University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Carolyn S. Calfee, MD

Carolyn S. Calfee, MD

Associate Professor, Department of Medicine, UCSF

Cancer Center Program Memberships

Tobacco Control

Research Summary

My research program focuses on clinical and translational approaches to studying the development of the Acute Respiratory Distress Syndrome (ARDS) in critically ill patients. I have two major areas of focus: (1) the prognostic and pathogenetic value of biomarkers of lung epithelial and endothelial injury in ARDS, including novel approaches to molecular phenotyping of ARDS; and (2) the epidemiology and mechanisms of association between active and passive cigarette smoke exposure and the development of ARDS. I also have a particular interest in the early identification of patients with or at high risk for ARDS, with several publications on clinical and biological approaches to early detection of ARDS.

Education

Yale University, BA, 1991-1995, English
University of Pennsylvania, MD, 1995-1999, Medicine
University of California, San Francisco Internship/Residency, 1999-2002, Internal Medicine
University of California, San Francisco Chief Residency, 2002-2003, Internal Medicine
University of California, San Francisco Fellowship, 2003-2007, Pulmonary/Critical Care
University of California, San Francisco Masters in Clinical Research (expected), 2007-2009, Clinical Research


Professional Experience

  • PROFESSIONAL EXPERIENCE
  • 1999-2002
    Internship and Residency, Internal Medicine, University of California, San Francisco
  • 2002-2003
    Chief Medical Resident, Internal Medicine, Moffitt-Long Hospital, UCSF
  • 2002-2003
    Clinical Instructor, Department of Medicine, UCSF
  • 2002-2003
    Attending Physician, Medical Service, Moffitt-Long Hospital, UCSF
  • 2003-2004
    Clinical Fellow, Pulmonary and Critical Care Division, UCSF
  • 2005-2006
    Advanced Training in Clinical Research Program, UCSF Department of Epidemiology and Biostatistics
  • 2005-2007
    Research Fellow, Pulmonary and Critical Care Division, UCSF
  • 2007-2012
    Assistant Professor, Pulmonary and Critical Care Division, UCSF Dept of Medicine
  • 2012-present
    Associate Professor, Pulmonary and Critical Care Division, UCSF Depts of Medicine and Anesthesia
  • 2007-present
    Faculty, Center for Tobacco Control, Research, and Education, UCSF

Honors & Awards

  • 1994
    Phi Beta Kappa, Yale University
  • 1995
    Bachelor of Arts awarded magna cum laude, with Distinction in the Major
  • 1998
    Alpha Omega Alpha, University of Pennsylvania School of Medicine
  • 1999
    Julia M. Glasgow Award, University of Pennsylvania School of Medicine
  • 1999
    Spencer Morris Prize, University of Pennsylvania School of Medicine
  • 2000
    Intern of the Year, University of California, San Francisco, Department of Medicine
  • 2005
    Walter Travel Award, American Lung Association
  • 2012
    Associate Scientific Advisor, Science Translational Medicine
  • 2013
    American Society for Clinical Investigation Young Physician-Scientist Award
  • 2013
    Highlighted abstract, 2013 American Thoracic Society International Conference (sr. author)
  • 2013
    Finalist, UCSF Pathways to Discovery Mentor Award

Selected Publications

  1. Fan E, Beitler JR, Brochard L, Calfee CS, Ferguson ND, Slutsky AS, Brodie D. COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? Lancet Respir Med. 2020 Jul 06.
    View on PubMed
  2. Sinha P, Matthay MA, Calfee CS. Is a "Cytokine Storm" Relevant to COVID-19? JAMA Intern Med. 2020 Jun 30.
    View on PubMed
  3. Moazed F, Hendrickson C, Conroy A, Kornblith LZ, Benowitz NL, Delucchi K, Cohen MJ, Calfee CS. Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices. Chest. 2020 Jun 20.
    View on PubMed
  4. Sinha P, Churpek MM, Calfee CS. Machine Learning Classifier Models Can Identify ARDS Phenotypes Using Readily Available Clinical Data. Am J Respir Crit Care Med. 2020 Jun 18.
    View on PubMed
  5. Sarma A, Calfee CS. Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention. JAMA Intern Med. 2020 Jun 17.
    View on PubMed
  6. Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS. Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Crit Care Med. 2020 Jun; 48(6):830-837.
    View on PubMed
  7. Reddy K, Sinha P, O'Kane CM, Gordon AC, Calfee CS, McAuley DF. Subphenotypes in critical care: translation into clinical practice. Lancet Respir Med. 2020 Jun; 8(6):631-643.
    View on PubMed
  8. Auriemma CL, Delucchi K, Liu KD, Calfee CS. The attributable mortality of acute respiratory distress syndrome. Intensive Care Med. 2020 May 25.
    View on PubMed
  9. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castaneda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C. Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. medRxiv. 2020 May 19.
    View on PubMed
  10. Wang C, Wolters PJ, Calfee CS, Liu S, Balmes JR, Zhao Z, Koyama T, Ware LB. Long-term ozone exposure is positively associated with telomere length in critically ill patients. Environ Int. 2020 Aug; 141:105780.
    View on PubMed
  11. Wang RJ, Katha G, Phiri M, Delbridge P, Gordon SB, Calfee CS, Huang L, Rylance J. Sonographic B-lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis. Am J Respir Crit Care Med. 2020 Apr 14.
    View on PubMed
  12. Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M. Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Respir Res. 2020 Apr 07; 21(1):81.
    View on PubMed
  13. Crotty Alexander LE, Ware LB, Calfee CS, Callahan SJ, Eissenberg T, Farver C, Goniewicz ML, Jaspers I, Kheradmand F, King TE, Meyer NJ, Mikheev V, Shields PG, Shihadeh A, Strongin R, Tarran R. NIH Workshop Report: E-cigarette or Vaping Product Use Associated Lung Injury (EVALI): Developing a Research Agenda. Am J Respir Crit Care Med. 2020 Apr 03.
    View on PubMed
  14. Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ. Gender Differences in Authorship of Critical Care Literature. Am J Respir Crit Care Med. 2020 04 01; 201(7):840-847.
    View on PubMed
  15. Wilson JG, Calfee CS. ARDS Subphenotypes: Understanding a Heterogeneous Syndrome. Crit Care. 2020 Mar 24; 24(1):102.
    View on PubMed
  16. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med. 2020 Jun; 46(6):1222-1231.
    View on PubMed
  17. Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med. 2020 Mar 09.
    View on PubMed
  18. Shankar-Hari M, Calfee CS. Lack of Clinical Benefit of Interferon ß-1a Among Patients With Severe Acute Respiratory Distress Syndrome: Time to Overhaul Drug Trials in ARDS? JAMA. 2020 Feb 17.
    View on PubMed
  19. Langelier C, Fung M, Caldera S, Deiss T, Lyden A, Prince BC, Serpa PH, Moazed F, Chin-Hong P, DeRisi JL, Calfee CS. Detection of Pneumonia Pathogens from Plasma Cell-Free DNA. Am J Respir Crit Care Med. 2020 02 15; 201(4):491-495.
    View on PubMed
  20. Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN. Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Crit Care Med. 2020 Feb; 48(2):200-209.
    View on PubMed

Go to UCSF Profiles, powered by CTSI