. Khalil R, Kenny C, Hill RS, Mochida GH, Nasir R, Partlow JN, Barry BJ, Al-Saffar M, Egan C, Stevens CR, Gabriel SB, Barkovich AJ, Ellison JW, Al-Gazali L, Walsh CA, Chahrour MH. PSMD12 haploinsufficiency in a neurodevelopmental disorder with autistic features. Am J Med Genet B Neuropsychiatr Genet. 2018 12; 177(8):736-745.
    View on PubMed
  12. Tymofiyeva O, Gano D, Trevino RJ, Glass HC, Flynn T, Lundy SM, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D. Aberrant Structural Brain Connectivity in Adolescents with Attentional Problems Who Were Born Prematurely. AJNR Am J Neuroradiol. 2018 11; 39(11):2140-2147.
    View on PubMed
  13. D'Arco F, Alves CA, Raybaud C, Chong WKK, Ishak GE, Ramji S, Grima M, Barkovich AJ, Ganesan V. Expanding the Distinctive Neuroimaging Phenotype of ACTA2 Mutations. AJNR Am J Neuroradiol. 2018 11; 39(11):2126-2131.
    View on PubMed
  14. Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, Andreassen OA, Jernigan T, Dale A, Barkovich AJ, Desikan RS, Sugrue LP. Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Sci Rep. 2018 09 06; 8(1):13373.
    View on PubMed
  15. Barkovich MJ, Tan CH, Nillo RM, Li Y, Xu D, Glastonbury CM, Glenn OA, Dillon WP, Hess CP, Mueller S, Kline C, Dale AM, Jernigan TL, Sugrue LP, Barkovich AJ, Desikan RS. Abnormal Morphology of Select Cortical and Subcortical Regions in Neurofibromatosis Type 1. Radiology. 2018 11; 289(2):499-508.
    View on PubMed
  16. Smith RS, Kenny CJ, Ganesh V, Jang A, Borges-Monroy R, Partlow JN, Hill RS, Shin T, Chen AY, Doan RN, Anttonen AK, Ignatius J, Medne L, Bönnemann CG, Hecht JL, Salonen O, Barkovich AJ, Poduri A, Wilke M, de Wit MCY, Mancini GMS, Sztriha L, Im K, Amrom D, Andermann E, Paetau R, Lehesjoki AE, Walsh CA, Lehtinen MK. Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development. Neuron. 2018 09 05; 99(5):905-913.e7.
    View on PubMed
  17. Jakchairoongruang K, Khakoo Y, Beckwith M, Barkovich AJ. New insights into neurocutaneous melanosis. Pediatr Radiol. 2018 11; 48(12):1786-1796.
    View on PubMed
  18. Guo T, Chau V, Peyvandi S, Latal B, McQuillen PS, Knirsch W, Synnes A, Feldmann M, Naef N, Chakravarty MM, De Petrillo A, Duerden EG, Barkovich AJ, Miller SP. White matter injury in term neonates with congenital heart diseases: Topology & comparison with preterm newborns. Neuroimage. 2019 01 15; 185:742-749.
    View on PubMed
  19. Bierstone D, Wagenaar N, Gano DL, Guo T, Georgio G, Groenendaal F, de Vries LS, Varghese J, Glass HC, Chung C, Terry J, Rijpert M, Grunau RE, Synnes A, Barkovich AJ, Ferriero DM, Benders M, Chau V, Miller SP. Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates. JAMA Pediatr. 2018 06 01; 172(6):534-541.
    View on PubMed
  20. Peyvandi S, Chau V, Guo T, Xu D, Glass HC, Synnes A, Poskitt K, Barkovich AJ, Miller SP, McQuillen PS. Neonatal Brain Injury and Timing of Neurodevelopmental Assessment in Patients With Congenital Heart Disease. J Am Coll Cardiol. 2018 05 08; 71(18):1986-1996.
    View on PubMed

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