University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Carolyn S. Calfee, MD

Carolyn S. Calfee, MD

Associate Professor, Department of Medicine, UCSF

Cancer Center Program Memberships

Tobacco Control

Research Summary

My research program focuses on clinical and translational approaches to studying the development of the Acute Respiratory Distress Syndrome (ARDS) in critically ill patients. I have two major areas of focus: (1) the prognostic and pathogenetic value of biomarkers of lung epithelial and endothelial injury in ARDS, including novel approaches to molecular phenotyping of ARDS; and (2) the epidemiology and mechanisms of association between active and passive cigarette smoke exposure and the development of ARDS. I also have a particular interest in the early identification of patients with or at high risk for ARDS, with several publications on clinical and biological approaches to early detection of ARDS.

Education

Yale University, BA, 1991-1995, English
University of Pennsylvania, MD, 1995-1999, Medicine
University of California, San Francisco Internship/Residency, 1999-2002, Internal Medicine
University of California, San Francisco Chief Residency, 2002-2003, Internal Medicine
University of California, San Francisco Fellowship, 2003-2007, Pulmonary/Critical Care
University of California, San Francisco Masters in Clinical Research (expected), 2007-2009, Clinical Research


Professional Experience

  • PROFESSIONAL EXPERIENCE
  • 1999-2002
    Internship and Residency, Internal Medicine, University of California, San Francisco
  • 2002-2003
    Chief Medical Resident, Internal Medicine, Moffitt-Long Hospital, UCSF
  • 2002-2003
    Clinical Instructor, Department of Medicine, UCSF
  • 2002-2003
    Attending Physician, Medical Service, Moffitt-Long Hospital, UCSF
  • 2003-2004
    Clinical Fellow, Pulmonary and Critical Care Division, UCSF
  • 2005-2006
    Advanced Training in Clinical Research Program, UCSF Department of Epidemiology and Biostatistics
  • 2005-2007
    Research Fellow, Pulmonary and Critical Care Division, UCSF
  • 2007-2012
    Assistant Professor, Pulmonary and Critical Care Division, UCSF Dept of Medicine
  • 2012-present
    Associate Professor, Pulmonary and Critical Care Division, UCSF Depts of Medicine and Anesthesia
  • 2007-present
    Faculty, Center for Tobacco Control, Research, and Education, UCSF

Honors & Awards

  • 1994
    Phi Beta Kappa, Yale University
  • 1995
    Bachelor of Arts awarded magna cum laude, with Distinction in the Major
  • 1998
    Alpha Omega Alpha, University of Pennsylvania School of Medicine
  • 1999
    Julia M. Glasgow Award, University of Pennsylvania School of Medicine
  • 1999
    Spencer Morris Prize, University of Pennsylvania School of Medicine
  • 2000
    Intern of the Year, University of California, San Francisco, Department of Medicine
  • 2005
    Walter Travel Award, American Lung Association
  • 2012
    Associate Scientific Advisor, Science Translational Medicine
  • 2013
    American Society for Clinical Investigation Young Physician-Scientist Award
  • 2013
    Highlighted abstract, 2013 American Thoracic Society International Conference (sr. author)
  • 2013
    Finalist, UCSF Pathways to Discovery Mentor Award

Selected Publications

  1. Morales-Quinteros L, Schultz MJ, Bringué J, Calfee CS, Camprubí M, Cremer OL, Horn J, van der Poll T, Sinha P, Artigas A, Bos LD. Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS. Ann Intensive Care. 2019 Nov 21; 9(1):128.
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  2. Langelier C, Fung M, Caldera S, Deiss T, Lyden A, Prince BC, Hayakawa Serpa P, Moazed F, Chin-Hong P, DeRisi JL, Calfee CS. Detection of Pneumonia Pathogens from Plasma Cell-Free DNA. Am J Respir Crit Care Med. 2019 Oct 24.
    View on PubMed
  3. Sarma A, Calfee CS, Ware LB. Biomarkers and Precision Medicine: State of the Art. Crit Care Clin. 2020 Jan; 36(1):155-165.
    View on PubMed
  4. Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. Peripheral Blood Leukocyte Telomere Length is Associated with Survival of Sepsis Patients. Eur Respir J. 2019 Oct 16.
    View on PubMed
  5. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. Clinically Relevant Model of Pneumococcal Pneumonia, ARDS, and Non-Pulmonary Organ Dysfunction in Mice. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11.
    View on PubMed
  6. Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ. Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. Am J Respir Crit Care Med. 2019 Sep 05.
    View on PubMed
  7. Quan J, Langelier C, Kuchta A, Batson J, Teyssier N, Lyden A, Caldera S, McGeever A, Dimitrov B, King R, Wilheim J, Murphy M, Ares LP, Travisano KA, Sit R, Amato R, Mumbengegwi DR, Smith JL, Bennett A, Gosling R, Mourani PM, Calfee CS, Neff NF, Chow ED, Kim PS, Greenhouse B, DeRisi JL, Crawford ED. FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences. Nucleic Acids Res. 2019 Aug 22; 47(14):e83.
    View on PubMed
  8. Hendrickson CM, Calfee CS. A new frontier in ARDS trials: phenotyping before randomisation. Lancet Respir Med. 2019 Oct; 7(10):830-831.
    View on PubMed
  9. Sinha P, Calfee CS. Inflammasomes Assemble: Cytoplasmic Guardians or Fallen Heroes? Crit Care Med. 2019 Aug; 47(8):1161-1163.
    View on PubMed
  10. Kornblith LZ, Robles AJ, Conroy AS, Redick BJ, Howard BM, Hendrickson CM, Moore S, Nelson MF, Moazed F, Callcut RA, Calfee CS, Cohen MJ. Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation. J Trauma Acute Care Surg. 2019 Aug; 87(2):371-378.
    View on PubMed
  11. Sinha P, Calfee CS. Peeking under the Hood of Acute Respiratory Distress Syndrome Phenotypes: Deeper Insights into Biological Heterogeneity. Am J Respir Crit Care Med. 2019 Jul 01; 200(1):4-6.
    View on PubMed
  12. Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA. Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. Respir Care. 2019 Sep; 64(9):1101-1108.
    View on PubMed
  13. Reilly JP, Calfee CS, Christie JD. Acute Respiratory Distress Syndrome Phenotypes. Semin Respir Crit Care Med. 2019 Feb; 40(1):19-30.
    View on PubMed
  14. Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM. Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy. Am J Respir Crit Care Med. 2019 Apr 01; 199(7):863-872.
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  15. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 Apr; 20(4):323-331.
    View on PubMed
  16. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 Apr; 7(4):e14.
    View on PubMed
  17. Fielding-Singh V, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2019 Apr; 47(4):e375-e376.
    View on PubMed
  18. Fielding-Singh V, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2019 Apr; 47(4):e380-e381.
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  19. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019 03 14; 5(1):18.
    View on PubMed
  20. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M. Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Ann Am Thorac Soc. 2019 03; 16(3):356-362.
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