University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Katja Brueckner, PhD

Katja Brueckner, PhD

Associate Professor, Departments of Cell/Tissue Biology and Anatomy, UCSF

Cancer Center Program Memberships

Hematopoietic Malignancies

Research Summary

Katja Brueckner received her PhD. in biology and cell signalling from the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany. She performed her postdoctoral studies at the EMBL and Harvard Medical School. Katja was a Howard Hughes Medical Institute Associate, long-term post-doctoral fellow of the European Molecular Biology Organization (EMBO) and Human Frontier Science Program (HFSP), and Special Fellow of the Leukemia & Lymphoma Society (LLS). For her post-doctoral studies, the LLS awarded Katja with the Brian P. ODell Memorial Research Award. Since joining the faculty of UCSF in late 2006, Katja has received a Hellman Family Scholar Award, an American Cancer Society Research Scholar Award, an American Heart Association career development award, and she is funded by research grants from the National Science Foundation and the National Institutes of Health.


Max-Planck-Institute for Biochemistry and Ludwig-Maximilians-University, Munich, Dipl. Biol. (Masters), 1994, Genetics, Biochemistry, Microbiology, Medical Microbiology; Thesis in Signal Transduction
European Molecular Biology Laboratory (EMBL), Heidelberg, and University of Heidelberg, Ph.D., 1994-1999, Cell Signaling
European Molecular Biology Laboratory (EMBL), Heidelberg, Postdoc, 1999-2000, Developmental Biology and Cell Signaling
Harvard Medical School, Boston, Postdoc, 2000-2006, Developmental Biology and Cell Signaling

Professional Experience

  • 2006-2015
    Assistant Professor, Department of Cell and Tissue Biology, Department of Anatomy, UCSF
  • 2015-present
    Associate Professor, Department of Cell and Tissue Biology, Department of Anatomy, UCSF

Honors & Awards

  • 1994
    Diploma degree received with highest mark
  • 1999
    Ph.D. degree received with summa cum laude
  • 1994-1999
    EMBL predoctoral fellow
  • 2000-2001
    Howard Hughes Medical Institute associate
  • 2001
    EMBO long-term fellow
  • 2001-2006
    HFSP long-term fellow
  • 2003-2007
    The Leukemia & Lymphoma Society Special Fellow
  • 2005
    Brian P. O'Dell Memorial Research Award from The Leukemia & Lymphoma Society
  • 2011
    Hellman Fellows Program Scholar
  • 2013
    American Cancer Society Research Scholar

Selected Publications

  1. Brückner K. Renal Function: Guardian of Immune Homeostasis. Immunity. 2019 10 15; 51(4):596-598.
    View on PubMed
  2. Petraki, S., Alexander, B., Brückner, K... Assaying blood cell populations of the Drosophila melanogaster larva. Journal of Visualized Experiments (JoVE). 2015; (In press).
    View on PubMed
  3. Gold KS, Brückner K. Drosophila as a model for the two myeloid blood cell systems in vertebrates. Exp Hematol. 2014 Aug; 42(8):717-27.
    View on PubMed
  4. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19.
    View on PubMed
  5. Makhijani K, Brückner K. Of blood cells and the nervous system: hematopoiesis in the Drosophila larva. Fly (Austin). 2012 Oct-Dec; 6(4):254-60.
    View on PubMed
  6. Kelsey EM, Luo X, Brückner K, Jasper H. Schnurri regulates hemocyte function to promote tissue recovery after DNA damage. J Cell Sci. 2012 Mar 15; 125(Pt 6):1393-400.
    View on PubMed
  7. Brückner K. Blood cells need glia, too: a new role for the nervous system in the bone marrow niche. Cell Stem Cell. 2011 Dec 02; 9(6):493-5.
    View on PubMed
  8. Makhijani K, Alexander B, Tanaka T, Rulifson E, Brückner K. The peripheral nervous system supports blood cell homing and survival in the Drosophila larva. Development. 2011 Dec; 138(24):5379-91.
    View on PubMed
  9. Kockel L, Kerr KS, Melnick M, Brückner K, Hebrok M, Perrimon N. Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet. 2010 Jun 17; 6(6):e1000990.
    View on PubMed
  10. Brückner K, Kockel L, Duchek P, Luque CM, Rørth P, Perrimon N. The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell. 2004 Jul; 7(1):73-84.
    View on PubMed
  11. Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Mañes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martínez C, Klein R. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001 May; 2(5):446-52.
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  12. Brückner K, Perez L, Clausen H, Cohen S. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature. 2000 Jul 27; 406(6794):411-5.
    View on PubMed
  13. Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 1999 Mar; 22(3):511-24.
    View on PubMed
  14. Brückner K, Klein R. Signaling by Eph receptors and their ephrin ligands. Curr Opin Neurobiol. 1998 Jun; 8(3):375-82.
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  15. Brückner K, Pasquale EB, Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science. 1997 Mar 14; 275(5306):1640-3.
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  16. Brambilla R, Brückner K, Orioli D, Bergemann AD, Flanagan JG, Klein R. Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Mol Cell Neurosci. 1996; 8(2-3):199-209.
    View on PubMed

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